• 대한예방한의학회지
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• 제19권3호
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• pp.11-19
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• 2015

Objective : This study aimed to develop and preliminary validate the Mibyeong Questionnaire (MQ) based on Deficiency-Stagnation pattern, which was report of a person's health condition that comes directly from the person. Method : The first phage of developing a MQ was to generate and exhaustive list of all MQ issue that are relevant to the domain of interest, using literature research and expert group discussions. Through those steps, we established MQ with 33 items divided into two parts: 21-item deficiency pattern and 12-item stagnation pattern. The second phage, we examined the preliminary tests of reliability and validity including the 16-item Deficiency of MQ (16D-MQ), with data (n=1,890) already collected on the Korean medicine data center in KIOM. Results : Exploratory factor analysis revealed three factors of the 16D-MQ. These factors were fatigue(Qi, 氣); psychic and physical elements(Shen, 神); and skin and hair(Jing, 精). Cronbach's coefficient alpha was 0.876 and the intraclass correlation coefficients was 0.368-0.538. In support of criteria validity, the 16D-MQ was weakly correlated with EQ-5D and physicians's opinion, but it was acceptable. Conclusion : The MQ shows that it has an appropriate level of internal consistency and validity. We think further study to reveal its reliability and validity, including stagnation pattern as well as deficiency pattern, is needed.

• 한방안이비인후피부과학회지
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• 제28권2호
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• pp.23-32
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• 2015

Objective : The purpose of this study was to develop a Pattern Diagnosis Instrument of Acne in traditional Korean Medicine. Methods : Data was collected by structured survey papers from 20 professors of The Korean Oriental Medical Ophthalmology & Otolaryngology & Dermatology Society(Delphi method). We investigated importance rates of the symptoms of each Pattern in the survey papers, then calculated Weighted Value of the symptoms. Results : Nine objective symptoms and nine subjective symptoms were selected by investigated importance rate in the survey from 20 professors of The Korean Oriental Medical Ophthalmology & Otolaryngology & Dermatology Society. In Wind-Heat pattern(WHP, 風熱型), inflammatory lesion of acne was the most important symptom. Oily skin, nodule and effect of menstruation are the most important symptoms in Dampness-Heat pattern(DHP, 濕熱型), Phlegm-Stasis pattern(PSP, 痰瘀型) and Disharmony of the thoroughfare and conception vessels pattern(DTCVP, 衝任不調型) each. Conclusions : The results might provide backgrounds and methods for clinical care of acne and follow-up study.

• 대한의용생체공학회:의공학회지
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• 제11권2호
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• pp.305-314
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• 1990

In this paper we have implemented and tested TPN which is system to supply sufficent nutrition to nutritionally deficient patient by means of ES (expert system) a kind of A.1 (artificial intelligence) . This system affords to evaluation of nutritional state of patient which is essential to physi- cian. who performs TPN, decision of performing TPN and management of patient-data & calculation of information needing to making TPN fluid. The features were as follolv 1. we input data, take ideal weight of patient and 24hr's creatlnln In urine according to chart in system compare TSF (triceps skin fold), MAC (mid-arm circumference), AMC (arm muscle circumference) to 5th, 15th, 50th percentile and evaluate the nutritional state of patient. 2. Calculation of protein & nonprotein calorie needing to treament of patient can be made exactly by stress factor, activity factor and body temperature. 3. patient's personal recording needing to management of patient date name of chief doc- tor, name of department of admission, chart number, history can by taken very easily. 4. The way of system operating is pull-down Menu one, It can be processing very efficiently. 5. Date processing in system, we can manage memory volume of computer verlr efficiently using of dynamic allocation variables. 6. We can make it very easy to edit & revise the input data, processed data is saved to diskette in 2 files (TDF, THF) , these are semipermanent preservation.

• 대한한의학회지
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• 제30권1호
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• pp.40-50
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• 2009

Objectives: The clinical document forms, a format for collecting clinical data, is the most fundamental object of standardization. Doctors must have a mutual understanding of the clinical chart. Methods: Clinical document forms were developed by investigating existing conditions in hospitals and conducting demand surveys, doing literature research, and seeking expert advice for the improvement of version 1.0. In addition, an organization of a network of 19 Oriental medical doctors and nurses, 190 patients, and users of collected and assessed data was formed to come up with version 2.0. Results: The overall format was divided into different portions that the patient, nurse, and doctor must fill out, respectively. The patient's section consists of demographic data, lifestyle details, history, and symptoms. The data to be supplied by the nurse include the patient's vital signs and anthropometric parameters. As for the doctors, they are to supply data regarding the patient's palpitation, the detailed symptoms of the patient's head, ophthalmological and otorhinolaryngological symptoms (mouth), respiration, circulatory organ and chest conditions, digestive-organ conditions (thirst), neuropsychiatric conditions, reproductive system, musculoskeletal system, skin (depilation), etc. Conclusions: Common clinical chart development is the prior question to Traditional Korean Medicine standardization. A web-based clinical document format should be developed to support diagnosis and treatment, and furthermore EMR (electronic medical record system) and EHR (electronic health record) developed. Clinical information could be shared through a network of medical institutions and be useful Traditional Korean Medicine for evidence-based medicine.

• 임상간호연구
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• 제18권2호
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• pp.317-328
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• 2012

Purpose: This study was done to provide oncology nurses systemic guidelines designed to perform telephone counseling in outpatient settings treating patients with chemotherapy. Methods: Symptoms which are frequently questioned were identified through case reports recorded by 4 clinical nurse specialists from January 4 to December 31. 2010. Fifteen clinical experts and two hemato-oncologists reviewed the developed draft. Their opinions were synthesized to arrive at consensus on the ideal guidelines. This process confirmed content validity. The two hemato-oncologists also verified the face validity. Results: The six symptoms which were most frequently asked about were identified through 4,644 case reports and concerned pain, fever, skin alteration, nausea/vomiting, stomatitis and diarrhea. Evidence-based telephone triage guidelines for the 6 major symptoms in patients receiving chemotherapy were developed. Conclusion: These guidelines will help oncology nurses from novice to expert incorporate evidence-based telenursing into their practice.

• 기본간호학회지
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• 제7권1호
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• pp.122-136
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• 2000

Stroke patient needs rehabilitation after receiving an acute treatment in a hospital. When stroke patient gets involved in an early discharge program, home care nurse plays a pivotal role to make them to gain a full strength and to come back to his/her prior life before he/she is sick. In spite of the importance of home care nursing intervention protocol for home care nurses to perform home care nursing autonomously, home care nursing intervention protocol for stroke patient is rarely developed. Therefore this study was conducted to develop home care nursing protocol that is applicable for stroke patients in home care nursing area. 41 home care nursing charts for stroke patients registered in home care nursing agencies from December 1st 1994 to August 31st 1999 at Y hospitals in Seoul and Won-Ju city were analyzed. 44 home care nurses who were having over three years' experience on stroke patients were participated in this study as a user validity validation group. The results of this study are as follows. 1. 28 nursing diagnoses were selected on the basis of evaluation of nursing diagnoses of stroke patients presented in a previous literature and case studies on home care nursing. 2. 17 nursing diagnoses were classified through the frequency analysis of home care nursing charts for 41 stroke patients who had received home care nursing. The order of sequence was like these: impaired skin integrity, risk for infection, nutritional deficit, impaired physical mobility, constipation, knowledge deficit, ineffective airway clearance, anxiety in family members, risk for aspiration, self care deficit, altered urinary elimination, ineffective individual coping, social isolation, risk for injury, self-esteem disturbance, impaired verbal communication, fatigue of family caregiver. 3. Based on validation on expert and user validities, 44 nursing interventions which were above ICV=.80 were chosen. 4. Nursing intervention protocols which showed above ICV=.90 were developed and were like these; pressure ulcer care, position change, preventive care for circulatory dysfunction, tube care : catheter, vital sign monitor, constipation/impaction management, artificial airway management, suction of airway secretion, environmental management : safety, and fall prevention.

• 한국미생물·생명공학회지
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• 제47권2호
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• pp.220-233
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• 2019

Bacterial lysates have become a common ingredient for natural health care. Lactic acid bacteria (LAB) could serve as potential candidates for lysate production: the lactic acids produced by LAB have been utilized for their moisturizing, antimicrobial, and rejuvenating effects, while other substances provide topical benefits and health effects for the skin. Our study aimed to obtain lysate from a LAB S. macedonicus MBF 10-2 through an optimized fermentation using the Response Surface Methodology. Strain MBF10-2 was cultivated in a 2L fermenter tank in de Man Rogosa and Sharpe (MRS) medium and in plant-based peptone modified MRS, i.e. Soy-peptone and Vegitone. The duration and the medium composition (dextrose and soy peptone or proteose peptone) were adjusted to obtain an optimum production of cell lysate. Central Composite Design was employed for Design Expert 7.0.0 by adjusting 3 factors: dextrose (1%, 1.5%, 2%, 2.5%, 3%), soy or proteose peptone (0.5%, 0.75%, 1%, 1.25% and 1.5%), and duration of fermentation (8, 10, 12 14, and 16 h for MRS-Soy peptone and 15, 17, 19, 21, and 23 h for MRS Vegitone). Bacteriocin-Like Inhibitor Substance activity of lysate and pH were used as indicators. The optimum condition for lysate production using MRS Soy Peptone and Vegitone are as follows: dextrose concentration 2.5%, plant-based peptone 1.25%, while optimum fermentation duration were 11.18 h (MRS Soy Peptone) and 17 h (MRS Vegitone) with a starter concentration of 10% at $OD_{600nm}$ $0.2{\pm}0.05$. However, the standard MRS medium produced better quality lysate compared to MRS plant-based peptones.

• 한국응용과학기술학회지
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• 제38권6호
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• pp.1433-1444
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• 2021

본 연구는 코로나 시대이후로 가속화된 뷰티분야의 4차 산업들과 융합으로 산업에서 요구되는 실무능력을 교육하기 위한 교육과정 개발을 목적으로 진행되었다. 여러 문헌의 탐색적 조사와 전문가의견을 수렴한 결과 뷰티산업은 앞으로 단일 아이템 또는 서비스 제공이 아닌 의료, 바이오, ICT, 인공지능 기술 등이 결합된 개인맞춤형 서비스 제공 산업으로 분야가 확장될 것으로 분석되었다. 분석 내용을 바탕으로 전통적인 뷰티산업에서 요구하는 기본 직무 능력 외에 갖추어야 할 디지털 활용능력을 추가하여 교육과정을 구성하고 과목을 도출하였다. 코로나 이후의 시대는 4차 산업혁명을 기반으로 다양한 산업의 변화를 가져올 것이며 이러한 변화에 대응하여 뷰티산업의 발전과 지속가능성을 위한 인재 개발을 위해 대학에서는 산업의 변화에 항상 주목해야 할 것이다.

• 지능정보연구
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• 제25권1호
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• pp.179-196
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• 2019

최근의 '똑똑한 소비자(Smart Consumer)'라 불리는 소비자가 많아지고 있는데, 이들은 제조사나 광고를 통해 전달되는 정보에 의존하지 않고, 기존 사용자나 전문가들의 후기, 여러 과학 지식을 획득하여 제품에 대한 이해를 높이고, 본인 스스로가 직접 판단하여 구매하고 있다. 특히나 화장품 분야는 인체 유해성과 같은 부정적인 요소에 대한 민감도가 높고, 자신의 고유한 피부 특성과의 조화도 고려되어야 하기 때문에, 전문적인 지식과 타인의 경험, 본인의 과거 경험 등을 종합적으로 생각하여 구매 의사결정을 내려야 하고, 이에 대해서 적극적인 소비자가 많아지고 있다. 이러한 움직임은 '셀프 뷰티' 와 같은 '셀프' 문화의 열풍과 함께, 문화 현상인 '그루밍족'의 등장, 사회적 트렌드인 'K-뷰티' 와도 동행한다고 할 수 있다. 맞춤형 화장품에 대한 관심의 급부상도 이러한 현상 중 하나라 볼 수 있다. 소비자들의 맞춤형 화장품의 니즈를 충족시키기 위해, 화장품 제조사나 관련 기업들은 ICT기술과의 융합을 통하여 프리미엄 서비스를 중심으로 소비자의 니즈에 대응하고 있다. 그러나 기업 및 시장 현황이 맞춤형 화장품을 향해 진화하고 있지만, 소비자의 피부 상태, 추구하는 감성, 실제 제품이나 서비스까지 소비자 경험을 전체적으로 완전하게 다루는 지능형 데이터 플랫폼은 부재한다. 본 연구에서는 소비자 경험에 대한 지능형 데이터 플랫폼 구축을 위한 첫 단계로 소비자 언어 기반의 화장품 감성 분석을 수행하였다. 소비자들 개인의 선호나 취향이 분명한 앰플/세럼 카테고리를 중심으로 매출 순위 1위에서 99위까지의 99개 제품을 선정하여, 블로그와 트위터 등의 SNS 상에 언급되는 후기 내에 화장품 경험에 대한 소비자 감성을 수집하였다. 총 357개의 감성 형용사를 수집하였고, 고객 여정 워크샵을 통해 유사 감성을 합치고, 중복 감성을 통합하는 작업을 수행하였으며, 최종 76개 형용사를 구축했다. 구축한 형용사에 대한 SOM 분석을 통해 화장품에 대한 소비자 감성에 대한 클러스터링을 실시했다. 분석 결과, 총 8개의 클러스터를 도출했고, 클러스터 별 각 노드의 벡터 값을 기준으로 소비자 감성 Top 10을 도출했다. 소비자 감성을 기준으로 클러스터별 소비자 감성에 서로 다른 특징이 발견됐으며, 소비자에 따라 다른 소비자의 감성을 선호, 기존과는 다른 소비자 감성을 고려한 추천 및 분류 체계가 필요함을 확인했다. 연구 결과를 통해 감성 분석의 활용 도메인이 화장품만이 아닌 다양한 영역으로 확장될 수 있음 확인했으며, 감성 분석을 통한 소비자 인사이트를 도출할 수 있다는 점을 시사했다. 또한, 본 연구에서 활용한 디자인 씽킹(Design Thinking)의 방법론의 적용하여 화장품 특화된 감성 사전을 과학적인 프로세스로 구축했으며, 화장품에 대한 소비자의 인지 및 심리에 대한 이해를 도울 수 있을 것으로 기대한다.

• 대한유전성대사질환학회지
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• 제10권1호
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• pp.59-66
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• 2010

Enzyme replacement of therapy (ERT) is one of the most promising therapeutic strategies for the treatment of lysosomal storage disorders. ERT is available in three types of Mucopolysaccharidosis (MPS): for MPS I (Aludrazyme$^{(R)}$), MPS II (Elaprase$^{(R)}$) and MPS VI (Naglazyme$^{(R)}$) patients who are over 5 years old. But recently, early diagnosis can be done by expert clinicians and even in prenatal case. We describe the case of ERT under 5 years old MPS patients. Up to June, 2010 in Samsung Medical Center, there are 6patients who were diagnosed as MPS and started ERT under 5 years old. 3 patients were MPS I, 3 patients were MPS II. 2 patient who was diagnosed as MPS I was female and others were male. Their age at diagnosis were 4 to 37month-old (4, 13, 16, 25, 27, 37 month-old) and they are now 9 to 60 month-old (9, 39, 32, 81, 60 month-old). The youngest patient was started ERT at 4 month-old and others were started at their 13 to 49 month-old (13, 29, 27, 28, 49 month-old). First manifested symptoms of patients were macrocephaly, kyphosis and coarse face appearance. Especially, in 2 of them, one was MPS I and the other was MPS II had elder brother with same disease. And the youngest one was diagnosed by the iduronate-2-sulfatase (IDS) gene analysis from chorionic villi sampling. His mother knew that she was a heterozygous carrier of IDS gene mutation because her younger brother died from MPS II. All of them confirmed as MPS by the enzyme assay in leukocytes and fibroblast skin culture. We started ERT with ${\alpha}$-L-iduronidase(Aldurazyme$^{(R)}$) to MPS I and did recombinant human iduronate-2-sulfatase (Elaprase$^{(R)}$) to MPS II patients as recommended dose as over 5 years old. But for MPS II patient who was 4 month old, we started ERT by recombinant human IDS (Elaprase$^{(R)}$) with reduced dose 0.1 mg/kg and increased dose every 2 weeks by 0.1mg/kg up to 0.5mg/kg IV infusion. During ERT, all patients had no adverse effects and the excretion of GAGs were decreased. We have evaluated other clinical symptoms such as liver/ spleen volume, heart function and neurologic evaluation. We describe a successful ERT to MPS I and MPS II patient under 5 years old without any adverse event. It indicates that ERT in young children are well tolerated and that it has several effects which may confer clinical benefits with long-term therapy.