• Korean Journal of Computational Design and Engineering
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• v.13 no.2
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• pp.89-97
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• 2008

Today's manufacturing environment is becoming a distributed manufacturing process in which a unique and specialized technological background is required in specific domains rather than having a single company execute all the manufacturing processes. This phenomenon is especially true in the automotive industry, where the sharing of product data between companies is rampant; however, this kind of interoperability causes many problems. When each company has its own method of managing product data, the sharing of product data in a distributed environment is a major problem. A data translator module or a data mapping module had to be developed for the exchange of data in heterogeneous systems of product data management (PDM); moreover, this type of module must be continually changed and improved due to the fact that PDM systems change for many reasons. In addition, the growth in corporate partnerships deepens the burden of developing and maintaining this module and creates further data exchange problems due to the increasing complexity of the system. This paper introduces a way of exchanging product data among heterogeneous PDM systems through the use of OpenPDM, which is a kind of virtual data warehouse. The implementation of a PDM integrating system is also discussed with respect to the requirement for a logical integration of product data which are physically distributed.

• Journal of the Korean Chemical Society
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• v.34 no.6
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• pp.555-560
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• 1990

High temperature superconducting films of $YBa_2Cu_3O_{7-x}$ were fabricated on the (100) single crystal faces of YSZ (yttria stabilized zirconia) and SrTi$O_3$ by aerosol spray using ultrasonic atomization. The superconducting phase was formed by a three-step process: (a) spraying of a stoichiometric solution of nitrates of yttrium, barium, and copper on heated substrates kept at 250$^{\circ}C$, (b) preheating of the sprayed films in air at 550$^{\circ}C$, and (e) sintering of the films in flowing oxygen at 950$^{\circ}C$, followed by furnace cooling. Resistances of the films were measured by the dc four-probe method and superconductivity was confirmed above the liquid nitrogen temperature.

• Bulletin of the Korean Chemical Society
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• v.30 no.6
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• pp.1325-1330
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• 2009

A general method has been developed for the solid phase synthesis of drug-like 7-aryl-benzo[b][1,4]oxazin-3(4H)- one derivatives 6. The method relies on a novel, microwave irradiation promoted cyclization reaction of the BOMBA resin bound, N-substituted-$\alpha$-(2-chloro-4-bromophenoxy)acetamide 3 that takes place via a Smiles rearrangement. The 7-bromobenzo[1,4]oxazine 4, produced in this process is converted to 7-aryloxazin analogs 5 by utilizing Suzuki coupling with various substituted arylboronic acids. Finally, the target 7-aryl-benzo[b][1,4]oxazin-3(4H)-ones 6 are liberated from the resin by treatment with 5% TFA. The progress of the reactions involved in this preparative route can be monitored by using ATR-FTIR spectroscopy on a single bead. The target compounds, obtained by using this five-step sequence, are produced in high yields and purities.

• Journal of the Computational Structural Engineering Institute of Korea
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• v.27 no.4
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• pp.313-320
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• 2014

A tensegrity structure consists of a set of continuous cables in tension and a set of discontinuous struts in compression. The tensegrity structure can be classified into self-stressed and pre-stressed pin-jointed structure. A key step in the design of tensegrity structures is the determination of their equilibrium configuration, known as form-finding. In this paper, three effective methods are presented for form-finding of tensegrity structures. After performing form-finding process, a set of force density and corresponding topology results can be obtained. Then the force density method combined with a genetic algorithm is adopted to uniquely define a single integral feasible set of force densities. Numerical examples are presented that demonstrate the excellent performance of the algorithms.

• Korean Chemical Engineering Research
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• v.54 no.2
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• pp.229-233
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• 2016

In this study, an efficient ultrasound-assisted liquid-liquid extraction process was developed for recovering of paclitaxel from plant cell cultures. The optimal ultrasonic power and operating time were 250 W and 15 min at fixed ratio of bottom phase, methylene chloride to top phase, MeOH (25%, v/v). Under the optimal conditions developed in the present method, most of the paclitaxel (~92%) was recovered from crude extract by a single extraction step. Due to the synergistic effect of ultrasound by the addition of inorganic salt, an appropriate inorganic salt concentration and the ultrasonic power were found to be required for the effective recovery of paclitaxel using ultrasound-assisted liquid-liquid extraction.

• Proceedings of the Korean Institute of Electrical and Electronic Material Engineers Conference
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• 2003.05c
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• pp.158-161
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• 2003

The primary aim of this study is to investigate new semi-abrasive free slurry including acid colloidal silica and hydrogen peroxide for copper chemical-mechanical planarization (CMP). In general, slurry for copper CMP consists of colloidal silica as an abrasive, organic acid as a complex-forming agent, hydrogen peroxide as an oxidizing agent, a film forming agent, a pH control agent and several additives. We developed new semi-abrasive free slurry (SAFS) including below 0.5% acid colloidal silica. We evaluated additives as stabilizers for hydrogen peroxide as well as accelerators in tantalum nitride CMP process. We also estimated dispersion stability and Zeta potential of the acid colloidal silica with additives. The extent of enhancement in tantalum nitride CMP was verified through anelectrochemical test. This approach may be useful for the application of single and first step copper CMP slurry with one package system.

• Proceedings of the Korean Institute of Electrical and Electronic Material Engineers Conference
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• 2000.07a
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• pp.916-919
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• 2000

A great deal of research has been done in the field of characterization for piezoelectric thin films after the first report on the measurement for the piezoelectric coefficient of thin films in 1990. The main idea of this research is to provide a distinctive solution for the measurement of both the longitudinal and the transverse piezoelectric d-coefficients, d$\sub$33/ and d$\sub$3l/, of ferroelectric thin films and also thick films. In general, to get these two coefficients of thin films, two different measuring systems are required. Here, we propose the improved method for the evaluation of these two coefficients with single equipment and with the relatively convenient procedure. The two-step loading process of applying the both positive and the negative pressure has been designed to acquire the piezoelectric coefficients. These results have beer calibrated for both the longitudinal and the transverse piezoelectric d-coefficients, d$\sub$33/ and d$\sub$31/, of thin films. In the first stage of the experiments, we have obtained d$\sub$33/ of 108pC/N and d$\sub$31/ of 57pC/N for the PZT thin films.

• Transactions of Materials Processing
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• v.11 no.6
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• pp.487-494
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• 2002

A new method of optimal blank shape design using the initial nodal velocity (INOV) has been proposed for the drawings of arbitrary shaped cups. With the given information of tool shape and the final product shape, corresponding initial blank shape has been found from the motion of boundary nodes. Although the sensitivity method, the past work of the present authors, has been proved to be excellent method to find optimal blank shapes, the method has a problem that a couple of deformation analysis is required at each design step and it also exhibits an abnormal behaviors in the rigid body rotation prevailing region. In the present method INOV, only a single deformation analysis per each design stage is required. Drawings of practical products as well as oil-pan, have been chosen as the examples. At every case the optimal blank shapes have been obtained only after a few times of modification without predetermined deformation path. The deformed shape with predicted optimal blank almost coincides with the target shape at every case. Through the investigation the INOV is found to be very effective in the arbitrary shaped drawing process design.

• Journal of Information Processing Systems
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• v.13 no.5
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• pp.1135-1148
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• 2017

Speech recognition is one of the fascinating fields in the area of Computer science. Accuracy of speech recognition system may reduce due to the presence of noise present in speech signal. Therefore noise removal is an essential step in Automatic Speech Recognition (ASR) system and this paper proposes a new technique called combined thresholding for noise removal. Feature extraction is process of converting acoustic signal into most valuable set of parameters. This paper also concentrates on improving Mel Frequency Cepstral Coefficients (MFCC) features by introducing Discrete Wavelet Packet Transform (DWPT) in the place of Discrete Fourier Transformation (DFT) block to provide an efficient signal analysis. The feature vector is varied in size, for choosing the correct length of feature vector Self Organizing Map (SOM) is used. As a single classifier does not provide enough accuracy, so this research proposes an Ensemble Support Vector Machine (ESVM) classifier where the fixed length feature vector from SOM is given as input, termed as ESVM_SOM. The experimental results showed that the proposed methods provide better results than the existing methods.

• Journal of Microbiology and Biotechnology
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• v.29 no.1
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• pp.55-58
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• 2019

Development of stable rCHO cell lines is still time consuming and labor intensive, although it is a critical step in the commercial development of recombinant antibodies. The current work demonstrates, for the first time, that electroporation of CHO cells with DMSO can enhance stable expression of recombinant antibodies in rCHO cells. Electroporation with DMSO resulted in an average 3.7-fold and 2.8-fold increases in expression levels of aflibercept and pembrolizumab, respectively, in pools of stable rCHO cells. It also resulted in an average of 2.2-fold and 2.6-fold increases in the expression of aflibercept and pembrolizumab, respectively, in single-cell derived rCHO clones. Simple batch cultures of rCHO cell clones with the highest expression produced 1.0 g/l for aflibercept and 1.4 g/l for pembrolizumab without a time-consuming gene amplification process. Electroporation with DMSO also shortened the development of rCHO cell lines to 2-3 months, allowing rapid establishment of stable rCHO cell lines with a desirable expression level antibodies.