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http://dx.doi.org/10.1016/j.jgr.2019.05.003

Korean Red Ginseng extract ameliorates melanogenesis in humans and induces antiphotoaging effects in ultraviolet B-irradiated hairless mice  

Saba, Evelyn (Laboratory of Physiology and Cell Signalling, Kyungpook National University)
Kim, Seung-Hyung (Institute of Traditional Medicine and Bioscience, Daejeon University)
Lee, Yuan Yee (Laboratory of Physiology and Cell Signalling, Kyungpook National University)
Park, Chae-Kyu (R&D Headquarters, Korean Ginseng cooperation)
Oh, Jae-Wook (Department of Stem Cell and Regenerative Biotechnology, Konkuk University)
Kim, Tae-Hwan (Laboratory of Physiology and Cell Signalling, Kyungpook National University)
Kim, Hyun-Kyoung (5Department of Food Science and Engineering, Seowon University)
Roh, Seong-Soo (6 College of Korean Medicine, Daegu Haany University)
Rhee, Man Hee (Laboratory of Physiology and Cell Signalling, Kyungpook National University)
Publication Information
Journal of Ginseng Research / v.44, no.3, 2020 , pp. 496-505 More about this Journal
Abstract
Background: Panax ginseng is a marvelous herbal remedy for all ailments of body. That may be why it is called Panax, which means "cure for all". Melanin is a pigment that gives color to our skin; however, increased melanin production can lead to tumor formation. Human exposure to ultraviolet B radiation has increased extensively owing to the increased sunlight due to global warming. Consequently, a phenomenon called photoaging has been observed for all skin colors and types. As a result of this phenomenon, a set of enzymes called matrix metalloproteinases, which serve as degradation enzymes for extracellular matrix proteins, mainly collagen, is increased, causing depletion of collagen and resulting in early wrinkle formation. Methods: Therefore, in our study, we used the murine melanoma cell line B16/F10 to study the inhibition of melanogenesis by Korean Red Ginseng (KRG) extract in vitro and HRM-2 hairless mice exposed to artificial ultraviolet B to examine the efficacy of KRG in vivo. We prepared a 3% red ginseng extract cream and evaluated its effects on human skin. Results: Our results demonstrated that KRG induced potent suppression of tyrosinase activity and melanin production in B16/F10 cells; moreover, it reduced the transcription and translation of components involved in the melanin production pathway. In the in vivo experiments, KRG potently suppressed the expression of matrix metalloproteinases, reduced wrinkle formation, and inhibited collagen degradation. On human skin, ginseng cream increased skin resilience and skin moisture and enhanced skin tone. Conclusion: Therefore, we conclude that KRG is an excellent skin whitening and antiaging product.
Keywords
Antiaging; Human trials; Korean Red Ginseng extract; Melanogenesis; Wrinkles;
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Times Cited By KSCI : 7  (Citation Analysis)
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