• The Journal of Korean Physical Therapy
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• v.20 no.1
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• pp.57-65
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• 2008

Purpose: Heat shock proteins (HSPs) are a group of proteins that are activated when cells are exposed to a variety of environmental stresses, such as infection, inflammation, exposure to toxins, starvation, hypoxia, brain injury, or water deprivation. The activation of HSPs by environmental stress plays a key role in signal transduction, including cytoprotection, molecular chaperone, anti-apoptotic effect, and anti-aging effects. However, the precise mechanism for the action of small HSPs, such as HSP27 and mitogen-activated protein kinases (MAPKs: extracellular-regulated protein kinase 1/2 (ERK1/2), p38MAPK, stress-activated protein kinase/c-Jun N-terminal kinase (SAPK/JNK), is not completely understood, particularly in application of cell stimulators including platelet-derived growth factor (PDGF), angiotensin II (AngII), tumor necrosis factor $\alpha$ (TNF$\alpha$), and $H_2O_2$. This study examined the relationship between stimulators-induced enzymatic activity of HSP27 and MAPKs from rat smooth and skeletal muscles. Methods: 2-dimensional electrophoresis (2DE) and matrix assisted laser desorption ionizationtime-of-flight/time-of-flight (MALDI-TOF/TOF) analysis were used to identify HSP27 from the intact vascular smooth and skeletal muscles. Three isoforms of HSP27 were detected on silver-stained gels of the whole protein extracts from the rat aortic smooth and skeletal muscle strips. Results: The expression of PDGF, AngII, TNF$\alpha$, and $H_2O_2$-induced activation of HSP27, p38MAPK, ERK1/2, and SAPK/JNK was higher in the smooth muscle cells than the control. SB203580 (30${\mu}$M), a p38MAPK inhibitor, increased the level of HSP27 phosphorylation induced by stimulators in smooth muscle cells. Furthermore, the age-related and starvation-induced activation of HSP27 was higher in skeletal muscle cells (L6 myoblast cell lines) and muscle strips than the control. Conclusion: These results suggest, in part, that the activity of HSP27 and MAPKs affect stressors, such as PDGF, AngII, TNF$\alpha$, $H_2O_2$, and starvation in rat smooth and skeletal muscles. However, more systemic research will be needed into physical therapy, including thermotherapy, electrotherapy, radiotherapy and others.

• Proceedings of the KIEE Conference
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• 2006.10d
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• pp.143-145
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• 2006

This paper presents an overall control algorithm for a grid-connected wind-power generation system using a DFIG(doubly-fed induction generator) fed by back-to-back PWM converters. The control of DFIG is based on a stator-flux oriented vector control. The system enables not only fast and smooth synchronization but also high performance regulation of active and reactive power. Experimental results shows The feasibility of the control algorithm.

• Management Science and Financial Engineering
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• v.6 no.1
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• pp.37-63
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• 2000

An important objective of pull-based production control is to achieve synchronized and smooth production flow in a multi-stage system that is subject to uncertainty. To our knowledge, previous research has not generated a performance measure that captures this objective of pull-based probased production control system. This performance material with respect to the instant when the operation is required. We examine the issue of asynchronous waste in a two-stage kanban control system.

• 제어로봇시스템학회:학술대회논문집
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• 2005.06a
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• pp.174-178
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• 2005

This paper presents a novel fuzzy logic based control method for shunt active filters. Since the fuzzy sets are based on linguistic description, therefore they don't need to the mathematical model of the investigated systems. The proposed method is very suitable to nonlinear and time variant loads. The controller is robust, reliable and it has a smooth response. Also transient response of method is much better than the other classical methods. The simulation results confirm the suitable performance of the filter using this control method.

• Proceedings of the Korean Operations and Management Science Society Conference
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• 2003.05a
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• pp.417-424
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• 2003

In this paper, we introduce and analyze a feedback control model of TCP/AQM dynamics. Then, we propose the Pro-active Queue Management (PAQM) mechanism, which can provide proactive congestion avoidance and control using an adaptive congestion indicator and a control function for wide range of traffic environments. The PAQM stabilizes the queue length around a desired level while giving smooth and low packet loss rates independent of the traffic load level under a wide range of traffic environment. The PAQM outperforms other AQM algorithms such as Random Early Detection (RED) [1] and PI-controller [2]

• Proceedings of the KIEE Conference
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• 2001.07d
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• pp.1993-1995
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• 2001

The subject of nonlinear control is an important area of automatic control. The behavior of nonlinear systems is much more complex. If the operating range of a control system is small, and if the involved nonlinearities are smooth, then the control system may be resonably approximated by a set of linear differential equations. This paper presents the deadbeat response attribute of some nonlinear systems, e.g., magnetic levitation, pendulum, van der pol oscillator etc.. The studied results through the computer simulation are shown a promising attribute of deadbeat response that the outputs of the systems are reached relatively fast the steady state.

• Anatomy and Cell Biology
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• v.55 no.1
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• pp.79-91
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• 2022

In this study, the effect of oral ciprofloxacin on the structure of the thoracic aorta in rats was investigated. Twenty four male albino rats were divided into 4 groups (6 rats/group): group I (adult control), group II (adult rats treated with ciprofloxacin), group III (senile control), and group IV (senile rats treated with ciprofloxacin). Rats in groups II and IV received ciprofloxacin via oral gavage in a daily dose of 3.5 mg/kg/d for 14 days, while control rats received equivalent amount of distilled water used to dissolve the drug. After 2 weeks, all rats were sacrificed, thoracic aortae were dissected, and half of the specimens were processed for paraffin sections and examined by light microscopy. The other half of the specimens were prepared for scanning electron microscopy. Sections from rats treated with ciprofloxacin showed evident damaging effect on aortic wall particularly in (group IV). Aortic intima showed, focal desquamation of the lining epithelium. Tunica media exhibited loss of the normal concentric arrangement and degeneration of the smooth muscle cells. Immune staining for alpha smooth muscle actin showed muscle damage. Interestingly, some sections in (group IV) showed out-pouch (aneurysm like) of the aortic wall. There was dense collagen fibers deposition. Scanning electron microscopic observations of (group IV) revealed uneven intima, adherent blood cells and fibrin filaments to damaged intima, and out-pouch formation. It was concluded that oral ciprofloxacin caused deleterious structural changes in the thoracic aortic wall of rats explaining clinical observations of fluoroquinolones induced risk of aortic dissection and aneurysm.

• The Korean Journal of Physiology and Pharmacology
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• v.1 no.5
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• pp.547-553
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• 1997

It has been known that activation of tyrosine kinases is involved in signal transduction. Role of the tyrosine kinase in vascular smooth muscle contraction was examined in deoxycorticosterone acetate (DOCA)-salt hypertensive rats. Male Sprague-Dawley rats underwent uninephrectomy, one week after which they were subcutaneously implanted with DOCA (200 mg/kg) and supplied with 1% NaCl and 0.2% KCl drinking water for $4{\sim}6$ weeks. Control rats were treated the same except for that no DOCA was implanted. Helical strips of carotid arteries were mounted in organ baths for measurement of isometric force development. Genistein was used as a tyrosine kinase inhibitor. Concentration-response curves to 5-hydroxytryptamine (5-HT) shifted to the right by genistein in both DOCA-salt hypertensive and control rats. Although the sensitivity to genistein was similar between the two groups, the maximum force generation by 5-HT was less inhibited by genistein in arteries from DOCA-salt hypertensive rats than in those from controls. Genistein-induced relaxations were attenuated in arteries from DOCA-salt rats. Genistein affected the contraction to phorbol 12, 13-dibutyrate (PDBu) neither in DOCA-salt nor in control arteries. These observations suggest that tyrosine kinase is involved in 5-HT-induced vascular contraction, of which role is reduced in DOCA-salt hypertension.

• International Journal of Fuzzy Logic and Intelligent Systems
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• v.10 no.2
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• pp.113-118
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• 2010

This paper proposed an ECAM (Electronic cam) control system which has simple and general structure. The proposed cam controller adopted the linear and polynomial curve-fitting method to generates a smooth cam profile curve function. Smooth motion trajectory of master actuator guarantees the good performance of slave motion and has an important effect on the interpolation quality of ECAM. The auto-tuning PID velocity controller was applied to overcome the uncertainties in ECAM, and the gains of the controller are updated continuously to ensure the consistency of system performance under varying working conditions. The robustness of system against the varying load torque disturbances and noises is guaranteed by using the load torque disturbance observer to suppress the disturbance on master actuator. The velocity compensator was applied to compensate the degradation of performance of slave motion caused from the varying driving speed of master motion. The stability and validity of the proposed ECAM control system was verified by simulation results.

• Applied Microscopy
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• v.27 no.3
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• pp.243-255
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• 1997

To investigate detoxification effects of aqua-acupuncture; Bovis Calculus and Susi Fei extract against the toxicity of aconitine were studied. We examined the GOT activities, GPT activities, $\gamma-GPT$ activites, ALP activities and ultrastructural changes of hepatocytes in rats. The GOT activities were decreased in the aqua-acupuncture group compared with control at the 48-hours and 96-hours. The $\gamma-GTP$ and ALP activities were decreased in the aqua-acpuncture group compared with control at 96-hours. We observed the ultrastructural changes of hepatocytes compared the detoxification effects of acua-acupuncture with toxicity of aconitine by transmission electron microscope. In the 24-hours group, the cisternae of rough and smooth endoplasmic reticulum hepatocytes are dilated more or less. In the 48-hours group, the nuclear envelope are irregured, and chromatins of nucleus are condensed. The cisternae of rough endoplasmic reticulum are dilated/branched. In the 96-hours group, the rough and smooth endoplasmic reticulum are well developed in aqua-acpuncture group compared with control. These results suggest that acua-acpuncture groups of the Bovis calculus and Susi fei extract showed detoxification effects against cytotoxicity of aconitine in the hepatocyte of rats.