• Journal of Ginseng Research
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• 제44권3호
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• pp.496-505
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• 2020

Background: Panax ginseng is a marvelous herbal remedy for all ailments of body. That may be why it is called Panax, which means "cure for all". Melanin is a pigment that gives color to our skin; however, increased melanin production can lead to tumor formation. Human exposure to ultraviolet B radiation has increased extensively owing to the increased sunlight due to global warming. Consequently, a phenomenon called photoaging has been observed for all skin colors and types. As a result of this phenomenon, a set of enzymes called matrix metalloproteinases, which serve as degradation enzymes for extracellular matrix proteins, mainly collagen, is increased, causing depletion of collagen and resulting in early wrinkle formation. Methods: Therefore, in our study, we used the murine melanoma cell line B16/F10 to study the inhibition of melanogenesis by Korean Red Ginseng (KRG) extract in vitro and HRM-2 hairless mice exposed to artificial ultraviolet B to examine the efficacy of KRG in vivo. We prepared a 3% red ginseng extract cream and evaluated its effects on human skin. Results: Our results demonstrated that KRG induced potent suppression of tyrosinase activity and melanin production in B16/F10 cells; moreover, it reduced the transcription and translation of components involved in the melanin production pathway. In the in vivo experiments, KRG potently suppressed the expression of matrix metalloproteinases, reduced wrinkle formation, and inhibited collagen degradation. On human skin, ginseng cream increased skin resilience and skin moisture and enhanced skin tone. Conclusion: Therefore, we conclude that KRG is an excellent skin whitening and antiaging product.

• 한국자기공명학회논문지
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• 제10권1호
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• pp.105-114
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• 2006

Purpose: We achieved high resolution MR imaging and spectra of human skin in vitro with using a 14.1 T MRI/MRS system, and evaluated the hydration effect of various cosmetic products by measuring the skin's. moisture concentration. Materials and Methods: We used the Bruker 14.1 T MRI/MRS system with a vertical standard bore that was equipped with a DMX spectrometer gradient system (200 G/cm at a maximum 40 A), RF resonators (2, 5 and 10 mm) and Para Vision software. Spin echo and fast spin echo pulse sequences were employed for obtaining the high resolution MR images. The 3D-localized point resolved spectroscopy (PRESS) method was used to acquire the MR spectra. Results: The high resolution MR images and spectra of human skin in vitro were successfully obtained on a 14.1 T system. The water concentration of human skin after applying a moisturizer was higher than that before applying a moisturizer. Conclusions: The present study demonstrated that the high-resolution MR images and spectra of human skin from a high field NMR instrument could be applicable to evaluating the hydration state of the stratum corneum.

• Journal of Ginseng Research
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• 제42권2호
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• pp.218-224
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• 2018

Background: Compound K (CK) is a ginsenoside, a metabolite of Panax ginseng. There is interest both in increasing skin health and antiaging using natural skin care products. In this study, we explored the possibility of using CK as a cosmetic ingredient. Methods: To assess the antiaging effect of CK, RT-PCR was performed, and expression levels of matrix metalloproteinase-1, cyclooxygenase-2, and type I collagen were measured under UVB irradiation conditions. The skin hydrating effect of CK was tested by RT-PCR, and its regulation was explored through immunoblotting. Melanin content, melanin secretion, and tyrosinase activity assays were performed. Results: CK treatment reduced the production of matrix metalloproteinase-1 and cyclooxygenase-2 in UVB irradiated NIH3T3 cells and recovered type I collagen expression level. Expression of skin hydrating factors-filaggrin, transglutaminase, and hyaluronic acid synthases-1 and -2-were augmented by CK and were modulated through the inhibitor of ${\kappa}B{\alpha}$, c-Jun N-terminal kinase, or extracellular signal-regulated kinases pathway. In the melanogenic response, CK did not regulate tyrosinase activity and melanin secretion, but increased melanin content in B16F10 cells was observed. Conclusion: Our data showed that CK has antiaging and hydrating effects. We suggest that CK could be used in cosmetic products to protect the skin from UVB rays and increase skin moisture level.

• 한국식품영양과학회지
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• 제45권8호
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• pp.1147-1152
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• 2016

본 연구는 돈피 젤라틴 분말의 첨가 수준이 떡갈비의 품질특성에 미치는 영향을 규명하고자 실시하였다. 떡갈비의 단백질 함량은 대조구가 가장 낮은 수치를 나타내었으며 돈피젤라틴 분말 4% 처리구가 가장 높은 수치를 나타내었다(P<0.05). 수분 함량은 돈피 젤라틴 분말을 첨가할수록 점차 높아지는 경향을 보였으나, 지방 함량은 돈피 젤라틴 분말 첨가량이 증가함에 따라 점차 감소하는 경향을 나타내었다. 가열 전과 후 명도와 적색도는 돈피 젤라틴 분말 첨가량이 증가함에 따라 유의적으로 감소하였으며, 황색도는 증가하였다(P<0.05). 가열감량, 직경감소율과 두께감소율은 돈피 젤라틴 분말 첨가량이 증가할수록 감소하였으며, 경도는 돈피 젤라틴 분말을 첨가할수록 높은 수치를 나타내었고 3% 처리구와 4% 처리구가 가장 높은 수치를 나타내었다. 검성과 씹음성은 돈피 젤라틴 분말의 첨가량이 증가함에 따라 높은 수치를 나타내었다. 관능적 특성은 모든 돈피 젤라틴 분말을 첨가할수록 색도와 다즙성에서 대조구보다 우수한 평가를 받았으며, 이외 모든 관능평가 항목에서 3% 처리구가 유의적으로 가장 우수한 평가를 받는 것으로 나타났다(P<0.05). 이러한 연구 결과를 바탕으로 돈육 떡갈비에 돈피 젤라틴 분말을 첨가하여 품질 특성을 분석한 결과 2~3%의 돈피 젤라틴 분말을 첨가하여 우수한 떡갈비를 제조할 수 있을 것으로 판단된다.

• 대한화장품학회지
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• 제39권4호
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• pp.281-288
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• 2013

히알루론산(HA)은 피부의 세포외기질을 구성하는 주성분이다. 인간의 피부에서 히알루론산의 양은 노화와 함께 감소되는 것으로 보고되어 있으며, 이것은 노화에 따른 피부 수분 감소, 주름 형성 및 피부 탄력 저하에 관여한다고 알려져 있다. 지금까지 밝혀진 히알루론산 합성효소(hyaluronan synthase, HAS)들 중에 HAS-2가 사람의 피부 섬유아세포에서의 히알루론산의 합성을 조절하는 것으로 알려져 있다. 본 연구에서는 천궁으로부터 분리된 ferulic acid가 사람의 피부 유래 섬유아세포에서 히알루론산의 생성에 미치는 효과를 확인하였다. Semi-quantitative RT-PCR과 quantitative real-time PCR을 통해 ferulic acid가 HAS-2의 발현을 증가시키는 것을 확인하였으며 ELISA assay를 통해 ferulic acid가 히알루론산의 생성을 증가시키는 것을 확인하였다. 결론적으로 본 연구를 통해 ferulic acid는 피부 노화에 따른 히알루론산의 감소에 의해 나타나는 건조, 주름 및 탄력 저하와 같은 현상을 개선시킬 가능성을 가진 물질임을 확인하였다.

• International Journal of Advanced Culture Technology
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• 제7권4호
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• pp.125-136
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• 2019

The radish skin and radish greens are an edible part of the radish. But they are removed before eating the radish and used as a byproduct or an animal feed material because of their tough and rough texture. Melanin is a pigment that gives colour to our skin. But increased production of melanin can turn into benign or malignant tumours. These days due to global warming, the amount of Ultra violet (UVB) rays has been extensively increased with sunlight. Due to this, a phenomenon called exogenous photo aging is widely observed for all skin colour and types. As a result of this phenomenon, a set of enzymes called matrix metalloproteinases (MMP's) that serves as degradation enzymes for extracellular matrix proteins mainly collagen is increased, causing depletion in collagen and resulting in early wrinkles formation. Therefore in our study we used the murine melanoma cell line B16/F10 to study the melanogenesis inhibition by Heated radish extract (HRE) in vitro and we used HRM-2 hair less mice exposed to artificial UVB for checking the efficacy of Heated radish extract in vivo. Furthermore, we prepared a 3% Heated radish extract (HRE) cream and checked its effects on human skin. Our results have clearly demonstrated that Heated radish extract (HRE) have potently suppressed the tyrosinase activity and melanin production in B16/F10 cells. It had also reduced the expression of components involved in melanin production pathway both transcriptionally and transitionally. In in vivo studies, HRE had potently suppressed the expression of MMP's and reduced the wrinkle formation and inhibited collagen degradation. Moreover, on human skin, ginseng cream increased the resilience, skin moisture and enhanced the skin tone. Therefore in light of these findings, we conclude that HRE is an excellent skin whitening and antiaging product.

• 한국축산식품학회지
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• 제41권4호
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• pp.674-686
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• 2021

This study aimed to enhance the quality of broiler breast meat by adding pig skin collagen to feed. A total of 50 Ross 308 broilers were classified according to the following feeding regime for two weeks: basal diet (NC), basal diet+0.1% fish collagen (PC), basal diet+0.1% pig skin collagen (T1), basal diet+0.5% pig skin collagen (T2), and basal diet+1.0% pig skin collagen (T3). The moisture content was the highest in the PC group, and the protein content was the lowest in the T1 group (p<0.05). The fat content was higher in the T1 and PC groups, whereas the ash content was higher in the T3 group (p<0.05). Drip loss was the highest in the NC group and the lowest in the T2 group (p<0.05). Lightness was low in groups T2 and T3, redness was low in groups T2 and PC, and yellowness was low in groups T1, T2, and PC (p<0.05). The collagen content of the chicken breast was the highest in the T3 group, and that of the skin was the highest in the T1 group (p<0.05). The texture characteristics of springiness, cohesiveness, chewiness, and hardness were the highest in the T3 group (p<0.05). In conclusion, the supplementation of a broiler diet with pig skin collagen was found to increase the collagen content of the breast meat, indicating the improved quality of the broiler breast meat.

• 대한본초학회지
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• 제29권4호
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• pp.9-12
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• 2014

Objectives : Atopic dermatitis is a skin problem that causes dry skin, intense itching, and then a red, raised rash. It may be a long-lasting (chronic) skin problem that requires more than one treatment. The cause of atopic dermatitis isn't clear, but it affects the skin's ability to hold moisture. The skin becomes dry, itchy, and easily irritated. The purpose of this study was to report the clinical effects of herbal medicine on atopic dermatitis. Methods : We employed oriental medical treatments; herbal-medication (Cheonggisanbyeonbang), acupuncture, moxibustion and cupping therapy. At the same time, the patient sweated out the skin poison. We treated him two times a week with oriental therapy method. He took medicine three times a day after a meal. During taking medicine, we let him avoid fatty food, flour based food, and alcohol. We took a picture the patient's body parts and compared the symptom with previous symptom. With the picture, we evaluated the patient's condition. Results : After taking treatment - 17 times' acupuncture, moxibustion and cupping therapy during 4 months- and taking herbal-medicine, the skin condition of the patient was much improved. At first, he was troubled with itching and hot feeling at reddish area, time after time the itching and hot feeling was weakened. The reddish area was changed to dry condition and changed to normal state. In advance, the symptom of arms was improved, and later the symptom of legs was started to improve. Conclusion : Herbal medicine (Cheonggisanbyeonbang) was an effective in the treatment of atopic dermatitis and it helped to improve regenerating the skin in the body.

• 한국산학기술학회논문지
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• 제19권4호
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• pp.492-504
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• 2018

본 연구는 에스테틱과 메디컬에서 여드름 치료제로 잘 알려진 글리콜릭산필링과 해초필링, 일반스크럽제를 사용하여 모공각화증 피부에 미치는 영향을 살펴보고 모공각화증 피부 개선 프로그램의 기초 자료로 제시하고자 수행하였다. 실험방법은 실험군인 글리콜릭산필링(GP)군과 해초필링(SP)군, 대조군인 일반스크럽제(GS)군으로 분류하였으며, 모공각화증이 다소 많은 팔과 다리 부위를 각 군별 5부위씩 선정하여 6주간 시행하였다. 피부측정은 실험 전 0주차, 실험 2주차, 실험 4주차, 실험 6주차에 각질량, 유분량, 수분량, 색소침착을 측정하여 실험 전 후를 비교 분석하였다. 분석결과 실험군인 GP군은 실험 후 수분량 증가(t=-4.064, p<0.01)와 색소침착 감소(t=3.536, p<0.01), SP군은 실험 후 각질량의 감소(t=2.370, p<0.05)와 색소침착의 감소(t=4.017, p<0.01) 대조군인 GS군은 각질량의 감소(t=2.834, p<0.05)와 수분량의 증가(t=-7.589, p<0.001)로 유의미한 차이가 있는 것으로 나타났다. 또한 피부 자극 반응 차이에서는 GS군이 가장 자극일 적은 것으로 나타났다. 모공각화증 관리의 개선 만족도는 실험군의 SP군이 만족도가 가장 높은 것으로 나타났다. 동일한 제품으로 관리를 받은 의향에서는 실험군의 SP군과 GP군이 동일하게 높게 나타났으며, 실험군과 대조군 모두 모공각화증의 관리가 필요한 것으로 나타났다. 결론적으로 여드름의 치료제로도 많이 사용되는 해초필링, 글리콜릭산필링, 일반스크럽제는 모공 주변에 쌓인 각질을 제거하여 각질주기를 정상화시키고, 피부의 수분을 증가시켜 모공각화증 피부를 개선시키는 효과가 있음을 알 수 있었다. 따라서 모공각화증 피부 개선을 위해서는 적절한 각질제거와 피부장벽을 보호하는 보습제 사용이 꾸준히 함께 적용되어야 할 것이며, 향후 본 연구가 모공각화증 피부 개선 프로그램의 기초 자료로 사용이 가능할 것으로 사료된다.

• 융합정보논문지
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• 제11권5호
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• pp.206-214
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• 2021

본 연구는 인삼저온숙성비누의 세안효과를 연구하기 위하여 진행하였다. 피부상태에 영향을 줄 수 있는 외부적 환경인자를 배제하기 위하여 동일한 환경에서 동일한 물과 타월을 사용하였으며, 세안 전과 세안 직후 10분의 피부변화를 조사하였다. 대조군으로는 세안제를 사용하지 않고 물세안만 한 경우와 시중에서 일반적으로 사용되고 있는 폼클렌저 타입의 세안제를 사용한 경우를 설정하였다. 물세안, F/C세안, 인삼cp비누 세안의 세 가지 케이스를 비교 분석하였으며 물세안의 경우 모공과 색소침착을 유의성있게 감소시켰으나 F/C세안과 인삼cp비누에 비하여는 유의성이 크지는 않았다. F/C세안의 경우 모공과 색소침착을 유의성이 크게 감소시켰으나 세안 후 급격한 수분감소가 나타났다. 인삼cp비누를 이용한 세안의 경우 모공과 색소침착을 유의성 크게 감소시키면서도 수분의 손실은 크게 나타나지 않았다. 그러므로 인삼cp비누는 피부관리를 함에 있어서 가장 적합한 세안제의 형태라고 사료된다.