• 대한치과교정학회지
• /
• 제49권4호
• /
• pp.254-264
• /
• 2019

Objective: To evaluate the short-term changes in masticatory muscle activity and mandibular movement patterns after orthognathic surgery in skeletal Class III patients with facial asymmetry. Methods: Twenty-seven skeletal Class III adult patients were divided into two groups based on the degree of facial asymmetry: the experimental group (n = 17 [11 male and 6 female]; menton deviation ${\geq}4mm$) and control group (n = 10 [4 male and 6 female]; menton deviation < 1.6 mm). Cephalography, electromyography (EMG) for the anterior temporalis (TA) and masseter muscles (MM), and mandibular movement (range of motion [ROM] and average chewing pattern [ACP]) were evaluated before (T0) and 7 to 8 months (T1) after the surgery. Results: There were no significant postoperative changes in the EMG potentials of the TA and MM in both groups, except in the anterior cotton roll biting test, in which the masticatory muscle activity had changed into an MM-dominant pattern postoperatively in both groups. In the experimental group, the amount of maximum opening, protrusion, and lateral excursion to the non-deviated side were significantly decreased. The turning point tended to be shorter and significantly moved medially during chewing in the non-deviated side in the experimental group. Conclusions: In skeletal Class III patients with facial asymmetry, the EMG activity characteristics recovered to presurgical levels within 7 to 8 months after the surgery. Correction of the asymmetry caused limitation in jaw movement in terms of both ROM and ACP on the non-deviated side.

• 대한치과교정학회지
• /
• 제29권3호
• /
• pp.317-325
• /
• 1999

골격성 III급 부정교합 환자의 정확한 진단과 분석에 있어서 삼차원적인 골격부조화의 양상이나 안면부조화의 원인을 파악하는 것은 중요하다. 본 연구에서는 정모 두부규격방사선 사진 상에서 나타나는 골격성 III급 부정교합자의 계측학적 특성을 파악하기 위하여, 양호한 안모와 교합을 가지는 성인 남녀 정상교합자 60명과 전후방적 부조화가 심한 III급 부정교합을 가지는 성인 남녀 60명을 대상으로 측모와 정모 두부규격방사선 사진의 투사도를 작성하여 안면폭경, 고경, 각각의 비율, 측모계측치에 대응되는 정모계측치의 비율을 구하였고, 각각의 계측치와 비율을 비교, 분석하여 다음과 같은 결론을 얻었다. 1. 골격성 III급 부정교합자에서 골격의 전후방적 부조화는 정상군보다 상악골길이(Cd-A)가 짧은 것보다는 하악골길이(Cd-Gn)가 긴 것에 기인하였다. 2. 골격성 III급 부정교합자는 정상교합자보다 긴 안모를 가지는데, 이는 상안면고경(Cg-ANS)보다는 하안면 고경(ANS-Me), 특히 하악골 고경(Cd-Me)의 증가로 인한 것이었다. 3. 골격성 III급 부정교합자의 폭경은 단지 여자의 상$\cdot$하악 대구치간 폭경(U6-U6, L6-L6)과, 하악폭경(Ag-Ag)만 정상교합자보다 컸을 뿐, 이외 어떤 폭경항목도 정상과 차이가 없었다. 4.골격성 III급 부정교합자의 하악골 길이의 증가는 안모의 고경 특히 하안면 고경의 증가로 나타나지만, 하악골 폭경에서는 영향이 나타나지 않았다.

• 대한치과교정학회지
• /
• 제24권4호
• /
• pp.799-817
• /
• 1994

The purpose of this study was to evaluate the initial skeletal pattern and growth change of whom had responsed well to chincap therapy. 93 patients seleted for this study were in mixed dentition and treated with chincap for more than 2 years. And 54 subjects were selected from these total samples and classified into two groups by the improvement of four measurements : ANB difference, APDI, Wits appraisal, and AF-BF. One was good response group which consisted of 26 children and the other was poor response group with 19 patients. Various measures of the craniofacial structure in the initial lateral cephalograms and the annual increments were calculated and analyzed by comparing two groups with t-test. The results were as follows : 1. Good response group had more horizontal growth pattern in initial stage of treatment than poor response group, and the contributing factors of this result were anterior posterior facial height ratio, gonial angle, lower genial angle and SN-mandibular plane angle. 2. The maxilla was positioned more anteriorly in good response group. 3. The amounts of vertical growth of maxilla was smaller but the horizontal growth of maxilla was larger in good response group. 4. The mandible rotated more infero-posteriorly in good response group. 5. The good response group had more vertical growth pattern of mandibular condyle.

• 대한치과교정학회지
• /
• 제40권5호
• /
• pp.304-313
• /
• 2010

본 연구는 한국인 정상교합자와 부정교합자 사이의 교합력의 크기와 교합 시의 접촉 면적의 차이 및 골격 형태와 교합 관계, 연령, 성별이 교합력의 크기에 영향을 미치는지 알아보기 위해 시행되었다. 정상교합자 15명, 부정교합자 636명에서 일회용 pressure sensitive sheet (Dental $Prescale^{(R)}$ 50H, typeR, Fuji Film Corp., Tokyo, Japan)를 자연 두부위에서 최대 근력으로 교합하도록 한 후, CCD camera ($Occluzer^{(R)}$ FPD 707, Fuji Film Corp., Tokyo, Japan)로 판독하여 교합력의 크기 및 접촉 면적을 측정하였다. 정상교합자군의 교합력의 크기는 $744.5{\pm}262.6N$, 접촉면적은 $24.2{\pm}8.2mm^2$으로, 부정교합자군의 $439.0{\pm}229.9N$, $12.4{\pm}10.7mm^2$에 비해 교합력의 크기와 접촉 면적이 유의하게 컸다 ($p$ < 0.05). 부정교합자군의 경우 연령에 따른 교합력의 차이는 없었으나, 남자가 여자에 비해 큰 교합력을 가지고 있었다 ($p$ < 0.05). 악안면의 전후방적인 골격 형태를 나타내는 ANB 및 골격성 1급 부정교합에서의 구치부의 Angle 분류는 교합력에 유의한 차이를 나타내지 않았으나, 수직적인 골격 형태를 구분하는 mandibular plane angle, gonial angle이 큰 경우, 교합력이 유의하게 작았다 ($p$ < 0.05). 하지만, 교합력의 크기와 접촉 면적간에는 높은 상관관계가 존재하는 점과 접촉 면적을 통제한 상태에서의 골격 형태와 교합력의 크기 사이에는 유의할 만한 상관관계가 없는 점을 고려한다면 수직적인 골격 형태가 직접적으로 교합력에 영향을 주기보다는 수직적인 골격 형태에 따른 접촉 면적의 감소가 교합력 저하에 관여한다고 판단된다.

• Fisheries and Aquatic Sciences
• /
• 제15권4호
• /
• pp.325-335
• /
• 2012

The present study characterized the fast skeletal myosin light chain-2 gene (mlc2f) in the euryhaline Javanese ricefish (Oryzias javanicus: Beloniformes). Coding nucleotide and deduced amino acid sequences of Javanese ricefish mlc2f were well conserved in the vertebrate lineage. Javanese ricefish mlc2f showed a typical seven-exon structure, and its promoter exhibited transcription factor binding motifs common to most muscle-specific genes. However, Javanese ricefish mlc2f also displayed tandem duplications of intronic sequences in both intron 1 and intron 3. Based on quantitative reverse transcription-polymerase chain reaction, the mlc2f transcripts were highly predominant in skeletal muscles of adults and were differentially modulated during embryonic development. Microinjection of the mlc2f promoter-driven red fluorescent protein (RFP) reporter construct successfully exhibited heterologous expression of the fluorescent reporter, primarily in muscular areas of hatchlings, although the distribution pattern of RFP signals was not uniform due to the mosaic nature of the introduced transgene. Data from this study indicate that the Javanese ricefish mlc2f gene has undergone "intra-intronic" duplication events in a species-specific manner and that the mlc2f regulator may also be useful in heterologous expression assays of the skeletal muscles of this species.

• 대한치과교정학회지
• /
• 제37권1호통권120호
• /
• pp.29-43
• /
• 2007

본 연구는 성장기 II급 부정교합자를 골격 형태에 따라 분류하여 액티베이터 사용 효과를 비교, 분석하고 그 결과를 진단, 치료 계획 수립 등 임상 과정에 연계시키기 위해 시행되었다. 실험은 수완부 방사선 사진상 Fishman 분류의 2, 3, 4 단계로 최대성장기 이전의 II급 부정교합자를 대상으로 하였다. 대조군은 ANB 3도 이상이며 악정형 장치 치료를 받지 않고 치열교정 치료만 받은 환자로 총 25명(남자 15명, 여자 10명)이고 실험군은 액티베이터 치료를 받은 환자로 총 116명(남자 53명, 여자 63명)이었다. Articular angle과 gonial angle을 이용하여 골격 형태를 hyperdivergent type과 hypodivergent type으로 분류하여 액티베이터 치료효과를 비교한 결과 hypodivergent한 골격 형태를 가진 환자에서 더 큰 효과를 보였다. 따라서 성장기 II급 부정교합자의 진단과 치료계획 수립 시 안모의 골격 형태 분류를 통해 액티베이터의 효과를 예측할 수 있다고 생각한다.

• 대한치과교정학회지
• /
• 제17권1호
• /
• pp.135-148
• /
• 1987

To investigate the relationship between craniofacial growth and bone maturity of the hand wrist in normal occlusion, the author took cephalogram and handwrist radiogram of 391 students (male 192, female 199) and assessed the measurements of cephalogram according to skeletal maturity stages of the hand and wrist. In this study, four skeketal stages and 36 linear, angular measurements of the cephalometrics were selected. In hand-wrist X-ray the bones used to determine skeletal maturity were the middle phalanges of the third finger, and distal epiphysis of the radius. In cephalogram, the landmark used to measure the angle and length were N, S, Po., Ar., Go., Me., Gn., Pog., Point B, Point A, ANS, PNS, Or., U1, L1, U6, L6 etc.. The results were as follows, 1. The table of mean, standard deviation, p-value from measurements were made in each group and both sex. 2. The increased measurements according to skeletal maturity were anterior cranial bese length, posterior cranial base length, ramus height, anterior facial height, posterior facial height, L1 to mandibular plane (mm), facial plane angle. In contrast to, decreased measurements were genial angle, facial cnvexity and facial plane angle. 3. Denture pattern measurements (IMPA, FMIA, occlusal plane to Go-Gn, interincisal angle, U1 to SN plane, U1 to SN plane, U1 to facial plane, L1 to facial plane etc.) .had nothing to do with skeletal maturity. 4. Skeletal maturity had close relationship with craniofacial growth, but had little to do with tooth development.

• 대한치과교정학회지
• /
• 제42권5호
• /
• pp.227-234
• /
• 2012

Objective: To evaluate the presurgical orthodontic tooth movement of mandibular teeth after dental decompensation for skeletal Class III deformities on the basis of vertical skeletal patterns. Methods: This cohort was comprised of 62 patients who received presurgical orthodontic treatment. These patients were divided into 3 groups according to their vertical skeletal patterns. Changes in the positions of the mandibular central incisor, canine, premolar, and 1st molar after presurgical orthodontic treatment were measured using a cone-beam computed tomography (CBCT) superimposition method. Results: The incisors moved forward after dental decompensation in all 3 groups. The canines in group I and the 1st premolars in groups I and III also moved forward. The incisors and canines were extruded in groups I and II. The 1st and 2nd premolars were also extruded in all groups. Vertical changes in the 1st premolars differed significantly between the groups. We also observed lateral movement of the canines in group III and of the 1st premolar, 2nd premolar, and 1st molar in all 3 groups (p < 0.05). Conclusions: Movement of the mandibular incisors and premolars resolved the dental compensation. The skeletal facial pattern did not affect the dental decompensation, except in the case of vertical changes of the 1st premolars.

• Animal Bioscience
• /
• 제34권1호
• /
• pp.134-142
• /
• 2021

Objective: To understand the athletic characteristics of Thoroughbreds, high-throughput analysis has been conducted using horse muscle tissue. However, an in vitro system has been lacking for studying and validating genes from in silico data. The aim of this study is to validate genes from differentially expressed genes (DEGs) of our previous RNA-sequencing data in vitro. Also, we investigated the effects of exercise-induced stress including heat, oxidative, hypoxic and cortisol stress on horse skeletal muscle derived cells with the top six upregulated genes of DEGs. Methods: Enriched pathway analysis was conducted using the Database for Annotation, Visualization, and Integrated Discovery (DAVID) tool with upregulated genes in horse skeletal muscle tissue after exercise. Among the candidates, the top six genes were analysed through geneMANIA to investigate gene networks. Muscle cells derived from neonatal horse skeletal tissue were maintained and subjected to exercise-related stressors. Transcriptional changes in the top six genes followed by stressors were investigated using quantitative reverse transcription-polymerase chain reaction (qRT-PCR). Results: The inflammation response pathway was the most commonly upregulated pathway after horse exercise. Under non-cytotoxic conditions of exercise-related stressors, the transcriptional response of the top six genes was different among types of stress. Oxidative stress yielded the most similar expression pattern to DEGs. Conclusion: Our results indicate that transcriptional change after horse exercise in skeletal muscle tissue strongly relates to stress response. The qRT-PCR results showed that stressors contribute differently to the transcriptional regulation. These results would be valuable information to understand horse exercise in the stress aspect.

• 대한치과교정학회지
• /
• 제27권2호
• /
• pp.209-219
• /
• 1997

본 연구는 골격성 III급 부정교합자에서 상하악절치의 치성보상 양상과 골격형태 사이의 상관관계를 규명하기 위해 시행되었다. 정상교합자 59명, 미약한 골격성 III급 부정교합자 91명 그리고 심한 골격성 III급 부정교합자 58명을 연구대상으로 선정하였으며 특히 미약한 골격성 III급 부정교합자는 전치부 반대교합의 유무에 따라 반대교합이 없는 군과 반대교합군으로 세분하여 연구하였다. 측모두부방사선규격사진을 15개의 골격 형태 계측항목과 16개의 상하악절치 경사도 및 위치 계측항목으로 분석한 뒤 통계 처리하여 다음과 같은 결과를 얻었다. 1. 각 군의 상하악 전치부 치성보상 양상을 보면 II-B군에 비해 II-A군과 III군의 상악 중절치는 순측경사 되어 있으며 II-A군이 III군 보다 크게 순측경사 되어 있었다. 하악절치는 II-A군과 II-B군에 비해 III군이 설측경사 되었으며 II-A군과 II-B군의 차이는 없었다. 2. II-A군과 II-B군 사이의 수직적인 골격형태 차이는 크지 않았고 하악절치 보다는 상악절치 위치 및 경사도에서 큰 차이를 보였다. 3. II- A군의 하악절치와 II-B군의 상악절치 계측항목이 골격형태와 상관성이 높았으며 특히 하악절치 계측항목중에서는 ∠IMPA, ∠FMIA, 상악절치 계측항목중에서는 ∠U1-FH, ∠U1-SN이 높은 상관성을 보였다. 4. 하악절치 계측항목중 ∠IMPA, ∠FMIA는 모든 군에서 골격형태와 높은 상관성을 보였다. 상악절치 계측항목중에서는 ∠U1-SN, ∠U1-FH, U1-facial plane(mm)이 다른 계측 항목에 비해 상관성이 높았다.