• 한국동물위생학회지
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• 제45권2호
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• pp.133-137
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• 2022

Lumpy skin disease (LSD) is a severe cross-border infectious disease that causes fever, skin and visceral nodules in cattle. LSD is caused by the lumpy skin disease virus (LSDV), a dsDNA virus that belongs to the genus Capripoxvirus. Although LSD has been found only in Southern Africa traditionally, in the last decade it is spreading very quickly through the Middle East and into Eastern Europe and China. It usually affects cattle and water buffalos being transmitted by blood-feeding insects. As it causes a huge economic impact, LSD is a notifiable disease by World Organisation for Animal Health, and managed as the legal infectious disease class I in Korea. Therefore, the purpose of this study was to confirm the existence of LSDV antigens or antibodies in Korean livestock. We collected 1,200 blood samples from cattle (Korean native and dairy cattle) and Korean water deer in 4 major provinces of the country, then tested the existence of LSDV antigen and antibody. None (0.0%) of the 1,200 blood samples were positive for both antigen and antibody of LSDV. To the best of our knowledge, this is the first study that examines the prevalence of LSDV in Korea. Our study aims to report the LSDV occurrence situation obtained by surveillance in Korea and provide information that may help prevention of LSD epidemics.

• 혜화의학회지
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• 제9권1호
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• pp.113-120
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• 2000

This study was carried out to investigate the relation between the Onbyung and the skin disease, and classify the medical treatment by some categories. The results were as follows ; 1. Onbyung reduces the Eun(陰) by the fever and the skin disease results from the deficiency of the Eun and blood. 2. We can grasp the depth of the disease and the damage of the Jung Gi(正氣) by the observation of the every condition on the skin disease. 3. Medical treatment 1. Hae Phyo Bub(解表法) Using the method of the perspiration, we take care of the preservation of the sap. 2. Cheong Gi Bub(淸氣法) of the using Gypsum and Tong Ha Bub(通下法) of the using Dae Whang(大黃). A. Cheong Gi Bub(淸氣法) When the Sa(邪) stay the Gi area(氣分), we use the radiational material or the Wha Sub(化濕) material with Gypsum. B. Tong Ha Bub(通下法) We reduce the evil fever by the Ha Bub(下法). 3. Cheong Yul Hae Dog Bub(淸熱解毒法) and Ja Eum Bub(滋陰法) 4. Wha Sub Bub(化濕法) This treatment reduce the fever by eliminating the urine or the sweat.

• 한국컴퓨터정보학회논문지
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• 제25권12호
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• pp.25-34
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• 2020

본 논문에서는 딥러닝 지도학습 알고리즘을 사용한 학습 모델을 대상으로 미용 관련 피부질환 인식의 효과성을 실험적으로 비교한다. 최근 딥러닝 기술을 산업, 교육, 의료 등 다양한 분야에 적용하고 있으며, 의료 분야에서는 중요 피부질환 중 하나인 피부암 식별의 수준을 전문가 수준으로 높인 성과를 보이고 있다. 그러나 아직 피부미용과 관련된 질환에 적용한 사례가 다양하지 못하다. 따라서 딥러닝 기반 이미지 분류에 활용도가 높은 CNN 알고리즘을 비롯하여 ResNet, SE-ResNet을 적용하여 실험적으로 정확도를 비교함으로써 미용 관련 피부질환을 판단하는 효과성을 평가한다. 각 알고리즘을 적용한 학습 모델을 실험한 결과에서 CNN의 경우 평균 71.5%, ResNet은 평균 90.6%, SE-ResNet은 평균 95.3%의 정확도를 보였다. 특히 학습 깊이를 다르게하여 비교한 결과 50개의 계층 구조를 갖는 SE-ResNet-50 모델이 평균 96.2%의 정확도로 미용 관련 피부질환 식별을 위해 가장 효과적인 결과를 보였다. 본 논문의 목적은 피부 미용과 관련된 질환의 판별을 고려하여 효과적인 딥러닝 알고리즘의 학습과 방법을 연구하기 위한 것으로 이를 통해 미용 관련 피부질환 개선을 위한 서비스 개발로 확장할 수 있을 것이다.

• 한방안이비인후피부과학회지
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• 제30권1호
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• pp.1-9
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• 2017

Objectives : This study was performed to review the overseas clinical research trends on the effect of On cheong eum on skin disease. Methods : We searched articles in the Pubmed using keywords "On cheong eum", "On sei in", "Wen qing yin", "Jie du si wu tang" and "Jie du si wu decoction". We also searched in the China National Knowledge Infrastructure(CNKI) using key words "温清饮" and "解毒四物汤", We selected 5 studies after excluding non-clinical or unrelated studies. Results : One pre-post comparison study and four controlled clinical trials were performed. On cheong eum and modified On cheong eum were used for the treatment of skin disease-recurrent aphthous ulcer, psoriasis vulgaris, neurodermatitis, and skin pruritus. All of the studies showed positive results, and they reported that the treatment group had higher effective rate than control group. However, the quality of these clinical studies were not evaluated. Conclusions : According to this study, On cheong eum would be an effective and safe intervention in skin disease. Therefore, based on this study, more clinical research using On cheong eum should be performed in Korean medicine in the near future.

• Asian Pacific Journal of Cancer Prevention
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• 제13권9호
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• pp.4655-4660
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• 2012

Opuntia humifusa, member of the Cactaceae family, was previously demonstrated to have radical scavenging, anti-inflammatory and anti-proliferative effects in in vitro models. It was suggested that O. humifusa could function in the prevention of carcinogenesis. To investigate the in vivo chemopreventive effect of O. humifusa, mice were fed a diet containing either 1% or 3% following 7, 12-dimethylbenz[a] anthracene (DMBA) and 12-O-tetradecanoylphorbol-13-acetate (TPA) induction of skin carcinogenesis. Significant decrease in the numbers of papilloma and epidermal hyperplasia were observed in mice fed with O. humifusa, compared to the control group. O. humifusa also upregulated high total antioxidant capacity and level of phase II detoxifying enzyme such as superoxide dismutase and glutathione S-transferase activity in the skin. Lipid peroxidation activity level was measured in skin cytosol and significantly inhibited in 3% OH fed group compared to the control group. These results suggest that O. humifusa exerts chemopreventive effects on chemical carcinogenesis in mouse skin and that prevention effects are associated with reduction of oxidative stress via the modulation of cutaneous lipid peroxidation, enhancing of total antioxidant capacity especially in phase II detoxifying enzyme system and partial apoptotic influence.

• 대한두개안면성형외과학회지
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• 제21권6호
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• pp.372-375
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• 2020

Congenital midline cervical cleft is a rare congenital disease. The disease is often misdiagnosed as a branchial cleft deformity, thyroglossal duct cyst, or other skin diseases. It has the following characteristics: skin defect at the midline of the anterior neck, a skin tag at the upper end of the lesion, and a blind sinus tract at the caudal aspect with or without mucoid discharge. Treatment is usually for aesthetic purposes; therefore, early surgical en bloc resection with Z-plasty or W-plasty is recommended to reduce recurrence and scar formation.

• Journal of Veterinary Science
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• 제23권5호
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• pp.73.1-73.8
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• 2022

Background: Lumpy skin disease (LSD), a disease transmitted by direct and indirect contact with infected cattle, is caused by the Lumpy skin disease virus (LSDV). The disease affects cattle herds in Africa, Europe, and Asia. The clinical signs of LSD range from mild to the appearance of nodules and lesions in the skin leading to severe symptoms that are sometimes fatal with significant livestock economic losses. Objectives: This study aimed to characterize LSDV strains in the blood of infected cattle in Thailand based on the GPCR gene and determine the phylogenetic relationship of LSDV Thailand isolates with published sequences available in the database. Methods: In total, the blood samples of 120 cattle were collected from different farms in four provinces in the northeastern part of Thailand, and the occurrence of LSDV was examined by PCR based on the P32 antigen gene. The genetic diversity of LSDV based on the GPCR gene was analyzed. Results: Polymerase chain reaction assays based on the P32 antigen gene showed that 4.17% (5/120) were positive for LSDV. All positive blood samples were amplified successfully for the GPCR gene. Phylogenetic analysis showed that LSDV Thailand isolates clustered together with LSDVs from China and Russia. Conclusions: The LSD outbreak in Thailand was confirmed, and a phylogenetic tree was constructed to infer the branching pattern of the GPCR gene from the presence of LSDV in Thailand. This is the first report on the molecular characterization of LSDV in cattle in Thailand.

• 한방안이비인후피부과학회지
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• 제23권3호
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• pp.11-32
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• 2010

Objective : The aim of this study is to determine the effects of Dendrobii herba extract and Punica granatum extract on skin disease and skin beauty. Methods : To investigate in vitro anti-oxidant activity assay, ethanol extracts of medicinal plants tested by DPPH radical, xanthine oxidase activity. In the next experiment, to investigate anti-inflammatory activity assay, examined by relations in NO synthesis, IL-$1{\beta}$, IL-6, TNF-${\alpha}$, NF-${\kappa}B$, COX-2, MAP kinase. To study Skin wrinkle formation effect, we were examined by tyrosinase activities, melanin synthesis in MNT-1 cell. Results : 1. In an anti-oxidant test, Dendrobii and Punica granatum extract showed high radical scavenging activity. 2. In an anti-inflammatory test, Dendrobii herba and Punica granatum extract weakly inhibited the lipopolysaccharide(LPS)-induced nitric oxide(NO) release from RAW 246.7 macrophage cells. Dendrobii herba and Punica granatum extract also inhibited LPS-induced IL-$1{\beta}$ and COX-2 expressions. The inhibitory effect of Dendrobii herba and Punica granatum extract on macrophage activation were via the inhibition of NF-${\kappa}B$, evidenced by transient transfection assay. however, Dendrobii herba and Punica granatum extract did not have any effects about activation of Jun-N-terminal kinase(JNK) and inhibition of p38 MAP kinase in RAW 264.7 cells. 3. In the skin wrinkle formation assay, Dendrobii herba and Punica granatum extract weakly inhibited collagenase and elastase, however it was not statistically significant. 4. In the skin whitening assay, Dendrobii herba and Punica granatum extract weakly inhibited tyrosinase activity, however, it was not statistically significant. They did not have any effect on melanin synthesis, indicating that they could not be applicable for skin whitening. Conclusion : Dendrobii herba extract and Punica granatum extract may play a significant role in skin disease and skin beauty.

• 한방안이비인후피부과학회지
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• 제23권1호
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• pp.23-43
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• 2010

Objective : This study was performed to assess the effects of Aloe and Violae herba extracts on skin disease and skin beauty. Methods : Anti-oxidant effects were measured by the scavenging for DPPH radical, xanthine oxidase activity. Anti-inflammatory effects were examined by relations in NO synthesis, IL-$1{\beta}$, IL-6, TNF-$\alpha$, NF-kB, COX-2, MAP kinase. The skin wrinkle formation effects were measured by collagenase and elastase activities. The whitening effects were examined by tyrosinase activities, melanin synthesis in MNT-1 cell. Results : 1. In an anti-oxidant test, Aloe and Violae herba extracts showed high radical scavenging activity. 2. In an anti-inflammatory test, Aloe and Violae herba extracts strongly inhibited the lipopolysaccharide(LPS)-induced nitric oxide(NO) release from the RAW 246.7 macrophage cells. Aloe and Violae herba extracts also inhibited the LPS-induced IL-$1{\beta}$ and COX-2 expressions. The inhibitory effects of Aloe and Violae herba extracts on macrophage activation were via the inhibition of NF-kB, evidenced by transient transfection assay. Furthermore, Aloe and Violae herba extracts weakly inhibited the activation of Jun-N-terminal kinase(JNK) but they did not have any effects on p38 MAP kinase in RAW 264.7 cells. 3. In the skin wrinkle formation assay, Aloe extract strongly inhibited collagenase and elastase, whose activity are tightly related with the wrinkle formation. 4. In the skin whitening assay, Aloe and Viloae herba extracts weakly inhibited tyrosinase activity, however, it was not statistically significant. Besides they did not have any effects on melanin synthesis, indicating that they could not be applicable for skin whitening. Conclusion : This study show that Aloe and Violae herba extracts may play a significant role in skin disease and skin beauty.

• 정보처리학회논문지:소프트웨어 및 데이터공학
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• 제10권12호
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• pp.555-560
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• 2021

최근 안면 피부 미용에 대한 사람들의 관심이 높아짐에 따라 딥 러닝을 활용한 안면 피부 미용을 위한 피부 질환 인식 연구가 진행되고 있다. 이러한 연구들은 여드름을 비롯한 다양한 피부 질환을 인식한다. 기존의 연구들은 단일 피부 질환만을 인식하지만, 안면에 발생하는 피부 질환은 더 다양하고 복합적으로 발생할 수 있다. 따라서 본 논문에서는 Inception-ResNet V2 모델을 활용하여 다중 레이블 분류 방법으로 여드름, 블랙헤드, 주근깨, 검버섯, 일반 피부, 화이트헤드에 관한 복합적인 피부 질환을 인식한다. 사용한 평가 지표 중 정확도는 98.8%, 해밍 손실은 0.003을 달성하였고, 단일 클래스별 정밀도, 재현율, F1-점수는 모두 96.6% 이상을 달성하였다.