• Journal of the Korean Solar Energy Society
• /
• v.32 no.spc3
• /
• pp.245-254
• /
• 2012

In photovoltaic system, the characteristics of photovoltaic module such as open circuit voltage and short circuit current will be changed because of cell temperature and solar radiation. Therefore, the boost converter of a PV system connects between the output of photovoltaic system and DC link capacitor of grid connected inverter as controlling duty ratio for maximum power point tracking(MPPT). This paper shows the dynamic characteristics of the boost converter by comparing single-loop and two-loop control algorithm using both analog and digital control. Both proposed compensation methods have been verified with computer simulation to demonstrate the validity of the proposed control schemes.

• Asian Pacific Journal of Cancer Prevention
• /
• v.13 no.6
• /
• pp.2593-2596
• /
• 2012

Aims: A case-control study of 300 gastric cancer patients and 300 controls was conducted to investigate whether the polymorphisms rs2294008 in PSCA and rs2070803 in MUC1 might be associated with risk of gastric cancer in a Chinese population. Methods: Single nucleotide polymorphisms (SNPs) were genotyped using the Sequenom MassARRAY platform. Results: The data showed that the rs2294008 TT genotype increased gastric cancer risk to an adjusted odds ratio (OR) of 2.26 (95%CI 1.25-4.07), TC to 1.72 (95%CI 1.23-2.42) and TC/TT to 1.81 (95% CI 1.31-2.50), while the rs2070803 GA genotype was associated with a decrease in risk to an adjusted OR of 0.42 (95% CI 0.28-0.62) and rs2070803 GA / AA to 0.46 (95% CI 0.32-0.67). Further stratification analysis revealed that rs2294008 in PSCA consistently increased risk of both intestinal and diffuse-type gastric cancers. The effect of rs2070803 in MUC1 was noteworthily also consistent with both subtypes. Conclusions: Our study suggested rs2294008 in the PSCA gene to be associated with increased risk of gastric cancer and rs2070803 in MUC1 to play a protective role in a Chinese population.

• Genomics & Informatics
• /
• v.12 no.4
• /
• pp.181-186
• /
• 2014

Genome-wide association studies have proven the highly polygenic architecture of complex diseases or traits; therefore, single-locus-based methods are usually unable to detect all involved loci, especially when individual loci exert small effects. Moreover, the majority of associated single-nucleotide polymorphisms resides in non-coding regions, making it difficult to understand their phenotypic contribution. In this work, we studied epistatic interactions associated with three common diseases using Korea Association Resource (KARE) data: type 2 diabetes mellitus (DM), hypertension (HT), and coronary artery disease (CAD). We showed that epistatic single-nucleotide polymorphisms (SNPs) were enriched in enhancers, as well as in DNase I footprints (the Encyclopedia of DNA Elements [ENCODE] Project Consortium 2012), which suggested that the disruption of the regulatory regions where transcription factors bind may be involved in the disease mechanism. Accordingly, to identify the genes affected by the SNPs, we employed whole-genome multiple-cell-type enhancer data which discovered using DNase I profiles and Cap Analysis Gene Expression (CAGE). Assigned genes were significantly enriched in known disease associated gene sets, which were explored based on the literature, suggesting that this approach is useful for detecting relevant affected genes. In our knowledge-based epistatic network, the three diseases share many associated genes and are also closely related with each other through many epistatic interactions. These findings elucidate the genetic basis of the close relationship between DM, HT, and CAD.

• 제어로봇시스템학회:학술대회논문집
• /
• 2003.10a
• /
• pp.2295-2297
• /
• 2003

The major problem encountered in satellite design is EMI (Electro-Magnetic Interference) and EMC (Electro-Magnetic Compatibility). Here, our focus is on the effects of protons on the electronic system. The SEU (Single Event Upset) results from the level change of stored information due to photon radiation and temperature in the space and the nuclear power plant environment. The impact of SEU on PLD (Programmable Logic Devices) technology is most apparent in ROM/SRAM/DRAM devices wherein the state of storage cell can be upset. In this paper, a simple and powerful test techniques is suggested, and the results are presented for the analysis and future reference. The test results are compared with that of JPL test report. In our experiment, the proton radiation facility available at KIRAMS (Korea Institute of Radiological Medical Sciences) has been applied on a commercially available SRAM manufactured by Hynix Semiconductor Company.

• Journal of Integrative Natural Science
• /
• v.8 no.1
• /
• pp.75-79
• /
• 2015

Thromboxane A2 receptors (TXA2-R) are the G protein coupled receptors localized on cell membranes and intracellular structures and play pathophysiological role in various thrombosis/hemostasis, modulation of the immune response, acute myocardial infarction, inflammatory lung disease, hypertension and nephrotic disease. TXA2 receptor antagonists have been evaluated as potential therapeutic agents for asthma, thrombosis and hypertension. The role of TXA2 in wide spectrum of diseases makes this as an important drug target. Hence in the present study, homology modeling of TXA2 receptor was performed using the crystal structure of squid rhodopsin and night blindness causing G90D rhodopsin. 20 models were generated using single and multiple templates based approaches and the best model was selected based on the validation result. We found that multiple template based approach have given better accuracy. The generated structures can be used in future for further binding site and docking analysis.

• Composites Research
• /
• v.13 no.1
• /
• pp.11-24
• /
• 2000

In this paper, finite thickness and tow phase effects on the mechanical behavior were studied numerically for plain weave textile composites. Unit cell analysis based on a superposition method was employed to simulate uniaxial tensile loading condition and macro-element post-processor was used to reduce computer resource requirement. The effective moduli and micro-stress distribution were calculated for finite thick plain weave composites with phase shifts. Single layer and infinitely thick configurations were also considered for comparison.

• Proceedings of the KSME Conference
• /
• 2004.11a
• /
• pp.545-550
• /
• 2004

KSTAR cryostat is a 8.8 m diameter vacuum vessel that provides the necessary thermal barrier between the ambient temperature test cell and the supercritical helium cooled superconducting magnet providing the base pressure of 1 ${\times}$ $10^{-3}Pa$. The cryostat is a single walled vessel consisting of central cylindrical section and two end closures, a flat base structure with external reinforcements and a dome-shaped lid structure. The base structure has 8 equally spaced support legs anchored on the concrete base. The cryostat vessel design was executed to satisfy the performance and operation requirements. The major loads considered in the structural analysis were vacuum pressure, dead weight, electromagnetic load driven by plasma disruption, and seismic load. Based on the fabrication and inspection procedures for the vessel, cryostat vessel was fabricated and inspected. It was confirmed that the inspection results were acceptable.

• Environmental Mutagens and Carcinogens
• /
• v.16 no.2
• /
• pp.77-82
• /
• 1996

The RAD3 gene of Saccharomyces cerevisiae is required for excision repair and is essential for cell viability. RAD3 encoded protein possesses a single stranded DNA-dependent ATPase and DNA-RNA helicase activies. To examine the extent of conservation of structure and function of RAD3 during eukaryotic evolution, we have cloned the RAD3 homolog, HRD3, from the distantly related yeast Schizosaccharomyces pombe. Here, we report the partial cloning and characterization of HRD3 gene (Homologous of RAD3 gene) which was isolated by PCR amplification using conserved domain of Saccharomyces cerevisiae RAD3 gene. Chromosomal DNA isolated from S. pombe had similar restriction patterns to those from S. cerevisiae, as determined by Southern blot analysis. The 2. 8 kb transcript of mRNA was identified by Northern hybridization. The level of transcript did not increase upon UV-irradiation, suggesting that the HRD3 gene in S. pombe is not UV-inducible.

• Microbiology and Biotechnology Letters
• /
• v.27 no.5
• /
• pp.391-398
• /
• 1999

A methylotrophic actinomycetes strain MO-16, which produce the antimicrobial compound, was isolated from soil and supposed as Amycolatopsis sp. based on taxonomic studies. The cell-free extract of methanol-grown strain MO-16 showed dehydrogenase activity for methanol and formaldehyde when various electron acceptors were added for oxidation. On the other hand, methanol did not affect the production of antimicrobial compounds, and organic nitrogen sources such as corn steep liquor and peptone were better than inorganic nitrogen sources. These compounds showed broad antimicrobial spectrum to the tested strains such as bacteria and yeast. The antimicrobial comounds were very stable under heat(121$^{\circ}C$), acid(pH2.0), alkali(pH11.0) treatments. These compounds were isolated by ethylacetate extract, silica gel column chromatography and reverse phase HPLC. Two compounds(peak 1 and 2) were detected as antimicrobial compounds through the HPLC analysis. The peak 2 was purified as a single compound and revealed a 98% purity.

• Proceedings of the KSR Conference
• /
• 2003.10b
• /
• pp.522-530
• /
• 2003

Generally, diaphragms are installed in the box girder to prevent or decrease the distortion of the cross section. In engineering practice, diaphragms are spaced in 5m intervals without reasonable basis. the usual diaphragm type is solid-plate type. It is considered to be noneconomical design to the almost design engineers. In this paper, the parametric study was performed to present the design proposal about the diaphragm stiffness and spacing only in the single cell box girder. For that, the distortional warping normal stress, bending normal stress and transverse bending normal stress were analyzed using finite element program 'SMB' for the accurate structural analysis.