• Archives of Pharmacal Research
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• v.9 no.2
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• pp.75-79
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• 1986

The effect of phenothiazine derivatives on the thermotropic transition of liposomal lipid bilayer made of dipalmitoyl phosphatidylchline and dipalmitoyl phosphatidic acid was investigated with differential scanning calorimetry. The thermograms of the liposomal bilayer incorporated with levomepromazine, chlopromazine, prochloperazine, perphenazine and fluphenazine were obtained and the size of cooperative unit of the transition were calculated from the ratio of the van't Hoff enthalpy change to the calculated enthalpy change of the transition. The results showed that incorporation of phenothiazine derivatives into the liposomal bilayer reduced the transition temperature at which the transition from solid state to liquid-crystalline state occurs, and broadened the thermogram peaks. Phenothiazine derivatives also significantly reduced the size of cooperative unit of the transition. The effect of the drugs was proportional to the concentration of the drug in the bilayer. This means that phenothiazine derivatives might have significant fluidizing effects on the biomembrane. The sizes of cooperative unit were successfully corrlated with phar-macological activities of the drugs and the surface pressure increases of lipid monolayer by these drugs. These correlations might be ascribed to a possible hydrophobic nature of interaction between the biomembrane and the drugs involved in their pharmacology.

• Archives of Pharmacal Research
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• v.11 no.3
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• pp.181-184
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• 1988

The effect of clover saponin on the phase transition of liposomal lipid bilayers of dimyristoyl phosphatidylcholine was investigated with differential scanning calorimetry. The thermograms of the liposomal bilayers incorporated with the clover saponin were obtained, and the enthalpy changes and the sizes of cooperative unit of the transition were calculated. The results showed that incorporation of the clover saponin into the liposomal bilayers effectively reduced the transition temperature at which the transition from solid state to liquid-crystalline state occurs, and broadened the thermogram peaks. It also reduced the size of cooperative unit of the transition. These results indicate that the clover saponin might have significant effect on the fluidity of biological membranes.

• Land and Housing Review
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• v.5 no.2
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• pp.57-68
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• 2014

As social needs are increasing to minimize the occurrence of external effect due to urban development and to diffuse the benefits of development to surrounding areas, diverse cooperative planning methods are increasingly being discussed. In the long term, laws and systems need to be refined to support cooperative planning, but prior to such development, elements, procedures, and methodologies wherein cooperative planning in U.S.A cases could be implemented were examined to derive the alternative to and implications of cooperative planning that can apply not only to single administrative districts but also to complex boundary new towns being developed by various local governments. This paper surveyed and analyzed the cases of Wisconsin State of the U.S.A, thereby deriving the following implications. First, joint planning areas should be established within the boundary area of various local governments to establish cooperative planning areas in special areas such as complex boundary new towns, and to this end, urban planning means should be prepared. Together with such efforts, to boost the flexibility of cooperative planning, life sphere unit-based planning unit should be established, and a well-organized operation system to activate communities should be prepared. Also, revenues, generated through regional growth, should be distributed to individual local governments through joint tax according to the agreed-upon ratios, and as such, measures to share services and operate joint tax in small-size regions should be secured. Together with such efforts, to establish cooperative governance, measures to manage conflicts through the participation by stakeholders and arbitrators should be prepared from the planning stage, and measures for implementing cooperative planning at the level of basic urban planning should be prepared.

• Journal of the Architectural Institute of Korea Planning & Design
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• v.34 no.11
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• pp.113-123
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• 2018

First of all, the multi-story Housing applying resident's participation in europe was classified by the menu selection method, the two-step supply method and the cooperative method. And then I analyzed flexible unit plan of cases for deriving the planning methode and the characteristics of flexibility. First, I analyzed the area and form of the unit plan, structure and Installation, fixed and variable elements to derive the planning method. The area of units are distributed from a minimum of $35m^2$ to a maximum of $150m^2$, and many of the unit planes have a narrow front and a deep depth. The structure is a long-span wall-structure or a skeleton structure, and is designed without any columns and bearing walls in the interior space for flexibility in spatial composition. The vertical shafts are located in the center of the unit in a box-form or in the corner at the unit dividing wall for free placement of interior wall. Fixed elements are framework and facility systems. Most of the future residents in the two-steps supply method and the cooperative method were able to freely design the internal space within the zoning concept proposed by the architect and change the location of the facade element within module system proposed by the architect. Second, the characteristics of the flexibility applied to the unit plan were divided in integrated flexibility, functional flexibility, construction flexibility, and supply flexibility. The integrated flexibility enables residents to give the variable space combination based on the complex structure of the inner space for providing various living experiences. Regarding functional flexibility, the three-dimensional spatial structure with neutral space has multi-functionality according to the needs of residents and easily accepts mixing of hybrid programs such as work and residence. Constructive flexibility allows residents to create identity by freely planning interior space and changing the size or location of facade components in a determined system of architects. Finally, various types of size and space composition are proposed and realized in the whole building applying menu selection method, so that flexibility in the offer can accommodate and integrate various types of living.

• Journal of the Korean Society for Library and Information Science
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• v.3
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• pp.25-46
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• 1973

The recent situation on developments in an expanding field of reference and information service is reviewed through the cooperative arrangements and comprehensive planning among libraries in America. The growth of reference cooperation is examined first along with the social forces that influenced the library interdependence for service. Of the various interlibrary programs identified in relation to the cooperative reference work, interlibrary loan is viewed as the key to the use of library resources based on equal access and making use of the tools for information and research, therefore a reference principle. Several kinds of library systems specifically intended to improve the reference situation are identified and described in detail without any attempt to evaluate their performance in terms of unit size, cost, or quality of the service.

• Journal of the Korean housing association
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• v.13 no.6
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• pp.101-110
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• 2002

The purpose of this study was to examine needs of residents on the storage according to unit size in apartment. In order to achieve our goal, the questionnaire survey was used. We sampled the questionnaire surveys of 250 households in Seoul whose apartment sizes had been more than 20 pyung. The data collected by the questionnaire survey was analyzed by examining the frequency, percentage on the SPSS/PC+. The results of the study were obtained as follows: 1) In research on the actual storage condition, Residents tended to feel constraint on the storage of the season goods and the storage satisfaction on the service area was found lowest. Therefore, there needed to design the balcony more efficiently for the storage and the interior storage for the season goods. 2) In research on consciousness and attitude about the storage, residents tended to keep the goods of no use and prefered to arrange neatly rather than use conveniently. Therefore, there needed more efficient space in the balcony for the storage of the goods of no use and the closed furniture rather than the open furniture was suited for arrangement. 3) In research on the storage needs, needs for the built-in furniture in all apartment sizes showed highly and residents wanted a space for the exclusive use of the storage. In a solution, it was proposed to equip with the interior storage and the exterior cooperative storage. In the conclusion, needs of residents on the storage according to apartment size were different little. The small size apartment had the serious storage problems and wanted the efficient space plan for storage.

• Journal of Korea Multimedia Society
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• v.8 no.7
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• pp.943-952
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• 2005

This paper proposes a user's mobility based cooperative proxy caching policy for effective resource management of continuous media objects in mobile environments. This policy is different from the existing proxy caching policies in terms of how to exploit users' mobility. In other words, existing caching policies work based on the information about objects by referring to users' requests within a specified domain whereas the proposed caching policy runs by utilizing a number of users' requests across several domains. So, the proposed policy is applicable to random requests in mobile environments. Moreover, we also propose a replacement policy based on weights and playback time. To check the efficiency of the proposed caching policy, the proposed replacement policy is run with different size of caching unit: object or segment. The result of performance evaluation tells that segment sizes, ratio of users' mobility and weights are major factors for the efficient operation of the cooperative caching.

• The Korean Journal of Pharmacology
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• v.24 no.1
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• pp.43-52
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• 1988

To elucidate the mechanism of action of local anesthetics, the effects of local anethetics on the microenvironment of the lipid bilayers of synaptosomal plasma membrane vesicles (SPMV) isolated from bovine brain and dimyristoylphosphatidylcholine (DMPC) multilamellar liposomes were investigated employing the intermolecular excimer fluorescence technique and differential scanning calorimetry (DSC). The relative intensities of excimer and monomer fluorescence of pyrene are a simple linear function of the viscosity of a homologous series of solvents. The microviscosity(${\eta}$)of the hydrocarbon region of SPMV was measured by this method and the value was $57.3{\pm}5.3\;cP$ at $37^{\circ}C$. In the presence of lidocaine-HCl and procaine-HCl, the values decreased to $46.5{\pm}5.1\;cP$ and $54.7{\pm}4.8\;cP$, respectvely. The differential scanning thermograms of DMPC multilamellar liposomes showed that local anesthetics significantly lowered the phase transition temperature, broadened the thermogram peaks, and reduced the size of the cooperative unit. These results indicate that local anesthetics have significant fluidizing effects on biomembranes and perturbation of membrane lipids may produce some, but not all, of their pharmacological actions.

• The KIPS Transactions:PartB
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• v.11B no.6
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• pp.691-700
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• 2004

This paper proposes a user's mobility based cooperative proxy caching policy for effective resource management of continuous media objects in mobile environments. This policy is different from the existing proxy caching policies in terms of how to exploit users' mobility. In other words, existing caching policies work based on the information about objects by referring to user's requests within a specified domain whereas the proposed caching policy runs by utilizing a number of user's requests across several domains. So, the proposed policy is applicable to random requests in mobile environments Moreover, we also propose a replacement policy based on weights and playback time. To check the efficiency of the proposed caching policy, the proposed replacement policy is run with different size of caching unit object or segment. The result of performance analyze tells what a ratio of user's mobility is are major factors for the efficient operation of the cooperative caching.

• Journal of the Korean Geosynthetics Society
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• v.12 no.3
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• pp.31-41
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• 2013

In this study, the properties of mudstone weathered soils related to landslides were analyzed at the area of landslide induced by heavy rainfall in Pohang. The soil tests were carried out to the soils obtained from landslide and non landslide sites, and the soil properties were investigated. The correlation between soil properties and landslides were analyzed using statistical technique, and then the soil factors were extracted from the correlation analysis. The correlation equation which can calculate the coefficient of permeability influenced on landslides was proposed using the soil factors. As the result of analysis, the porosity and unit weight of soils from the landslide area is smaller than those of soils from the non landslide area. The soils with poor grain size distribution and loose unit weight are prone to landslides because the soils have a large void ratio and a low unit weight. The permeability of soils from the landslide area is larger than that of soils from the non landslide area. According to the result of correlation analysis, the effective grain size, the saturated unit weight and silt and clay contents are evaluated as the influence factors. These factors were considered to estimate the coefficient of permeability of mudstone weathered soils.