• Biomolecules & Therapeutics
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• 제23권2호
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• pp.165-173
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• 2015

Most skin damage caused by ultraviolet B (UVB) radiation is owing to the generation of reactive oxygen species. Phytochemicals can act as antioxidants against UVB-induced oxidative stress. This study investigated the protective effects of the flavone galangin against UVB-induced oxidative damage in human keratinocytes. Galangin efficiently scavenged free radicals and reduced UVB-induced damage to cellular macromolecules, such as DNA, lipids, and proteins. Furthermore, galangin rescued cells undergoing apoptosis induced by UVB radiation via recovering mitochondrial polarization and down-regulating apoptotic proteins. These results showed that galangin protects human keratinocytes against UVB radiation-induced cellular damage and apoptosis via its antioxidant effects.

• 대한기계학회논문집A
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• 제31권8호
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• pp.870-879
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• 2007

In this study, various damage modes in bending unimorph piezoelectric composite actuators with a thin sandwiched PZT plate during bending fracture tests have been evaluated by monitoring acoustic emission (AE) signals in terms of waveform and peak frequency as well as AE parameters. Three kinds of actuator specimens consisting of woven fabric fiber skin layers and a PZT ceramic core layer are loaded with a roller and an AE activity from the specimen is monitored during the entire loading using an AE transducer mounted on the specimen. AE characteristics from a monolithic PZT ceramic with a thickness of $250{\mu}m$ are examined first in order to distinguish different AE signals from various possible damage modes in piezoelectric composite actuators. Post-failure observations and stress analyses in the respective layers of the specimens are conducted to identify particular features in the acoustic emission signal that correspond to specific types of damage modes. As a result, the signal classification based on waveform and peak frequency analyses successfully describes the failure process of the bending piezoelectric composite actuator exhibiting diverse failure mechanisms. Furthermore, it is elucidated that when the PZT ceramic embedded actuators are loaded mechanical bending loads, the failure process of actuator specimens with different lay-up configurations is almost same irrespective of their lay-up configurations.

• 한국유기농업학회지
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• 제22권4호
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• pp.789-799
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• 2014

본 연구는 친환경단감과원의 부유(Diospyros kaki 'Fuyu') 과실을 대상으로 창원과 창녕지역에서 발생한 저온내습(2012년 11월 2일)으로 인한 가을 동상해발생과 식재위치(표고) 및 나무 내에서의 착과 방향의 관계를 알아보고자 수행되었다. 창녕지역 과원의 과중과 과실횡경은 착과방향에 의해 강하게 영향을 받았으며(p<0.01), 과실종경과 동상해발생은 식재위치(p<0.01)와 깊은 관계가 있는 것으로 나타났다. 과실경도와 과실종경은 각각 착과방향과 식재위치의 영향을 받는 것으로 밝혀졌다(p<0.05). 특히 동상해는 과원 하단에 식재된 나무의 과실(15.2%)과 잎(약 90%)에서 심하게 나타나 동상해의 주요 요인이 과원의 지형적 특징인 것으로 나타났다. 과실 동상해를 입은 과실은 과피에 수침상 반점이나 흔적이 발생했다. 한편 창원지역의 과원에서는 과실횡경이 식재위치의 영향을 받은 것(p<0.05)을 제외하고 식재위치와 착과방향이 과실의 생육 및 동상해발생에 영향을 주지 않았다.

• 한국환경농학회지
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• 제33권3호
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• pp.198-204
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• 2014

'신고'배에서 나타나는 과피얼룩과 발생을 경감하기 위하여 생육기 동안 몇 가지를 처리한 결과는 다음과 같다. 배과피얼룩 증상은 유과기(5월 25일)부터 발생하기 시작하여 수확 시까지 나타났으며 과육에는 전혀 발생하지 않았다. 과피얼룩과 발생은 수세가 정상적인 나무, 지베렐린 과경 도포 처리에서 현저하게 낮았으나, 아미노산 수체살포는 큰 차이가 없었다. 봉지에서는 칼슘이 코팅된 봉지 및 석회유황합제가 코팅된 봉지에서 과피얼룩과 발생이 낮았다. 봉지 내지에 석회유황합제 및 콩기름 도포는 과피얼룩이 아닌 약해를 유발시켰다. 과피얼룩 발생과의 수피 및 과피는 K 농도가 높았으나 엽에서는 T-N 및 K 농도는 오히려 낮았다.

• 한국가스학회지
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• 제22권6호
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• pp.1-7
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• 2018

최근 화학공장에서 사고가 빈번히 발생하여 화학공장의 위험성에 대한 논란이 다시 대두되고 있다. 화학공장에서 발생하는 사고유형은 대부분 화재, 폭발, 누출사고이다. 화재, 폭발사고의 경우는 사고발생 직후 사상자가 발생하지만 누출사고는 즉각적으로 대처하지 못해 사상자가 발생하는 경우가 많다. 특히 화학물질이 피부에 침투하는 경우는 즉시 물로 씻어주면 사망, 실명, 화상과 같은 비가역적인 건강장애를 예방할 수 있다. 이렇게 화학물질이 피부, 눈 등에 노출된 경우 씻을 수 있는 장소가 바로 세안 등의 설비(이하 safety shower)이다. 하지만 국내 화학공장은 대부분 1980년대에 건설되어 노후화, 관리미흡 등으로 safety shower가 비상상황 시 정상 작동하지 못하는 경우가 많다. 따라서 설치/관리기준을 통해 safety shower에 대한 성능을 확보하는 것이 필요하다. 이 논문에서는 safety shower의 설치 및 점검기준을 통해 safety shower의 신뢰도를 향상시키는 연구를 수행하였다.

• 임상간호연구
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• 제24권3호
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• pp.263-272
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• 2018

Purpose: This study was done to develop an evidence-based nursing clinical practice guideline for Moisture associated skin damage (MASD) prevention and management for patients in Korea. Methods: The guideline adaptation process was used and conducted according to the guideline adaptation manual developed by the Korean Hospital Nurses Association. It consists of three main phases and 9 modules including a total of 24 steps. Results: The adapted MASD clinical practice guideline consisted of 4 sections, 8 domains and 28 recommendations. The number of recommendations in each section was: 7 on MASD assessment, 14 on MASD prevention and management, 4 on education, and 3 on organizational policy. Of the recommendations, 3.6% were marked as A grade, 28.6% as B grade, and 67.8% as C grade. Conclusion: This MASD clinical practice guideline is the first to be developed in Korea. The developed guideline will contribute to standardized and consistent MASD prevention and management. The guideline can be recommended for dissemination and utilization by nurses nationwide to improve the quality of MASD prevention and management. Regular revision is recommended.

• 대한한의학회지
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• 제39권4호
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• pp.74-85
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• 2018

Objectives: HTD treatment is a traditional preventive therapy for neonatal inflammatory diseases such as AD. The aim of this study was to investigate the efficacy of HTD treatments for the maintenance and formation of lipid barrier in Dermatophagoides farina-induced obese NC/Nga mice. Methods: 20 mg/kg of CRGR extracts as HTD treatments were orally administered to NC/Nga mice. To induce obesity, high fat diet was served. Dermatophagoides farina extracts was applied on the 4th-6th and 8th-10th weeks to induce AD-like skin lesions in NC/Nga mice. Changes of skin conditions in mice were observed by histochemistry and immunohistochemistry. Results: The results showed that HTD treatments effectively maintained and formed the lipid barrier. In the experimental groups, restorations of Lass2 expression and distributions of filaggrin, involucrin, loricrin, ASM, and LXR means that HTD treatments maintained and generated the lipid barrier. In the dermal papillae, HTD treatments reduced PKC production accompanied by epidermis damage. Furthermore, levels of IL-4, and STAT6 was low. HTD treatment may be effective for preventing inflammation induced by Th2-skewed condition by suppressing the main pathway of Th2 differentiation. Conclusions: HTD treatment alleviated the inflammatory damage in the skin tissues of the NC/Nga mice by maintaining the lipid barrier and suppressing Th2 differentiation.

• 대한화상학회지
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• 제16권2호
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• pp.99-103
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• 2013

Purpose: The biggest problem of wound healing is a possible occurrence of lesion. Especially, in the case of patients who have a skin injury around exposed body parts, if their treatment period drag on for long time, they can suffer from aftereffects and the costs can be passed on to a society. Therefore, in this research, we investigated the need to develop the effective medicine and appliances for the patients by examining which therapy methods are being applying to the skin damage and what is the advantage and limit by evaluating the patient's satisfaction level. Methods: We carried out an online and offline survey targeting medical teams in order to analyze device for wound care. A total of 125 medical teams applied to the research, and investigate the level of customer satisfaction. Results: The moist dressings are the most used method for wound healing. When it comes to the level of customer satisfaction, biological dressing product also has a high satisfaction level. However its high cost tends to limit the use. Conclusion: This research reached a conclusion that it is need to develop a low cost and high efficiency wound care product considering the fact that its high cost and low efficiency induced economic problems. Generally, it is needed to develop a product for skin regeneration based on biological technologies, not a product just for damage cure.

• Biomolecules & Therapeutics
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• 제32권4호
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• pp.499-507
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• 2024

Specific sensitivity of the skin to ultraviolet B (UVB) rays is one of the mechanisms responsible for widespread skin damage. This study tested whether 1,3,5-trihydroxybenzene (THB), a compound abundant in marine products, might inhibit UVB radiationinduced NADPH oxidase 4 (NOX4) in both human HaCaT keratinocytes and mouse dorsal skin and explore its cytoprotective mechanism. The mechanism of action was determined using western blotting, immunocytochemistry, NADP⁺/NADPH assay, reactive oxygen species (ROS) detection, and cell viability assay. THB attenuated UVB-induced NOX4 expression both in vitro and in vivo, and suppressed UVB-induced ROS generation via NADP⁺ production, resulting in increased cell viability with decreased apoptosis. THB also reduced the expression of UVB-induced phosphorylated AMP-activated protein kinase (AMPK) and phosphorylated c-Jun N-terminal kinase (JNK). THB suppressed UVB-induced NOX4 expression and ROS generation by inhibiting AMPK and JNK signaling pathways, thereby inhibiting cellular damage. These results showed that THB could be developed as a UV protectant.

• 한국항공우주학회지
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• 제37권8호
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• pp.780-788
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• 2009

복합재 날개 구조물에 대한 구조 건전성 및 손상을 평가하기 위하여 정적 구조강도시험에 음향방출(AE)법이 응용되었다. 시험중 스트레인과 변위측정기법을 통하여 정적구조강도를 확인하였고, 음향방출요소 분석과 위치표정기법을 통하여 구조물의 내부 손상을 평가하고 손상위치를 찾을 수 있었다. 시험은 설계제한하중시험, 2차에 걸친 설계극한 하중시험, 파단시험이 수행되었다. 주요한 AE신호는 front lug근처의 표면에 부착된 센서에 의하여 감지되었다. 특히 1차 설계극한하중시험에서 스트레인 및 변위결과는 내부 손상을 보이지 않았으나 AE신호는 내부 손상이 이미 형성된 현상을 나타내었다. 파단시험에서는 AE활성도가 매우 활발하였고, 스트레인 및 변위의 결과는 심한 손상에 의하여 하중경로가 바뀌는 경향을 나타내었다. 음향방출법을 적용하여 정적 구조시험이 진행되는 동안 내부손상이 발생되는 하중과 위치를 정확하게 평가할 수 있었다. 본 연구로부터 음향방출법은 정적 구조강도시험에 있어 내부 손상을 평가하는데 유용한 기법임이 확인되었다.