• 한국콘크리트학회:학술대회논문집
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• 한국콘크리트학회 2008년도 춘계 학술발표회 제20권1호
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• pp.941-944
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• 2008

PVA 섬유, 강섬유를 다량으로 혼입한 고인성 시멘트 복합체가 개발되고 이를 구조물에 활용하고자 하는 연구가 전 세계적으로 수행되고 있다. DFRCC는 경제적 효율성을 고려한다면 현재까지 구조물 전체 부분에 적용하기보다는 특별한 요소나 보수재료서 적용하는 것이 경쟁력이 있을 것으로 사료된다. 저자들은 DFRCC를 FRP-콘크리트 합성 바닥판과 습식 스프레이 보수공법에 적용하는 기술을 개발하고 있다. FRP-콘크리트 합성 바닥판에 적용할 경우에는 현장 적용하여 3개월 경과하더라도 구조성능 또는 내구성능이 저하되는 문제가 발생하지 않았고 매우 양호한 상태를 유지하였다. 그리고 국산 PVA 섬유 사용 DFRCC 보수 모르타르를 20년이 경과된 하수박스암거에 적용한 경우에는 한 결과, 일본산 PVA 섬유를 사용한 경우와 차이가 거의 없었다. 관련 규격인 KS F 4042의 압축 및 휨 강도기준을 모두 만족하는 것으로 나타났다. 이상과 같이 DFRCC를 구조물에 적용할 경우에는 구조물 종류에 따라서 경제적으로 성능 향상에 크게 기여할 수 있을 것으로 판단된다.

• Bulletin of the Korean Chemical Society
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• 제31권4호
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• pp.901-904
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• 2010

Decylthiocyanate (DTC) self-assembled monolayers (SAMs) on Au(111) were prepared by solution and vapor phase deposition methods at $50^{\circ}C$ for 24 h. The formation and surface structure of DTC SAMs were examined using scanning tunneling microscopy (STM). STM imaging revealed that DTC SAMs formed in 1 mM ethanol solution at $50^{\circ}C$ were composed of small ordered domains with lateral dimensions of a few nanometers and disordered phases, whereas DTC SAMs formed in the vapor phase at $50^{\circ}C$ contained two ordered phases: a closely packed c($4{\times}2$) superlattice and a striped phase with an interstripe spacing of 2.6 - 2.8 nm. It was also found that the ordered domain and vacancy island formation for DTC SAMs on Au(111) differs significantly from that of decanethiol SAMs, suggesting that adsorption mechanism is different from each other. From this study, it was confirmed that DTC SAMs with a high degree of structural order can be obtained by vapor phase deposition.

• Bulletin of the Korean Chemical Society
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• 제33권6호
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• pp.2005-2011
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• 2012

Nopp140 is a highly phosphorylated protein that resides in the nucleolus of mammalian cell and is involved in the biogenesis of the nucleolus. It interacts with a variety of proteins related to the synthesis and assembly of the ribosome. It also can bind to a ubiquitous protein kinase CK2 that mediates cell growth and prevents apoptosis. We found that Nopp140 is an intrinsically unfolded protein (IUP) lacking stable secondary structures over its entire sequence of 709 residues. We discovered that mitoxantrone, an anticancer agent, was able to enhance the interaction between Nopp140 and CK2 and maintain suppressed activity of CK2. Surface plasma resonance studies on different domains of Nopp140 show that the C-terminal region of Nopp140 is responsible for binding with mitoxantrone. Our results present an interesting example where a small chemical compound binds to an intrinsically unfolded protein (IUP) and enhances protein-protein interactions.

• 한국콘텐츠학회논문지
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• 제17권5호
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• pp.18-33
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• 2017

학교폭력의 연장선상에서 상시적으로 괴롭힘이 이루어지는 '사이버불링'이 심각한 사회적 문제로 대두되고 있다. 본 연구에서는 청소년 사이버불링에 관한 선행연구를 분석하여 사이버불링 가해행동에 미치는 개인, 가정, 또래, 학교, 사이버환경, 폭력경험 등과 관련된 변인들의 효과크기를 알아보았다. 국내학술논문 검색사이트(RISS)를 이용하여 2010년 1월 1일부터 2016년 10월 31일까지 학술지게제 논문 및 석 박사학위논문을 대상으로 '사이버불링', '사이버따돌림', '사이버폭력', '사이버괴롭힘', '온라인 및 SNS 또래괴롭힘' 이란 검색어로 선정된 총 43편의 논문을 대상으로 분석하였다. 그 결과 개인, 폭력경험 변인이 중간크기의 효과(0.28~0.29)를 나타냈고 또래, 가정, 사이버환경, 학교변수 순으로 작은 크기의 효과(0.08~0.13)를 나타냈다. 본 연구 결과는 청소년 사이버불링에 대한 교육적, 사회정책적 대응방안 마련과 직접적인 예방 및 개입을 위한 구체적 프로그램 개발의 기초자료로 활용될 것이다.

• 정보보호학회논문지
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• 제31권5호
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• pp.959-972
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• 2021

분산 신원증명은 정보주체가 자신의 신원정보를 직접 관리하고, 필요시 제공한다는 자기주권 신원증명의 개념을 기반으로 하고 있다. 하지만, 발급기관으로부터 신원정보를 발급받아 온다는 절차가 필요하고, 발급기관의 관리 소홀로 인한 대량의 정보 유출 우려가 존재한다. 본 논문에서는 정보주체와 발급기관을 일치시켜 1:1 또는 1:N 소규모 그룹에서 참여자들만 신원증명이 가능한 Peer DID 기술을 기반으로 개인 간 분산 신원증명 시스템을 제안한다. 블루투스와 같은 단거리 무선 통신을 이용하여 모바일 디바이스로 직접 연결하고, 정보주체가 직접 자신의 정보를 생성하여 상대방에게 제공하므로 정보의 자기주권을 실현한다. 제안 시스템을 통하여 신원증명 절차를 간소화하고, 보안 및 프라이버시를 개선할 수 있으며, 비용도 절감할 수 있다. 나아가 제안 시스템과 분산 원장을 연결하여 다른 도메인의 이용자와 상호 신원증명 할 수 있도록 확장된 구성도 가능하다. 향후에는 다양한 기술을 기반으로 사람과 사물, 사물과 사물 인증에도 활용할 수 있는 신원증명 시스템에 대한 확장 연구가 필요하다.

• Molecules and Cells
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• 제44권9호
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• pp.627-636
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• 2021

The three-dimensional organization of chromatin and its time-dependent changes greatly affect virtually every cellular function, especially DNA replication, genome maintenance, transcription regulation, and cell differentiation. Sequencing-based techniques such as ChIP-seq, ATAC-seq, and Hi-C provide abundant information on how genomic elements are coupled with regulatory proteins and functionally organized into hierarchical domains through their interactions. However, visualizing the time-dependent changes of such organization in individual cells remains challenging. Recent developments of CRISPR systems for site-specific fluorescent labeling of genomic loci have provided promising strategies for visualizing chromatin dynamics in live cells. However, there are several limiting factors, including background signals, off-target binding of CRISPR, and rapid photobleaching of the fluorophores, requiring a large number of target-bound CRISPR complexes to reliably distinguish the target-specific foci from the background. Various modifications have been engineered into the CRISPR system to enhance the signal-to-background ratio and signal longevity to detect target foci more reliably and efficiently, and to reduce the required target size. In this review, we comprehensively compare the performances of recently developed CRISPR designs for improved visualization of genomic loci in terms of the reliability of target detection, the ability to detect small repeat loci, and the allowed time of live tracking. Longer observation of genomic loci allows the detailed identification of the dynamic characteristics of chromatin. The diffusion properties of chromatin found in recent studies are reviewed, which provide suggestions for the underlying biological processes.

• Archives of Plastic Surgery
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• 제46권3호
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• pp.221-227
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• 2019

Background Gynecomastia is a common condition that can cause severe emotional and physical distress in both young and older men. Patients in whom symptomatic recalcitrant gynecomastia persists for a long time are potential candidates for surgery. Methods From January 2014 to January 2016, 15 patients underwent correction of gynecomastia through a single 3-mm incision at our institution. Only patients with true gynecomastia underwent surgery with this new technique. Through the small incision, sharp dissection was performed in a clockwise and counterclockwise direction describing two half-circles. Health-related quality of life and aesthetic outcomes were evaluated using a modified version of the Breast Evaluation Questionnaire (BEQ). Results The patients' average age was 23.5 years (range, 18-28 years), and their average body mass index was $23.2kg/m^2$ (range, $19.2-25.3kg/m^2$). One case was unilateral and 14 cases were bilateral. The weight of glandular tissue resected from each breast ranged from 80 to 170 g. No excess skin was excised. Bleeding was minimal. The mean operating time was 25 minutes (range, 21-40 minutes). No complications were recorded. All lesions were histologically benign. The patients' average score was 3.5 (on a 5-point Likert scale) in all domains of the BEQ for themselves and their partners. Conclusions In this study, we demonstrated the safety and reliability of a new technique that allows mastectomy through an imperceptible 3-mm incision. We obtained high patient satisfaction scores using our surgical technique, and patients reported considerable improvement in their social, physical, and psychological well-being after surgery.

• Bulletin of the Korean Chemical Society
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• 제22권2호
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• pp.213-218
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• 2001

Presented are the STM images of self-assembled monolayer of 2-mercaptoethanol on Au(111). Striped structures of ($6{\times}3_{\frac{1}{2}}$), ($5{\times}3_{\frac{1}{2}}$), ($4{\times}3_{\frac{1}{2}}$) and compact-($5{\times}3_{\frac{1}{2}}$) were observed after annealing at $80^{\circ}C.$ Analysis of the ordered structures revealed that the basic fundamental units of the ordered structures were three crystallographically non-equivalent ($3_{\frac{1}{2}}{\times}3_{\frac{1}{2}}$) $R30^{\circ}$ assemblies, and that the way of combination of the assemblies produced the four different structures. The($6{\times}3_{\frac{1}{2}}$) structure ( $\theta$ = 0.33) was composed of one ($3_{\frac{1}{2}}{\times}3_{\frac{1}{2}}$)$R30^{\circ}$ assembly, while the ($5{\times}3_{\frac{1}{2}}$) ( $\theta$ = 0.30) and ($4{\times}3_{\frac{1}{2}}$) ( $\theta$ = 0.38) structures were consisted of two ($3_{\frac{1}{2}}{\times}3_{\frac{1}{2}}$) $R30^{\circ}$ assemblies, separated by 5a and 4a, respectively. Furthermore, the compact-(5X 3½) structure ( $\theta$ = 0.50) was obtained by overlapping three ($3_{\frac{1}{2}}{\times}3_{\frac{1}{2}}$) $R30^{\circ}$ assemblies. In spite of the diversity in the adsorption structures, all the adsorption sites of 2-mercaptoethanol were fundamentally identical. On the other hand, the unannealed primitive SAM of 2-mercaptoethanol was characterized by two observations: a short-range order keeping the adsorbed molecules at approximately $3_{\frac{1}{2}}$ a and the small domains of the striped structures supporting that the observed surface structures on the annealed surface were the extension of the primitive layer of 2-mercaptoethanol. Comparing these observations with the already published structures of ethanthiol, it was concluded that the interaction between the hydroxyl groups of 2-mercaptoethanol might play a significant role in the adsorption step of 2-mercaptoethanol on Au(111) to organize the adsorption structures different from those of ethanthiol.

• 대기
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• 제31권1호
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• pp.17-28
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• 2021

We investigated the impact of domain size on the simulated summer precipitation over the Korean Peninsula using the Weather Research and Forecasting (WRF) model. Two different domains are integrated up to 72-hours from 29 June 2017 to 28 July 2017 when the Changma front is active. The domain sizes are adopted from previous RDAPS (Regional Data Assimilation and Prediction System) and current LDAPS (Local Data Assimilation and Prediction System) operated by the Korea Meteorological Administration, while other model configurations are fixed identically. We found that the larger domain size showed better prediction skills, especially in precipitation forecast performance. This performance improvement is particularly noticeable over the central region of the Korean Peninsula. Comparisons of physical aspects of each variable revealed that the inflow of moisture flux from the East China Sea was well reproduced in the experiment with a large model domain due to a more realistic North Pacific high compared to the small domain experiment. These results suggest that the North Pacific anticyclone could be an important factor for the precipitation forecast during the summer-time over the Korean Peninsula.

• Smart Structures and Systems
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• 제30권6호
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• pp.687-701
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• 2022

Inevitable response loss under complex operational conditions significantly affects the integrity and quality of measured data, leading the structural health monitoring (SHM) ineffective. To remedy the impact of data loss, a common way is to transfer the recorded response of available measure point to where the data loss occurred by establishing the response mapping from measured data. However, the current research has yet addressed the structural condition changes afterward and response mapping learning from a small sample. So, this paper proposes a novel data driven structural response reconstruction method based on a sophisticated designed generating adversarial network (UAGAN). Advanced deep learning techniques including U-shaped dense blocks, self-attention and a customized loss function are specialized and embedded in UAGAN to improve the universal and representative features extraction and generalized responses mapping establishment. In numerical validation, UAGAN efficiently and accurately captures the distinguished features of structural response from only 40 training samples of the intact structure. Besides, the established response mapping is universal, which effectively reconstructs responses of the structure suffered up to 10% random stiffness reduction or structural damage. In the experimental validation, UAGAN is trained with ambient response and applied to reconstruct response measured under earthquake. The reconstruction losses of response in the time and frequency domains reached 16% and 17%, that is better than the previous research, demonstrating the leading performance of the sophisticated designed network. In addition, the identified modal parameters from reconstructed and the corresponding true responses are highly consistent indicates that the proposed UAGAN is very potential to be applied to practical civil engineering.