• 제목/요약/키워드: Skeletal analysis

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유치열기 골격성과 비골격성 3급 부정교합 환아의 제1대구치 성숙도 비교 (Maturation of the First Molars in Primary Dentition with Class III Malocclusion)

  • 정보람;김신;정태성;김지연
    • 대한소아치과학회지
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    • 제42권2호
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    • pp.144-150
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    • 2015
  • 유치열기의 3급 부정교합은 조기 치료가 추천되지만 정확한 진단이 쉽지 않다. 3급 부정교합의 골격성 특성과 치아 발육상태 사이에 연관성이 있다면 골격성 3급 부정교합의 감별 진단을 위한 평가 항목으로 치아성숙도가 활용될 수 있을 것이다. 본 연구는 유치열기의 골격성 혹은 비골격성 3급 부정교합으로 진단받은 환아를 대상으로 치아 석회화도 및 제 1대구치의 맹출률을 비교, 분석하여 상하악의 치아성숙도 차이가 유치열기 3급 부정교합의 감별 진단시 평가 항목으로 사용될 수 있는지 알아보기 위한 목적으로 시행되었다. 전치부 반대교합을 주소로 부산대학교 치과병원 소아치과에 내원한 유치열기 아동 중 비골격성 3급 부정교합군 18명과 골격성 3급 부정교합군 34명을 연구대상으로 선정하였다. 파노라마 방사선사진상에서 치령 및 제1대구치 맹출률을 비교, 분석하여 다음과 같은 결과를 얻었다. 골격 및 성별에 따른 역령과 치령의 차이는 존재하지 않았으며, 두 군 모두 역령에 비해 치령이 높게 나타났다(p < 0.05). 비골격성군과 골격성군의 상하악 맹출률의 차이는 각각 16.53%, 18.91%로 통계학적으로 유의한 차이를 보여(p < 0.05), 3급 부정교합의 감별 진단을 위한 평가 항목으로서 제1대구치 치아성숙도의 활용 가능성을 시사한다.

한국아동의 악안면성장에 관한 유한요소법적 연구 (A STUDY ON CRANIOFACIAL GROWTH ANALYSIS OF KOREAN CHILDREN BY THE FINITE ELEMENT METHOD)

  • 탁선근
    • 대한치과교정학회지
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    • 제18권2호
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    • pp.343-366
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    • 1988
  • Craniofacial complex is influenced by numerical skeletal elements. Though the analysis of growth change has been done by various analytical methods, it was dependent on any method of registration and superimposition, based on reference plane and reference point. However, the craniofacial growth is composed of a number of local growth elements. Therefore, it will be necessary to use a clinically useful method for estimating craniofacial skeletal growth independently. The author analysed longitudinal cephalometric roentgenogram of 15 Korean males and 15 Korean females aged from 6 to 12 years by the finite element method and results were as follows : 1. The finite element method for craniofacial skeletal complex and soft tissue made it possible to analyze the independent local growth. 2. Regression equations from the value of each strain will make it possible to predict the craniofacial growth. 3. The growth of anterior cranial base was different from that of other facial bone. 4. The growth of posterior cranial base influenced the growth of upper pharyngeal region, midfacial region, maxilla and posterior region of mandible. 5. The growth of maxillary complex was vertical rather than horizontal. 6. The growth direction of ramus, mandibular body, alveolar bone was various. 7. The relation between hard tissue and soft tissue by finite element method was variant.

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Proteome Analysis of Bovine Longissimus dorsi Muscle Associated with the Marbling Score

  • Shen, Y.N.;Kim, S.H.;Yoon, D.H.;Lee, H.G.;Kang, H.S.;Seo, K.S.
    • Asian-Australasian Journal of Animal Sciences
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    • 제25권8호
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    • pp.1083-1088
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    • 2012
  • The breeding value of marbling score in skeletal muscle is an important factor for evaluating beef quality. In the present study, we investigated proteins associated with the breeding value of the marbling score for bovine sirloin to select potential biomarkers to improve meat quality through comparative proteomic analysis. Proteins isolated from muscle were separated by two-dimensional gel electrophoresis. After analyzing images of the stained gel, seven protein spots for the high marbling score group were identified corresponding to changes in expression that were at least two-fold compared to the low marbling score group. Four spots with increased intensities in the high marbling score group were identified as phosphoglycerate kinase 1, triosephophate isomerase, acidic ribosomal phosphoprotein PO, and capping protein (actin filament) Z-line alpha 2. Spots with decreased intensities in the high marbling score group compared to the low score group were identified as 14-3-3 epsilon, carbonic anhydrase II, and myosin light chain 1. Expression of myosin light chain 1 and carbonic anhydrase 2 was confirmed by Western blotting. Taken together, these data could help improve the economic performance of cattle and provide useful information about the underlying the function of bovine skeletal muscle.

Genetic determinants of periosteum-mediated craniofacial bone regeneration: a systematic review

  • Eyituoyo Okoturo
    • 대한두개안면성형외과학회지
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    • 제24권6호
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    • pp.251-259
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    • 2023
  • Background: Periosteum-mediated bone regeneration (PMBR) is a recognized method for mandibular reconstruction. Despite its unpredictable nature and the limited degree to which it is understood, it does not share the concerns of developmental changes to donor and recipient tissues that other treatment options do. The definitive role of the periosteum in bone regeneration in any mammal remains largely unexplored. The purpose of this study was to identify the genetic determinants of PMBR in mammals through a systematic review. Methods: Our search methodology was designed in accordance with the PRISMA (Preferred Reporting Items for Systematic Review and Meta-Analysis) guidelines. We conducted a quality assessment of each publication, and evaluated the differences in gene expression between days 7 and 15. Results: A total of four studies satisfied the inclusion criteria. The subjects and tissues examined in these studies were Wistar rat calvaria in two studies, mini-pigs in one study, and calves and mice in one study. Three out of the four studies achieved the necessary quality score of ≥ 3. Gene expression analysis showed increased activity of genes responsible for angiogenesis, cytokine activities, and immune-inflammatory responses on day 7. Additionally, genes related to skeletal development and signaling pathways were upregulated on day 15. Conclusions: The results suggest that skeletal morphogenesis is regulated by genes associated with skeletal development, and the gene expression patterns of PMBR may be characterized by specific pathways.

한국 재래닭의 부화 후 성장단계별 넙다리뼈와 정강뼈 성장에 관한 연구 (The growth stage study on the femur and tibia of Korean native chicken after hatching)

  • 태현진
    • 한국동물위생학회지
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    • 제38권3호
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    • pp.181-188
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    • 2015
  • Skeletal development of chicken has been widely discussed in industrial forums and various research reports. However, these studies were emphasis on the commercial chicken strains for improve egg and meat production whereas the skeletal quiet remains as a potential weak link related to facilitating in the physical support of heavier carcasses at ever younger ages. For that, the study of standardization of skeletal development is important but it was rarely reported in Korean native chicken (KNC). The study was investigated the skeletal characteristics of KNC for international standardization. We studied in KNC at 2, 14, 28, 42, 56, 70, 84, 98, 112, 126, 147, 168, 196, 224, 336 and 448 days after hatch (male and female, n=13 for each group). We measured the body weight (BW), and after sacrifice measured organs and remove muscle from femur & tibia and measured bone weight. Data were analyzed by ANOVA, Duncan test, correlation analysis and regression analysis of SAS 9.1. We analyzed the data of BW, femur & tibia and made growth curve also. The BW was significantly increased up to 147 days after hatch (male, $1,927.88{\pm}68.92g$; female, $1,456.00{\pm}50.11g$), and then increased gradually. At 336 days, these growth was stop (male, $2,467.00{\pm}42.84g$; female, $1,568.71{\pm}62.62g$). The growth of femur & tibia length and width was stop on 98~126 days after hatch. At 98 days, we measured the length and width of femur & tibia in male were $132.39{\pm}3.18mm$ & $25.98{\pm}0.59mm$ whereas in female at 112 days the length of femur & tibia was $116.40{\pm}1.55mm$ and at 126 days width was $21.41{\pm}0.38mm$. Our study suggests that the growth of male KNC was classified pre-puberty (0~98 days), puberty (98~336 days) and maturity (after 336 days), meanwhile female was shown similar trend however puberty period of KNC was 112 or 126 days after hatch.

Posterior dental compensation and occlusal function in adults with different sagittal skeletal malocclusions

  • Hwang, Soonshin;Choi, Yoon Jeong;Jung, Sooin;Kim, Sujin;Chung, Chooryung J.;Kim, Kyung-Ho
    • 대한치과교정학회지
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    • 제50권2호
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    • pp.98-107
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    • 2020
  • Objective: The aim of this study was to compare posterior tooth inclinations, occlusal force, and contact area of adults with different sagittal malocclusions. Methods: Transverse skeletal parameters and posterior tooth inclinations were evaluated using cone beam computed tomography images, and occlusal force as well as contact area were assessed using pressure-sensitive films in 124 normodivergent adults. A linear mixed model was used to cluster posterior teeth into maxillary premolar, maxillary molar, mandibular premolar, and mandibular molar groups. Differences among Class I, II, and III groups were compared using an analysis of variance test and least significant difference post-hoc test. Correlations of posterior dental inclinations to occlusal function were analyzed using Pearson's correlation analysis. Results: In male subjects, maxillary premolars and molars had the smallest inclinations in the Class II group while maxillary molars had the greatest inclinations in the Class III group. In female subjects, maxillary molars had the smallest inclinations in the Class II group, while maxillary premolars and molars had the greatest inclinations in the Class III group. Occlusal force and contact area were not significantly different among Class I, II, and III groups. Conclusions: Premolar and molar inclinations showed compensatory inclinations to overcome anteroposterior skeletal discrepancy in the Class II and III groups; however, their occlusal force and contact area were similar to those of Class I group. In subjects with normodivergent facial patterns, although posterior tooth inclinations may vary, difference in occlusal function may be clinically insignificant in adults with Class I, II, and III malocclusions.

인체모델을 이용한 농작업자의 밀기 작업시 요추부 생체 역학적 평가 (Bio-mechanical Analysis on the Lower Back using Human Model during Pushing the Manual Vehicles)

  • 임대섭;이경숙;최안렬;김영진;문정환
    • Journal of Biosystems Engineering
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    • 제34권4호
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    • pp.286-294
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    • 2009
  • A high prevalence of protected horticulture farmer's work-related musculo-skeletal disorders (MSDs) have been reported in precedent studies. One of the tasks required ergonomic intervention to reduce the musculo-skeletal risks is the task of product transporting. The purpose of this study is to evaluate quantitatively the spinal load of operator using manual vehicles to predict and prevent musculo-skeletal risks. Spinal load in operators using 4 kinds of manual vehicle were analyzed. Before evaluating spinal load on operator using the manual vehicles by bio-mechanical approach, it is needed to validate human model. In this study, ADAMS LifeMOD human model shows satisfactory results, comparing with already validated model's results or measured results. While Operators pushed the manual vehicles(wheelbarrow, Trolley, 2 wheel cart, and 4 wheel cart) contained loads that were 0 N and 800 N, their spinal loads(compression force, shear force) were evaluated. The compression force demonstrated under the NIOSH action limits - 3410N - for all 4 manual vehicle's operators(McGill 1997; Marras 2000). However, the lateral shear force demonstrated over the University of Waterloo - 500N - for all 3 manual vehicle's operators except 4Wheel cart (Yingline and McGill, 1999). Therefore, operators have risks in prevalence of the musculo-skeletal disorders due to shear force. The findings of this study suggest that it need to be determine the spinal load, especially lateral shear force in designing the manual vehicles in the future.

신경근전기자극이 체중 부하를 제거한 신생 흰쥐 골격근 조직의 MEF2C 및 VEGF 발현에 미치는 영향 (Influence of Neuromuscular Electrical Stimulation on MEF2C and VEGF Expression of Neonatal Rat Skeletal Muscle During Suspension Unloading)

  • 구현모;이선민
    • 한국전문물리치료학회지
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    • 제14권1호
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    • pp.28-36
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    • 2007
  • The aim of this study was to identify the effect of suspension unloading (SU) and electrical stimulation upon the development of neonatal muscular system. For this study, the neonatal rats were randomly divided into three groups: a control group, an experimental group I, and an experimental group II. The SU for experimental group I and II was applied from postnatal day (PD) 5 to PD 30. The electrical stimulation for soleus muscle of experimental group IIwas applied from PD 16 to PD 30 using neuromuscular electrical stimulation (NMES), which gave isometric contraction with 10 pps for 30 minutes twice a day. In order to observe the effect of SU and ES, this study observed myocyte enhancer factor 2C (MEF2C) and vascular endothelial growth factor (VEGF) immunoreactivity in the soleus muscles at PD 15 and PD 30. In addition, the motor behavior test was performed through footprint analysis at PD 30. The following is the result. At PD 15, the soleus muscles of experimental group Iand II had significantly lower MEF2C, VEGF immunoreactivity than the control group. It proved that microgravity conditions restricted the development of the skeletal muscle cells at PD 15. At PD 30, soleus muscles of the control group and experimental group II had significantly higher MEF2C, VEGF, immunoreactivity than experimental group I. It proved that the NMES facilitated the development of the skeletal muscle cells. At PD 30, it showed that SU caused the decrease in stride length of parameter of gait analysis and an increase in toe-out angle, and that the NMES decreased these variations. These results suggest that weight bearing during neonatal developmental period is essential for muscular development. They also reveal that NMES can encourage the development of muscular systems by fully supplementing the effect of weight bearing, which is an essential factor in the neonatal developmental process.

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Ginsenoside Rg1 augments oxidative metabolism and anabolic response of skeletal muscle in mice

  • Jeong, Hyeon-Ju;So, Hyun-Kyung;Jo, Ayoung;Kim, Hye-Been;Lee, Sang-Jin;Bae, Gyu-Un;Kang, Jong-Sun
    • Journal of Ginseng Research
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    • 제43권3호
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    • pp.475-481
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    • 2019
  • Background: The ginsenoside Rg1 has been shown to exert various pharmacological activities with health benefits. Previously, we have reported that Rg1 promoted myogenic differentiation and myotube growth in C2C12 myoblasts. In this study, the in vivo effect of Rg1 on fiber-type composition and oxidative metabolism in skeletal muscle was examined. Methods: To examine the effect of Rg1 on skeletal muscle, 3-month-old mice were treated with Rg1 for 5 weeks. To assess muscle strength, grip strength tests were performed, and the lower hind limb muscles were harvested, followed by various detailed analysis, such as histological staining, immunoblotting, immunostaining, and real-time quantitative reverse transcription polymerase chain reaction. In addition, to verify the in vivo data, primary myoblasts isolated from mice were treated with Rg1, and the Rg1 effect on myotube growth was examined by immunoblotting and immunostaining analysis. Results: Rg1 treatment increased the expression of myosin heavy chain isoforms characteristic for both oxidative and glycolytic muscle fibers; increased myofiber sizes were accompanied by enhanced muscle strength. Rg1 treatment also enhanced oxidative muscle metabolism with elevated oxidative phosphorylation proteins. Furthermore, Rg1-treated muscles exhibited increased levels of anabolic S6 kinase signaling. Conclusion: Rg1 improves muscle functionality via enhancing muscle gene expression and oxidative muscle metabolism in mice.