• Journal of Physiology & Pathology in Korean Medicine
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• v.31 no.6
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• pp.374-379
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• 2017

Hair loss affects interpersonal relationships and causes psychological stress. In this study, we investigated the antioxidant activity of Cynanchi Wilfordii Radix (CWR) and its effects on dermal papilla (DP) cells. Antioxidant efficacy was examined by ABTS assay. To confirm the effect on cell activity, MTS assay was performed and cell count was directly measured by hemocytometer. The mRNA expression of genes involved in hair formation and hair loss formation was confirmed by quantitative RT-PCR. CWR has a strong antioxidant activity. Cell viability of DP cells was increased to 118.5% by treatment of 0.5 mg/ml CWR for 24 hours, but the effect on the cell number was insignificant. These results suggest that CWR increases mitochondrial activity without promoting cell proliferation. Treatment of DP cells with 0.5 mg/ml CWR resulted in 48.5% reduction of mRNA expression of type 2 $5{\alpha}$-reductase, a major cause of male hair loss. In addition, mRNA expression of bone morphogenetic pretein (BMP), fibroblast growth factor (FGF)7, and FGF10, which are closely related to hair growth, was also decreased. Reactive oxygen species (ROS) acts as a cause of hair loss. The excellent antioxidant efficacy of CWR is thought to be able to effectively remove ROS. The dihydrotestosterone produced by type 2 $5{\alpha}$-reductase in DP cells is a potent inducer of male pattern hair loss. The inhibitory effect of type 2 $5{\alpha}$-reductase mRNA on DP cells induced by CWR may induce a positive therapeutic effect of male pattern hair loss.

• Biomolecules & Therapeutics
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• v.19 no.2
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• pp.187-194
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• 2011

Atherosclerosis and post-angiography restenosis are associated with intimal thickening and concomitant vascular smooth muscle cell (VSMC) proliferation. Obovatol, a major biphenolic component isolated from the Magnolia obovata leaf, is known to have anti-inflammatory and anti-tumor activities. The goal of the present study was to enhance the inhibitory effects of obovatol to improve its potential as a preventive or therapeutic agent in atherosclerosis and restenosis. Platelet-derived growth factor (PDGF)-BB-induced proliferation of rat aortic smooth muscle cells (RASMCs) was examined in the presence or absence of a newly synthesized obovatol derivative, OD78. The observed anti-proliferative effect of OD78 was further investigated by cell counting and [$^3H$]-thymidine incorporation assays. Treatment with 1-4 ${\mu}M$ OD78 dose-dependently inhibited the proliferation and DNA synthesis of 25 ng/ml PDGF-BB-stimulated RASMCs. Accordingly, OD78 blocked PDGF-BB-induced progression from the $G_0/G_1$ to S phase of the cell cycle in synchronized cells. OD78 decreased the expression levels of CDK4, cyclin E, and cyclin D1 proteins, as well as the phosphorylation of retinoblastoma protein and proliferating cell nuclear antigen; however, it did not change the CDK2 expression level. In addition, OD78 inhibited downregulation of the cyclin-dependent kinase inhibitor (CKI) $p27^{kip1}$. However, OD78 did not affect the CKI $p21^{cip1}$ or phosphorylation of early PDGF signaling pathway. These results suggest that OD78 may inhibit PDGF-BB-induced RASMC proliferation by perturbing cell cycle progression, potentially through $p27^{kip1}$ pathway activation. Consequently, OD78 may be developed as a potential anti-proliferative agent for the treatment of atherosclerosis and angioplasty restenosis.

• Journal of Korean Academy of Fundamentals of Nursing
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• v.7 no.2
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• pp.271-286
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• 2000

This study is designed to investigate what elders think about the meaning of aging. We have used Q-methods to identify meaning of aging from elders, and developed self-referenced surveys to analyze characteristics In this study, we used a non-structured method to select Q sampling. From 183 Q populations, we selected 36 Q sampling. A total of 32 persons sixty-years or older were randomly selected for P samples, When the Q-sorting was complete, we interviewed the participants at both end of the extremes(agree or disagree), and documented their responses. We used PC QUANL to process the data and used principal component analysis for Q factor analysis. There were five subjective types for the meaning of aging by elders. Of the 32 P-samples of elders, 11 were identified as Type 1, 7 as Type 2, 2 as Type 3, 8 as Type 4, and 4 as Type 5. Type 1 : 'Matured elders' Elders wished the well being of their children, thought older persons should maintain good health, worried about becoming senile, and dependent God believing in life after death. Type 2 : 'Assertive-Rights' Elders categorized as Assertive-Rights insisted on their rights to life as a person. Type 2 elders characterized themselves as people who should keep themselves healthy, become weak and lack sexual desires, act selfish like a child, need to be protected, and be financially independent. Type 3 : 'Passive-Dependents' Elders characterize themselves as those who pray for their children's well being, worry about the children even after their death. and becoming senile. Type 4 : 'Hopeless' The 'Hopeless' type of elders characterized aging as a time to pray for their children, insignificant beings, thoughts were selfish and child-like, poor, worried about going senile, regret their life overall, and preferred to die than to live as an old person. Type 5 : 'Attached-Present' The 'Attached-Present' type of elders thought elderly characterized themselves as acting selfish and child-like, wiser, anxious, regret their life, stand aloof of greed and worldly things, being a model for the society, and deserving to be treated with filial respect. Thus far, Korean elders seemed to have a positive and negative meaning of aging due to the current changes in the society, value system, and family structures. The above five subjective meanings of aging confirm that we need to approach and nurse the elderly differently. Years of aging are a part of and a natural process of life with various physical, psychological, and sociological changes. Nurses need to assist elderly to find the positive meaning of their life by providing appropriate physical, psychological, and social support at an earlier stage in nursing. Based on this study, we could derive the following two implication from the perspectives of science of nursing to care for elders. 1) Based on the studies investigating the type of meaning of aging, we could develop tools to assist in nursing intervention programs for elderly. 2) Based on research on the meaning of aging for different developmental stages of life, we could develop a model for roles for different family members in nursing and caring for the elders.

• Journal of the Korea Convergence Society
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• v.9 no.9
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• pp.293-297
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• 2018

The purpose of this study was to determine the influence of video modeling observational learning intervention on the learning and performance of a bowling skill in adolescents with intellectual disabilities. Thirty special middle school students whose ages ranged from 14 to 16 years were recruited from Daegu, Korea. Intellectual disabilities of the participants were assessed by Korean version of the Wechsler intelligence scale for adolescent and a social maturity scale. During the experiment, participants repeatedly watched the one-minute action observation film for three minutes before beginning each frame and played 60 frames. Statistical comparisons were performed using a 2 (groups) ${\times}$ 6 (trials) ANOVA, with repeated measures on the last factor of the acquisition stage (p<0.05). Factors of the retention stage scores were analyzed by one-way ANOVA. The sources of any significant main effects were tested using a Tukey's HSD (honest significant difference) approach. SPSS 21.0 was used for statistical analyses. The performance scores of the action observation group were significantly higher than those of the control group. The findings showed that observational learning in the form video modeling has the potential to enhance acquisition and learning of a bowling sport skill in intellectual disability individuals; however, these findings are limited to adolescents with moderate intellectual disabilities.

• Journal of the Economic Geographical Society of Korea
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• v.4 no.2
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• pp.57-77
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• 2001

The Honam region has been recognized as one of the most lagging regions in Korea. Drawing upon some decompositions oi Gross Regional Domestic Product(GRDP) per head and labor productivity, the overall trend of inequalities in Korea has been revealed and the trajectory of the Honam region's economic change has been identified by examining how the region's economic performance changed relative to that of Korea in the 1990s. There are some findings. First of all, Korea is characterized by strong divergence in the development of its region economies, in terms o\ulcorner per capita GRDP, which relies upon productivity differentials rather than differences in employment rates. Second, the Honam region has displayed poor economic performances in terms of GRDP per head except for Jeonnam. Third, the dramatic fall in cumulative population growth relative to the national average has been an important factor in the Jeonnam's overwhelming economic performance measured by per capita GRDP. Fourth, the decline in the relative productivity of the Honam region is mostly explained by falling relative regional productivity growth in construction, transport and manufacturing, although it should be noted that the latter sector has made positive contribution to raising relative regional productivity of Jeonnam. Fifth, overall the shift in employment to service sector, especially to social, personal, public, health, education, other services other than distribution, hotels, catering has tended to support relative regional productivities, along with the positive contribution being made oi agriculture, forestry and fishing to relative regional productivity growth in the Honam region.

• The Korean Journal of Emergency Medical Services
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• v.13 no.2
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• pp.99-108
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• 2009

Purpose : The purpose of this study is to offer basic data in arranging the improved working environment to Emergency Medical Technicians, by analyzing the influence of job satisfaction in Emergency Medical Technician within hospital upon organizational commitment. Method : This study was carried out targeting 203 Emergency Medical Technicians who are working at hospitals in B Metropolitan City, U Metropolitan City, D Metropolitan City, an d G Province. The data collection was performed from April 1, 2009 to June 10. The statistical processing was used a program of SPSS WIN 12.0 Version. The statistical significance was set to p<.05. Results : 1. In the descriptive statistics of the job satisfaction and the organizational commitment. the whole average for job satisfaction was 3.06 points. The whole average for organizational commitment was 3.05 points. 2. In the difference between job satisfaction and organizational commitment, the group for job satisfaction was indicated to be statistically significant in job-choice motive(F=2.710, p<.05) and turnover propensity(t=.662, p<.001). The group for organizational commitment was indicated to be statistically significant in working department(F=2.871, p<.05), job-choice motive(F=2.944, p<.05), turnover propensity(t=.903, p<.001), and turnover reason(F=3.415, p<.01). 3. In the correlation between job satisfaction and organizational commitment, the job satisfaction showed positive correlation(r=.736, p<.01) with organizational commitment. 4. As for the influence of job-satisfaction factor upon organizational commitment, salary(${\beta}$=.162, t=2.739, p<.01), autonomy(${\beta}$=.372, t=4.633, p<.001), working environment(${\beta}$=.139, t=1.968, p<.05), and organizational needs(${\beta}$=.172, t=2.291, p<.05) were indicated to have significant effect on organizational commitment. Conclusion : The institutional arrangement is considered to be likely to be necessarily made highly for improving social image and enhancing salary and working environment so that Emergency Medical Technician within hospital can be enhanced job satisfaction and organizational commitment.

• Journal of Korean Society of Forest Science
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• v.96 no.3
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• pp.325-337
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• 2007

Illegal slash-and-bum fields and slash-and-bum farmers in Korea had increased in spite of Japanese Joseon Government's strong regulations and clearance measures, and land reform after the 1945 Liberation of Korea until 1970s. This study is to inquire into the necessary and sufficient conditions to disappear entirely the matters from 1974 to 1979 that illegal slash-and-bum fields and slash-and-burn farmers continued long in existence until the early 1970s. The findings are as follows; Firstly, the population pressure to agricultural lands that main factor of generation of illegal slash-and-bum fields had decreased rapidly because the rural populations and less income farmers have decreased after 1967. Especially, the decrease of the rural populations had never seen to the 1970s. It is recognised that the social condition for the success in 1970s. Secondly, the continuous economic growth from the early 1960s enabled the Korean government to solve the matter through the sufficient financial investment from the Government. For example, the gross national product (GNP) and the government budget in 1974 increased around 25 times after 1960. It is recognised that the economic condition for the success in 1970s. Finally, it was enabled to remove the concealment from the slash-and-bum farmers and to monitor illegal re-cultivation thoroughly because the development of forest inventory technique using an aerial photograph and the expansion of road facilities. It is recognised that the technical condition for the success in the 1970s.

• Asian Pacific Journal of Cancer Prevention
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• v.15 no.7
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• pp.2959-2964
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• 2014

While several reproductive and lifestyle-related factors are already well-known as established risk factors for breast cancer, environmental factors have attracted attention only recently. The objective of the current study was to assess the association between the breast cancer incidences in females, the mortality rate and the number of motor vehicles on the one side and the consumption of gasoline which could work as a major source of air pollution at the other side. The breast cancer incidences and the mortality trends were compared with various indices of westernization like dietary patterns or industrialization with 10 years lag of time. Geographical variations with 10, 15 and 20 years lag of time were assessed between the breast cancer incidence in 2010 and the number of motor vehicles as well as the consumption of gasoline. The upward trend of motor vehicle numbers proved to be comparable to those of breast cancer incidence and mortality. However, the consumption of gasoline started to decrease since the mid-1990s. The geographic distribution of motor vehicle numbers and gasoline consumption in 1990 is in a positive correlation with the breast cancer incidence rates in 2010 and the 20-year lag time ($R^2$ 0.379 with the number of motor vehicles and 0.345 with consumption of gasoline). In a linear relationship between the breast cancer incidences in 2010 and the log transformed number of motor vehicles, the log transformed consumption of gasoline in 2000 also showed a positive relationship ($R^2$ 0.367 with the number of motor vehicles and 0.329 with consumption of gasoline). The results of the current study indicate that there may be a positive relation between the number of vehicles, gasoline consumption and the incidence of breast cancer from the aspects of long-term trends and geographical variation.

• Asia-Pacific Journal of Business Venturing and Entrepreneurship
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• v.2 no.2
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• pp.49-68
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• 2007

This paper develop self pre-checkup lists for the validity of business model as web business starters can utilize to open business. In particular, self pre-checkup lists invented by Dr. Bruce Merrifield, is reapplied and modified in appropriate to internet shopping mall business. This paper complete many literature reviews to identify appropriate factors of evaluation such as about the characters of internet business, business validity testing theory for internet business model, pros and cons of e-business and startup ventures, factor analysis of technology valuation, and pros and cons for internet shopping mall. This paper define six different factors; scale of sales, the growth rate of market, competitiveness, risk portfolio, industry upside down, and social conditions, as the factors of evaluating the business attractiveness. Meanwhile, it define characters of CEO, content's power, mutual inclusion, commerce, fulfillment, marketing power as the factors of business appropriateness. This paper also conducts several case studies; company I, D, G of applying the former model. This paper sort out internet business model in imaginations by utilizing self pre-checkup lists of business evaluation. Also, the outcomes of evaluation is expected to provide meaningful future business implications.

• The Journal of the Korea Contents Association
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• v.11 no.8
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• pp.353-364
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• 2011

The present study began from the criticism that the discussions related to the existing digital media have focused on the technical productivity and effectiveness to focus on the positive perspective. Therefore, this study will concretely confirm the dangers that may be caused by digital media and confirm the overall risk perception for digital media such as the user's opinions for risk evaluations and risk management for such dangers. As a result of making the digital convergence media, the smart phone, as the detail study subject, the 17 risk types including the 'risks of financial dimensions, risks of social-cultural dimensions, risks of individual dimensions and risks of pathological dimensions' were classified. Furthermore, the users appeared to highly evaluate the seriousness and possibilities of risks as a result of analyzing the risk-factor per each risk type(risk magnitude ${\times}$ development possibility). Next, it appeared that the users did not have high degree of reliability for the government in the aspects of countermeasures and prevention of risks and appeared to highly evaluate their expectation and liability for their individual roles. If the seriousness and development possibilities, the evaluations for liability, preventative measures and post-management methods for the risks of smart phones can be thoroughly analyzed and applied, it will be able to expand them as significant political countermeasures that can reduce the risks of other digital media in the future.