• Childhood Kidney Diseases
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• v.14 no.1
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• pp.22-31
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• 2010

Purpose : This study was performed to evaluate the relationship between glomerular basement membrane (GBM) alterations to epithelial cell (EpC) structure and renal function in Alport Syndrome (AS) patients. Methods : Fifteen patients diagnosed with AS (4-26yrs) were examined. The GBM in AS was categorized as : C1) normal, C2) minor alterations (widening of lamina rara interna or externa without lamina densa change), C3) nonspecific splitting of lamina densa, C4) basket-weaving pattern of lamina densa splitting. The length of each GBM portion along the epithelial side was measured on the systematically obtained electron microscopic photographs. Furthermore to obtain an objective assessment of the degree of glomerular EpC foot process change, the number of slit pores along $10\;{\mu}m$ of peripheral GBM in each category was obtained. Results : The percentage of normal GBM portion (C1) correlated inversely with daily protein excretion (g/day/$m^2$, P<0.05) and sum of the percentage of abnormal GBM portion (C2+C3+C4) had direct correlation with daily protein excretion (g/day/$m^2$, P<0.05). There were no significant relationships between the percentages of other categories of GBM alterations and creatinine clearance or protein excretion. There were no significant relationships between of creatinine clearance in relation to normal GBM(C1) portion as well as that in relation to sum of the percentage of abnormal GBM portion (C2+C3+C4). GBM abnormality did not correlate with age at biopsy. Conclusion : The extent of GBM structural abnormality is related to proteinuria in AS but the epithelial response is uniform even though the GBM ultrastructural lesions are not.

• Transactions of the Korean Society of Mechanical Engineers B
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• v.27 no.8
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• pp.1023-1032
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• 2003

The effect of local forcing on the separated flow over a backward-facing step is investigated through hot-wire measurements and flow visualization with multi-smoke wires. The boundary layer upstream of the separation point is laminar and the Reynolds number based on the free stream velocity and the step height is 13800. The local forcing is given from a slit located at the step edge and the forcing signal is always defined when the wind tunnel is in operation. In case of single frequency forcing, the streamwise velocity and the reattachment length are measured under forcing with various forcing frequencies. For the range of 0.010〈S $t_{\theta}$〈0.013, the forcing frequency component of the streamwise velocity fluctuation grows exponentially and is saturated at x/h = 0.75 , while its subharmonic component grows following the fundamental and is saturated at x/h = 2.0. However, the saturated value of the subharmonic is much lower than that of the fundamental. It is observed that the vortex formation is inhibited by the forcing at S $t_{\theta}$ = 0.019 . For double frequency forcing, natural instability frequency is adopted as a fundamental frequency and its subharmonic is superposed on it. The fundamental frequency component of the streamwise velocity grows exponentially and is saturated at 0.5 < x/ｈ < 0.75, while its subharmonic component grows following the fundamental and is saturated at x/ｈ= 1.5 . Furthermore, the saturated value of the subharmonic component is much higher than that for the single frequency forcing and is nearly the same or higher than that of the fundamental. It is observed that the subharmonic component does not grow for the narrow range of the initial phase difference. This means that there is a range of the initial phase difference where the vortex parring cannot be enhanced or amplified by double frequency forcing. In addition, this effect of the initial phase difference on the development of the shear layer and the distribution of the reattachment length shows a similar trend. From these observations, it can be inferred that the development of the shear layer and the reattachment length are closely related to the vortex paring.

• Korean Journal of Environmental Biology
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• v.36 no.2
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• pp.107-116
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• 2018

In this study, the distribution of sedimentary environment and benthic macro-fauna in habitats and non-habitats of Zostera marina were investigated. The purpose of this study was to obtain basic data about the sedimentary environment and benthic macro-fauna in the habitats and non-habitats of Z. marina. Sand was dominant within habitat environments, whereas the non-habitats were predominantly composed of silt. As a result, the habitats of Z. marina have a different grain size and organic matter content compared to the non-habitats. These differences in the sedimentary environment were expected to influence the species composition of benthic animals. Benthic communities in the habitats of Z. marina showed a higher density and a greater number of species than in the non-habitats. As a result of an ecological index evaluation, the species diversity index (H') was $3.44{\pm}0.10$ for the habitat; the non-habitat was analyzed as $2.34{\pm}0.35$. It was also found that the stability of community in the habitats was higher than that in the non-habitats. The cluster analysis also clearly showed that habitats and non-habitats of Z. marina have distinct characteristics.

• Radiation Oncology Journal
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• v.19 no.1
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• pp.74-80
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• 2001

Purpose : Irradiation cones by using backscatter electrons are made for the treatment of superficial small lesions of skin, oral cavity, and rectum where a significant dose gradient and maximum surface dose is desired. Methods and Materials : Backscatter electrons are produced from the primary electron beams from the linear accelerators. The design consists of a cylindrical cone that has a thick circular plate of high atomic number medium (Pb or Cu) attached to the distal end, and the plate can be adjusted the reflected angle. Primary electrons strike the metal plate perpendicularly and produce backscatter electrons that reflect through the lateral hole for treatment. Using film and a parallel plate ion chamber, backscatter electron dose characteristics are measured. Results : The depth dose characteristic of the backscatter electron is very similar to that of the hard x-ray beam that is commonly used for the intracavitary and superficial lesions. The basckscatter electron energy is nearly constant and effectively about 1.5 MeV from the clinical megavoltage beams. The backscatter electron dose rate of $35\~85\;cGy/min$ could be achieved from modern accelerators without any modification. and the depth in water of $50\%$ depth dose from backscatter electron located at 6mm for $45^{\circ}$ angled lead scatter. The beam flatness is dependent on the slit size and the depth of treatment, but is satisfactory to treat small lesions. Conclusions : The measured data for backscatter electron energy, depth dose flatness dose rate and absolute dose indicates that the backscatter electrons are suitable for clinical use.

• Journal of The Korean Ophthalmological Society
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• v.58 no.6
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• pp.706-711
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• 2017

Purpose: To analyze blinking patterns when watching an ultra-high definition (UHD) television and to compare the results between normal eyes and dry eyes. Methods: A total of 59 participants aged from 13 to 69 years were instructed to watch a colorful and dynamic video on a UHD television for 10 minutes. Before and after watching the UHD television, we measured the best corrected visual acuities, autorefraction, tear-break-up-time, degree of corneal erosion and conjunctival hyperemia via slit lamp biomicroscopy. In addition, questionnaires for the evaluation of eye fatigue and symptoms of a dry eye were completed. The definition of dry eye syndrome was that the tear-break-up-time of one of the eyes was less than 5 seconds, conjunctival injection, or marked corneal erosion. The number of blinks and the duration of blinking were both measured and analyzed at the early and late phases of video-watching. Results: After watching the UHD television in the normal eye group, the tear-break-up-time was significantly decreased (p < 0.001) and the degree of corneal erosion was significantly increased (p = 0.023). However, the subjective symptoms of participants were not aggravated (p = 0.080). There were no significant differences in blinking patterns in the dry eye group. On the other hand, in the normal eye group, the mean blinking time was significantly increased (p = 0.030). Conclusions: Watching an UHD television changes the tear-break-up-time, degree of corneal erosion, and blinking pattern in normal eyes, which may increase the risk of dry eye syndrome.