• 한국사회복지학
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• 제60권3호
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• pp.83-106
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• 2008

본 연구는 지적장애인은 의사소통능력이 부족하고 진술에의 진실성을 담보하기 어렵기 때문에 연구과정에 이들을 포함시키는데 소극적인 입장에서 탈피, 지적장애인의 적극적인 참여 패러다임으로의 변화를 강조한다. 이와 관련하여 '언어를 매개로 한 의사소통능력의 부족'은 지적장애인의 특성을 고려한 면접도구 개발과 대화분석방법을 도입함으로써, '진술의 진실성'에 대해서는 사회적 실재의 재현(representation)을 둘러싼 다양한 질적연구방법을 개발하고 진술 의미를 재구조화함으로써, 그리고 무지에 따른 배제와 억압의 메커니즘은 지적장애인의 삶 드러내기를 통해 극복될 수 있음을 보여주고 있다. 동 연구결과는 앞으로 장애정도별로 다양한 자료 수집 및 분석방법이 개발되어야 하며 아울러 각종 정부연구용역에서 지적장애인이 연구과정에 포함되도록 하는 연구방법론의 변혁이 필요하다는 함의를 제공해 준다.

• Biomolecules & Therapeutics
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• 제30권3호
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• pp.232-237
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• 2022

Autism spectrum disorder (ASD) having core characteristics of social interaction problems and repetitive behaviors and interests affects individuals at varying degrees and comorbidities, making it difficult to determine the precise etiology underlying the symptoms. Given its heterogeneity, ASD is difficult to treat and the development of therapeutics is slow due to the scarcity of animal models that are easy to produce and screen with. Based on the theory of excitation/inhibition imbalance in the brain with ASD which involves glutamatergic and/or GABAergic neurotransmission, a pharmacologic agent to modulate these receptors might be a good starting point for modeling. N-methyl-D-aspartic acid (NMDA) is an amino acid derivative acting as a specific agonist at the NMDA receptor and therefore imitates the action of the neurotransmitter glutamate on that receptor. In contrast to glutamate, NMDA selectively binds to and regulates the NMDA receptor, but not other glutamate receptors such as AMPA and kainite receptors. Given this role, we aimed to determine whether NMDA administration could result in autistic-like behavior in adolescent mice. Both male and female mice were treated with saline or NMDA (50 and 75 mg/kg) and were tested on various behavior experiments. Interestingly, acute NMDA-treated mice showed social deficits and repetitive behavior similar to ASD phenotypes. These results support the excitation/inhibition imbalance theory of ASD and that NMDA injection can be used as a pharmacologic model of ASD-like behaviors.

• The Korean Journal of Pain
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• 제35권1호
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• pp.22-32
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• 2022

Background: Migraine headaches have been associated with sensory hyperactivity and anomalies in social/emotional responses. The main objective of this study was to evaluate the potential involvement of orexin 1 receptors (Orx1R) within the basolateral amygdala (BLA) in the modulation of pain and psychosocial dysfunction in a nitroglycerin (NTG)-induced rat model of migraine. Methods: Adult male Wistar rats were injected with NTG (5 mg/kg, intraperitoneal) every second day over nine days to induce migraine. The experiments were done in the following six groups (6 rats per group): untreated control, NTG, NTG plus vehicle, and NTG groups that were post-treated with intra-BLA microinjection of Orx1R antagonist SB-334867 (10, 20, and 40 nM). Thermal hyperalgesia was assessed using the hot plate and tail-flick tests. Moreover, the elevated plus maze (EPM) and open field (OF) tests were used to assess anxiety-like behaviors. The animals' sociability was evaluated using the three-chamber social task. The NTG-induced photophobia was assessed using a light-dark box. Results: We observed no change in NTG-induced thermal hyperalgesia following administration of SB-334867 (10, 20, and 40 nM). However, SB-334867 (20 and 40 nM) aggravated the NTG-induced anxiogenic responses in both the EPM and OF tasks. The NTG-induced social impairment was overpowered by SB-334867 at all doses. Time spent in the dark chamber of light-dark box was significantly increased in rats treated with SB-334867 (20 and 40 nM/rat). Conclusions: The findings suggest a role for Orx1R within the BLA in control comorbid affective complaints with migraine in rats.

• Journal of the Korean Academy of Child and Adolescent Psychiatry
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• 제12권1호
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• pp.79-93
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• 2001

목 적：주의력결핍/과다활동장애(ADHD) 아동들은 또래관계를 영위하는데 필요한 것을 포함한 다양한 사회기술에 결함을 보인다. 이들의 치료에 약물치료를 포함한 부모훈련, 교육적 접근 등이 필요하지만 이와 함께 이들에 대한 사회기술훈련이 시도되고 있다. 이들에게서 사회기술훈련을 적용하여 그 효과를 검증해보고자 한다. 방 법：ADHD로 진단 받은 초등학교 아동 5명과 그들의 부모 5명을 대상으로 Pfiffner와 McBurnett이 제안한 프로그램을 중심으로 총 8회기의 프로그램을 수행하고, 사회기술, 문제행동, 또래의 사회적 수용도, 양육태도 및 양육스트레스, 프로그램 만족도를 비교해 보았다. 결 과：교사와 부모가 평가한 내용이 다소 달랐는데, 교사는 사회기술과 또래의 사회적 수용도에서, 부모는 문제행동의 감소에서 유의미한 호전을 보고하였다. 부모들은 양육태도에서는 별 변화가 없었지만 양육스트레스에서는 현저한 감소를 보고하였으며, 프로그램 만족도는 상당히 높았다. 결 론：ADHD 아동에서 사회기술훈련은 최근에, 주로 보조적이거나 매우 제한적으로 시행되고 있다. 하지만 상당히 많은 아동들이 사회기술의 결함을 호소하고 있기 때문에 이들이 통합적 접근에서 이들의 치료 프로그램에 포함되어 시행하는 것이 바람직하겠다.

• 생물정신의학
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• 제24권3호
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• pp.149-154
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• 2017

Objectives This study investigated associations between symptom severity and neurocognitive functions in patients with major depressive disorder using comprehensive neuropsychological tests. Methods Ten patients with low depression (LD) and 22 patients with high depression (HD) participated. Symptom severity was determined by both the Beck Depression Inventory and the Hamilton Depression Rating Scale. Additionally, anxiety was measured by the Korean version of the State-Trait Anxiety Inventory (STAI-KYZ). Ten subtests of the Korean-Wechsler Adult Intelligence scale (K-WAIS), Stroop test, the word/design fluency tests were administered to assess cognition. Results The LD and HD groups did not differ in any of cognitive measures but anxiety level. Namely, the HD group obtained significantly higher scores on the state (U = 29.50, p < 0.01) and trait (U = 28.50, p < 0.001) anxiety scales than the LD group. A significant interaction effect between trait anxiety and depression severity was observed on the picture arrangement subtest of the K-WAIS [F (1, 27) = 5.09, p < 0.05]. Conclusions Cognitive deficits observed in patients with major depressive disorder may be related to other factors rather than current symptom severity. Trait anxiety possibly moderates the effect of current symptom severity on social judgment in these patients.

• Clinical and Experimental Pediatrics
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• 제58권1호
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• pp.8-14
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• 2015

In patients with a language developmental delay, it is necessary to make a differential diagnosis for autism spectrum disorders (ASDs), specific language impairment, and mental retardation. It is important that pediatricians recognize the signs and symptoms of ASDs, as many patients with language developmental delays are ultimately diagnosed with ASDs. Pediatricians play an important role in the early recognition of ASDs, because they are usually the first point of contact for children with ASDs. A revision of the diagnostic criteria of ASDs was proposed in the Diagnostic and Statistical Manual of Mental Disorders, fifth edition (DSM-5) that was released in May 2013. The autism spectrum describes a range of conditions classified as neurodevelopmental disorders in the fifth edition of the DSM. The new diagnostic criteria encompasses previous elements from the diagnosis of autistic disorder, Asperger disorder, childhood disintegrative disorder, and pervasive developmental disorder-not otherwise specified. An additional change to the DSM includes synthesizing the section on social and communication deficits into one domain. In ASD patients, the appropriate behavioral therapies and rehabilitation treatments significantly affect the prognosis. Therefore, this makes early diagnosis and treatment very important. In conclusion, pediatricians need to be able to recognize the signs and symptoms of ASDs and be attentive to them in order to make an early diagnosis and provide treatment.

• 농촌지도와개발
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• 제15권4호
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• pp.551-576
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• 2008

The European Union has an active rural development policy because this helps us to achieve valuable goals for our countryside and for the people who live and work there. Rural development policy involves the cofinancing by the EU and Member States of a variety of measures. Member States decide on the most appropriate measures for their rural areas from a menu of measures proposed at EU level. There are 18 Leader+ programs in Spain. Program supports Local Action Groups which are located in two or more autonomous regions. The Valle del Jerte, located in the northwest of the province of Caceres is one of the districts making up what is known as the Alta Extremadura. The rural development strategy in this area is to overcome the great deficits of the rural world, prevent rural exodus by improving the quality of life of the population,and improve the soicoeconomic environment of the district in order to help create jobs and improve family incomes. Specifically they try to create a mechanism to improve involvement, communication and social cohesion in the district, with a view to improving the internal structure of organizations and establishing rural channels for cooperation between district institutions for integrated development of the district.

• 농촌계획
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• 제24권3호
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• pp.43-54
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• 2018

The residential population of Jeju Island has increased more than 10% for last 10 years. Especially, the tourist population is more than twice comparing to 2005. The population growth of Jeju has brought about large-scale urban development and increased land demands for tourism services. The goal of this study is to analyze the human, social, and environmental status of Jeju Island and to evaluate the environmental capacity of land use using ecological footprint (EF) model. This study shows the changes in ecological deficits of Jeju Island through estimating ecological productive land (EPL) considering EF from 2005 to 2015. The categories of total EF consists of food land, built-up land, forestry, and energy consumption. In order to reflect the characteristics of resort island, we consider not only residential population but also tourist population who can increase land demands. The outputs of this study also provide the potential excess demands of EPL and suggest needs of sustainable management plans for the limited land of Jeju Island.

• Journal of Preventive Medicine and Public Health
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• 제46권sup1호
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• pp.50-54
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• 2013

Out-of-home mobility is necessary for accessing commodities, making use of neighborhood facilities, and participation in meaningful social, cultural, and physical activities. Mobility also promotes healthy aging as it relates to the basic human need of physical movement. Mobility is typically assessed either with standardized performance-based tests or with self-reports of perceived difficulty in carrying out specific mobility tasks. Mobility declines with increasing age, and the most complex and demanding tasks are affected first. Sometimes people cope with declining functional capacity by making changes in their way or frequency of doing these tasks, thus avoiding facing manifest difficulties. From the physiological point of view, walking is an integrated result of the functioning of the musculoskeletal, cardio-respiratory, sensory and neural systems. Studies have shown that interventions aiming to increase muscle strength will also improve mobility. Physical activity counseling, an educational intervention aiming to increase physical activity, may also prevent mobility decline among older people. Sensory deficits, such as poor vision and hearing may increase the risk of mobility decline. Consequently, rehabilitation of sensory functions may prevent falls and decline in mobility. To promote mobility, it is not enough to target only individuals because environmental barriers to mobility may also accelerate mobility decline among older people. Communities need to promote the accessibility of physical environments while also trying to minimize negative or stereotypic attitudes toward the physical activity of older people.

• 의학교육논단
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• 제24권3호
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• pp.180-192
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• 2022

Research suggests that medical students frequently experience mental health problems such as stress, burnout, and depression, which may, in turn, affect suicidal ideation and behaviors. Since mental health problems profoundly impact academic achievement and professionalism, it is vital to understand factors influencing students' mental health and identify strategies to provide the necessary support. Some relevant influencing factors range from the personal level, including gender, personality traits, perfectionism, and social support, to the environmental level, including the grading system, educational phases, exposure to patients' death, mistreatment, and culture of medicine. In this regard, a comprehensive mental health support system that encompasses environmental interventions, as well as personal-level support, is needed. Simultaneously, proactive approaches that address the improvement of self-care and alleviation of systemic burdens are essential, together with the predominant reactive approaches focusing on problems and deficits. Altogether, we proposed a framework for enhancing mental health constructed by four categories (personal-reactive, environmental-reactive, personal-proactive, environmental-proactive) based on the intervention level and goal of support. All four categories have important implications, and one cannot replace the other, but expanding environmental-proactive support will allow more students to learn how to pursue health independently. We expect that this comprehensive framework for enhancing mental health could expand support systems for medical students' personal and professional development.