• Biomolecules & Therapeutics
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• v.15 no.2
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• pp.127-132
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• 2007

The object of this study was to evaluate the acute toxicity of lyophilized water extract of Radix Araliae Cordatae (RA) in male and female mice. The extract was administered to female and male ICR mice as an oral dose of 2000 mg/kg (body wt.) according to the recommendation of KFDA Guidelines. Animals were monitored for the mortality and changes in body weight, clinical signs and gross observation during 14 days after dosing, upon necropsy, organ weight and histopathology of 12 principle organs were examined. As results, we could not find any mortality, clinical signs, changes in the body weight and gross findings except for increases of hypertrophy of lymph nodes in male RA extracts-dosing group. In addition, no RA extracts-treatment related abnormal changes in the organ weight and histopathology of principle organs except for some sporadic accidental findings. The results obtained in this study suggest that the RA extracts does not cause any toxicological signs. The LD$_{50}$ and approximate LD of RA extracts in both female and male mice were considered as over 2000 mg/kg.

• Journal of the Korean earth science society
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• v.36 no.5
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• pp.437-446
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• 2015

Many edge detection methods, based on horizontal and vertical derivatives, have been introduced to provide us with intuitive information about the horizontal distribution of a subsurface anomalous body. Understanding the characteristics of each edge detection method is important for selecting an optimized method. In order to compare the characteristics of the individual methods, this study applied each method to synthetic magnetic data created using homogeneous prisms with different sizes, the numbers of bodies, and spacings between them. Seven edge detection methods were comprehensively and quantitatively analyzed: the total horizontal derivative (HD), the vertical derivative (VD), the 3D analytic signal (AS), the title derivative (TD), the theta map (TM), the horizontal derivative of tilt angle (HTD), and the normalized total horizontal derivative (NHD). HD and VD showed average good performance for a single-body model, but failed to detect multiple bodies. AS traced the edge for a single-body model comparatively well, but it was unable to detect an angulated corner and multiple bodies at the same time. TD and TM performed well in delineating the edges of shallower and larger bodies, but they showed relatively poor performance for deeper and smaller bodies. In contrast, they had a significant advantage in detecting the edges of multiple bodies. HTD showed poor performance in tracing close bodies since it was sensitive to an interference effect. NHD showed great performance under an appropriate window.

• Asian-Australasian Journal of Animal Sciences
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• v.19 no.12
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• pp.1706-1710
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• 2006

Leptin receptor (OBR) is a member of the class I cytokine receptor family. It signals mainly via the JAK/STAT pathway and plays an important role in regulating body energy storage and metabolism. This study was designed to investigate the effects of the OBR gene on chicken growth and body composition. Broiler lines selected divergently for or against abdominal fat were used. Primers for the exon9-region in the OBR gene were designed using chicken genomic sequences from the public genome domain. A C/A single nucleotide polymorphism (SNP) was found and its three genotypes (AA, AB and BB) were identified in this population. The results showed that the OBR polymorphism was associated with fatness traits, such as abdominal fat weight and abdominal fat percentage. This research suggests that OBR or a linked gene has effect on fat deposition in the chicken.

• International Journal of Internet, Broadcasting and Communication
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• v.13 no.3
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• pp.155-162
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• 2021

With the global COVID-19 pandemic, the tourism sector and all consumption have contracted with the untact era. Wine will also be sold and developed in various ways non-face-to-face in the future. Therefore, it is necessary to develop apps and web servers that focus on health in the era of single-person households and non-face-to-face. This study used facial recognition data based on photos of adult men and women in their 40s and 50s to analyze the Sasang constitution through a mobile app and web server, and suggested wine recommendations suitable for their constitution. First, the user's body information is entered. And through the facial recognition mobile app, recommend the right wine after analyzing the body type. if it's not like the first recommended wine, it is configured to receive another wine recommendation. In the future, the number of single-person households will increase further, and in the age of well-being, wine recommendations that fit my body will be useful. Wine recommendation suitable for Sasang constitution will be a useful mobile application to manage personal healt

• The Journal of Korean Medicine
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• v.44 no.3
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• pp.29-38
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• 2023

Objectives: This study aimed to investigate the acute oral toxicity of 77 herbal formulas and performed in male and female Sprague-Dawley (SD) rats as per the guidelines mentioned in Ministry of Food and Drug Safety. Methods: Each sex of SD rat were administered a single dose (2000 or 5000 mg/kg) of 77 herbal formulas via oral gavage; the control group received vehicle only. After administration, the mortality, clinical signs, gross findings, and body weight were followed up for 15 days. Results: After administration of 77 herbal formulas, mortality, clinical signs, body weight changes, and gross findings related to the test substances were not observed in both male and female groups. Conclusion: Our results demonstrate the single-dose oral administration of 77 herbal formulas produced no mortality indicating the approximate lethal dose is greater than 2000 or 5000 mg/kg body weight.

• Journal of Conservation Science
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• v.37 no.1
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• pp.43-54
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• 2021

In this study, a scientific analysis of the gold leaf layers and internal structure of the Clay Seated Vairocana Buddha Triad in Seonunsa Temple, Gochang (Treasure No. 1752) was conducted. The surface of the Buddha statues is a gold foil, and the gold leaf layer consists of four layers. The gold leaf layer first composed on the molding clay was produced in the order of lacquer-fabrics-lacquer-gold foil. Subsequently, it was confirmed that the work was performed three times in the same way. The composition of the Buddha statues was divided into the head, body or upper body, lower body, and pedestal. The body was made in a cylindrical form by connecting vertically oriented wooden materials, and the head and lower body were also connected to the body in an empty form. Thus, the head, body, and lower body are grafted structures that are connected to a single Bokjang-gong. It was confirmed that the Clay Seated Vairocana Buddha Triad in Seonunsa Temple was made using wood materials for the basic form, after which the detailed form was created with molding clay, and the surface was finished with a process of layering gold foil and substances presumed to be lacquer.

• Biomedical Science Letters
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• v.22 no.2
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• pp.46-52
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• 2016

Salicornia herbacea L. (S. herbacea) is an annual herbaceous plant of Chenopodiaceae. It grows in groups on the coast or mud flat of Korea is known to be rich in minerals. S. herbacea has potent anti-cancer, antioxidant, anti-obesity, bowel function improvement. However, pharmacological mechanisms of S. herbacea extract (SHE) remain poorly understood. The aim of this study was to investigate the potential acute toxicity of SHE in ICR mice administered a single oral dose of 0, 500, 1,000, and 2,000 mg/kg by gavage. After administration of the extract, signs of toxicity were observed every day for 14 days. No mortality, abnormal clinical signs, body weight, organ weight or pathological changes were observed compared to a control group, and there were no differences in the body weights of the control and treatment groups. Biological serum activities and histological tests were not significantly changed in the treatment group compared to the control group. Especially, treatment of SHE was significantly decreased of total cholesterol and triglyceride levels. These results indicated that a single oral administration of SHE does not exerts any toxic effects at a dose of 2,000 mg/kg and that the $LD_{50}$ of SHE is greater than 2,000 mg/kg. Accordingly, SHE appears to have potential in various functional agents of foods, without toxicity.

• Journal of the Korean Crystal Growth and Crystal Technology
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• v.7 no.4
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• pp.528-535
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• 1997

$LiTaO_3$ single crystals of congruently melting composition were grown by the halogen lamp type floating zone system. Calcination and sintering parameters for the growth were established. Optimum crystal growth conditions were investigated by a controlling of growth rates, rotation speeds and atmospheres. Based on the melting aspect and the shape of molten zone, stable conditions could not be found in air or Na atmosphere. However the growth stability in Ar atmosphere was more regular than that in air or $N_2$. The grown crystals were characterized using Laue back reflection, Curie temperature, refractive index and transmittance. Curie temperature fluctuation in the section of the grown crystal part of top, body and tail was $1^{\circ}C$.

• Biomolecules & Therapeutics
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• v.2 no.2
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• pp.161-172
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• 1994

This study was conducted to examine DA-3002, a biosynthetic human growth hormone, for its acute and subacute toxicities in mice and rats. The drug was administered subcutaneously and orally at a dose level of 1.0, 3.0, 8.9, 26.7 or 80.0 lU/kg once for single dose toxicity and given subcutaneously at a dose level of 0.34, 1.7 or 8.4 lU/kg daily for 13 weeks to investigate repeated dose toxicity. In the acute toxicity study, doses up to 80 lU/kg had no adverse effect on the behavior or body weight gain. Pathological examinations revealed no abnormal changes which could be attributed to toxic effect of DA-3002. In the subacute toxicity study, the growth hormone was tolerated well in broth mice and rats. No drug related deaths occurred and all animals appeared to be normal throughout the dosing period. Increases in body weight gain, food utilisation and absolute organ weights were observed in the rats in the high dose group. Mild changes in the blood chemical parameters were also seen in the treated groups. Histopathologically, however, no abnormal changes were observed in any organ. The changes noted during the treatment periods presumably represent exaggerated pharmacological effects of the growth hormone, and no observed adverse effect level (NOAEL) was considered to be more than 8.4 lu/kg/day.

• Journal of the Korean Society of Clothing and Textiles
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• v.46 no.5
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• pp.723-740
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• 2022

This study aimed to develop an Arduino-based garment pressure device (APD) on the basis of using Single-Tact sensor by suggesting the reliable clothing pressure range and coefficient of selected sensors through the APD calibration process. Once the APD was validated, the pressure of the experimental men's lower body compression wears was measured using the APD and was compared to the pressure measured using the existing air-pack type pressure meter. The subjects were one mannequin and eight men in their 20's, and the trial compression wears were calf sleeves and pants. Clothing pressures were measured in hip, mid-thigh, calf, and ankle. In terms of the 99% confidence level, the experimental clothing pressure measured at the designated measuring points using the APD was considered identical to the one measured using an existing clothing pressure meter. Therefore, on the basis of the experiment results, this study demonstrated that the APD is as reliable as the existing clothing pressure meter within the pressure ranges of 0.54-16.79 kPa and 0.18-25.47 kPa as provided by the SingleTact sensor supplier's data on the basis of using an external ADC (Analog to Digital Converter) module.