• 한국CDE학회논문집
• /
• 제13권2호
• /
• pp.89-97
• /
• 2008

Today's manufacturing environment is becoming a distributed manufacturing process in which a unique and specialized technological background is required in specific domains rather than having a single company execute all the manufacturing processes. This phenomenon is especially true in the automotive industry, where the sharing of product data between companies is rampant; however, this kind of interoperability causes many problems. When each company has its own method of managing product data, the sharing of product data in a distributed environment is a major problem. A data translator module or a data mapping module had to be developed for the exchange of data in heterogeneous systems of product data management (PDM); moreover, this type of module must be continually changed and improved due to the fact that PDM systems change for many reasons. In addition, the growth in corporate partnerships deepens the burden of developing and maintaining this module and creates further data exchange problems due to the increasing complexity of the system. This paper introduces a way of exchanging product data among heterogeneous PDM systems through the use of OpenPDM, which is a kind of virtual data warehouse. The implementation of a PDM integrating system is also discussed with respect to the requirement for a logical integration of product data which are physically distributed.

• 대한화학회지
• /
• 제34권6호
• /
• pp.555-560
• /
• 1990

$YBa_2Cu_3O_{7-x}$ 초전도 필름을 초음파에 의한 aerosol spray 법을 이용하여 YSZ (yttria stabilized zirconia) 및 SrTi$O_3$의 (100) 결정면 위에 만들었다. 초전도상은 세 단계의 과정을 거쳐서 형성되었다 : (가) 이트륨, 바륨, 구리의 질산염을 화학 양론비로 섞어 만든 용액을 250$^{\circ}C$로 가열된 기질에 분무하여, (나) 형성된 필름을 공기 중에서 550$^{\circ}C$로 예열하고, (다) 흐르는 산소 분위기에서 950$^{\circ}C$로 소결한 뒤 노냉하였다. 필름의 저하을 dc four-point probe 법으로 측정하여 액체질소 온도 이상에서 초전도성을 확인하였다.

• Bulletin of the Korean Chemical Society
• /
• 제30권6호
• /
• pp.1325-1330
• /
• 2009

A general method has been developed for the solid phase synthesis of drug-like 7-aryl-benzo[b][1,4]oxazin-3(4H)- one derivatives 6. The method relies on a novel, microwave irradiation promoted cyclization reaction of the BOMBA resin bound, N-substituted-$\alpha$-(2-chloro-4-bromophenoxy)acetamide 3 that takes place via a Smiles rearrangement. The 7-bromobenzo[1,4]oxazine 4, produced in this process is converted to 7-aryloxazin analogs 5 by utilizing Suzuki coupling with various substituted arylboronic acids. Finally, the target 7-aryl-benzo[b][1,4]oxazin-3(4H)-ones 6 are liberated from the resin by treatment with 5% TFA. The progress of the reactions involved in this preparative route can be monitored by using ATR-FTIR spectroscopy on a single bead. The target compounds, obtained by using this five-step sequence, are produced in high yields and purities.

• 한국전산구조공학회논문집
• /
• 제27권4호
• /
• pp.313-320
• /
• 2014

텐세그리티 구조물은 인장력을 받는 연속된 케이블 안에 압축력을 받는 스트럿이 결합된 형태로 구성된다. 텐세그리티 구조물은 자기 응력 상태를 갖는 프리스트레스 핀 접합 구조물에 속한다. 텐세그리티 구조물 설계의 핵심은 평형 배열상태를 구하는 일명 형상탐색 과정이다. 본 논문에서는 세 가지의 효과적인 텐세그리티 구조물의 형상탐색 기법을 제안하였다. 형상탐색과정을 수행하면 평형상태의 내력 밀도와 그에 대응하는 위상을 얻을 수 있다. 이 때 평형상태를 형성하는 적절한 내력밀도 값을 얻기 위해 유전자 알고리즘을 결합한 내력밀도법이 사용되었다. 수치해석 예제를 통해 제안 알고리즘의 효율성을 입증하였다.

• Korean Chemical Engineering Research
• /
• 제54권2호
• /
• pp.229-233
• /
• 2016

본 연구에서는 식물세포배양액으로부터 파클리탁셀을 효율적으로 회수하기 위하여 초음파를 이용한 액-액 추출 공정을 개발하였다. 액-액 추출을 위한 최적의 초음파 파워와 조업 시간은 주어진 하층(메틸렌 클로라이드 층)/상층(메탄올 농축액 층) 비(25%, v/v)에서 각각 250W와 15 min임을 알 수 있었다. 최적 조건 하에서 초음파를 이용한 액-액 추출 공정의 경우 단 1 회 추출로 대부분의 파클리탁셀을 하층(메틸렌 클로라이드 층)으로부터 회수(~92%) 가능하였다. 또한 무기염 첨가에 의한 초음파 상승효과로 인하여 액-액 추출을 위하여 적절한 무기염 농도와 초음파 파워가 요구됨을 알 수 있었다.

• 한국전기전자재료학회:학술대회논문집
• /
• 한국전기전자재료학회 2003년도 춘계학술대회 논문집 센서 박막재료 반도체 세라믹
• /
• pp.158-161
• /
• 2003

The primary aim of this study is to investigate new semi-abrasive free slurry including acid colloidal silica and hydrogen peroxide for copper chemical-mechanical planarization (CMP). In general, slurry for copper CMP consists of colloidal silica as an abrasive, organic acid as a complex-forming agent, hydrogen peroxide as an oxidizing agent, a film forming agent, a pH control agent and several additives. We developed new semi-abrasive free slurry (SAFS) including below 0.5% acid colloidal silica. We evaluated additives as stabilizers for hydrogen peroxide as well as accelerators in tantalum nitride CMP process. We also estimated dispersion stability and Zeta potential of the acid colloidal silica with additives. The extent of enhancement in tantalum nitride CMP was verified through anelectrochemical test. This approach may be useful for the application of single and first step copper CMP slurry with one package system.

• 한국전기전자재료학회:학술대회논문집
• /
• 한국전기전자재료학회 2000년도 하계학술대회 논문집
• /
• pp.916-919
• /
• 2000

A great deal of research has been done in the field of characterization for piezoelectric thin films after the first report on the measurement for the piezoelectric coefficient of thin films in 1990. The main idea of this research is to provide a distinctive solution for the measurement of both the longitudinal and the transverse piezoelectric d-coefficients, d$\sub$33/ and d$\sub$3l/, of ferroelectric thin films and also thick films. In general, to get these two coefficients of thin films, two different measuring systems are required. Here, we propose the improved method for the evaluation of these two coefficients with single equipment and with the relatively convenient procedure. The two-step loading process of applying the both positive and the negative pressure has been designed to acquire the piezoelectric coefficients. These results have beer calibrated for both the longitudinal and the transverse piezoelectric d-coefficients, d$\sub$33/ and d$\sub$31/, of thin films. In the first stage of the experiments, we have obtained d$\sub$33/ of 108pC/N and d$\sub$31/ of 57pC/N for the PZT thin films.

• 소성∙가공
• /
• 제11권6호
• /
• pp.487-494
• /
• 2002

A new method of optimal blank shape design using the initial nodal velocity (INOV) has been proposed for the drawings of arbitrary shaped cups. With the given information of tool shape and the final product shape, corresponding initial blank shape has been found from the motion of boundary nodes. Although the sensitivity method, the past work of the present authors, has been proved to be excellent method to find optimal blank shapes, the method has a problem that a couple of deformation analysis is required at each design step and it also exhibits an abnormal behaviors in the rigid body rotation prevailing region. In the present method INOV, only a single deformation analysis per each design stage is required. Drawings of practical products as well as oil-pan, have been chosen as the examples. At every case the optimal blank shapes have been obtained only after a few times of modification without predetermined deformation path. The deformed shape with predicted optimal blank almost coincides with the target shape at every case. Through the investigation the INOV is found to be very effective in the arbitrary shaped drawing process design.

• Journal of Information Processing Systems
• /
• 제13권5호
• /
• pp.1135-1148
• /
• 2017

Speech recognition is one of the fascinating fields in the area of Computer science. Accuracy of speech recognition system may reduce due to the presence of noise present in speech signal. Therefore noise removal is an essential step in Automatic Speech Recognition (ASR) system and this paper proposes a new technique called combined thresholding for noise removal. Feature extraction is process of converting acoustic signal into most valuable set of parameters. This paper also concentrates on improving Mel Frequency Cepstral Coefficients (MFCC) features by introducing Discrete Wavelet Packet Transform (DWPT) in the place of Discrete Fourier Transformation (DFT) block to provide an efficient signal analysis. The feature vector is varied in size, for choosing the correct length of feature vector Self Organizing Map (SOM) is used. As a single classifier does not provide enough accuracy, so this research proposes an Ensemble Support Vector Machine (ESVM) classifier where the fixed length feature vector from SOM is given as input, termed as ESVM_SOM. The experimental results showed that the proposed methods provide better results than the existing methods.

• Journal of Microbiology and Biotechnology
• /
• 제29권1호
• /
• pp.55-58
• /
• 2019

Development of stable rCHO cell lines is still time consuming and labor intensive, although it is a critical step in the commercial development of recombinant antibodies. The current work demonstrates, for the first time, that electroporation of CHO cells with DMSO can enhance stable expression of recombinant antibodies in rCHO cells. Electroporation with DMSO resulted in an average 3.7-fold and 2.8-fold increases in expression levels of aflibercept and pembrolizumab, respectively, in pools of stable rCHO cells. It also resulted in an average of 2.2-fold and 2.6-fold increases in the expression of aflibercept and pembrolizumab, respectively, in single-cell derived rCHO clones. Simple batch cultures of rCHO cell clones with the highest expression produced 1.0 g/l for aflibercept and 1.4 g/l for pembrolizumab without a time-consuming gene amplification process. Electroporation with DMSO also shortened the development of rCHO cell lines to 2-3 months, allowing rapid establishment of stable rCHO cell lines with a desirable expression level antibodies.