• 한국환경보건학회지
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• 제31권1호
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• pp.7-14
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• 2005

Exposure of skin to UVB radiation can cause the induction of inflammation and impairment of contact hypersensitivity(CHS) response. Several studies have shown that polyphenolic compounds isolated from EGb 761 afford protection against UVB. In this study, we demonstrated that topical application of EGb 761, before 1MED(1.4 KJ/$m^2$), 1.5MED (2.1 KJ/$m^2$), 2MED (2.8 KJ/$m^2$) of UVB exposure to ICR mice prevented UVB-induced inflammation and inhibition of the contact hypersensitivity response. The skin-fold swelling from 1MED, 1.5MED, 2MED of UVB exposure highly significantly increased after twice irradiation. Topical application of EGb 761(0.1%, 1%, 4%), 5 days prior to UVB exposure reduced skin thickness compared to non-treated mice. Exposure of shaved abdominal skin of mice to 1MED, 1.5MED and 2MED of UVB radiation resulted in suppression of contact sensitization through the skin to 56.23%, 65.12%, 74.02%, compared to normal unirradiated skin. Topical application of EGb 761(0.1%, 1%, 4%), 5 days prior to or 5 days after exposure to 1MED and 2MED of UVB resulted in protection against suppression of contact hypersensitivity in mouse dorsal skin. These protective effects were dependent on the dose of EGb 761 employed. The present study show that EGb 761 protect UVB-induced inflammation and immune suppression. Also, we suggest that EGb 761 can provide protection from photoimmunosuppression.

• 대한가정학회지
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• 제23권4호
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• pp.69-78
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• 1985

The effects of the garlic preparation on the response of normal and cancer-stricken mice were studied. Food consumption of skin cancer-stricken group decrease more rapidly than that of normal group as cancer of skin develops, but here was no observable change in garlic groups. The rate of weight of increase was the highest in skin cancer-stricken group whereas that of garlic groups was reduced. The feed efficiency ratio was found to be very high in the normal group, whereas that in other goups after inculation of cancer cell was lower. The total protein content of serum was the highest in skin cancer-stricken group was observed to have more conspicuous tumor than other groups, the simultaneous administration of experimental diet and but inoculation of cancer cell produced more severe tumours. It appears that the garlic may exhibit the tendency to reduce the propagation of skin cancer of mice.

• 한국의류산업학회지
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• 제14권1호
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• pp.130-135
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• 2012

The purpose of this study was to investigate the variation of regional skin temperature with thermography during exercise. Seven men completed 82-min trials which consisted of rest, exercise of $VO_2$ max 60% and recovery period at $30{\pm}0.5^{\circ}C$ and $60{\pm}5%RH$. Changes in skin temperature due to physical activity varied, depending region of the body. The skin temperature of the chest was significantly lowered and that of the back was significantly increased after exercise period(p < 0.05). There were significant negative relationship between the skin temperature of the chest and thermal comfort sensation, and positive relationship between skin temperature of the back and thermal comfort sensation(p < 0.05). It would be better to keep the chest warm, and the back cool during exercise. The skin temperature changed differently on body site due to exercise, and it was influenced by blood flow, sweating and air movement. This study would be meaningful in that the change of regional skin temperature during exercise was investigated consecutively with thermography. In further study, it would be more realistic to measure physiological response with functional sportswear which applies different functional fabric based on skin temperature.

• Journal of Photoscience
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• 제9권2호
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• pp.205-208
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• 2002

Nitric oxide (NO) is a newly described transmitter involved with cell to cell communication that is generated in biologic tissues by specific types of nitric oxide synthase (NOS), which metabolize L-arginine and molecular oxygen to citrulline and nitric oxide. In the skin. NO has been reported to play an important role in such diseases as psoriasis, atopic dermatitis, and contact dermatitis, as well as act as an important modulator in UVB-induced erythema. Ultraviolet B irradiation to the skin evokes an increase in NO production in the epidermis through two pathways; induction of inducible NOS, mediated by inflammatory cytokines, and elevation of constitutive neuronal NOS activity. In a cell culture system, it has been demonstrated that NO functions as a melanogen after being produced in keratinocytes in response to UVB-irradiation. NO-stimulated melanogenesis in melanocytes is mediated by the cGMP/PKG pathway. In this study, up-regulation of tyrosinase gene expression by NO-stimulation and the involvement of NO in UVB-induced pigmentation were examined. In NO-induced melanogenesis, protein synthesis and tyrosinase activity increased along with an up-regulation of tyrosinase gene expression. In an animal model, UVB-induced pigmentation in skin was suppressed by sequential daily treatments with a specific inhibitor of NOS. Thus, NO plays an important role in UVB-induced pigmentation, where its function as a melanogen is considered to be one of the mechanisms. Together with its role in the development of erythema, NO contributes to the total protective response of skin against UVB-irradiation.

• Asian Pacific Journal of Cancer Prevention
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• 제16권15호
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• pp.6477-6480
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• 2015

Purpose: Given the importance of sun protection in the prevention of skin cancer, this study was designed to determine predictors of sun-protective practices among a sample of Iranian female college students based on protection motivation theory (PMT) variables. Materials and Methods: In this cross-sectional study, a total of 201 female college students in Iran University of Medical Sciences were selected. Demographic and PMT variables were assessed with a 67-item questionnaire. Multiple linear regression was used to identify demographic and PMT variables that were associated with sun-protective practices and intention. Results: one percent of participants always wore a hat with a brim, 3.5% gloves and 15.9% sunglasses while outdoors. Only 10.9% regularly had their skin checked by a doctor. Perceived rewards, response efficacy, fear, self-efficacy and marital status were the five variables which could predict 39% variance of participants intention to perform sun-protective practices. Also, intention and response cost explained 31% of the variance of sun-protective practices. Conclusions: These predictive variables may be used to develop theory-based education interventions to prevent skin cancer among college students.

• Steel and Composite Structures
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• 제41권5호
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• pp.649-661
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• 2021

This paper presents experimental and analytical studies to understand the behavior of crumb rubber concrete (CRC)-filled fiber reinforced polymer (FRP) and steel tube double skin column (DSC) and beam (DSB) members under cyclic loading. The main test variable was the percentage of rubber which ranged from 0 to 40%. For column members, different heights corresponding to different aspect ratios were examined to understand the to understand the effect of DSCs' slenderness on the cyclic response of the columns. the. The behavior of the specimens in terms of failure mode, strain development, energy dissipation, load-displacement response were presented and compared. The ability of the current provisions of the Australian codes to predict the capacity of such double skin members was also evaluated based on the test results. This study concluded that the reduction in the concrete strength was more severe at the material level compared to structural level. Also, as the load changed from axial compression in columns to pure moment in beams the negative effect of rubber percentage on the strength became less significant.

• Radiation Oncology Journal
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• 제7권1호
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• pp.15-22
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• 1989

Diethone의 피부에 대한 방사선 보호작용을 평가하기 위하여 Wistar계 랫드에 단일 X-선(20, 30, 40 Gy) 조사 후 시간경과와 선량변화에 따른 급성 피부반응을 연구하였다. 40Gy 선량에서 Diethone군의 피부반응기간은 24.7일로 대조군(29.8일)과 바셀린(29.2일) 투여군에 비하여 약$17\%$의 피부반응 기간이 뚜렷이 감소되었다. 피부반응이 최고도에 달한 10일 동안의 평균치는 Diethone군(2.43)이 대조군(2.91)과 바셀린(2.81)군에 비하여 현저히 감소되었다. 피부반응 Score 2.5에서 구한 등가효과 선량의 반응감소 계수(DRF)는 1.41로 피부보호효과가 있었다. 본 실험 결과로 보아 방사선 피부보호제를 국소적으로 도포함으로써 일반적인 치료선량보다 많은 방사선량을 거대하고 방사선내성이 있는 종양에 조사함으로로써 치료효과를 향상시킬 수 있을 것으로 기대한다.

• 한국응용과학기술학회지
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• 제37권6호
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• pp.1738-1751
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• 2020

피부는 표피, 진피, 피하지방의 세 부분으로 나누어져 있으며, 표피의 가장 윗부분에 존재하는 각질층은 약물의 피부 전달을 방해하는 장벽 역할을 한다. 나노에멀젼은 특유의 작은 입자크기 때문에 세포간 지질을 통과하여 약물의 피부전달에 효과적이라고 알려져 있다. 본 연구에서는 α-bisabolol의 효과적인 피부흡수를 위해 반응표면분석법(response surface methodology, RSM)을 이용하여 상반전온도(phase inversion temperature, PIT) 유화법으로 제조한 α-bisabolol을 함유한 나노에멀젼을 최적화하였다. 예비실험으로 25-2 일부요인배치법과 23 요인배치법이 수행되었다. 요인배치법의 결과를 바탕으로 계면활성제(6.3~12.6%), 보조계면활성제(5.2~7.8%) 및 α-bisabolol (0.5~5.0%) 함량을 인자로 하고 반응 변수를 나노에멀젼의 입자크기로 하는 Box-Behnken design을 수행하였다. RSM 결과에 따라 PIT 나노에멀젼 최적화를 수행하였고, 그 결과 최적의 나노에멀젼 처방 조건은 계면활성제 함량 10.4%, 보조계면활성제 함량 6.3%, α-bisabolol 함량 5.0%로 예측되었다. 피부흡수시험 결과 PIT 나노에멀젼의 최종 피부흡수율은 35.11±1.01%, 대조군인 일반에멀젼의 최종 피부흡수율은 28.25±1.69%로 PIT 나노에멀젼의 피부흡수율이 더 우수함을 확인하였다.

• 대한본초학회지
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• 제21권1호
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• pp.9-15
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• 2006

Objectives : Lonicerae Flos has been known as a useful plant with anti-inflammatory, antioxidative and immunosuppressive activity. To evaluate anti-inflammatory effect of Lonicerae Flos, we treated Lonicerae Flos-skin in animal model system induced contact hypersensitivity. Methods : Contact hypersensitivity, a local inflammatory response of the skin, was induced by spreading the right ear of BALB/c mouse with 1% DNCB. Lonicerae Flos-skin was prepared by dissolving 1% water extract of Lonicerae Flos in skin vehicle and treated everyday for 2 weeks on the right ear. Results : Lonicerae Flos-skin significantly reduced a mouse ear thickness swelled by 1% of DNCB treatment compared with skin vehicle-treated control group. Lonicerae Flos-skin also reduced IgG and IgE in serum obtained from blood of 1% DNCB-treated mouse. Conclusion : These results showed that Lonicerae Flos-skin could be used as a pharmaceutical material with antiinflammatory effects by reducing IgG and IgE in contact hypersensitivity mouse model by DNCB.

• 감성과학
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• 제20권3호
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• pp.13-22
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• 2017

감성은 의사 결정, 지각 등에 직접적으로 영향을 미치며 인간의 삶에서 중요한 역할을 한다. 본 논문에서는 고각성 부정 감성의 편리하고 정확한 인식에 있어서, 생체신호를 이용한 분석 알고리즘을 설계하고자 한다. 이를 위해 본 연구에서는 보통 / 공포 감성 유발 영상을 이용하여 두 감성을 유도한 후, 생체신호 중 간단한 피부전도도 신호를 측정하였다. 측정된 피부전도도에 대해 Tonic 성분과 Phasic 성분으로 분해하고 감성 자극과 관련된 Phasic 성분을 더 상세하게 SCVSR, SCSR로 분해하여 각 성분의 주요한 특징들을 추출함으로써, 정확한 분석을 하기 위해 기존의 사용된 방법이 아닌 우수한 시간-주파수 지역화 특성을 가진 이산 웨이브렛 변환을 사용하였다. 추출된 특징들은 Phasic 성분의 최댓값, Phasic 성분의 진폭, SCVSR의 영교차율, SCSR의 영교차율이다. 분석 결과, 4가지 특징들 모두 고각성 부정 감성의 경우가 저각성 보통 감성의 경우보다 더 높은 값을 나타내고, 기존의 분석 방법보다 통계적으로 두 감정 사이의 더 유의미한 차이를 확인할 수 있었다. 이에 따라 본 연구의 결과는 피부전도도가 고각성 부정 감성 측정에 대해 유용한 지표라는 것을 확인하였으며, 향후 피부전도도를 이용한 실시간 부정 감성 평가 시스템 개발에 기여할 수 있을 것을 나타낸다.