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http://dx.doi.org/10.7314/APJCP.2014.15.1.145

A Genetic Variant in MiR-146a Modifies Digestive System Cancer Risk: a Meta-analysis  

Li, Ying-Jun (Department of Epidemiology and Biostatistics, Zhejiang University School of Public Health)
Zhang, Zhen-Yu (Department of Epidemiology and Biostatistics, Zhejiang University School of Public Health)
Mao, Ying-Ying (Department of Epidemiology and Biostatistics, Zhejiang University School of Public Health)
Jin, Ming-Juan (Department of Epidemiology and Biostatistics, Zhejiang University School of Public Health)
Jing, Fang-Yuan (Department of Epidemiology and Biostatistics, Zhejiang University School of Public Health)
Ye, Zhen-Hua (Department of Epidemiology and Biostatistics, Zhejiang University School of Public Health)
Chen, Kun (Department of Epidemiology and Biostatistics, Zhejiang University School of Public Health)
Publication Information
Asian Pacific Journal of Cancer Prevention / v.15, no.1, 2014 , pp. 145-150 More about this Journal
Abstract
MicroRNAs (miRNAs) negatively regulate gene expression and act as tumor suppressors or oncogenes in oncogenesis. The association between a single nucleotide polymorphism (SNP) in miR-146a rs2910164 and susceptibility to digestive system cancers was inconsistent in previous studies. In this study, we conducted a literature search of PubMed to identify all relevant studies published before August 31, 2013. A total of 21 independent case-control studies were included in this updated meta-analysis with 9,558 cases and 10,614 controls. We found that the miR-146a rs2910164 polymorphism was significantly associated with decreased risk of digestive system cancers in an allele model (OR=0.90, 95%CI 0.87-0.94), homozygote model (OR=0.84, 95%CI 0.77-0.91), dominant model (OR=0.90, 95%CI 0.84-0.96), and recessive model (OR=0.85, 95%CI 0.79-0.91), while in a heterozygous model (OR = 0.99, 95% CI 0.89-1.11) the association showed marginal significance. Subgroup analysis by cancer site revealed decreased risk in colorectal cancer above allele model (OR=0.90, 95%CI 0.83-0.97) and homozygote model (OR=0.85, 95%CI 0.72-1.00). Similarly, decreased cancer risk was observed when compared with allele model (OR=0.87, 95%CI 0.81-0.93) and recessive model (OR=0.81, 95%CI 0.72-0.90) in gastric cancer. When stratified by ethnicity, genotyping methods and quality score, decreased cancer risks were also observed. This current meta-analysis indicated that miR-146a rs2910164 polymorphism may decrease the susceptibility to digestive system cancers, especially in Asian populations.
Keywords
MiR-146a; polymorphism; digestive system cancers risk; meta-analysis; Asians;
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