• 대한치과교정학회지
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• 제29권3호
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• pp.317-325
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• 1999

골격성 III급 부정교합 환자의 정확한 진단과 분석에 있어서 삼차원적인 골격부조화의 양상이나 안면부조화의 원인을 파악하는 것은 중요하다. 본 연구에서는 정모 두부규격방사선 사진 상에서 나타나는 골격성 III급 부정교합자의 계측학적 특성을 파악하기 위하여, 양호한 안모와 교합을 가지는 성인 남녀 정상교합자 60명과 전후방적 부조화가 심한 III급 부정교합을 가지는 성인 남녀 60명을 대상으로 측모와 정모 두부규격방사선 사진의 투사도를 작성하여 안면폭경, 고경, 각각의 비율, 측모계측치에 대응되는 정모계측치의 비율을 구하였고, 각각의 계측치와 비율을 비교, 분석하여 다음과 같은 결론을 얻었다. 1. 골격성 III급 부정교합자에서 골격의 전후방적 부조화는 정상군보다 상악골길이(Cd-A)가 짧은 것보다는 하악골길이(Cd-Gn)가 긴 것에 기인하였다. 2. 골격성 III급 부정교합자는 정상교합자보다 긴 안모를 가지는데, 이는 상안면고경(Cg-ANS)보다는 하안면 고경(ANS-Me), 특히 하악골 고경(Cd-Me)의 증가로 인한 것이었다. 3. 골격성 III급 부정교합자의 폭경은 단지 여자의 상$\cdot$하악 대구치간 폭경(U6-U6, L6-L6)과, 하악폭경(Ag-Ag)만 정상교합자보다 컸을 뿐, 이외 어떤 폭경항목도 정상과 차이가 없었다. 4.골격성 III급 부정교합자의 하악골 길이의 증가는 안모의 고경 특히 하안면 고경의 증가로 나타나지만, 하악골 폭경에서는 영향이 나타나지 않았다.

• 대한치과의사협회지
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• 제12권6호
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• pp.419-423
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• 1974

The authors have investigated the roles of cortisone and calcium on the depressive effects of local anesthetics on the acetylcholine-induced skeletal muscle contraction in frog. The results are as follows. 1. Tetracaine, cocaine, lidocaine and procaine decreased the acetylcholine-induced skeletal muscle contraction. 2. Cortisone increased the depressive effects of local anesthetics on the acetyl-choline-induced skeletal muscle contraction. 3. There was a tendency that in high calcium concentration, the depressive effects of cocaine and lidocaine on acetylcholine-induced skeletal muscle contraction were increased.

• Journal of Korean Neurosurgical Society
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• 제63권5호
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• pp.649-656
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• 2020

Objective : Unclear mental state is one of the major factors contributing to diagnostic failure of occult skeletal trauma in patients with traumatic brain injury (TBI). The aim of this study was to evaluate the overlooked co-occurring skeletal trauma through whole body bone scan (WBBS) in TBI. Methods : A retrospective study of 547 TBI patients admitted between 2015 and 2017 was performed to investigate their cooccurring skeletal injuries detected by WBBS. The patients were divided into three groups based on the timing of suspecting skeletal trauma confirmed : 1) before WBBS (pre-WBBS); 2) after the routine WBBS (post-WBBS) with good mental state and no initial musculoskeletal complaints; and 3) after the routine WBBS with poor mental state (poor MS). The skeletal trauma detected by WBBS was classified into six skeletal categories : spine, upper and lower extremities, pelvis, chest wall, and clavicles. The skeletal injuries identified by WBBS were confirmed to be simple contusion or fractures by other imaging modalities such as X-ray or computed tomography (CT) scans. Of the six categorizations of skeletal trauma detected as hot uptake lesions in WBBS, the lesions of spine, upper and lower extremities were further statistically analyzed to calculate the incidence rates of actual fractures (AF) and actual surgery (AS) cases over the total number of hot uptake lesions in WBBS. Results : Of 547 patients with TBI, 112 patients (20.4 %) were presented with TBI alone. Four hundred and thirty-five patients with TBI had co-occurring skeletal injuries confirmed by WBBS. The incidences were as follows : chest wall (27.4%), spine (22.9%), lower extremities (20.2%), upper extremities (13.5%), pelvis (9.4%), and clavicles (6.3%). It is notable that relatively larger number of positive hot uptakes were observed in the groups of post-WBBS and poor MS. The percentage of post-WBBS group over the total hot uptake lesions in upper and lower extremities, and spines were 51.0%, 43.8%, and 41.7%, respectively, while their percentages of AS were 2.73%, 1.1%, and 0%, respectively. The percentages of poor MS group in the upper and lower extremities, and spines were 10.4%, 17.4%, and 7.8%, respectively, while their percentages of AS were 26.7%, 14.2%, and 11.1%, respectively. There was a statistical difference in the percentage of AS between the groups of post-WBBS and poor MS (p=0.000). Conclusion : WBBS is a potential diagnostic tool in understanding the skeletal conditions of patients with head injuries which may be undetected during the initial assessment.

• 대한소아치과학회지
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• 제41권3호
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• pp.225-232
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• 2014

이 논문의 목적은 골 성숙도와 치아의 성숙도를 골격적 부정교합에 따라 관련성을 알아보는 것이다. 6세에서 14세에 이르는 총 192명의 환자(89명의 남자, 103명의 여자)를 대상으로 하였으며 측모 두부 방사선 사진, 파노라마 방사선 사진, 수완부 방사선 사진을 사용하였고 심한 질환을 가진 경우는 제외하였다. 통계는 이분법, chi-square, logistic regression analysis, independent t-test를 사용하여 분석하였다. 견치, 제1대구치, 제2대구치의 석회화는 골 성숙도와 연관성(p < 0.05)을 보였고 또한 골 성숙도가 높은 경우, 여자어린이 일 경우가 11.43배 높았다(p < 0.001). class II 부정교합일 경우, 견치, 제1소구치, 제1대구치, 제2대구치의 치아 석회화 정도가 class III 부정교합자에 비해 높았다(p < 0.05). 치아의 석회화와 골 성숙도의 연관성은 높았으며 class II와 class III 부정교합환자의 치아의 성숙도는 치아에 따라 다른 성숙도를 보였다.

• 대한소아치과학회지
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• 제48권2호
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• pp.140-150
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• 2021

이번 연구는 2017 - 2019년에 서울대학교치과병원 소아치과에 내원하여 교정 진단을 받은 580명의 환자를 대상으로 조사를 시행하였다. 이 연구는 소아치과에 내원하는 교정환자의 골격 형태를 측모두부방사선 분석으로 파악하고 골격 형태와 관련된 임상적 특징과의 상관관계를 분석하고자 하였다. 또한, 골격 형태에 따라 행해진 치료방법에 대해 조사하여 임상의가 교정치료 계획 수립시 도움이 되고자 시행되었다. 연령분포는 7세 연령군이 교정진단을 받은 환자 중 가장 많은 분포를 차지하였다. 골격분포는 골격성 1급 부정교합이 54.2%로 가장 많았고 2급은 22.2%, 3급은 23.6%를 차지하였다. 골격성 1급의 경우 상하악 모두 후퇴인 환자가 34.4%, 골격성 2급의 경우 상악은 정상범주이나 하악이 후퇴인 경우가 39.5%, 골격성 3급의 경우 상악 후퇴 및 하악 전돌이 35.0%로 가장 높은 비율을 보였다. 수직적 골격형태는 brachyfacial type이 55%으로 가장 많았고 mesofacial type은 31.9%, dolichofacial type은 13.1%로 나타났다. 전체 환자 중 43.3%가 전치부 반대교합을 보였다.

• Journal of the Korean Association of Oral and Maxillofacial Surgeons
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• 제34권3호
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• pp.355-364
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• 2008

Skeletal anterior open bite is a difficult problem to correct in orthodontic treatment. To treat adult patients who have skeletal anterior open bite, we considered two methods. Combination treatment of orthodontics & surgery and camouflage orthodontic treatment. In adults, treatment of severe skeletal anterior open bite consists mainly of surgically repositioning the maxilla or the mandible. However, camouflage therapy is often the treatment of choice for skeletal open bite patients who have mild to moderate skeletal discrepancies when growth modification is no longer possible. But excellent results generally require careful coordination of the orthodontic and surgical phases of treatment. This is a case report of a skeletal anterior open bite patients who were treated with orthodontic treatment and orthognathic surgery. First case was diagnosed as skeletal class I malocclusion & bimaxillary protrusion with anterior open bite, and finally treatment ended for removal of open bite with orthodontic procedure and bimaxillary anterior segmental osteotomy surgery. Second case was diagnosed as skeletal class II malocclusion with open bite & mandibular retrusion, and was treated with only camouflage orthodontics because she feared to have a surgery. In a regular follow up visit after debonding we proposed to the patient advanced genioplasty, and in her agreement her facial esthetics was improved through the surgery.

• 대한한방소아과학회지
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• 제26권3호
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• pp.1-11
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• 2012

Objectives The purpose of this study is to examine the relationship between skeletal maturity and heart rate variability (HRV) based on the bone age and HRV parameters. Methods 103 children from 6 years to 17 years of age, who do not have any disease-related symptom, and visited ${\bigcirc}{\bigcirc}$ oriental medicine hospital, are measured based on their bone age and short-term spectral analysis of HRV. Results 1. Skeletal maturity was significantly correlated with HRV indices: mean HRT and SDNN. As the skeletal maturity increases, the mean HRT was decreased and the SDNN was increased. 2. When classifying according to the skeletal maturity score, the mean HRT was higher in the 'below -0.4' group compare to '-0.3~0.7' group and '0.8~1.9' group. SDNN was higher in the '0.8~1.9' group compare to '-0.3~0.7' group, 'below -0.4' group 3. When classifying according to the sex, age and secondary sexual characteristics, as the skeletal maturity was increased, the mean HRT was significantly decreased and the SDNN was significantly increased only in the boys who did not develop secondary sexual characteristics. Conclusions Skeletal maturity could be statistically significant with HRV indices, especially to the boys and the children than the girls and the teenagers.

• The Korean Journal of Physiology and Pharmacology
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• 제21권2호
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• pp.205-213
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• 2017

Quercetin, a plant-derived flavonoid found in fruits, vegetables and tea, has been known to possess bioactive properties such as anti-oxidant, anti-inflammatory and anti-cancer. In this study, anti-cancer effect of quercetin and its underlying mechanisms in triple-negative breast cancer cells was investigated. MTT assay showed that quercetin reduced breast cancer cell viability in a time and dose dependent manner. For this, quercetin not only increased cell apoptosis but also inhibited cell cycle progression. Moreover, quercetin increased FasL mRNA expression and p51, p21 and GADD45 signaling activities. We also observed that quercetin induced protein level, transcriptional activity and nuclear translocation of Foxo3a. Knockdown of Foxo3a caused significant reduction in the effect of quercetin on cell apoptosis and cell cycle arrest. In addition, treatment of JNK inhibitor (SP 600125) abolished quercetin-stimulated Foxo3a activity, suggesting JNK as a possible upstream signaling in regulation of Foxo3a activity. Knockdown of Foxo3a and inhibition of JNK activity reduced the signaling activities of p53, p21 and GADD45, triggered by quercetin. Taken together, our study suggests that quercetin induces apoptosis and cell cycle arrest via modification of Foxo3a signaling in triple-negative breast cancer cells.

• 대한치과교정학회지
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• 제29권6호
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• pp.699-706
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• 1999

고정원의 조절은 교정치료에 있어서 매우 중요한 요소로 이를 보강하기 위한 많은 노력이 있어왔다. 골융합성 임프란트의 경우 확실한 고정원으로서 가능성이 인정되고 있고, 또 임상에서 많이 시도되고 있다. 그러나 임프란트를 매식하기 위해서는 무치악이 존재해야 하거나 하악구치 후방부위에 식립해야 하는 등 장소의 제약이 있고, 값이 비싸며, 골융합을 위하여 기다리는 시간이 필요하다는 등의 단점으로 인하여 보편화되고 있지는 않다. 최근 몇몇 임상가에 의하여 수술용 titanium microscrew 나 miniscrew를 교정치료시의 고정원으로 사용하려는 시도가 있었는데, 이것은 골융합성 임프란트보다 수술이 간단하며, 가격이 저렴하고, 치조골 어느 부위이든지 식립할 수 있다는 장점이 있다. 저자는 titanium microscrew implant를 사용한 skeletal cortical anchorage를 이용하여 통상적인 교정치료 동안 협조도가 고갈된 환자를 치료하였다. 6개월간의 titanium microscrew로 부터 가해진 교정력에 의하여 상악 전치부는 4 mm후방 치체이동과 압하이동을 얻었다. 통상의 교정치료에서 고정원역할을 하는 상악 구치부도 1.5 mm후방이동 되었다. titanium microscrew는 치료기간 동안 움직임없이 잘 유지되었다. 비록 과학적으로 밝혀져야할 임상적인 문제가 있기는 하나, skeletal cortical anchorage는 확실한 고정원으로서의 역할을 할 수 있을 것으로 생각된다.

• 대한한방소아과학회지
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• 제22권2호
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• pp.19-35
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• 2008

Objectives : As obese children have been increased, the interest in the impact of obesity on growth also have been increased. This study is to examine relations between obesity and skeletal maturity by analyzing body compositions and bone age. Methods : Subjects were composed of 233 children from 6 years to 17 years of age, without any other diseases related to growth, who visited the department of pediatrics, OO oriental medicine hospital and measured their body composition (body mass index, body fat ratio, fitness score) and bone age. Results : 1. As body mass index was increased, the skeletal maturity significantly was also increased. 2. As the mean of bone maturity was increased, the BMI was increased from the underweight type to the normal type to the overweight type; the bone maturity was increased as the fat ratio was increased from the normal type to the obese type to the excessively obese type; and the bone maturity was higher in the weak, obese type than the normal type when classified according to the Fitness Score. 3. The bone maturity of the overweight group in the BMI classification and excessively obese group in the fat ratio classification significantly were increased. 4. Skeletal maturity significantly was increased in children who developed secondary sexual character. 5. The significance of obesity causing increase of the skeletal maturity was higher in boys than in girls. 6. Only in the case of children without development of secondary sexual character, obesity caused an significant increases in the skeletal maturity. Conclusions : Obesity could cause the increase of skeletal maturity, and the obesity could affect more to the boys than girls and more to the children than teenagers.