• The Korean Journal of Physiology and Pharmacology
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• 제22권5호
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• pp.547-554
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• 2018

Itching is a common clinical symptom of skin disease that significantly affects a patient's quality of life. Transient receptor potential vanilloid 1 (TRPV1) receptors of keratinocytes and peripheral nerve fibers in skin are involved in the regulation of itching as well as pain. In this study, we investigated whether curcumin, which acts on TRPV1 receptors, affects histamine-induced itching in mice, using behavioral tests and electrophysiological approaches. We found that histamine-induced itching was blocked by topical application of curcumin in a concentration-dependent manner. In ex-vivo recordings, histamine-induced discharges of peripheral nerves were reduced by the application of curcumin, indicating that curcumin acts directly on peripheral nerves. Additionally, curcumin blocked the histamine-induced inward current via activation of TRPV1 (curcumin $IC_{50}=523nM$). However, it did not alter chloroquine-induced itching behavior in mice, which is associated with transient receptor potential ankyrin 1 (TRPA1). Taken together, our results suggest that histamine-induced itching can be blocked by topical application of curcumin through the inhibitory action of curcumin on TRPV1 receptors in peripheral nerves.

• Journal of Pharmaceutical Investigation
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• 제34권4호
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• pp.275-281
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• 2004

We have studied the effect of polarity, current density, current duration, crosslinking density, swelling ratio, and permeation enhancers on the transdermal flux of ketoprofen from acrylamide hydrogel. Hydrogel was prepared by free radical crosslinking polymerization of acrylamide. Drug loading was made just before transport experiment by soaking the hydrogel in solution containing drug. In vitro flux study using hairless mouse skin was performed at $36.5^{\circ}C$ using side-by-side diffusion cell, and the drug was analysed using HPLC/UV system. The result showed that, compared to passive flux, the total amount of drug transported increased about 18 folds by the application of $0.4\;mA/cm^2$ cathodal current. Anodal delivery with same current density also increased the total amount of drug transported about 13 folds. It seemed that the increase in flux was due to the electrorepulsion and the increase in passive permeability of the skin by the current application. Flux increased as current density, the duration of current application and loading amount (swelling duration) increased. As the cross linking density of the hydrogel increased, flux clearly decreased. The effect of hydrophilic enhancers (urea, N-methyl pyrrolidone, Tween 20) and some hydrophobic enhancers (propylene glycol monolaurate and isopropyl myristate) was minimal. However, about 3 folds increase in flux was observed when 5% oleic acid was used. Overall, these results provide some useful information on the design of an optimized iontophoretic delivery system of ketoprofen.

• 한국멀티미디어학회논문지
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• 제19권8호
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• pp.1225-1235
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• 2016

This paper presents a method for computer-assisted slide presentation using vision-based gesture recognition. The proposed method consists of a sequence of steps, first detecting a hand in the scene of projector beam, then estimating the smooth trajectory of a hand or a pointing finger using Kalman Filter, and finally interfacing to an application system. Additional slide navigation control includes moving back and forth the pages of the presentation. The proposed method is to help speakers for an effective presentation with natural improved interaction with the computer. In particular, the proposed method of using finger pointing is believed to be more effective than using a laser pointer since the hand, the pointing or finger are more visible and thus can better grab the attention of the audience.

• 한국유기농업학회지
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• 제14권3호
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• pp.325-331
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• 2006

The experiment fields consisted of five plots as follows; 2, 4, and $8\;tons{\cdot}ha^{-1}$ citrus skin in combination with starch sludge and pig manure mixing compost (CSSP), $4\;ton{\cdot}ha^{-1}$ fermented pig manure compost (FPMC) treated plot, and untreated control. Plant height and stem diameter were significantly increased by CSSP. Most of all, average tuber weight and tuber yield per plant were significantly increased in 4 and $8\;tons{\cdot}ha^{-1}$ CSSP plots compared to the other plots. Marketable tuber (>50 g fresh weight) yield were superior in order of 4 and $8\;tons{\cdot}ha^{-1}$ CSSP plot, $4\;tons{\cdot}ha^{-1}$ FPMC plot, and $2\;tons{\cdot}ha^{-1}$ CSSP plot.

• 한방비만학회지
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• 제7권1호
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• pp.107-115
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• 2007

존스킨한의원의 오행침법 시스템의 수침치료로 진피하층의 표층 근건막을 이루고 있는 섬유질을 끊어주고 위축된 진피층을 미세하게 침자극하여 상처치유기전에 의한 새로운 세포생성으로 원래의 자기 피부상태와 윤곽을 회복하는 것을 볼 수 있다.

• 대한화장품학회지
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• 제24권1호
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• pp.113-126
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• 1998

Inner nutshell of Castanea crenata has been used as an anti-aging and anti-wrinkle agent from the ancient time in east Asia. In order to develop new anti-aging and anti-wrinkle, ethanolic extract of inner nutshell of Castanea crenata was prepared and various biological activities were evaluated. Cor-285 possessed potent tree radical scavenging activity in vitro compared to gallic acid. Cor-285 showed the preventive effect against UV-induced cytotoxicity of fibroblast at concentration of 25-250mg/ml. When Cor-285 was evaluated for its anti-allergic activity, it effectively inhibited histamine release from mast cells induced by compound 48/80. The inhibitory activity was stronger than that of glycyrrhizinate. Cor-285 also showed on vivo inhibition against delayed hypersensitivity as well as croton-oil induced ear edema in mice when topically applied. These results strongly suggest that Cor-285 may reduce immunoregulatory/inflammatory skin trouble. From the attempts to isolate the scavenger, were isolated. In a clinical trial of twenty healthy volunteers with aged skin, 6 weeks application of Cor-285 decreased wrinkle about 26% and increased moisturizing 20% on the skin. All of these results indicate that Cor-285 may be an effective anti-aging and anti-wrinkle agent.

• 한국복합재료학회:학술대회논문집
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• 한국복합재료학회 2000년도 추계학술발표대회 논문집
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• pp.199-202
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• 2000

Compared with existing construction materials, ACM(Advanced Composites Material) possesses many advantage such as light-weight, high-strength, corrosion resistant properties, etc. In this study, utilizing those advantages of ACM, composite skin and comer plate for protection of concrete port structure are developed. Detailed procedure fur analysis, design and fabrication along with site installation for demonstration project are described. It is also demonstrated that pultrusion process for comer plate and VARTM process for composite skin are promising fabrication methods fer future civil infrastructure application.

• 한방안이비인후피부과학회지
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• 제27권4호
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• pp.251-260
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• 2014

Objectives : The purpose of this study is to investigate the effect of eating Saengshik and applying Hwangryunhaedok-tang on skin for pregnant woman diagnosed as Pruritus Gravidarum. Methods : This case study was done on 5 Pruritus Gravidarum patients who had visited Korean Medicine Clinic. All the patients are treated with Saengshik and Hwangryunhaedok-tang was applied on their skin. VAS(Visualanalogue scale) and photographs were used to evaluate the symptom change. Results & Conclusion : Most symptoms of patients were improved in this study. Saengshik and Hwangryunhaedok-tang can be effective in patients who were diagnosed as Pruritus Gravidarum.

• 대한건축학회논문집:계획계
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• 제33권12호
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• pp.29-39
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• 2017

The building skins are important architectural elements in both functional and aesthetical aspects. This study focuses on developing a responsive facade with autonomous opening and closing behaviors in accordance with environmental conditions and user requirements for natural ventilation for the office building. The pneumatic ETFE panels are applied as the skin materials taking advantage of the efficiency of the inflatable skin of lightness, architectural performance and sustainable material properties. The biomimetic design methodology is taken for its innovative and visionary concept for the facade design. The interpretation of the building facade in analogy to natural organisms delivers functional and aesthetic characters. By exploring the structural movements of the plant pores, the facade control is developed to be autonomous by the parameter values. The facade opening and closing configurations are derived through parametric modeling and visualization programming. Through the application of this study, expected results are to improve user comfort and energy efficiency.

• 동의생리병리학회지
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• 제27권5호
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• pp.650-659
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• 2013

To investigate the effects of facial blood flow rates(FBFR) and facial skin temperature(FST) generated by Gagam-Jawoonaek(GJ) application(appl.) after Miso Facial Rejuvenation Acupuncture(MFRA). Ten people in their twenties to fifties with no skin diseases were recruited. We randomly divided subjects two groups(A, B) and set the GJ appl. site(group A - right side, group B - left side). MFRA was performed on both sides of their face. Immediately after acupuncture treatment(AT treat.), GJ was applied only half of the face. We measured their FBFR using Laser Doppler Perfusion Imaging(LDPI) and FST using Digital Infrared Thermal Imaging(DITI) at pre-AT treat., immediately after AT treat., twenty and sixty minutes after GJ appl.. We analyzed data using Mann-Whitney test and Wilcoxon test(p < 0.05). After MFRA treat., FBFR on both sides increased. Twenty minutes after JW appl., the changes of FBFR on GJ appl. side($122.9{\pm}43.1PU$) were bigger than GJ non-appl. side($80.9{\pm}38.4PU$), a statistically significant decrease. Sixty minutes after application, FBFR on both sides were recovered almost at the same level as that of pre-AT treat. After MFRA treat., FST on both sides increased. Twenty minutes after GJ appl., the changes of FST on GJ appl. side($1.1{\pm}0.6^{\circ}C$) were comparable to that of GJ non-appl. side($1.2{\pm}0.5^{\circ}C$). Sixty minutes after application, FST on both sides were recovered almost at the same level as that of pre-AT treat.. Gagam-Jawoonaek could decrease facial blood flow rates.