• The Korean Journal of Physiology and Pharmacology
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• v.24 no.4
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• pp.287-298
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• 2020

Ca²⁺ signaling of endothelial cells plays a critical role in controlling blood flow and pressure in small arteries and arterioles. As the impairment of endothelial function is closely associated with cardiovascular diseases (e.g., atherosclerosis, stroke, and hypertension), endothelial Ca²⁺ signaling mechanisms have received substantial attention. Increases in endothelial intracellular Ca²⁺ concentrations promote the synthesis and release of endothelial-derived hyperpolarizing factors (EDHFs, e.g., nitric oxide, prostacyclin, or K⁺ efflux) or directly result in endothelial-dependent hyperpolarization (EDH). These physiological alterations modulate vascular contractility and cause marked vasodilation in resistance arteries. Transient receptor potential (TRP) channels are nonselective cation channels that are present in the endothelium, vascular smooth muscle cells, or perivascular/sensory nerves. TRP channels are activated by diverse stimuli and are considered key biological apparatuses for the Ca²⁺ influx-dependent regulation of vasomotor reactivity in resistance arteries. Ca²⁺-permeable TRP channels, which are primarily found at spatially restricted microdomains in endothelial cells (e.g., myoendothelial projections), have a large unitary or binary conductance and contribute to EDHFs or EDH-induced vasodilation in concert with the activation of intermediate/small conductance Ca²⁺-sensitive K⁺ channels. It is likely that endothelial TRP channel dysfunction is related to the dysregulation of endothelial Ca²⁺ signaling and in turn gives rise to vascular-related diseases such as hypertension. Thus, investigations on the role of Ca²⁺ dynamics via TRP channels in endothelial cells are required to further comprehend how vascular tone or perfusion pressure are regulated in normal and pathophysiological conditions.

• Tribology and Lubricants
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• v.30 no.2
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• pp.108-115
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• 2014

The friction behaviors of bulk amorphous thermal spray coating (BAC) and second phase-reinforced composite coatings using a high velocity oxy-fuel spraying process were investigated using a ball-on-disk test rig that slides against a ceramic ball in an atmospheric environment. The surface temperatures were measured using an infrared thermometer installed 50 mm from the contact surface. The crystallinities of the coating layers were determined using X-ray diffraction. The morphologies of the coating layers and worn surfaces were observed using a scanning electron microscope and energy-dispersive spectroscopy. The results show that the friction behavior of the monolithic amorphous coating was sensitive to the testing conditions. Under lower than normal loads, a low and stable friction coefficient of about 0.1 was observed, whereas under a higher relative load, a high and unstable friction coefficient of greater than 0.3 was obtained with an instant temperature increase. For the composite coatings, a sudden increase in friction coefficient did not occur, i.e., the transition region did not exist and during the friction test, a gradual increase occurred only after a significant delay. The BAC morphology observations indicate that viscous plastic flow was generated with low loads, but severe surface damage (i.e., tearing) occurred at high loads. For composite coatings, a relatively smooth surface was observed on the worn surface for all applied loads.

• International Journal of Automotive Technology
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• v.3 no.1
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• pp.27-32
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• 2002

Semi-active suspension systems are greatly expected to be in the mainstream of future controlled suspensions fur passenger cars. In this study, a continuous variable damper for a passenger car suspension is developed. It is controlled actively and exhibits high performance with light weight, low cost, and low energy consumption. To get fast response of the damper, reverse damping mechanism is adapted, and to get small pressure change rate after blow-off, a pilot controlled proportional valve is designed and analyzed. The reverse continuous variable damper is designed as a HS-SH damper which offers good body control with reduced transferred input force from tire, compared with any other type of suspension system. The damper structure is designed, so that rebound and compression damping force can be tuned independently, of which variable valve is placed externally. The rate of pressure change with respect to the flow rate after blow-offbecomes smooth when the fixed orifice size increases. Damping forces are measured with the change of the solenoid current at the different piston velocities to confirm the maximum hysteresis of 20N, linearity, and variance of damping farce. The damping farce variance is wide and continuous, and is controlled by the spoof opening, of which scheme is usually adapted in proportional valves. The reverse continuous variable damper developed in this study is expected to be utilized in the semi-active suspension systems in passenger cars after its performance and simplicity of the design is confirmed through real car test.

• Korean Journal of Materials Research
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• v.23 no.12
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• pp.732-736
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• 2013

AlN epilayers were grown on a c-plane sapphire substrate using hydride vapor phase epitaxy (HVPE). A series of AlN epilayers were grown at $1120^{\circ}C$ with V/III ratios 1.5, 2.5 and 3.5, and the influence of V/III ratio on their properties was investigated. As the V/III ratio was increased, the surface roughness (RMS roughness), Raman shift of $E_2$ high peaks and full-width at half-maximum (FWHM) of symmetrical (002) & asymmetrical (102) of the AlN epilayers increased. However, the intensities of the Raman $E_2$ high peaks were reduced. This indicates that the crystal quality of the grown AlN epilayers was degraded by activation of the parasitic reaction as the V/III ratio was increased. Smooth surface, stress free and high crystal quality AlN epilayers were obtained at the V/III ratio of 1.5. The crystal quality of AlNepilayers is worsened by the promotion of three-dimensional (3D) growth mode when the flow of $NH_3$ is high.

• The Journal of Internal Korean Medicine
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• v.15 no.1
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• pp.80-98
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• 1994

According to the original documents, Sagungsan is considered as an effective drug for controlling the hypertensive epistaxis induced by tension of autonomic nerve and it's hyperfunction. The present experiment was designed to understand the effect of Sagungsan extract on the hemostatic action, intracranial pressure, blood pressure and cardiovascular system in experimental animals. And thus the bleeding time, prothrombin time, capillary dilation, blood pressure, Intracranial pressure, and enzymatic analysis of the ATPase activities were studied. The result obtained here were as followings: 1. Sagungsan water extract reduced the bleeding time in mouse, and prolonged the prothrombin time in rabbits. 2. The drug extract increased the tail volume by capillary dilation in rats. 3. The drug extract inhibited the increase of intracranial pressure and arterial blood pressure in rabbits. 4. At the early time, the increase of arterial blood pressure by the drug extract significantly inhibited by pretreated atropin and regitine in rabbits. 5. The drug extract relaxed the smooth muscle by stimulating the Mg2+-Ca2+-ATPase activities of gastric sarcoplasmic reticulum isolated from rabbit stomach. 6. The drug extract stimulated the heart contraction by inhibiting the $Mg^{2+}-Ca^{2+}-ATPase$ activities of cardiac sarcoplasmic reticulum isolated from rabbit heart. The inhibitory mechanism was reversible and noncompatitive. 7. The drug extract increased the hepatic blood volume by stimulating the hepatic total ATPase activities and hepatic metabolism. 8. The drug extract acted as a tranquilizer by inhibiting the neural Na+-K+-ATPase activity. According to the results, Sagungsan water extract dilated the capillaries, stimulated the heart beat, and thus increased the blood flow with decreasing the intracranial pressure and blood pressure. These effects stanches the epistaxis collectively.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.13 no.5
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• pp.1954-1962
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• 2012

Recently the increase in the exchange of goods between Europe and Asia caused by social and economic factors creates good opportunities for railways. At the same time, however, it becomes an enormous challenge for railway transport. There are different rail track gauges (i.e narrow/standard/broad gauge) on the continental transportation between Korea (TKR) and Eurasian (TCR/TSR). The existence of various track gauges is one of obstacles preventing the smooth flow of goods by rail. The transferring process system from one track gauge to another could vary with the types of cargo. Service operation of these systems has a decisive effect on working time and cost of storage and transshipment facilities at border crossings. In relation to the above-mentioned factors, it is important to examine the comparison between different methods of transferring goods in different track gauges. In this study, it was performed to evaluate the effectiveness of continental railway transportation systems through analysis scenarios and to suggest technical factors of them.

• Analytical Science and Technology
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• v.8 no.3
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• pp.265-272
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• 1995

Schiff base ligand columns and glow discharge detector have been developed for the trace analysis of metal ions desolved in water. Various types of hydrazide Schiff base ligands have been used and, additionally, they were examined as a filling material of a HPLC column. The hydrazide Schiff base ligands used were N, N'-oxalybis(salicylaldehydrazone) (OBSH), N, N'-malonylbis(salicylaldehydrazone) (MBSH), and N, N'-succinylbis(salicylaldehydrazone) (SBSH). A mixture of Schiff base ligand and poly(styrene divinylbenzene) was examined and it showed a smooth flow of solution. The OBSH-polymer column demonstrated different effluent factors for different metal ions. Metal ions in eluates were detected by Hollow Cathode Glow Discharge-Atomic Emission Spectrometry(HCGD-AES). HCGD-AES showed good sensitivity and selectivity. This is only the preliminary results of new OBSH-polymer column and glow discharge detector.

• Proceedings of the Korean Institute Of Construction Engineering and Management
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• 2008.11a
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• pp.800-803
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• 2008

Road is one of the infrastructure facilities, on which lines include various information for guiding a smooth traffic flow. This line marking work is continually removed and re-marked during maintenance. However, some problems exist when the line marking work is conducted. Traditional methods of using grinders and torches have risk of repetitive skill, and workers are exposed directly to the hazardous situations. Moreover, even though the equipment has developed, the line removing work induces environmental contamination and pollution line on the road. Therefore, this study can become one of the eco-friendly cleaning technologies using dry ice blaster equipment, and the new development of equipment will improve method of pavement marking removal. Also, it can introduce innovative automation in construction.

• Korean Journal of Air-Conditioning and Refrigeration Engineering
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• v.19 no.9
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• pp.640-646
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• 2007

The cooling heat transfer coefficient of $CO_2$ (R-744) for tube and coil diameter (CD), inclined angle of tube and coil pitch of inclined helical coil type copper tubes were investigated experimentally. The main components of the refrigerant loop are a receiver, a variable-speed pump, a mass flow meter, a pre-heater and a inclined helical coil type gas cooler (test section). The test section consists of a smooth copper tube of 2.45 and 4.55 mm inner diameter (ID). The refrigerant mass flukes were varied from 200 to 800 [$kg/m^2s$] and the inlet pressures of gas cooler were 7.5 to 10.0 [MPa]. The heat transfer coefficients of $CO_2$ in inclined helical coil tube with 2.45 mm ID are $5{\sim}10.3%$ higher than those of 4.55 mm. The heat transfer coefficients of 41.35 mm CD are $8{\sim}32.4%$ higher than those of 26.75 mm CD. Comparison between $45^{\circ}\;and\;90^{\circ}$ of coil angle, the heat transfer coefficients of $45^{\circ}$ are higher than those of $90^{\circ}$. For coil pitch of gas cooler, the heat transfer coefficients of inclined helical coil gas cooler with coil pitch of 5 mm are similar to those of 10 and 15 mm.

• Journal of the Korea Society for Simulation
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• v.23 no.1
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• pp.11-20
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• 2014

In this paper, we analyze the performance and reliability of the next-generation KRTCS (Korea Radio Train System) network. The KRTCS has been designed to manage and control the overall status of trains including location, speed, stop position, door open/close status and interior monitoring and so forth. System faults of the KRTCS operation can lead to the disruption of smooth train flow, even to terrible traffic accident. Prior to installation we need to assure the reliability of the designed KRTCS system. For this purpose, we simulated and analyzed the KRTCS network using QualNet simulator, assuming the various environmental operation data of train flows and communication faults that can be found in real telecommunication networks.