• Journal of Gastric Cancer
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• v.21 no.2
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• pp.191-202
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• 2021

Purpose: A near-infrared (NIR) fluorescence imaging is a promising tool for cancer-specific image guided surgery. Human epidermal receptor 2 (HER2) is one of the candidate markers for gastric cancer. In this study, we aimed to synthesize HER2-specific NIR fluorescence probes and evaluate their applicability in cancer-specific image-guided surgeries using an animal model. Materials and Methods: An NIR dye emitting light at 800 nm (IRDye800CW; Li-COR) was conjugated to trastuzumab and an HER2-specific affibody using a click mechanism. HER2 affinity was assessed using surface plasmon resonance. Gastric cancer cell lines (NCI-N87 and SNU-601) were subcutaneously implanted into female BALB/c nu (6-8 weeks old) mice. After intravenous injection of the probes, biodistribution and fluorescence signal intensity were measured using Lumina II (Perkin Elmer) and a laparoscopic NIR camera (InTheSmart). Results: Trastuzumab-IRDye800CW exhibited high affinity for HER2 (K_D=2.093(3) pM). Fluorescence signals in the liver and spleen were the highest at 24 hours post injection, while the signal in HER2-positive tumor cells increased until 72 hours, as assessed using the Lumina II system. The signal corresponding to the tumor was visually identified and clearly differentiated from the liver after 72 hours using a laparoscopic NIR camera. Affibody-IRDye800CW also exhibited high affinity for HER2 (K_D=4.71 nM); however, the signal was not identified in the tumor, probably owing to rapid renal clearance. Conclusions: Trastuzumab-IRDye800CW may be used as a potential NIR probe that can be injected 2-3 days before surgery to obtain high HER2-specific signal and contrast. Affibody-based NIR probes may require modifications to enhance mobilization to the tumor site.

• Journal of the Korean GEO-environmental Society
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• v.12 no.12
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• pp.47-54
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• 2011

Consolidation behavior of soft clay is generally to be affected by its compressibility and deformation characteristics. Especially, soil permeability depends on soil characteristics including its type of anisotropy. Coefficient of permeability of soft clay is mostly estimated by using laboratory(Oedometer test) and in-stiu piezocone test. The permeability characteristics of soft clay is estimated by excess pore pressure dissipation test results. In this study, the tests were performed to find out the validity of the existing theoretical formula in clay by pore pressure dissipation test and laboratory test results. After grasping of variation the coefficient of permeability ratio(${k_{h}/k_{v}}$) in different clay soils, it was found out adequate solution of in-stiu permeability ratio(${k_{h}/k_{v}}$). Piezocone tests and laboratory tests were performed at the site of pilot project of ground improvement at Yangsan-Mulgeum, Gyeongsangnam-do. Comparisons of the estimated values of ${k_{h}/k_{v}}$ using piezocone tests results and those from laboratory consolidation tests were carried out. Test results show that values of ${k_{h}/k_{v}}$ by piezocone test result(5.85) is similar of it's laboratory test(5.28).

• Journal of the Korean Institute of Traditional Landscape Architecture
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• v.29 no.3
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• pp.97-105
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• 2011

In the modern urban landscape design, historical and cultural factors are drawing more and more attention in addition to the factor of beauty. To evaluate an urban landscape design, it's quite important to explore the history and culture background of the city. Color of a city reflects the city characteristics and shows the city image. Color planning has become an important part of city landscape design nowadays. A harmonious landscape cannot be without a unified color planning. The color planning should take not only the integrity but also the regionality into consideration. Color planning has a profound impact on public life. This paper studies on streetscape color of two famous places which are Seoul Insa-dong and Shanghai Xintiandi. According to the empirical and comparative study, this paper will give on-site assessment and comprehensive evaluation. Furthermore, this paper will indicate the differences and similarities of the traditional Streetscape of South Korea and China, using the color theories of Korea Image Resource Institute. This survey results will be helpful to the urban landscape color planning.

• Journal of fish pathology
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• v.34 no.1
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• pp.81-98
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• 2021

As Korea declared that the entire country is free from ISA (Infectious salmon anaemia) based on the OIE aquatic code in 2019, it is necessary to improve the import quarantine system that meets the level of ISA management in Korea. Currently, Korea imports Atlantic salmon and rainbow trout from countries which have history of ISA outbreak such as Norway and the United States, so there is a constant possibility that trade with these countries will bring ISAV (Infectious salmon anaemia virus) into Korea. Therefore, some amendments to the Aquatic Life Diseases Control Act (ALDCA) are needed to prevent the entry of ISAV into the Korea through international trade. The amendment to the ALDCA should contain a list of countries, zones or compartments that the Korean competent authority has allowed or banned imports of ISA-susceptible fish. In addition, the subordinate statutes or administrative rules of the ALDCA need to be revised so that on-site inspections/audit can be conducted for the evaluation of the ISA management system in exporting countries. After the revision of the subordinate statutes or administrative rules, it is necessary to strengthen the present import conditions in line with those that meet the level of ISA management in Korea. As for the strengthened import conditions, the competent authorities of exporting countries must export only salmonid fish produced in zones or compartments declared freedom of ISA to Korea, and must prove through lab-testing that ISAV should not be detected in the fish exporting to Korea. In addition, official veterinarians/fish health professionals of the exporting country should check the health status of the fish within 72 hours prior to export. Also, competent authorities of the exporting countries must attest that fish storage containers and water, ice and other equipment used for transportation should be cleaned and disinfected to avoid contamination with pathogens, including ISA. Therefore, the proposed measures presented here will further improve the current import condition for salmonid fish and assist decision-making on strategies to reduce the risk of ISA introduction into Korea. Also, it is expected to contribute to maintain the status of ISA-free country.

• Journal of Korea Water Resources Association
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• v.54 no.2
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• pp.81-91
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• 2021

Synthetic Apreture Radar (SAR) is attracting attentions with its possibility of producing high resolution data that can be used for soil moisture estimation. High resolution soil moisture data enables more specific observation of soil moisture than existing soil moisture products from other satellites. It can also be used for studies of wildfire, landslide, and flood. The SAR based soil moisture estimation should be conducted considering vegetation, which affects backscattering signals from the SAR sensor. In this study, a SAR based soil moisture estimation at regions covered with various vegetation types on the middle area of Korea (Cropland, Grassland, Forest) is conducted. The representative backscattering model, Water Cloud Model (WCM) is used for soil moisture estimation over vegetated areas. Radar Vegetation Index (RVI) and in-situ soil moisture data are used as input factors for the model. Total 6 study areas are selected for 3 vegetation types according to land cover classification with 2 sites per each vegetation type. Soil moisture evaluation result shows that the accuracy of each site stands out in the order of grassland, forest, and cropland. Forested area shows correlation coefficient value higher than 0.5 even with the most dense vegetation, while cropland shows correlation coefficient value lower than 0.3. The proper vegetation and soil moisture conditions for SAR based soil moisture estimation are suggested through the results of the study. Future study, which utilizes additional ancillary vegetation data (vegetation height, vegetation type) is thought to be necessary.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.21 no.12
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• pp.807-818
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• 2020

In this study, hydrophones using acoustic sensors were used to estimate the amount of bedload discharge in a forested watershed. The reaction characteristics were analyzed through hydrophone flume tests and field tests, and the quantitative bedload discharge was calculated and compared with that measured by a pit sampler. The hydrophone reaction changed the pulse according to the flow rate change, but did not react to standard sand. The pulse was different depending on the particle size and weight, and accordingly, there was a specific channel showing a suitable response. For a hydrophone installed in the field, by using an automatic impact device, the reaction characteristics of each channel were analyzed to confirm normal operation of the sensor and the suitability of the output value of each channel. In addition, a suitable channel was selected for the estimation of bedload discharge. The bedload discharge formula was developed using a hydrophone pulse and the average flow rate, and was compared with the measured data in the pit sampler in the study site. As a result of the study, if a hydrophone is used for monitoring the bedload in forested watersheds, it is considered effective in quantitatively estimating the weight of bedload discharge.

• Journal of Cadastre & Land InformatiX
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• v.51 no.2
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• pp.73-82
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• 2021

According to the government's announcement of the safety management enhancement policy for small and medium-sized private construction sites, the subject of mandatory CCTV installation has been expanded from large construction sites to small and medium-sized construction sites. However, since the existing CCTV at construction sites has been used for simple control for safety management, so research is needed for monitoring of construction sites. Therefore, in this study, three vanishing points were calculated based on a single image taken with a monocular camera, and then a camera matrix containing interior orientation parameters information was determined. And the accuracy was verified by calculating the height of the target object from the height of the reference object. Through height determination experiments using vanishing points based on a monocular camera, it was possible to determine the height of target objects only with a single image without separately surveying of ground control points. As a result of the accuracy evaluation, the root mean square error was ±0.161m. Therefore, it is determined that the progress of construction work at the construction sites can be monitored through the single image taken using the single camera.

• Journal of Korea Water Resources Association
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• v.55 no.7
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• pp.515-529
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• 2022

Identifying the available water resources amount is an essential process in establishing a sustainable water resources management plan. Dam facility is a major infrastructure storing and supplying water during the dry season, and the water supply yield of the dam varies depending on dam inflow conditions or operation rule. In South Korea, water supply yield of dam is calculated by reservoir simulation based on observed historical dam inflow data. However, the water supply capacity of a dam can be underestimated or overestimated depending on the existence of historical drought events during the simulation period. In this study, probabilistic inflow data was generated and used to estimate the appropriate range of the water supply yield of hydropower dams. That is, a method for estimating the probabilistic dam inflow that fluctuates according to climatic and socio-economic conditions and the range of water supply yield for hydropower dams was presented, and applied to hydropower dams located in the Han river in South Korea. It is expected that the understanding water supply yield of the hydropower dams will become more important to respond to climate change in the future, and this study will contribute to national water resources management planning by providing potential range of water supply yield of hydropower dams.

• Journal of Korea Water Resources Association
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• v.55 no.7
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• pp.531-543
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• 2022

Integrated water resources management (IWRM) has focused on efficient response to various water related disasters by climate change. In particular, more flexible usage of conventional water resources infrastructures is expected to provide an eco-friendly water management. Multi-purpose dams and water supply dams are well known as water management facilities for securing and supplying water in drought season. Recently, based on the report '2021 multi-purpose use of hydropower dams in Han river', contribution of hydropower dams on water resources management is becoming more significant beyond the traditional role of hydropower generation. In drought conditions, the dams control water supply depending on the pre-defined drought stages. In the case of multi-purpose dams, an operation standard during drought has been already prepared and applied; however, for the hydropower dams, specific standards are not fully prepared yet in South Korea. In this study, a method for calculation of standard water storage and discharge reduction of hydropower dams according to drought stage is newly proposed reflecting the characteristics of hydropower dams. The proposed method was applied to the hydropower dams in Han river, where six hydropower dams are located. A case study of the historical droughts occurred in 2014-2017 demonstrated that the proposed hydropower dam operation rule could improve the water supply stability under severe drought conditions compared to the conventional operations. In the future, the role of hydropower dams for water resources management is expected to become more important, and this study can be widely used for water supply planning such as drought response using hydropower dams.

• Korean Journal of Construction Engineering and Management
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• v.23 no.4
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• pp.15-25
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• 2022

As the incidence and mortality of serious disasters in the construction industry are the highest, various efforts are being made in Korea to reduce them. Among them, risk assessment is used as data for disaster reduction measures and evaluation of risk factors at the construction stage. However, the existing risk assessment involves the subjectivity of the performer and is vulnerable to the domestic construction site. This study established a DB classification system for risk assessment with the aim of early identification and pre-removal of risks by quantitatively deriving risk factors using BIM in the risk assessment field and presents a methodology for risk assessment using BIM. Through this, prior removal of risks increases the safety of construction workers and reduces additional costs in the field of safety management. In addition, since it can be applied to new construction methods, it improves the understanding of project participants and becomes a tool for communication. This study proposes a framework for deriving quantitative risks based on BIM, and will be used as a base technology in the field of risk assessment using BIM in the future.