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http://dx.doi.org/10.4062/biomolther.2014.130

Galangin (3,5,7-Trihydroxyflavone) Shields Human Keratinocytes from Ultraviolet B-Induced Oxidative Stress  

Madduma Hewage, Susara Ruwan Kumara (Jeju National University School of Medicine)
Piao, Mei Jing (Jeju National University School of Medicine)
Kim, Ki Cheon (Jeju National University School of Medicine)
Cha, Ji Won (Jeju National University School of Medicine)
Han, Xia (Jeju National University School of Medicine)
Choi, Yung Hyun (Department of Biochemistry, College of Oriental Medicine, Dongeui University)
Chae, Sungwook (Aging Research Center, Korea Institute of Oriental Medicine)
Hyun, Jin Won (Jeju National University School of Medicine)
Publication Information
Biomolecules & Therapeutics / v.23, no.2, 2015 , pp. 165-173 More about this Journal
Abstract
Most skin damage caused by ultraviolet B (UVB) radiation is owing to the generation of reactive oxygen species. Phytochemicals can act as antioxidants against UVB-induced oxidative stress. This study investigated the protective effects of the flavone galangin against UVB-induced oxidative damage in human keratinocytes. Galangin efficiently scavenged free radicals and reduced UVB-induced damage to cellular macromolecules, such as DNA, lipids, and proteins. Furthermore, galangin rescued cells undergoing apoptosis induced by UVB radiation via recovering mitochondrial polarization and down-regulating apoptotic proteins. These results showed that galangin protects human keratinocytes against UVB radiation-induced cellular damage and apoptosis via its antioxidant effects.
Keywords
Apoptosis; Galangin; Human keratinocytes; Oxidative damage; Ultraviolet B;
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