• Journal of Sericultural and Entomological Science
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• v.55 no.2
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• pp.40-43
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• 2019

Mature silkworms (MS) of Bombyx mori have enlarged silk glands, which are known to be enriched with various functional materials. A special steaming method has been developed for processing MS with enlarged silk glands edible, by which the MS have become a potential health supplement for improving the quality of life. Steamed and lyophilized MS powder (SMSP) has been strongly believed to have various unidentified beneficial effects for humans. Therefore, the purpose of this mini-review is to summarize the various health promoting functionalities of SMSP, which have been published in the paper so far. Firstly, SMSP increased healthspan as well as lifespan, locomotor ability, and resistance to Parkinson's disease by enhancing olfaction and mitochondrial activity in neurons. Secondly, SMSP increased resistance to carcinogens causing liver cancers, improved both acute and chronic liver function with alcohol metabolism, and prevented alcohol induced stomach ulcers. Thirdly, SMSP reduced UVB-induced skin pigmentations and melanogenesis. Taken together, SMSP can be regarded as a promising natural health product to increase incomes for sericultural farm households in Korea as well as global human health and welfare.

• Physical Therapy Rehabilitation Science
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• v.2 no.2
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• pp.63-69
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• 2013

Objective: To assess the effect of vitamin D administration on the skin blood flow response to occlusion and heat. Design: Cross-sectional study. Methods: Twenty age matched subjects; 10 who had diabetes and 10 who were controls were administered 4,000 IU of vitamin D3 for 3 weeks at breakfast. The function of the endothelial cells was evaluated in 2 ways; first, the response to 4 minutes of vascular occlusion of the skin was measured with a laser Doppler flow meter. Second, the skin blood flow response to local heat at 42 degrees C for 6 minutes was examined. Results: The results of the experiments showed that the blood flow response to heat was reduced after 3 weeks administration of vitamin D in the subjects with diabetes and in the control subjects (p<0.05). The response to occlusion was not significantly different within each group before and after vitamin D administration, but the group with diabetes had a significantly lower blood flow response to occlusion than did the controls (p<0.05). Conclusions: Acute doses of vitamin D may impair nitric oxide production and reduce blood flow to tissue during stressors in people with diabetes.

• Journal of Fashion Business
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• v.19 no.4
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• pp.92-108
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• 2015

This study aimed at developing a down jacket prototype that utilized sunlight as an alternative energy source with no air pollution. The jacket is filled with flexible solar panels and has a heat-generating function and LED function. In this study, three smart down jacket prototypes were developed, and the jacket's capabilities were demonstrated through the thermal effect on the performance test. The typical output voltage of the flexible solar panels was 6.4V. By connecting the 2 solar cell modules in series, the final output voltage was 12.8V. A battery charge regulator module was used the KA 7809 (TO-220) of 9V. Three heating pads were to be inserted into the belly of the jacket as direct thermal heating elements, and the LED module was configured, separated by a flash and an indicator. The smart down jacket was designed to prevent damage to the down pack without the individual devices' interfering with the human body's motion. Because this study provides insulation from extreme cold with a purpose, the jacket was tested for heat insulation properties of non-heating, heating on the back, heating on the abdomen, and heating on both the back and abdomen in a sitting posture in a static state. Thermal property analysis results from examining the average skin temperature, core temperature, and the temperature and humidity within clothing showed, that placing a heating element in one place was more effective than distributing the heating elements in different locations. Heating on the back was the most effective for maintaining optimal skin temperature, core temperature, and humidity, whereas heating on the abdomen was not effective for maintaining optimal skin temperature, core temperature, or humidity within clothing because of the gap between the jacket and the body.

• Korean Journal of Food Science and Technology
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• v.49 no.5
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• pp.519-523
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• 2017

We investigated the applications of functional materials through the examination of a variety of physiological activities of Ipomoea aquatica extract. I. aquatica extract showed low cytotoxicity against murine melanoma B16F10 cells. At concentrations that exerted little or no cytotoxicity to the cells, I. aquatica extract showed high DPPH radical scavenging activity ($ID_{50}$, $7.84{\mu}g/mL$), inhibited tyrosinase activity ($ID_{50}$, $106.56{\mu}g/mL$), and decreased melanin content ($ID_{50}$, $41.75{\mu}g/mL$). The treatment of B16F10 cells with I. aquatica extract suppressed the protein expression of tyrosinase in a dose-dependent manner. These findings suggested that I. aquatica extract inhibited melanin synthesis in murine melanoma B16F10 cells through the suppression of intracellular tyrosinase expression, as well as the simultaneous direct inhibition of tyrosinase activity. Additionally, I. aquatica extract promoted the expression of involucrin, which is related to skin barrier protection. These results indicate that I. aquatica extract may be an appropriate material for the improvement of skin barrier function.

• Korean Journal of Food Science and Technology
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• v.50 no.3
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• pp.344-348
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• 2018

We investigated the application of functional materials by examining a variety of physiological activities of Abelmoschus esculentus extract. A. esculentus extract had a low cytotoxicity against murine melanoma B16F10 cells. At concentrations showing little or no cytotoxicity, A. esculentus extract showed high a DPPH radical scavenging activity ($ID_{50}$, $5.24{\mu}g/mL$), inhibited tyrosinase activity ($ID_{50}$, $102.12{\mu}g/mL$), and decreased melanin content ($ID_{50}$, $17.85{\mu}g/mL$). The treatment of B16F10 cells with A. esculentus extract suppressed the protein expression of tyrosinase in a dose-dependent manner. These findings suggest that A. esculentus extract inhibits melanin synthesis in murine melanoma B16F10 cells by suppressing intracellular tyrosinase expression, as well as directly inhibits tyrosinase activity simultaneously. Additionally, A. esculentus extract promotes the expression of involucrin, which is related to skin barrier protection. These results indicate that A. esculentus extract is an appropriate material for improving skin barrier function.

• Science of Emotion and Sensibility
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• v.14 no.3
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• pp.435-444
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• 2011

The development of ubiquitous healthcare technology and portable electronic devices requires new energy sources for providing continuous power supply. This study particularly focuses on an energy harvesting system capable of charging energy using clothing. One of the sources for energy harvesting is heat energy, which is the difference in temperature of the body and the surrounding environment. In this study, the skin temperature distribution of the human body was empirically measured to determine the basic materials needed to develop heat energy harvesting clothing. The distribution of skin temperature in different sections of the human body was analyzed. The analysis found that the skin temperature of the upper body was higher than that of the lower body. The area close to the heart with a lot of blood flow was especially high. The skin temperature of the back side of the body, such as the back of the neck, upper back, and waist, was higher than that of the front side of the body. As for the arms, the skin temperature of the upper arms was higher than that of the lower arms, and the skin temperature of the back side of the arms was lower than that of the front and the flank side of the arms. The difference in the average skin temperature and the environment temperature was highest at the back of the neck, and thereby is considered to be the most appropriate section to integrate the heat energy harvesting function and structure. The following sections had the next highest difference in values, listed in descending order: the back of the waist, the sides of shoulders, the front chest area, the front side of the upper arms, and the front abdomen. Based on the skin temperatures of the different sections of the human body, this study outlines the basic guidelines for developing heat energy harvesting clothing.

• Journal of the Society of Cosmetic Scientists of Korea
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• v.46 no.3
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• pp.307-317
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• 2020

The barrier structure of the skin's epidermis is a key structure to prevent the loss of water inside the body and the invasion of foreign substances, and is composed of keratinocytes and intercellular lipids. At this time, the intercellular lipids of the skin barrier has the strongest structure when packed in an orthorhombic structure. However, it is damaged by various external causes and changes to a hexagonal structure. This change in physical structure can be analyzed non-invasively by analyzing the signal of the CH₂-CH₂ scissoring band of lipids using FT-IR. In this study, SDS was treated on porcine skin to construct a skin barrier damage model, and the degree of change in packing structure was quantified by analyzing FT-IR signals. We then judged whether the barrier of the damage model was recovered according to the treatment of the cosmetic formulation. From these results, an indirect method of measuring the water evaporation of the skin barrier to date can be supplemented. In addition, physical changes in the structure of the skin barrier can be utilized in a direct and efficient manner to identify the function and verify the formulation of various materials.

• Korean Journal of Food Science and Technology
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• v.43 no.4
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• pp.458-463
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• 2011

Recent studies have revealed that collagen peptide (CP) plays a protective role in skin by improving the activity of antioxidants and acts as an inducer of skin regeneration by positive feedback. In this study, we focused on the beneficial effect of reinforcing the CP skin barrier. To evaluate the skin barrier, hairless mice were exposed to UVB irradiation and acetone-treatment, with or without oral administration of CP. The effects on skin appearance, trans-epidermal water loss, epidermal thickness, and cytokine content were measured using bioengineering and histochemical methods. In the CP treated group, the skin had better appearance and less damage than that of the control. Furthermore, in HaCaT cells, the amount of serinepalmytoyl transferase (SPT) mRNA increased by about 1.6-fold after treatment (CP, 100 mg/L), reflecting that CP can induce SPT expression and reinforce the recovery of skin barrier function. These results suggest that CP is not only an anti-wrinkling agent but also a potent candidate as an epidermal moisturizer.

• Journal of the Society of Cosmetic Scientists of Korea
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• v.50 no.2
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• pp.153-161
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• 2024

Vitamin D is a fat-soluble vitamin that is mainly produced in the skin by UV rays. Along with melatonin, it is a representative chronobiotic substance, and the skin plays an important role in distinguishing between day and night. However, vitamin D cannot be used directly in cosmetics because it is a vitamin that acts as a coenzyme and plays a hormonal role in regulating the expression of various types of genes. Therefore, it was to investigate the skin efficacy of provitamin D (7-dehydrocholesterol), a vitamin D precursor that can be used in cosmetics. Our findings reveal that pro vitamin D can effectively inhibit the expression of tyrosinase, the melanin-producing enzyme, thereby attenuating melanin synthesis. This skin tone regulatory effect has been corroborated in vitro using artificial skin models. Additionally, pro vitamin D demonstrated anti-inflammatory properties by suppressing the expression of TNFa and, upon conversion to vitamin D through UV exposure, it was observed to induce the production of the antimicrobial peptide CAMP (LL-37). The inhibitory effect of pro vitamin D on melanin production appears to be a result of it reducing the UV absorption capacity of melanin, thereby inducing the conversion of pro D to vitamin D. Utilizing pro vitamin D in cosmetic formulations could not only modulate skin tone and enhance skin immunity but also expect to contribute to other cutaneous benefits as anti-aging and barrier function improvement with everyday UV exposure. This multifaceted efficacy positions pro vitamin D as a promising ingredient in advancing the formulation of skin care products.

• KSCE Journal of Civil and Environmental Engineering Research
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• v.9 no.2
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• pp.107-114
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• 1989

Model pile pull-out tests have been executed to investigate the characteristics of the critical relative displacement at which the critical pile skin resistance is mobilized. Test result shows that the critical relative displacement is neither constant nor pile size dependent, but it is the most closely related with the magnitude of the critical skin resistance. The empirical relationship between the two quantities has been established. Behavior of centrifuge physical models of skin-resistance-related problems has been investigated on a quantitative basis by a computational method. A pile downdrag problem has been employed as an example of the skin-resistance-related problems. A simple transfer function type method has been developed for the analysis of the downdrag. It is concluded from the analysis that centrifuge physical modeling of skin-resistance-related problems may lead to an erroneous result on an unconservative side, as may have been expected due to the violation of the similarity rule by the quantity of the critical relative displacement.