• Asian Pacific Journal of Cancer Prevention
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• v.15 no.1
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• pp.145-150
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• 2014

MicroRNAs (miRNAs) negatively regulate gene expression and act as tumor suppressors or oncogenes in oncogenesis. The association between a single nucleotide polymorphism (SNP) in miR-146a rs2910164 and susceptibility to digestive system cancers was inconsistent in previous studies. In this study, we conducted a literature search of PubMed to identify all relevant studies published before August 31, 2013. A total of 21 independent case-control studies were included in this updated meta-analysis with 9,558 cases and 10,614 controls. We found that the miR-146a rs2910164 polymorphism was significantly associated with decreased risk of digestive system cancers in an allele model (OR=0.90, 95%CI 0.87-0.94), homozygote model (OR=0.84, 95%CI 0.77-0.91), dominant model (OR=0.90, 95%CI 0.84-0.96), and recessive model (OR=0.85, 95%CI 0.79-0.91), while in a heterozygous model (OR = 0.99, 95% CI 0.89-1.11) the association showed marginal significance. Subgroup analysis by cancer site revealed decreased risk in colorectal cancer above allele model (OR=0.90, 95%CI 0.83-0.97) and homozygote model (OR=0.85, 95%CI 0.72-1.00). Similarly, decreased cancer risk was observed when compared with allele model (OR=0.87, 95%CI 0.81-0.93) and recessive model (OR=0.81, 95%CI 0.72-0.90) in gastric cancer. When stratified by ethnicity, genotyping methods and quality score, decreased cancer risks were also observed. This current meta-analysis indicated that miR-146a rs2910164 polymorphism may decrease the susceptibility to digestive system cancers, especially in Asian populations.

• The Journal of the Korea Contents Association
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• v.4 no.4
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• pp.45-51
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• 2004

The number of development in educational software is currently decreasing despite rapid improvement in computer technology. This is partly due to the fact that the current software relies on the conventional hypermedia method or on the hierarchical method, both of which have inherent limitations. To compensate their limitations while keeping their merits, a hybrid method called the structured hypermedia link method has recently been proposed in the literature. It has been found that the structured hypermedia link method is far superior than the conventional methods in terms of educational effectiveness because it can help a learner to search various data by navigating between the study topics on his own while maintaining his level of cognitively overloaded stress to the minimum. The clinical microbiology laboratories were chosen as the candidate site for this study because its educational system has not been standardized and has been relying heavily on the personal experience. In this study, the hypermedia link method was applied to the development of an education system for the image analysis in clinical microbiology laboratories. For this purpose, a web-based computer aided instruction(CAI) program was designed to systematically organize the Gram stain method based on the standardized image data. In the future, CAI program must be intended to educate for beginner and developed to accept for variable knowledge. And it will be useful program for technicians in case of applying various examinations based Gram stain method of this study.

• Journal of Korea Multimedia Society
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• v.8 no.11
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• pp.1439-1448
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• 2005

In this paper, after similarity of color information in above toro and geometry position analysis of important characteristic information in face and abstraction object that is inputted detects face area using comparison, describe about method to do user certification using ratio information and hair spring degree. Face abstraction algorithm that use color information has comparative advantages than face abstraction algorithm that use form information because have advantage that is not influenced facial degree or site etc. that tip. Because is based on color information, change of lighting or to keep correct performance because is sensitive about color such as background similar to complexion is difficult. Therefore, can be used more efficiently than method to use color information as that detect characteristic information of eye and lips etc. that is facial importance characteristic element except color information and similarity for each object achieves comparison. This paper proposes system that eye and mouth's similarity that calculate characteristic that is ratio red of each individual after divide face by each individual and is segmentalized giving weight in specification calculation recognize user confirming similarity through search. Could experiment method to propose and know that the awareness rate through analysis with the wave rises.

• The Korean Journal of Pesticide Science
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• v.14 no.3
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• pp.183-190
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• 2010

To search the new potent herbicidal agents by receptor-based approach, the interactions between receptor and substrate molecules from molecular docking to acetyl-CoA carboxylase(PDB code: 3K8X) of 2-(4-(6-chloro-2-benzoxazolyl)oxy)phenoxy-N-phenylpropionamide analogues (1-38) as substrate molecules were performed and discussed quantitatively. The most of the substrate molecules were formated 2 H-bonds between carbonyl oxygen atom of the substrate molecules and the amino acid residues (Ala1627 and Ile1735) in binding site of acetyl-CoA carboxylase (ACCase). But, the substrate molecules such as $R_l$=Acetyl substituents (6 & P9) were formated 3 H-bonds between H-bond acceptors in the substrate molecules and the H-bond donors in three amino acid residues including the rest residue (Gly 1998). Therefore, the inhibitory activity factors of the substrate molecules against ACCase are due to the H-bonding characters that will be able to apply to the optimization of herbicidal agents.

• Journal of Environmental Policy
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• v.14 no.4
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• pp.103-123
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• 2015

To provide effective management policy of geo-heritages, concept of Korean geo-heritage has been organized based on geo-diversity, geo-conservation, geo-tourism, and earth-heritage. In addition, current status of geo-heritage in Korea has been grasped, and categorized. In case GPS (Global Positioning System) coordinates exist, spatial information was constructed as GIS (Geographic Information System). Geo-heritages were classified into a total of six categories of natural monument, scenic site, coastal sand-dune, natural cave, world nature heritage, and other types of geo-heritage. By mapping 991 geo-heritages scattered nationwide using geographical information, all statuses can now be readily identified and enable the analysis of the distribution tendencies and correlation with topography. This study was aimed at searching the political connection based on quantitatively organized and analyzed geo-heritages, which have not been mapped thus far. In addition, this study organized data that have existed only in literature, and presented example verification. Moreover, these can be used as guidelines for the future search, discovery, registration and management of geo-heritage. If additional geo-heritages are discovered in field studies or with satellite images, then more correlations may be identified and help facilitate the research on geo-heritages management plans.

• Journal of Acupuncture Research
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• v.31 no.4
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• pp.81-97
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• 2014

Objectives : The purpose of this study is analyzing the current research methodology of pharmacopucture for the treatment of animal cancer models. Methods : Four electronic databases were searched for animal studies published from January 2000 to September 2014 onward using these search terms "cancer, anticancer, pharmacopuncture, beevenom". Selected articles were described about animal cancer models. The methods used to induce cancer and the outcome measures used to assess the effects of pharmacopuncture on animal cancer models were analyzed. Results : 37 articles were included. For producing animal cancer models BALB/C mice(n=22) and C57BL/6 mice(n=17) were selected. And intravenous injection of B16-F10 melanoma cells into tail vein(n=14) or intraperitoneal injection of sarcoma-180 cells(n=14) were frequently used to induce cancer. Various pharmacopunctures were injected into acupoints $CV_{12}(n=19)$, $ST_{36}(n=8)$, $BL_{18}(n=8)$ or peritoneal cavity(n=6), tumor site(n=2), tail vein(n=2). Outcome measures were categorized into anti-cancer, anti-metastasis, general condition, cytotoxicity, immune response, toxicity. Median Survival Time(MST) and increase of life span(ILS)(n=26) was frequently used for evaluating anti-cancer effects. And pulmonary colonization assay(n=13) was frequently used for evaluating anti-metastasis effects Conclusions : Based on these data, further research would be needed to ascertain the effectiveness of pharmacopuncture for treating cancer and broaden the range of clinical applications.

• The Journal of Bigdata
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• v.4 no.2
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• pp.23-34
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• 2019

Recently, the crime that utilizes the digital platform is continuously increasing. About 140,000 cases occurred in 2015 and about 150,000 cases occurred in 2016. Therefore, it is considered that there is a limit handling those online crimes by old-fashioned investigation techniques. Investigators' manual online search and cognitive investigation methods those are broadly used today are not enough to proactively cope with rapid changing civil crimes. In addition, the characteristics of the content that is posted to unspecified users of social media makes investigations more difficult. This study suggests the site-based collection and the Open API among the content web collection methods considering the characteristics of the online media where the infringement crimes occur. Since illegal content is published and deleted quickly, and new words and alterations are generated quickly and variously, it is difficult to recognize them quickly by dictionary-based morphological analysis registered manually. In order to solve this problem, we propose a tokenizing method in the existing dictionary-based morphological analysis through WPM (Word Piece Model), which is a data preprocessing method for quick recognizing and responding to illegal contents posting online infringement crimes. In the analysis of data, the optimal precision is verified through the Vote-based ensemble method by utilizing a classification learning model based on supervised learning for the investigation of illegal contents. This study utilizes a sorting algorithm model centering on illegal multilevel business cases to proactively recognize crimes invading the public economy, and presents an empirical study to effectively deal with social data collection and content investigation.

• Journal of Oriental Neuropsychiatry
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• v.26 no.2
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• pp.117-130
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• 2015

Objectives: Banhahoobak-tang has been used to treat plum-pit qi, chest and hypochondriac distension, moist or greasy tongue coat, and wiry slow or wiry slippery pulse. It might be used to control coughing and vomiting. We observed that Banhahoobak-tang extract (BHTe) had anti-psychological stress effect. The objective of this study was to determine the effect of BHTe on restoring the transcriptional regulation of genes related to psychological stress. Methods: After giving psychological stress to mice, BHTe was orally administered at 100 mg/kg/day for five days. After extracting whole brain tissue from the mice, the gene expression changes were determined by microarray. Transcription factor binding site (TFBS) analysis showed up- and down-regulated genes related to psychological stress were protected by BHTe and segregated according to the structure of TFBS. We performed text based Pubmed search to select significant target genes involved in psychological stress affected by BHTe. Results: 1. Serum corticosterone level was decreased in the BHTe administered group, although the psychological stress was increased. 2. The BHTe administered group had no significant change in noradrenaline content in brain tissue, but the psychological stress group had decreased level. 3. The BHTe administered group had increased time of staying at open-arm than the psychological stress group. 4. Microarray revealed that TANK and RARA genes were up-regulated genes while AES, CDC42, FOS, NCL, and PVR were down-regulated genes by psychological stress but restored by BHTe.

• Journal of Korean Society of Forest Science
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• v.101 no.3
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• pp.480-487
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• 2012

This study was conducted to search the effects of debris barrier on the benthic macroinvertebrate. Gimcheon was selected as the survey site as it has relatively stable ecosystem with constantly running water. The survey was conducted 6 times before and after the construction of debris barrier from February in 2009 to October in 2010. In the first survey before construction, the identified species were 36 species belonged to 22 families, 9 order, 4 class, and 4 phylum. The figure slightly decreased to 30 species belonged to 18 families, 7 order, 2 class, and 2 phylum in the sixth survey after construction. Before construction, occupation ratio of EPT taxa was showed in the following order: Ephemeroptera (50.0%, 85.0%), Trichoptera (35.3%, 10.0%), and Plecopteran (14.8%, 5.0%). After construction, it was showed in the following order: Trichoptera (50.3%, 68.0%), Ephemeroptera (42.1%, 29.4%), and Plecopteran (7.5%, 2.7%). Ephemeroptera was the highest before construction. Trichoptera increased rapidly after construction. The Diversity, Richness, Evenness, and Dominance indices were all turned low in the second survey right after the construction. However, each index tended to increase with the course of time. In Functional Feeding Groups, GC type was the highest of 60.7% before construction. After construction, SC(53.1%) and FC(35.4%) increased rapidly and they became stabilized since the third survey. The result of this study reveals that debris barrier greatly affects the Aquatic Ecosystem right after its construction, but the system becomes stable and returns to normal with the course of time (about 18 months). Therefore, the study considering various influence factors such as time is required to recover completely through further long-term monitoring.

• Asia pacific journal of information systems
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• v.22 no.4
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• pp.125-149
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• 2012

As the smart phone is propagating rapidly, the importance of mobile advertisement has also grown. One of the main characteristics of the Internet and smart phone advertising is that they can deliver personalized advertisements to each customer. The smart phone enables the identification of additional personalized information such as the customer's location and the accessibility to the site at any place any time. As the Internet platform becomes richer, firms that offer the ad services via the wired PC Internet and wireless smart phone are seeking various types of personalized ads. However, their service platform and Information and Communication Technology (ICT) platform should be suitable to the characteristics of personalized ads. This research explores various types of personalized ad methods and evaluates their adequacy encompassing four types of ad service platforms (such as search portal, news portal, e-mall servers, and SNS) and two types of ICT platforms (PC Internet and smart phone). To this end, we classified the personalized ads into seven types: three basic types and four composite types. The basic types of ad methods are identified by considering the current activity that the customer is engaged, the individual profile and log history, and the customer's current location or planning location. Four composite types of ad methods are constructed as the combination of these basic types. For those types of ad methods, we evaluate whether each ad method adequately maps with four types of ad service platforms and two types of ICT platforms. We proposed a metric of evaluation and demonstrated the concept with illustrative numbers. Specifically, we analyze and compare personalized ad methods in three ways. Firstly, the possibility of implementing a personalized ad method on the platform is analyzed to confirm the degree of suitability. Secondly, the value of personalized ad method is analyzed based on the customer accessibility. Lastly, expected effectiveness for each personalized ad method is computed by multiplying the possibility and the value. Through this kind of analysis, the ad service providers as well as advertising companies can evaluate what kinds of personalized ad methods and platforms are possible and suitable to maximize their ad effectiveness on the Internet and smart phone platforms.