• Toxicological Research
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• v.18 no.3
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• pp.267-273
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• 2002

Fructose 1,6-diphosphate(FDP), a glycolytic metabolite, is reported to ameliorate inflammation and inhibit the nitric oxide production in murine macrophages stimulated with endotoxin. It is also reported that FDP has cytoprotective effects against hypoxia or ischemia/reperfusion injury in brain and heart, and may play a protective role in ultraviolet B (UVB, 280~320 nm)-injured keratinocyte by attenuating prostaglandin (PG)-E$_2$production and cyclooxygenase (COX)-2 expression, which are possibly through blocking the intracellular reactive oxygen species (ROS) accumulation. Therefore FDP is considered to act as a potent antioxidant especially in the skin. We conducted the several safety tests (single-dose toxicity, primary skin irritation test, eye irritation test, skin sensitization test, phototoxicity test, photosenitization test and human patch test) to see if FDP is safe in case used for the skin application. Our data obtained hitherto suggest that FDP is very safe if applied to the skin.

• Steel and Composite Structures
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• v.33 no.6
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• pp.877-889
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• 2019

The developments of double skin composite (DSC) walls with novel enhanced C-channel connectors (DSCW-EC) were reported. Followed axial compression tests on prototype walls were carried to evaluate structural performances of this novel DSC composite structures. The testing program consists of five specimens and focused on the layout of the novel enhanced C-channel (EC) connectors, which include the web direction of C-channels, steel-faceplate thickness, vertical and horizontal spacing of C-channels. Crushing in concrete core and buckling of steel faceplate were two main observed failed modes from the compression tests. However, elastic or plastic buckling of the steel faceplate varies with designed parameters in different specimens. The influences of those investigated parameters on axial compressive behaviors of DSCW-ECs were analyzed and discussed. Recommendations on the layout of novel EC connectors were then given based on these test results and discussions. This paper also developed analytical models for predictions on ultimate compressive resistance of DSCW-ECs. Validation against the reported test results show that the developed theoretical models predict well the ultimate compressive resistance of DSCW-ECs.

• Steel and Composite Structures
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• v.37 no.5
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• pp.517-532
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• 2020

This paper firstly developed a new type of Double Skin Composite (DSC) beams using novel enhanced C-channels (ECs). The shear behaviour of novel ECs was firstly studied through two push-out tests. Eleven full-scale DSC beams with ECs (DSCB-ECs) were tested under four-point loading to study their ultimate strength behaviours, and the studied parameters were thickness of steel faceplate, spacing of ECs, shear span, and strength of concrete core. Test results showed that all the DSCB-ECs failed in flexure-governed mode, which confirmed the effective bonding of ECs. The working mechanisms of DSCB-ECs with different parameters were reported, analysed and discussed. The load-deflection (or strain) behaviour of DSCB-ECs were also detailed reported. The effects of studied parameters on ultimate strength behaviour of DSCB-ECs have been discussed and analysed. Including the experimental studies, this paper also developed theoretical models to predict the initial stiffness, elastic stiffness, cracking, yielding, and ultimate loads of DSCB-ECs. Validations of predictions against 11 test results proved the reasonable estimations of the developed theoretical models on those stiffness and strength indexes. Finally, conclusions were given based on these tests and analysis.

• Annals of Occupational and Environmental Medicine
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• v.34
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• pp.26.1-26.13
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• 2022

It is important to assess the blood flow of fingers in the verification of hand-arm vibration syndrome. In the Republic of Korea, most assessments of the blood flow in the fingers are performed using a cold provocation test with finger skin color change. However, this test is a non-objective method with a relatively low sensitivity, leading to possible social and legal problems. Thus, we reviewed the characteristics of several tests that assess the blood flow in the fingers. Among these tests, using the radioactive isotope method, Raynaud's scan has a relatively higher sensitivity and specificity than other tests, provides objective results, and is approachable in many hospitals. So we suggest using Raynaud's scan as an alternative test when cold provocation test with finger skin color change is negative in vibration exposed worker.

• Journal of Veterinary Clinics
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• v.21 no.2
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• pp.209-213
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• 2004

A 8 kg, 3-year-old male West Highland white terrier dog with a 1.5-year history of chronic, severely pruritic, seborrheic skin disorder was referred to the Veterinary Medical Teaching Hospital of the Tokyo University of Agriculture and Technology. On physical examination, lesions were observed on entire cutaneous surface, except for face, dorsum of body, and footpads. Skin lesions were characterized by diffuse erythema, erythematous papules, severe alopecia, hyperpigmentation, and lichenification. Tape strip tests of skin lesions revealed cocci and Malassezia infections. The intradermal allergy tests revealed positive reactions to Japanese cedar pollen, but the non-seasonal clinical signs were not compatible with atopic dermatitis caused by this pollen. Results of hematological examination, serum chemistry and thyroid gland profile were normal. Examination of skin biopsy exhibited hyperplastic superficial perivascular dermatosis with severe acanthosis, excessive keratinocyte mitoses, patchy or diffuse mild spongiosis, and lymphocytic exocytosis in epidermis. Perivascular to interstitial mononuclear cells infiltration was seen in the superficial dermis. Based on the results of examination described above, epidermal dysplasia was diagnosed. Treatments with administration of antibiotics, etretinate, and prednisolone orally combined with topical ketoconazole cream and antiseborreic shampoos had no good results. Following treatment with long-term oral itraconazole at 10 mg/kg daily and chlorhexidine shampoos was successful. However, when itraconazole therapy was stopped, the condition worsened twice within 2 or 3 months. Readministration of itraconazole produced improvement within 4 weeks. This dog has now been controlled periodical itraconazole therapy.

• Journal of the Korean Society of Safety
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• v.20 no.3 s.71
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• pp.152-157
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• 2005

This experimental study was devoted to investigate skin friction of H group piles with uplift loading conditions in granite soil under laboratory test. Model piles made of steel embedded in weathered granite soil were used in this study. Pile arrangements($2{\times}2,\;3{\times}3$), pile space(2D, 4D, 6D), and soil density($D_r=40%,\;80%$) were tested. The main results obtained from the model tests can be summarized as follows. The series of tests found that ultimate uplift load and displacement for group piles were increased as piles space ratio increases to $D_r=40%$ of soil density. In the relative density of $D_r=80%$, bearing capacity for group piles was greater than for single pile. In the relative density of $D_r=40%$, the theoretical value of skin friction for group piles was greater than practical value. In the relative density of $D_r=80%$, both theoretical and practical value of skin friction for group piles were increased as piles space ratio increases.

• Animal cells and systems
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• v.5 no.4
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• pp.303-308
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• 2001

The skin structure of Misgurnus mizolepis was studied based on the microanatomical investigation of skin fragments taken from four regions. The epidermis was distinguished by two types of skin glands, a small mucous cell and a large club cell. The mucous cell was acid sulfomucins (some sialomucins) but the club cell did not give any histochemical tests for mucosubstances. The presence of a well defined lymphatic system with small lymphocytes was established in the stratum germinativum layer of the epidermis. A large number of blood capillaries run very close to each other just below the basement membrane, and a definite area giving AB and PAS positive was present between the basement membrane and scale. These structural features of skin in M. mizolepis seem to be closely related with cutaneous respiration.

• Tribology and Lubricants
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• v.30 no.1
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• pp.36-45
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• 2014

Understanding steel/skin contact phenomena is important for the study of object manipulation in robotics and has been a topic of great interest. In this study, pig skin was taken as a surrogate model for human skin, and its adhesive, friction, and deformation behaviors were measured under various exposure times to air. Indentation, friction, and scratch tests were performed at $25^{\circ}C$ and 45% relative humidity. The influences of adhesion and deformation on the coefficient of friction were characterized; the pig skin was found to be sensitive to the sliding velocity and normal load under the controlled experimental conditions.

• Tuberculosis and Respiratory Diseases
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• v.38 no.1
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• pp.34-44
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• 1991

Restoration of skin reactivity to 1 TU of tuberculin (RT23) by repeated tests at 10 days interval has been investigated in the BCG vaccinated or unvaccinated primary school children. The results obtained are as follows. 1) Tuberculin reactors showing 6 mm or larger induration to the first tests were 20.0% in the first grade school children and 33.3% in the sixth grade children. Six millimeter or larger reaction than that of the first reaction was found in 14.9% of the first grade children and in 34.6% of the sixth grade children. 2) Six millimeter or larger reactors were 10.8% of the first grade children without BCG scar against both first and second tests and 11.8% of the sixth grade children on first tests and 10.6% on second tests. There was none or very few, if any, in number of 6 mm or larger difference between the first and second tests among children without BCG scar. In addition, there was no children shown 6 mm or larger second reaction than that of the first reaction and thus those reactors seemed to be natural infection. 3) From questionaire survey, parents of 73.3% of the first grade children and of 72.7% of the sixth grade children were aware of BCG vaccination of their children, while parents of 15.1% and 24.6% of the first and sixth grade children did not know their children's vaccination history even if children possessed BCG scar. 4) Of the first grade children whose parents remembered their BCG vaccination, 65.6% were vaccinated within 4 weeks after birth and 25.5% between 4 weeks and one year. Six millimeter or larger reaction on the first tests was observed in 20.2% of the former group and 15.9% of the latter group, however reactors on the second tests were 32.1% and 31.9% respectively. BCG scar was not observed in 13.9% of children. 5) The majority of children (87.3%) were vaccinated in the skin of deltoid area and some (7.7%) at buttock or other areas. Children received first vaccination at the health centers were 68.5% and 30.3% at hospitals. More than 5 mm reaction was found in 18.7% of the former children and in 15.0% of the latter children. From this study restoration of tuberculin reactivity by repeated tests was found very common among the vaccinated children and thus it should be taken into account for the vaccination policy if it is performed after tuberculin testing.

• Journal of the Korean Geotechnical Society
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• v.19 no.4
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• pp.191-200
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• 2003

This paper presents the rheological properties of bitumen for reducing negative skin friction. The bitumen has been widely used due to both the cost and construction effectiveness. Also, it is well known that the use of bitumen for reducing negative skin friction renders the best results among other available methods. Three different modified bitumens were used for the testing programs. The physical tests include the penetration, the softening point and penetration index. The rheological tests include phase angle, complex modulus, creep tests and flow tests. The tests were conducted at four different temperatures(15, 30, 45 and 6$0^{\circ}C$) in order to simulate the field condition. The test results were analyzed using the phase angle, G$^*$/sin $\delta$, creep compliance and shear viscosity. The result of tests showed that the phase angle increased and G$^*$/sin $\delta$ decreased with the increase of temperature. The creep compliance increased as the loading time increased. The difference of the creep compliance is detected as the time and temperature are varied, however, the difference of the shear viscosity is not significant among the samples tested in this study. The rheological properties of the bitumen also showed that the physical testing method and the temperature dependant testing method are somewhat limited to showing and expressing the full rheological properties of the modified bitumen. The introduction of the time and the temperature dependent testing method is necessary to find out the full rheological properties of the modified bitumen.