• Proceedings of the KSME Conference
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• 2001.06e
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• pp.536-541
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• 2001

A high resolution digital cinematic Particle Image Velocimetry(PIV) has been developed. The system consists of a high speed CCD camera, a continuous Ar-ion laser and a computer with camera controller. To improve the spatial resolution, we adopt a Recursive Technique for velocity interrogation. At first, we obtain a velocity vector for a larger interrogation window size based on the conventional two-frame cross-correlation PIV analysis using the FFT algorithm. Based on the knowing velocity information, more spatially resolved velocity vectors are obtained in the next iteration step with smaller interrogation windows. The correct velocity vector at the first step is found to be critical, so we apply a Multiple Correlation Validation(MCV) technique in order to decrease the spurious vectors. The MCV technique turns out to improve SNR(Signal to Noise Ratio) of the correlation table. The developed cinematic PIV method has been applied to the measurement of the unsteady flow characteristics of a Rushton turbine mixer. A total of 3,245 instantaneous velocity vectors were successfully obtained with 4 ms time resolution. The acquired spatial resolution corresponds the performance of the conventional high resolution digital PIV system using a $1K{\times}1K$ CCD camera.

• Transactions of the Korean Society of Mechanical Engineers B
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• v.25 no.11
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• pp.1535-1542
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• 2001

A high resolution digital cinematic Particle Image Velocimetry(PIV) has been developed. The system consists of a high speed CCD camera, a continuous Ar-ion laser and a computer with camera controller. To improve the spatial resolution, we adopt a Recursive Technique for velocity interrogation. At first, we obtain a velocity vector fur a larger interrogation window size based on the conventional two-frame cross-correlation PIV analysis using the FFT algorithm. Based on the knowing velocity information, more spatially resolved velocity vectors are obtained in the next iteration step with smaller interrogation windows. When the correct velocity vector at the first step is found to be critical, a Multiple Correlation Validation(MCV) technique is applied to decrease the spurious vectors. The MCV technique turns out to improve SNR(Signal to Noise Ratio) of the correlation table. The developed cinematic PIV method has been applied to the measurement of the unsteady flow characteristics of a Rushton turbine mixer. A total of 3,245 instantaneous velocity vectors were successfully obtained with 4 ms time resolution. The acquired spatial resolution corresponds to the conventional high resolution digital PIV system using a 1K ${\times}$ 1K CCD camera.

• Journal of ILASS-Korea
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• v.9 no.4
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• pp.17-23
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• 2004

Spray characteristics of a twin-hole air shrouded nonle designed for gasoline injectors was investigated by using laser diffraction particle analyzer (LDPA) and tomography reconstruction- A confined spray chamber which is optically accessible through a pair of glass windows was made to simulate the fuel injection condition in intake manifold of gasoline engine. The measurement was applied to the twin hole injector with and without an air shroud. It demonstrates that for the case with an air shroud, fine atomization is achieved and there exists a large number of fine droplets between the region of the main spray streams, which conforms with the spray visualization. The drop size distribution was investigated as a function of elapse time after fuel injection. The distribution was greatly affected by the measurement position from the injector exit. Also, the spatially resolved spray volume fraction and Sauter Mean Diameter (SMD) from line-of-sight data of the LDPA are tomographically reconstructed by Convolution Fourier transformation under the steady injection condition.

• Analytical Science and Technology
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• v.36 no.4
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• pp.180-190
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• 2023

The presence of process related impurities in any drug or the drug product was associated with its safety, stability and efficacy. The overall literature survey proved that there is no method published on the assessment of process related impurities in brigatinib. In this study, a simple, reliable and stable HPLC qualitative method was reported for quantification of process related impurities with easy and quick extraction procedure. The impurities along with standard brigatinib was resolved on Lichrospher^® C18 (250 mm × 4.6 mm; 5 ㎛ particle size) column in room temperature using methanol, acetonitrile, pH 4.5 phosphate buffer in 55:25:20 (v/v) at 1.0 mL/min as mobile phase and UV detection at 261 nm. The method produces well resolved peaks at retention time of 4.60 min, 12.28 min, 3.37 min, 7.34 min and 8.39 min respectively for brigatinib, impurity A, B, C and D. The method produces a very sensitive detection limit of 0.0065 ㎍/mL, 0.0068 ㎍/mL, 0.0053 ㎍/mL and 0.0058 ㎍/mL for impurity A, B, C and D respectively with calibration curve linear in the concentration range of 22.5-135 ㎍/mL for brigatinib and 0.0225-0.135 ㎍/mL for impurities. The method produces all the validation parameters under the acceptable level and doesn't produces any considerable changes in peak area response while minor changes in the developed method conditions. The method can effectively resolve the unknown stress degradation products along with known impurities with less % degradation. The method can efficiently resolve and quantify the impurities in formulation and hence can suitable for the routine quality analysis of brigatinib in raw material and formulation.

• Journal of the Optical Society of Korea
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• v.14 no.3
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• pp.178-184
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• 2010

We present linear particle depolarization ratios (LPDRs) retrieved from measurements with an AERONET Sun photometer at the Gwangju Institute of Science and Technology (GIST), Korea ($35.10^{/circ}N$, $126.53^{\circ}E$) between 19 October and 3 November 2009. The Sun photometer data were classified into three categories according to ${\AA}$ngstr$\ddot{o}$ exponent and size distribution: 1) pure Asian dust (19 October 2009), 2) Asian dust mixed with urban pollution observed in the period from 20-26 October 2009, and 3) clean conditions (3 November). We show that the LPDRs can be used to distinguish among Asian dust, mixed aerosol, and non-Asian dust in the atmosphere. The mean LPDR of the pure Asian dust case is 23 %. Mean LPDRs are 13 % for the mixed case. The lowest mean LPDR is 6 % in the clean case. We compare our results to vertically resolved LPDRs (at 532 nm) measured by a Raman LIDAR system at the same site. In most cases, we find good agreement between LPDRs derived with Sun photometer and measured by LIDAR.

• Toxicological Research
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• v.35 no.2
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• pp.161-165
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• 2019

Cysteamine has been used in cosmetics as an antioxidant, a hair straightening agent, and a hair waving agent. However, recent studies indicate that cysteamine can act as an allergen to hairdressers. The objective of this study was to develop and validate a simple and effective reversed-phase high-performance liquid chromatography (RP-HPLC) method for the measurement of cysteamine and its dimer, cystamine. Sodium 1-heptanesulfonate (NaHpSO) was used as an ion-pairing agent to improve chromatographic performance. Separation was performed on a Gemini C18 column ($250mm{\times}4.6mm$, $5{\mu}m$ particle size) using a mobile phase composed of 85:15 (v/v) 4 mM NaHpSO in 0.1% phosphoric acid:acetonitrile. UV absorbance was monitored at 215 nm. The RP-HPLC method developed in this study was validated for specificity, linearity, limit of detection, limit of quantitation, precision, accuracy, and recovery. Cysteamine and cystamine were chromatographically resolved from other reducing agents such as thioglycolic acid and cysteine. Extraction using water and chloroform resulted in the recovery for cysteamine and cystamine ranging from 100.2-102.7% and 90.6-98.7%, respectively. This validated RP-HPLC method would be useful for quality control and monitoring of cysteamine and cystamine in cosmetics.

• Korean Journal of Materials Research
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• v.22 no.6
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• pp.309-315
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• 2012

Metal foam has many excellent properties, such as light weight, incombustibility, good thermal insulation, sound absorption, energy absorption, and environmental friendliness. It has two types of macrostructure, a closed-cell foam with sealed pores and an open-cell foam with open pores. The open-cell foam has a complex macrostructure consisting of an interconnected network. It can be exploited as a degradable biomaterial and a heat exchanger material. In this paper, open cell Mg alloy foams have been produced by infiltrating molten Mg alloy into porous pre-forms, where granules facilitate porous material. The granules have suitable strength and excellent thermal stability. They are also inexpensive and easily move out from open-cell foamed Mg-Al alloy materials. When the melt casting process used an inert gas, the molten magnesium igniting is resolved easily. The effects of the preheating temperature of the filler particle mould, negative pressure, and granule size on the fluidity of the open cell Mg alloy foam were investigated. With the increased infiltration pressure, preheat temperature and granule sizes during casting process, the molten AZ31 alloy was high fluidity. The optimum casting temperature, preheating temperature of the filler particle mould, and negative pressure were $750^{\circ}C$, $400-500^{\circ}C$, and 5000-6000 Pa, respectively, At these conditions the AZ31 alloy had good fluidity and castability with the longest infiltration length, fewer defects, and a uniform pore structure.

• Asian Journal of Atmospheric Environment
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• v.9 no.3
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• pp.228-235
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• 2015

In order to clarify the thermal and hygroscopic properties of indoor particulate matter (PM) in a semiclosed subway space, which is critically important for understanding of the distinctive particle formation processes as well as the assessment of their health effects, the size-resolved PMs (i.e., $PM_{2.5}$ and $PM_{10-2.5}$) were intensively collected on the platform of Miasageori station on the Seoul Subway Line-4. The elemental concentrations in soluble and insoluble fractions were determined by PIXE from the bulkily pretreated $PM_{2.5}$. The thermal and hygroscopic characteristics of individual particles were investigated via a combination of the unique pretreatment techniques (i.e., the high-temperature rapid thermal process and the water dialysis) and SEM-EDX analysis. Iron and calcium were unequaled in insoluble and soluble $PM_{2.5}$ fractions, respectively, with overwhelming concentration. The SEM-EDX's elemental net-counts for the pre- and post-pyrolyzed PMs newly suggest that magnesium and several elements (i.e., silica, aluminum, and calcium) may be readily involved in the newly generated subway fine PM by a high-temperature thermal processing when trains are breaking and starting. Through the water dialysis technique, it turned out that calcium has meaningful amount of water soluble fraction. Furthermore, the concentrations of the counter-ions associated with the calcium in subway $PM_{10-2.5}$ were theoretically estimated.

• Asian Journal of Atmospheric Environment
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• v.9 no.2
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• pp.165-172
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• 2015

Under a very tough situation that there has been increasing concern to the air quality in underground subway spaces, this study set sights on the thorough estimation of the chemical properties and source apportionment of particulate matter (PM) collected on an underground subway platform by a cooperative approach of semi-bulk and single particle analyses. The size-resolved PMs were intensively collected on the platform of Miasageori station on the Seoul Subway Line-4, and then, they were semibulkily analyzed by a PIXE and the TOR$^{(R)}$ method, and individually analyzed by a SEM-EDX. Overwhelmingly enriched iron was a notable feature of elemental concentration of $PM_{2.5}$. Source classification of iron in $PM_{10-2.5}$ and $PM_{2.5}$ performed along with their elemental concentrations, indicates that the railway originated iron accounts for 95.71% and 66.39% of total iron in $PM_{10-2.5}$ and $PM_{2.5}$, respectively. Via a stoichiometric categorization, $Fe_2O_3$, $CaAl_2Si_2O_8$, $Al_2O_3$, and $CaCO_3$ show more than 85% abundance ratio in individual coarse particles. The result of theoretical estimation of the subway derived organic carbon ($OC_{Subway}$) suggests that $OC_{Subway}$ in $PM_1$ and $PM_{2.5-1}$ account for 75.86% and 51.88% of total organic carbon, respectively.

• Proceedings of the Korean Vacuum Society Conference
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• 1998.02a
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• pp.17-17
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• 1998

Synchrotron radiation is produced when charged particles moving with relativistic velocities a are accelerated - for example, deflected by the bending magnets which guide the electron or p positrons in circular accelerators or storage rings. By using special focusing magnetic lattices i in the particle accelerators it is possible to make the dimensions of the particle beam very small with a hi맹 charge density which results in a light source with high b디lIiance. Synchrotron light h has important properties which make it ideal for a wide range of investigations in surface s science. The fact that the spectrum of electromagnetic radiation emitted in a bending magnet e extends in a continuum from the 얹r infra red region to hard x-rays means that it is id않I for a v variety of spectroscopic studies. Since there are no convenient lasers, or other really bright l light sources, in the vacuum ultraviolet and soft x-ray re.밍ons the development of synchrotron r radiation has enabled enormous advances to be made in this di펌C비t spectr따 re밍on. P Polarization-dependent measurements, for ex없nple ellipsometry or circular dichroism studies a are possible because the radiation has a well-defined polarization - linear in the plane of orbit w with additional right-circular, or left-circular, components for emission an생es above, or below, t the horizontal, respectively. Since the synchrotron light is emitted from a bunch of charge c circulating in a ring the light is emitted with a well-defined time structure with a short flash of l light every time a bunch passes an exit port. The time structure depends on the size of the ring a and the number and sequence of filling of the bunches. A pulsed light source enables time¬r resolved studies to be performed which provide direct information on the lifetimes and decay m modes of excited states and in addition opens up the possibility of using time of flight t techniques for spectroscopic studies. The fact that synchrotron radiation is produced in a clean u ultrahi야 vacuum environment is of gr않t importance for surce science studies. The current t비rd generation synchrotron light sources provide exceptionally high baliance and stability a and open up possibilities for experiments which would have been inconceivable only a short time ago.