• Journal of Trauma and Injury
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• 제36권3호
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• pp.304-309
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• 2023

A Morel-Lavallée lesion (MLL) is a pathologic fluid collection within an abnormally formed space, resulting from an internal degloving injury between the muscle fascia and subcutaneous fat layer. Due to its resistance to conservative treatments such as drainage or compression dressing, various therapeutic methods have been developed for MLL. However, no standardized guidelines currently exist. Recently, endoscopic debridement and cutaneo-fascial suture (EDCS) has been introduced for the treatment of MLL, particularly for large lesions resistant to conservative approaches. While this procedure is known to be effective, limited reports are available on potential complications. The authors present a case of skin necrosis following EDCS for a massive MLL.

• Archives of Plastic Surgery
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• 제36권3호
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• pp.269-276
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• 2009

Purpose: Local skin necrosis after extravasation of adriamycin, a widely used chemotherapeutic agent, is a common problem in cancer patients. The extravasation of chemotherapeutic agents yields severe inflammatory responses, crust formation, skin necrosis, and ulceration. Even though several treatment options have been proposed for extravasation injury, there is still controversy regarding the management of such lesions. Thus the aim of this study was to compare the efficacy of saline injection(Group 1), hydrocortisone injection(Group 2), propranolol injection(Group 3) and early surgical excision as a treatment(Group 4) in a rat extravasation model. Methods: The authors planned forty mature male Sprague - Dawley rats were divided into 4 groups and each group contained 10 rats. Administration of adriamycin($1.0mg/m{\ell}$) $1.5m{\ell}$ by subcutaneous injection on the dorsal side of the rats was followed by protocol. The treatment options were applied 2 hours after adriamycin injection. At the end of the 5th days, the presence and size of ulcers at the injection site were measured. 3 weeks after injection, a histopathologic examination was performed for each treatment and control group. T - tests were used to analyze the differences between the measurements. Results: Propranolol significantly improved tissue recovery compared with control group and other groups. These data suggest that there is little role for saline and hydrocortisone in the treatment of adriamycin extravasation injury. Conclusion: In this study, we compared some treatment methods in adriamycin extravasation model. The findings support the propranolol injection may prevent extravasation injury. However this study was performed in the laboratory using rats, and the results could be different in clinical application. Thus, more needs further investigations and clinical application.

• Applied Microscopy
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• 제32권3호
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• pp.275-284
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• 2002

두꺼비 등 피부손상 후 과립선의 재생과정을 주사전자현미경과 투과전자현미경으로 관찰하였다. 절개에 의하여 피부손상을 가한 후 실험을 위하여 특수히 제작된 cage 내에서 최대 20일간 사육하였다. 투과전자현미경 관찰에서 손상 4일 후 미성숙 형태의 신생 과립선이 관찰되었으며, 상피세포는 신생 과립선의 첨단부로 이동하여 있었다. 상피세포의 표면은 편평하였으며 desmosome 에 의해 서로 연결되어 있지 않았다. 미토콘드리아를 많이 함유한 세포돌기 (MRC)들이 선의 내강을 형성하고 있었고, 이들 돌기에서는 hemidesmosome이 관찰되었다. 신생선의 기저강은 MRC, 과립형성전세포 및 과립형성 세포 등으로 이루어져 있었다. 특히, 손상 후 10일에 xanthophore가 상피세포의 기저부로 이동하여 있음이 관찰되었다. 이들 세포는 다수의 크기가 큰 pterinosome 과 중등도의 전자밀도를 가진 carotenoid vesicle을 포함하고 있었다. 손상 후 13일에, xanthophore는 많은 carotinoid vesicle과 lammelated pterinosomes을 포함하고 있었다. Iridophore는 손상 16일에 분화중인 xanthophore 주변에서 관찰되었다. 이러한 소견은 손상으로부터의 회복 과정에 선조세포(glandular precursor cell)로부터 과립선이 재생되며, 선세포의 팽대는 이들 신생 세포의 성숙 및 증식에 의한 것을 의미한다.

• 한국식품저장유통학회지
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• 제18권5호
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• pp.651-660
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• 2011

자두 '대석조생'의 생육단계별 수확시기 및 저온저장 온도에 따른 저온장해과 발생 양상과 품질 특성을 구명하고자 하고자, 자두 '대석조생'을 60%, 80% 그리고 90% 이상의 착색율로 구분하여 수확한 후, 1, 4, 5, $6^{\circ}C$ 그리고 $20^{\circ}C$에 최대 48일간 그리고 $20^{\circ}C$에서 3일간 숙성시키면서 호흡 변화, 품질 특성 및 저온 장해과 발생 양상을 조사하였다. 60% 착색기에 수확한 자두를 보다 낮은 저온에 저장하였을때 경도, 색도, 중량감소율과 적정산도의 유지에 효과적이었으며, 이 조건에서 에틸렌 발생량과 호흡량도 보다 낮게 유지되었다. '대석조생' 자두의 저온장해 증상은 주로 내부 갈변을 동반한 gel breakdown과 과육투명화 현상이었는데, 이러한 저온장해과는 모든 숙기별 처리구 그리고 $6^{\circ}C$ 이하의 모든 저장 온도에서 발생하였다. 그러나 성숙이 진행되지 않은 과일일수록, 그리고 저장 온도가 낮을수록 저온장해과 발생율을 낮게 나타났다. 이 결과는 '대석조생' 자두의 저온장해과 발생이 저장기간 동안의 호흡 양상과 관련되어 있음을 의미한다.

• Archives of Plastic Surgery
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• 제47권5호
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• pp.435-443
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• 2020

Background The innervated radial artery superficial palmar branch (iRASP) flap was designed to provide consistent innervation by the palmar cutaneous branch of the median nerve (PCMN) to a glabrous skin flap. The iRASP flap is used to achieve coverage of diverse volar defects of digits. However, unexpected anatomical variations can affect flap survival and outcomes. Methods Cases in which patients received iRASP flaps since April 1, 2014 were retrospectively investigated by reviewing the operation notes and intraoperative photographs. The injury type, flap dimensions, arterial and neural anatomy, secondary procedures, and complications were evaluated. Results Twenty-eight cases were reviewed, and no flap failures were observed. The observed anatomical variations were the absence of a direct skin perforator, large-diameter radial artery superficial palmar branch (RASP), and the PCMN not being a single branch. Debulking procedures were performed in 16 cases (57.1%) due to flap bulkiness. Conclusions In some cases, an excessively large RASP artery was observed, even when there was no direct skin perforator from the RASP or variation in the PCMN. These findings should facilitate application of the iRASP flap, as well as any surgical procedures that involve potential damage to the PCMN in the inter-thenar crease region. Additional clinical cases will provide further clarification regarding potential anatomical variations.

• Archives of Reconstructive Microsurgery
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• 제14권1호
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• pp.70-76
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• 2005

The Z-plasty has been known as a most common surgical treatment of congenital circumferential constriction band syndrome of the hand. There were thirteen patients of congenital circumferential constriction band syndrome of the hand. All patients underwent Z-plasty under microscope. we did microsurgical dissection to minimize vascular, neural and lymphatic injury, and then considering secondary correction and scar contracture, tried to preserve as much subcutaneous fat and skin flap as possible without any excision. There were less skin necrosis and lymphedema as a result of vascular compromise. Using microscope offers several advantages. First, preventing vascular, neural and lymphatic injury. Second, getting an accurate suture approximation. finally, preserving as much subcutaneous fat and skin flap as possible without any excision. The outcome of digit growth and contour can be excellent than we expected. As a results, we believe that correction of congenital circumferential constriction band syndrome of the hand under the microscope have better results.

• 대한임상독성학회지
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• 제8권1호
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• pp.43-45
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• 2010

A 22-year-old woman was referred to our emergency department for the treatment of a chemical injury on her arm. She had accidentally spilled 99% trifluoroacetic anhydride (TFAA) over her left forearm during an organic chemistry experiment. She visited a primary care unit, and then she was referred to our hospital for inactivation of the released fluoride ions. Her skin lesions were different from those caused by hydrofluoric acid (HF) injury. The injured area showed painful whitish maculae and patchy areas with accentuated rim. No vesiculation and bulla formation was detected. We intradermally injected a 5% solution of calcium through a 24-gauge needle into the burned skin. After the injection, she complained of more severe pain. Although TFAA contains fluorine, it does not release free fluoride ions on contact with the skin, unlike HF. In fact, application of calcium gluconate for TFAA burns is not recommended. Rather, it should be avoided since it increases pain and local abscess formation.

• 한국자동차공학회논문집
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• 제20권2호
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• pp.64-69
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• 2012

Head injury is one of the most common cause of deaths in car-to-pedestrian collisions. To reduce the severity of such injuries, many international safety committees have performed headform impact test for pedestrian protection. In this paper, an adult headform impactor model is developed based on the finite element (FE) method and validated through the numerical simulation. The skin material of headform impactor is known as polyvinyl chloride skin (PVC) and its material was assumed as viscoelastic. The viscoelastic parameters of headform skin are identified by a series of trial and error methods. The new developed FE adult headform impactor is verified by the drop test and FE JARI adult headform impactor provided by Madymo program.

• 대한의생명과학회지
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• 제7권3호
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• pp.139-143
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• 2001

The present study was conducted to determine whether skin spread of Myrrha has an effect on the cell regeneration as well as wound healing following dermal scald burn injury, keratinocyte growth factor (KGF) level was analyzed immunologically in conjunction with the histological changes occurred in skin tissue. The KGF contents in Myrrha skin spread group, which shows cell regeneration ability in skin tissue after burn, increased after 5 hours. After 24 hours, 'the content of Myrrha skin spread group is noticeably higher than at 5 hours postburn. After 72 hours, KGF was decreased compared to at 24 hours postburn. Acceleration effect of KGF production in Myrrha skin spread group was high. Together with the result of histological changes, skin spread of Myrrha reduced protein degeneration and edema in dermis, and induced proliferation of epithelial cells. The data suggest that Myrrha has accelerate cell regeneration and wound healing in case of scald burn skin by spreading of paste.

• 대한두개안면성형외과학회지
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• 제21권1호
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• pp.49-52
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• 2020

The specialized structure of the upper eyelid ensures complete closure of the eye and eyeball sealing. An upper eyelid injury can cause various symptoms associated with eyeball trauma, not just scar formation or eyelid deformity. In this report, we describe a case of lagophthalmos observed after wound repair in a patient with a crushing injury caused by a grinder. Several surgical techniques are used to treat lagophthalmos or scar contracture. In most cases, a releasing procedure is performed after 6 months of initial repair. However, if the patient has severe symptoms that are not relieved by conservative care, early revision is inevitable. We describe a case of early lagophthalmos successfully resolved with pentagonal wedge resection, fat redistribution, and full-thickness skin grafting. After the revisional surgery, we observed that the patient regained the ability to completely close the injured eyelid, with restoration of function and favorable cosmetic outcomes. Pentagonal wedge resection to release a retracted structure, fat redistribution to prevent readhesion, and full-thickness skin grafting for enough amount of skin to regain upper eyelid function is useful for scar release and lagophthalmos following crushing injuries of the upper eyelid.