• Asian Pacific Journal of Cancer Prevention
• /
• v.13 no.4
• /
• pp.1321-1324
• /
• 2012

Background: DNA polymerase beta ($pol{\beta}$) is a key enzyme in the base excision repair pathway. It is 39kDa protein, with two subunits, one large subunit of 31 kDa having catalytic activity between exon V to exon XIV, and an 8 kDa smaller subunit having single strand DNA binding activity. Exons V to VII have double strand DNA binding activity, whereas exons VIII to XI account for the nucleotidyl transferase activity and exons XII to XIV the dNTP selection activity. Aim: To examine the association between $pol{\beta}$ polymorphisms and the risk of ovarian cancer, the present case control study was performed using 152 cancer samples and non-metastatic normal samples from the same patients. In this study, mutational analysis of $pol{\beta}$ genomic DNA was undertaken using primers from exons IX to XIV - the portion having catalytic activity. Results: We detected alteration in DNA polymerase beta by SSCP. Two specific heterozygous point mutations of $pol{\beta}$ were identified in Exon 9:486, A->C (polymorphism 1; 11.18%) and in Exon 11:676, A->C (polymorphism 2; 9.86%). The correlation study involving polymorphism 1 and 4 types of tissue showed a significant correlation between mucinous type with a Pearson correlation value of 4.03 (p=0.04). The association among polymorphism 2 with serous type and stage IV together have shown Pearson ${\chi}^2$ value of 3.28 with likelihood ratio of 4.4 (p=0.07) with OR =2.08 (0.3-14.55). This indicates that there is a tendency of correlation among polymorphism 2, serous type and stage IV, indicating a risk factor for ovarian cancer. Conclusion: Hence, the results indicate that there is a tendency for $pol{\beta}$ polymorphisms being a risk factor for ovarian carcinogenesis in India.

• Asian Pacific Journal of Cancer Prevention
• /
• v.14 no.11
• /
• pp.6411-6413
• /
• 2013

Adenocarcinoma of esophagus (AE) is a complex disease, affected by a variety of genetic and environmental factors. Much evidence has shown that the MutY glycosylase homologue (MUTYH) plays a key role in the pathogenesis of many cancers. However, there have been no reports on influence on AE in the Han Chinese population. The objective of this study was to investigate this issue. A gene-based association study was conducted using three single nucleotide polymorphisms(SNPs) reported in previous studies. The three SNPs (rs3219463, rs3219472, rs3219489) were genotyped in 207 unrelated AE patients and 249 healthy controls in a case-control study using polymerase chain reaction and restriction fragment length polymorphism (PCR-RFLP). The results revealed that the genotype distribution of rs3219472 differed between the case and control groups (OR=1.66,95%CI=1.11-2.48, P=0.012), indicating that an association may exist between MUTYH and AE. These findings support a signifcant role for MUTYH in AE pathogenesis in the Han Chinese population.

• Research in Plant Disease
• /
• v.16 no.1
• /
• pp.97-100
• /
• 2010

Angular leaf spot of strawberry caused by Xanthomonas fragariae occurred sporadically in the farmers open field at Sugok-myon, Jinju city, and greenhouse at Okjong-myon, Hadong-gun, Gyeongnam province, Korea. Typical symptoms of angular leaf spot initially appeared as a minute, water-soaked, rotted lesion on the lower leaf surface and the minute spots expanded to form angular leaf spots, usually delimited by small veins. The lesion was translucent under the transmitted light and dark green under reflected light. The slow growing pathogen was a gram-negative, motile bacterium with single polar flagellum, and producing yellowish orange pigment on YDC medium. It showed very strong pathogenicity on the leaves of strawberry. On the basis of biological characteristics and pathogenicity test on host plants, the bacteria was identified as a Xanthomonas fragariae. This is the first report on angular leaf spot of strawberry caused by X. fragariae in Korea.

• 한국해양학회지
• /
• v.29 no.4
• /
• pp.376-382
• /
• 1994

Seasonal distribution of zooplankton community in Inchon Dock, an artificially closed marine embayment has been studied. Samples were collected monthly during the period from December 1989 to December 1991 at four stations in the dock and compared with that at a single station in neighbouring waters of the Yellow Sea. Copepods dominated both in and outside of the dock all the year round, except in late autumn and early winter when protozoans outnumbered. dominant species were Oithona davisae, Acartia bifilosa, Paracalanus crassirostris, Noctiluca scintillas and Tintinnopsis tubulosa. A sharp decline in the abundance was observed in summer 1990 in the dock apparently due to oxygen deficiency (anoxic condition). Although no distinct deference in the abundance of zooplankton was observed between populations in and outside of the dock except in summer 1990, waters out of the dock showed to have a prosperity in species number throughout the year. Moreover, four species of copepods, Centropages abdominalis, Pseudodiaptomus marinus, Tortanus forcipatus and T. spinicaudatus occurred solely at the outside of the dock.

• Journal of the Korean Society of Tobacco Science
• /
• v.14 no.1
• /
• pp.24-32
• /
• 1992

The present study was conducted to compare the relative efficiency of two different haploid breeding methods in tobacco varietal development. A single F t hybrid plant from cross of two flue-cured cultivars of Nicotiana tabacum L., Bright Yellow4(BY4) and NC 95, was used to develop the 30 dihaploid lines by anther culture(F1-ADH) and maternally-derived doubled haploid utilizing Nicotiana africana(F1-MDH), respectively. As compared with mid-parent, ADH lines showed increasing in number of leaves, delaying in days to flower and narrowing in leaf width. However, no significant differences in the other characters investigated were recognized. MDH lines also showed narrow leaf width, while no significant differences in the other characters were observed. The variations of the characters investigated were generally greater in ADH than MDH lines. MDH lines had higher plant height and shorter days to flower than ADH lines, while other characters did not show remarkable differences. The degree of heritability for each of the characters observed between ADH and MDH was almost the same. The characters showing high heritability value were plant height, leaf number, days to flower, and yield, while those showing relatively low value were leaf length, leaf width, and total alkaloid content. Predicted gains from selection for increased yield were calculated for both populations(F1-ADH, F1-MDH) and correlated responses associated with selection for yield were estimated. Plant height, leaf width, days to flower, percent reducing sugar and disease resistance would be expected to improve with selection for yield much faster in the MDH population than in the ADH.

• Industrial Engineering and Management Systems
• /
• v.10 no.3
• /
• pp.197-202
• /
• 2011

In traditional production lines, such as assembly lines, each worker is usually assigned to a particular fixed work, and decreasing the task to master the assigned work is valuated. However, when an imbalance exists between workers' speeds, if a worker delays the overall work in the production line, the production rate of the particular line will also decrease. To avoid this problem, the "Self-Balancing Production Line" was introduced. In this type of production line, each worker is assigned work dynamically, and when specific conditions are satisfied, production remains balanced. Characteristics of these lines that can be preempted at any place have already been analyzed by some researchers. A previous paper examined the situation in which only a single worker can process one machine and cannot preempt processing, and the improved policy of an ordinary selfbalancing production line, which specifies which stations workers can process and how workers can behave. This policy achieveda high production rate with only four stations and two workers (Buzacott, 2002). In that paper, worker processing stations and the behavior of a specific worker were limited, andthe paper focused only on specific stations and workers. Therefore, it is not applicable to any worker sequence. In this paper, we focus on other ways to decrease cycle time. In this kind of line, a worker processes at his or her speed. Therefore, if a worker is assigned stations according to his or her speed, the line can decrease cycle time. To do so, we relax the assumptions of this type of line and set a new condition. Under these conditions, we compare our results to the results of previous papers.

• Smart Structures and Systems
• /
• v.18 no.5
• /
• pp.885-909
• /
• 2016

Advances in low-cost wireless sensing have made instrumentation of large civil infrastructure systems with dense arrays of wireless sensors possible. A critical issue with regard to effective use of the information harvested from these sensors is synchronized sensing. Although a number of synchronization methods have been developed, most provide only clock synchronization. Synchronized sensing requires not only clock synchronization among wireless nodes, but also synchronization of the data. Existing synchronization protocols are generally limited to networks of modest size in which all sensor nodes are within a limited distance from a central base station. The scale of civil infrastructure is often too large to be covered by a single wireless sensor network. Multiple independent networks have been installed, and post-facto synchronization schemes have been developed and applied with some success. In this paper, we present a new approach to achieving synchronized sensing among multiple networks using the Pulse-Per-Second signals from low-cost GPS receivers. The method is implemented and verified on the Imote2 sensor platform using TinyOS to achieve $50{\mu}s$ synchronization accuracy of the measured data for multiple networks. These results demonstrate that the proposed approach is highly-scalable, realizing precise synchronized sensing that is necessary for effective structural health monitoring.

• Asian-Australasian Journal of Animal Sciences
• /
• v.14 no.4
• /
• pp.485-490
• /
• 2001

Farmers in the centre of Vietnam have a tradition of dosing young cattle with groundnut oil before fattening them on a diet of rice straw and road-side grass. These farmers claim the cattle grow faster. It was hypothesized that the effect of the oil could be to eliminate the protozoa from the rumen. This is known to increase the net microbial growth efficiency in the rumen and increase the protein supply to the animal. To test this hypothesis, two experiments were undertaken; one on-station with four cattle fitted with rumen cannulae and the second a growth trial with 25 young cattle in smallholder farms. When the cannulated animals were drenched with groundnut oil, the protozoa were eliminated from the rumen and animals could be kept free of protozoa by isolation. The ammonia concentration in the rumen fluid was decreased when the protozoa were eliminated and there was an indication of improved rumen dry matter degradability of the forage components of the diet. In the practical condition on the smallholder farms, the growth rates of cattle drenched with groundnut oil were increased considerably (65%) compared with untreated control animals. The laboratory results when taken together with the on-farm results indicate that these resource-poor farmers had been able to defaunate their cattle and to maintain the fauna-free state by isolation of their animals from extraneous stock. This traditional practice in Central Vietnam, whereby one family keeps only one or two animals that are hand fed and tethered, has quite a large potential for all of those countries where animals are fed agro-industrial by-products, as it is highly economic. The use of 1 litre of oil compared with 1 kg of rice polishing per day (300 kg over 300 days), would be highly profitable in all countries of South-East Asia.

• Journal of Communications and Networks
• /
• v.7 no.2
• /
• pp.157-170
• /
• 2005

The combination of multiple antennas and multi-carrier code division multiple-access (MC-CDMA) is a strong candidate for the downlink of the next generation mobile communications. The study of such systems in scenarios that model real-life trans-missions is an additional step towards an optimized achievement. We consider a realistic MIMO channel with two or four transmit antennas and up to two receive antennas, and channel state information (CSI) mismatches. Depending on the mobile terminal (MT) class, its number of antennas or complexity allowed, different data-rates are proposed with turbo-coding and asymptotic spectral efficiencies from 1 to 4.5 bit/s/Hz, using three algorithms developed within the European IST-MATRICE project. These algorithms can be classified according to the degree of CSI at base-station (BS): i) Transmit space-frequency prefiltering based on constrained zero-forcing algorithm with complete CSI at BS; ii) transmit beamforming based on spatial correlation matrix estimation from partial CSI at BS; iii) orthogonal space-time block coding based on Alamouti scheme without CSI at BS. All presented schemes require a reasonable complexity at MT, and are compatible with a single-antenna receiver. A choice between these algorithms is proposed in order to significantly improve the performance of MC-CDMA and to cover the different environments considered for the next generation cellular systems. For beyond-3G, we propose prefiltering for indoor and pedestrian microcell environments, beamforming for suburban macrocells including high-speed train, and space-time coding for urban conditions with moderate to high speeds.

• Journal of the Korean Association of Geographic Information Studies
• /
• v.11 no.2
• /
• pp.1-12
• /
• 2008

This paper identifies public transit-poors and derives spatial characteristics of the poors' distribution in an urban area by utilizing buffering analysis of geographic information systems and remote sensing techniques in the case of Daegu metropolitan city. Since special attention is given to elderlies, this study assigns three hundred meter buffer from bus/subway station as service boundary for elderlies. The results of this study tell us that 1) the transit-poors are concentrated on suburban and rural regions, 2) high proportions of the transit poors are elderlies with spatial variations in many regions, 3) the main housing type of the transit-poors is single detached house. We expect that this study can contribute to build an effective policy-making by showing essential technical processes and methods in identifying policy-need groups and their characteristics of spatial distribution.