• 한국통신학회논문지
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• 제38B권9호
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• pp.736-743
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• 2013

적외선 탐색 및 추적 시스템에서 원거리에 표적이 존재할 경우 표적의 크기가 매우 작고, 해무와 같은 클러터와 다양한 센서 잡음으로 인해 표적의 검출이 매우 어렵다. 특히 표적의 화소 값과 유사한 잡음이나 클러터가 존재하는 경우 일반적인 임계화 기법을 적용하는 경우 표적의 오검출 위험이 매우 높다. 이러한 이유로 본 논문에서는 영상의 밝기 정보와 표적에 대한 사전 정보를 이용하여 최적의 표적 검출 결과를 도출하기 위한 적응적 임계화 기법을 제안한다. 소형 표적을 강조하기 위하여 인간 시각 시스템을 반영한 CSF(Contrast Sensitivity Function)를 적용하고, 표적이 강조된 영상에서 영상의 밝기 정보와 거리 정보를 이용하여 표적을 검출한다. 다양한 환경 조건에서 획득된 적외선 영상에 대한 실험 결과들은 제안 알고리즘의 견실한 성능을 보여준다.

• 한국멀티미디어학회논문지
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• 제15권11호
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• pp.1305-1318
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• 2012

영상분할은 영상 처리 및 패턴 인식에서 매우 어려운 전처리 과정 중 하나이다. 일반적으로는 단순하고 구현이 쉽기 때문에 OTSU의 방법이 많이 사용되고 있지만, 영상의 히스토그램이 단일 분포를 갖거나 단일 분포에 가까울 경우에는 영상 분할이 정확히 되지 못한다. 또한, 만일 표적이 영상에 비해서 소형인 경우 표적의 히스토그램 분포가 작아져서 단일 분포에 가까워진다. 본 논문에서는 소형 표적 검출을 위한 개선된 영상 분할 기법을 제안하였다. 단일 분포 히스토그램의 단점을 극복하기 위하여 배경 히스토그램의 영향을 감소시키는 기법을 적용하였으며, SNR을 높이기 위하여 지역 평균화 기법을 1D OTSU에 적용하였다. 실제 열 영상을 기반으로 실험을 수행한 결과 2D OTSU 방법에 비해서 연산 시간은 크게 줄었으며, 영상 분할 결과는 개선되었음을 확인하였다.

• 한국인터넷방송통신학회논문지
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• 제21권5호
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• pp.11-18
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• 2021

소형 Radio Frequency 추적레이다는 표적에 대하여 전천후 Radio Frequency 신호 처리를 통하여 표적을 식별하고 주요 표적에 대하여 표적을 탐색, 탐지하여 추적하는 Radio Frequency 센서를 보유한 추적시스템이다. 본 논문에서는 전천후 Radio Frequency를 이용하여 표적 정보를 획득하여 실시간 신호처리를 통하여 표적을 식별하기 위한 고속의 멀티코어 DSP인 TMS320C6678과 XILINX FPGA(Field Programmable Gate Array)가 탑재된 보드 개발의 내용을 설명한다. DSP, FPGA 선정과 신호처리를 위한 DSP-FPGA 결합 아키텍처에 대하여 제안하고 또한 고속의 데이터 전송을 위한 SRIO의 설계에 대하여 설명한다.

• IMMUNE NETWORK
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• 제22권6호
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• pp.51.1-51.20
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• 2022

Trypanosoma cruzi, the etiological agent of Chagas disease, is an intracellular protozoan parasite, which is now present in most industrialized countries. About 40% of T. cruzi infected individuals will develop severe, incurable cardiovascular, gastrointestinal, or neurological disorders. The molecular mechanisms by which T. cruzi induces cardiopathogenesis remain to be determined. Previous studies showed that increased IL-6 expression in T. cruzi patients was associated with disease severity. IL-6 signaling was suggested to induce pro-inflammatory and pro-fibrotic responses, however, the role of this pathway during early infection remains to be elucidated. We reported that T. cruzi can dysregulate the expression of host PIWI-interacting RNAs (piRNAs) during early infection. Here, we aim to evaluate the dysregulation of IL-6 signaling and the piRNAs computationally predicted to target IL-6 molecules during early T. cruzi infection of primary human cardiac fibroblasts (PHCF). Using in silico analysis, we predict that piR_004506, piR_001356, and piR_017716 target IL6 and SOCS3 genes, respectively. We validated the piRNAs and target gene expression in T. cruzi challenged PHCF. Secreted IL-6, soluble gp-130, and sIL-6R in condition media were measured using a cytokine array and western blot analysis was used to measure pathway activation. We created a network of piRNAs, target genes, and genes within one degree of biological interaction. Our analysis revealed an inverse relationship between piRNA expression and the target transcripts during early infection, denoting the IL-6 pathway targeting piRNAs can be developed as potential therapeutics to mitigate T. cruzi cardiomyopathies.

• 셀메드
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• 제3권2호
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• pp.12.1-12.4
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• 2013

Identification of target protein is an important procedure in the course of drug discovery. Because of complexity, action mechanisms of herbal medicine are rather obscure, unlike small-molecular drugs. Inverse docking simulation is a reverse use of molecular docking involving multiple target searches for known chemical structure. This methodology can be applied in the field of target fishing and toxicity prediction for herbal compounds as well as known drug molecules. The aim of this review is to introduce a series of in silico works for predicting potential drug targets and side-effects based on inverse docking simulations.

• 한국통신학회논문지
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• 제21권4호
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• pp.834-847
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• 1996

A selective coding scheme is proposed that describes a method for coding image sequences distinguishing bits between background and target region. The suggested method initially estimates global motion parameters and local motion vectors. Then segmentation is performed with a hierarchical clustering scheme and a quadtree algorithm in order to divide the processing image into the backgraound and target region. Finally image coding is done by assigning more bits to the target region and less bits to background so that the target region may be reconstructed with high quality. Simulations show that the suggested algorithm performs well especially in the circumstances where background changes and target regionis small enough compared with that of background.

• Tribology and Lubricants
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• 제24권6호
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• pp.326-331
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• 2008

The contact surfaces between mold and target should be in parallel for a proper imprinting process. However, large size of contacting area makes it difficult for both mating surfaces (mold and target planes) to be in all uniform contact with the expected precision level in terms of thickness and position. This is caused by the waviness of mold and target although it is very small relative to the area scale. The gripping force for both mold and target by the vacuum chuck is other major effect to interrupt the uniform contact, which must be avoided in imprinting mechanism. In this study, the cause of non-conformal contact mechanism between mold and target is investigated with the consideration of deformation due to the vacuum gripping for the size $470{\times}370\;mm^2$ LCD panel.

• International Journal of Aeronautical and Space Sciences
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• 제2권2호
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• pp.73-81
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• 2001

This paper describes the procedure to develop a robust estimator design method for a target tracker that accounts for both structured real parameter uncertainties and unknown inputs. Two robust design approaches are combined: the Mini-p-Norm. design method to consider real parameter uncertainties and the $H_{\infty}$ design technique for unknown disturbances and unknown inputs. Constant estimator gains are computed that guarantee the robust performance of the estimator in the presence of parameter variations in the target model and unknown inputs to the target. The new estimator has two design parameters. One design parameter allows the trade off between small estimator error variance and low sensitivity to unknown parameter variations. Another design parameter allows the trade off between the robustness to real parameter variations and the robustness to unknown inputs. This robust estimator design method was applied to the longitudinal motion tracking problem of a T-38 aircraft.

• 대한의생명과학회지
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• 제17권1호
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• pp.1-5
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• 2011

Previously, we have identified 14 putative downstream target genes of Hoxc8 homeoprotein in F9 murine embryonic teratocarcinoma cells through proteomics analysis. Among those, we tested a possibility of a DNA-k type molecular chaperone, Grp78, as a direct downstream target of Hoxc8, by cloning a 2.4 kb upstream region of murine Grp78 into a reporter plasmid and by testing if Hoxc8 can regulate its expression. We observed that Hoxc8 proteins could transactivate the reporter gene, which was affected by small interference RNAs (siRNAs) against to Hoxc8, suggesting that Grp78 is a novel downstream target of Hoxc8 in vivo.

• BMB Reports
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• 제49권3호
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• pp.135-136
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• 2016

Small interfering RNAs (siRNAs) have been developed to intentionally repress a specific gene expression by directing RNA-induced silencing complex (RISC), mimicking the endogenous gene silencer, microRNAs (miRNAs). Although siRNA is designed to be perfectly complementary to an intended target mRNA, it also suppresses hundreds of off-targets by the way that miRNAs recognize targets. Until now, there is no efficient way to avoid such off-target repression, although the mode of miRNA-like interaction has been proposed. Rationally based on the model called "transitional nucleation" which pre-requires base-pairs from position 2 to the pivot (position 6) with targets, we developed a simple chemical modification which completely eliminates miRNA-like off-target repression (0%), achieved by substituting a nucleotide in pivot with abasic spacers (dSpacer or C3 spacer), which potentially destabilize the transitional nucleation. Furthermore, by alleviating steric hindrance in the complex with Argonaute (Ago), abasic pivot substitution also preserves near-perfect on-target activity (∼80-100%). Abasic pivot substitution offers a general means of harnessing target specificity of siRNAs to experimental and clinical applications where misleading and deleterious phenotypes from off-target repression must be considered.