• 대한한방소아과학회지
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• 제34권3호
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• pp.67-75
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• 2020

Objectives This study is conducted to evaluate Th2 skewed condition control through skin fat barrier formation from the treatment using Coptidis Rhizoma and Glycyrrhiza uralensis extract. Methods The 6-week-old NC/Nga mice were divided into 4 groups: Control group (Ctrl), lipid barrier eliminate treatment group (LBET), Coptidis Rhizoma and Glycyrrhiza uralensis feeding treatment after lipid barrier elimination group (CGFT), dexamethasone feeding treatment after lipid barrier elimination group (DxFT). After 3 days, differences in skin condition, improvement of skin fat barrier, and control of Th2 skewed condition of each group were observed. Results Pathologic skin damage and tissue changes were less in the CGFT group than in the LBET and DxFT groups, and Transepidermal water loss (TEWL) and pH were also significantly decreased (p < 0.05). The filaggrin intensity and positive response also increased significantly in the CGFT group (p < 0.05). Kallikrein-related peptidase (KLK) 7, Protease activated receptor (PAR)-2, Thymic stromal lymphopoietin (TSLP), Interleukin (IL)-4, and the products of the Th2 differentiation process also showed a significant decrease compared to the LBET and DxFT groups (all p < 0.05). Conclusions The Coptidis Rhizoma and Glycyrrhiza uralensis extract causes skin barrier recovery and function recovery through the formation of skin fat barrier. This leads to the conclusion that Coptidis Rhizoma and Glycyrrhiza uralensis extract can control Th2 differentiation through the formation of skin fat barrier.

• 패션비즈니스
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• 제25권4호
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• pp.1-13
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• 2021

As interest in skin care increases, this study aims to contribute to the development of the beauty self-care market by providing basic data through the measurement of the oil and moisture skin condition of women in their 20s and 30s. The study was conducted from November 27, 2020 to January 31, 2021, with 20 women in their 20s and 30s divided into 4 groups, A~D, by age, 5 per group. Skin measurements were taken four times at 4 hour intervals at 0H, 4H, 8H, and 12H based on the first measurement that was taken within 30 minutes after waking up, and the oil and moisture indices were observed over time. As a result, both T and U zones showed significant differences in moisture levels over time, with no difference between groups for both T and U zones. Moisture decreased the most between 0H to 4H, and moisture changed the least between 4H to 8H. Changes in moisture increased the similar at 0H and 12H. The oil condition changed more irregularly compared to moisture over time, but all groups showed lower oil content in the U-zone compared to the T-zone. Overall, the facial oil and moisture conditions of women in their 20s and 30s changed over time, indicating that the skin changes in real time. The fact that the skin data, which was measured in the primary activity living environment, can be used as basic research data in the beauty self-care market is meaningful.

• 한국환경보건학회지
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• 제43권1호
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• pp.77-86
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• 2017

Objectives: The purpose of this study was to compare permeation characteristics in three skin types using oil-soluble benzoic acid and water-soluble caffeine after method condition optimization based on OECD guideline 428. Methods: A Franz diffusion cell, a reliable alternative method for skin permeation, was used. One-milliliter samples were taken and immediately replaced with fresh solution in the receptor chamber at regular time intervals (1, 2, 4, 7, 10 and 24 hr). The amount of test substances was measured by LC-MS/MS. Results: The permeation rate increased dose-dependently, and the permeation orders were $KeraSkin^{TM}$ > hairless mouse full skin > human cadaver epidermis for skin types, and benzoic acid solution > caffeine solution > benzoic acid cream > caffeine cream for type of test materials. Conclusion: According to the definitions of Marzulli, benzoic acid and caffeine would be classified as 'fast' and 'moderate' compared with the permeation of other chemical species. The setting conditions and permeation characteristics performed in this study are expected to contribute to future permeation studies.

• 한국응용과학기술학회지
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• 제37권6호
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• pp.1798-1805
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• 2020

본 연구는 광원 중 낮은 출력의 미용기기용 LED 마스크의 모공, 주름, 피지 등 피부상태변화를 측정·비교하여 피부상태 개선에 대한 구체적인 효과를 수치적으로 검증하고자 하였다. 18명(통제군 4주, 실험군 4주)의 건강한 여성을 대상으로 매주 1회, 8주간 진행하였다. 모공, 주름, 피지의 피부상태 측정결과, LED 조사가 진행될수록 유의적으로 피부상태가 개선됨을 확인하였으며, 실험군과 대조군의 측정 시기별 집단 간 차이에서도 모공, 주름, 피지 모두 유의하게 나타났다(p<.001, p<.05). 이는 미용기기로서의 LED 마스크 개선 효과를 입증함으로써 학술적 의미에서 연속자료의 마련으로 임상정보와 양적자료로 제시될 수 있음에 의의가 있다. 또한 향 후, 더 많은 피부개선 효과를 입증하는 후속 연구가 이루어지기를 제언하는 바이다.

• 한국의류산업학회지
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• 제10권5호
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• pp.668-675
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• 2008

The purpose of this study was to collect data of skin temperature and physiological responses which is useful for standardization of insulation measurement in various garments. And we investigated sex and season difference of physiological responses of 60's males and 60's females in hot and cold environment. Healthy ten 60's males and ten 60's females volunteered as subjects. The experiment was conducted three times; One for winter condition($5^{\circ}C$, 45%), another for summer condition($30^{\circ}C$, 65%) and the other for nude condition as control($30^{\circ}C$, 65%). The subjects were sitting for 1 hour with suitable ensemble on each experimental condition in climate chamber. We measured skin temperature, rectal temperature, heart rate, oxygen uptake, sweat rate, blood flow, blood pressure and subjective sensations. We found that skin temperature and most of physiological responses were higher in male subject, summer condition than in female subject, winter condition.

• 한국임상수의학회지
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• 제38권2호
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• pp.56-62
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• 2021

Madecassoside, an active ingredient extracted from Centella asiatica, is used for treatment of various skin disorders in humans. However, the effect of madecassoside on the skin of dogs and cats has not been studied yet. The purpose of this study was to evaluate clinical efficacy of topical madecassoside cream in dogs and cats with skin diseases. A total of twenty-one dogs and ten cats with various skin diseases were included in the study. The 1% topical madecassoside cream was applied to the animal's skin lesion at least once a day for 7 days, and the skin condition was evaluated before the application of madecassoside cream (day 0) and 7 days after the application (day 7). The skin condition was scored by five clinical indices: canine atopic dermatitis extent and severity index-4 (CADESI-4), coat condition, pruritus, scale, and general condition. In dogs, all five clinical indices (CADESI-4, coat condition, pruritus, scale, and general condition) were significantly decreased on day 7 compared to those on day 0 (p < 0.0001, p < 0.05, p < 0.001, p < 0.01, and p < 0.05, respectively). In cats, the CADESI-4 and scale were significantly decreased on day 7 compared to those on day 0 (p < 0.01 and p < 0.05, respectively). No adverse effects were observed during the trial period in the dogs and cats included in this study. The results of this study demonstrate that the topical madecassoside cream is applicable to skin lesions in dogs and cats.

• 한국응용과학기술학회지
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• 제36권4호
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• pp.1219-1223
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• 2019

피부의 상태는 얼굴부위별로 차이가 있다. 본 연구에서는 안면피부를 9부위로 구획화하여 수분, 유분, 건조감, 각질량, 거칠음 등의 특성을 기준으로 부위별 피부 관리 후 개선효과를 확인하였다. 20~35세 여성 98명을 대상으로 지각하는 피부의 특성을 부위별로 선택하여 순서대로 나열하고 가장 강하게 느끼는 부위에 가중치를 두어 분석하고 그 결과를 토대로 부위별 보습 관리를 시행하였다. 가장 건조감을 느끼는 부위는 입가와 눈가, 각질량이 가장 많은 곳과 거친 곳은 턱으로 나타났다. 또 부위별 관리 후 특정 부위 및 안면 전체 수분량의 유의한 증가를 보였고(p<.05), 90.5%의 건조감 해소에 대한 만족도를 나타냈다. 이상의 결과로 안면 부위별 관리는 뷰티 디바이스 또는 안면 마스크팩 응용 개발에 도움이 될 것으로 판단된다.

• 한국임상수의학회지
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• 제36권4호
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• pp.219-224
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• 2019

The aim of this study was to evaluate the safety and effects of a soy lecithin-based supplement on the general health, skin condition, and blood lipid levels of dogs. Twenty-five, healthy, privately-owned dogs were enrolled in the study. Oral supplementation was administered for 8 weeks in the treatment group. Evaluation items included a thorough physical examination, owner responses to a questionnaire, blood analysis (CBC, CRP, serum chemistry, lipid profile). The results showed a significant improvement in amount of exercise, water intake, skin exfoliation in the treatment group (P < 0.05) but no significant changes in the other evaluation items, including no significant changes in blood component results following administration of the supplement. Most dogs well tolerated the treatment, and there were no serious adverse events. We suggest that soy lecithin has potential as a nutraceutical for the positive effect of general health condition such as activity and skin condition. Further studies are needed to establish the appropriate dose level and administration frequency of soy lecithin in dogs.

• 대한통합의학회지
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• 제10권3호
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• pp.27-36
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• 2022

Purpose : This study was aimed to analyze the effects of cosmetics containing Persicaria perfoliata water extract (PPWE) on the skin moisturizing and improvement of skin condition in clinical trials. Methods : Clinical trial was conducted for five weeks after IRB approval at Dong-Eui University. Out of a total of 64 people, 15 people each were assigned to four groups as follows; control group A, B, C and the experimental group A that using cosmetic containing PPWE. Skin condition was measured two times, before and after clinical trial, by a professional skin analyzer, SDM (skin diagnosis system). Moisture and oil value of participants was analyzed twice, each morning and evening, using a portable device on their cheeks. In addition, the survey was investigated subjective satisfaction on change in skin condition and the satisfaction on the use of cosmetics. Result : The experimental group exhibited subjectively significant changes before and after clinical trials on skin its dryness (p=.039), blush (p=.017), and redness (p<.001). In addition, subjective evaluation was also the highest satisfaction in aspects of number of application (p=.003), amount of application (p=.002), moisture maintenance, and skin scratching frequency. The satisfaction on the use of cosmetics was the highest in the intention to repurchase (p=.045), recommendation willingness to others (p=.020), and intention to use various products (p=.001). Skin moisture of the clinical trial participants using the SDM, moisture level and elasticity of the experimental group increased by 12.94 and 10.28. Moisture level, which was measured by a portable device, was the most potently increased in the experimental group. Conclusion : Consequently, PPWE containg cosmetics exhibited the effects of moisturization and attenuated skin dryness in clinical trials, which might be utilized as a fundamental data to develop numerous lines of cosmetics.

• 문화기술의 융합
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• 제7권2호
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• pp.207-216
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• 2021

본 연구는 경남 창원시내에 거주하는 20~40대 여성 315명을 조사대상으로 하여 단순무작위추출(simple landom sampling)하여 설문지조사 방법에 의해 자기 기록식으로 기록하였다. 본 연구는 피부상태에 따른 피부의 유형을 세안 후 30분간 아무것도 바르지 않은 상태에서 뺨부위를 검진법을 통하여 체크하여 지성, 중성, 건성, 지루성으로 구분하여 각 조건들과의 상호작용을 알아보았다. 각 요인들간의 관련성을 알아보기 위해 X²-검정을 실시하였으며, 자료처리는 PC/SAS를 이용하였다. 대상자의 일반적 특성과 피부상태에서 연령, 직장 및 결혼 여부는 통계적으로 유의성이 있었다(p<0.01). 연령이 많을수록 건성으로 진행되는 경향이 있고 직장여성과 기혼여성일 경우 건성의 비율이 높은 편이었다. 스트레스 후 피부반응과 일반적인 특성 및 생리적 현상과의 관련성에서 여드름이 나는 부위와 배변횟수 사이에는 통계적으로 유의한 차이가 있었고, 각 X²-검정의 값은 42.961(P<0.01), 7.345(P<0.05)였다. 피부트러블반응과 여드름 나는 시기와의 사이에는 유의성이 인정되었다(P<0.01).