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http://dx.doi.org/10.15230/SCSK.2013.39.4.281

Effect of Ferulic Acid Isolated from Cnidium Officinale on the Synthesis of Hyaluronic Acid  

Song, Hye Jin (R&D Center, LG Household & Healthcare, Ltd.)
Jin, Mu Hyun (R&D Center, LG Household & Healthcare, Ltd.)
Lee, Sang Hwa (R&D Center, LG Household & Healthcare, Ltd.)
Publication Information
Journal of the Society of Cosmetic Scientists of Korea / v.39, no.4, 2013 , pp. 281-288 More about this Journal
Abstract
Hyaluronic acid (HA) is one of the major extracellular matrix components in skin. The HA content is reported to decline with age, which may contribute to decrease in skin moisture, wrinkle formation and the decrease in elasticity of the skin. Among the family of HA synthase genes (HAS-1, 2, 3) identified so far, HAS-2 plays crucial roles in the regulation of HA synthesis in human skin fibroblasts. In this study, we elucidated the effects of ferulic acid isolated from Cnidium officinale on HA production. Semi-quantitative RT-PCR and quantitative real-time PCR showed that ferulic acid increased mRNA level of HAS-2 gene and ELISA assay also revealed that ferulic acid increased HA production in human skin fibroblasts. Our study suggests that ferulic acid might prevent age-dependent skin deteriorations such as wrinkles, dryness and elasticity decrease, all of which could be ascribed to the reduction of the HA content in human skin.
Keywords
skin; hyaluronic acid; Cnidium officinale; ferulic acid; HAS-2;
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