• 생약학회지
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• 제48권3호
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• pp.173-178
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• 2017

We investigated the efficacy of single compound of plant extract in coxsackievirus B3 (CVB3) infection. CVB3 is a main cause of Hand-foot-mouth diseases (HFMD) and viral myocarditis in children and adult. Several single compounds of plant extract were purified by HPLC and tested as antiviral drug candidate. Among them, kaempferol was selected to effective anti-enterovirus compound by HeLa cells survival assay. CVB3 infected HeLa cells were treated with kaempferol ($100{\mu}g/ml-100ng/ml$) and their antiviral effect was confirmed. After 16 hours of treatment, HeLa cells were lysed and proteins were extracted for western blot analysis. CVB3 viral capsid protein VP1 production and transcription factor eIF4G-1 cleavage was significantly decreased in $100{\mu}g/ml$ kaempferol treatment. Virus replication was observed by virus RNA amplification. Kaempferol strongly reduced virus positive and negative strand RNA amplification. Moreover, MAPK signal induced by CVB3 infection, pERK and pmTOR, kaempferol treatment significantly inhibited the activity. Plant extract single compound, kaempferol, is a strong candidate to be developed non-toxic anti-enterovirus treatment agent.

• 한국통신학회논문지
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• 제13권3호
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• pp.239-254
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• 1988

현대 통신에서 혼신방지및 보안유지를 위한 방법으로 ECCM기법이 개발되었다. 주파수 도약방식은 이러한 기법중의 하나이며 RF변조된 신호를 일정한 대역폭내에서 빠르게 움직여 신호의 추적을 어렵게 만드는 방법이다. 본 논문에서는 1.25MHz-800Hz의 FM변조된 기준 신호와 LO(Local Oscillator)에 의해 30-80MHz의 FM출력을 얻을 수 있는 PLL-Exciter를 구성하였다. Exciter의 LO로는 42.5-100.5 MHz에서 도약시킬 수 있는 주파수 합성기를 사용하였다.

• Bulletin of the Korean Chemical Society
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• 제34권11호
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• pp.3357-3361
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• 2013

Alumina microfibers with porous structures were prepared through hydrothermal reaction, and then used to modify the surface of carbon paste electrode (CPE). After modification with alumina microfibers, the electrochemical activity of CPE was found to be greatly improved. On the surface of alumina microfibers-modified CPE, the oxidation peak current of salvianolic acid B, a main bioactive compound in Danshen with anti-oxidative and anti-inflammatory effects, was remarkably increased compared with that on the bare CPE surface. The influences of pH value, amount of alumina microfibers and accumulation time were studied. Based on the strong signal amplification effects of alumina microfibers, a novel electrochemical method was developed for the detection of salvianolic acid B. The linear range was from 5 ${\mu}gL^{-1}$ to 0.3 mg $L^{-1}$, and the detection limit was 2 ${\mu}gL^{-1}$ (2.78 nM) after 1-min accumulation. The new method was successfully used to detect salvianolic acid B in ShuangDan oral liquid samples, and the recovery was over the range from 97.4% to 102.9%.

• 한국자기공명학회논문지
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• 제25권4호
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• pp.64-69
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• 2021

In the developed NMR hyperpolarization techniques, Signal amplification by reversible exchange (SABRE) technique is thought to be a promising method to overcome the low sensitivity of bio-NMR/MRI. Most experiments using SABRE have been done in methanol, which is biologically harmful solvent. Therefore, more biological friendly solvent, such as ethanol can be more appropriate solvent to be applicable in bio-NMR and MRI. As the proof of concept, successful hyperpolarization on pyridine via SABRE is carried out in ethanol and its enhancement factor is calculated to be more than 150 folds. To investigate more about its possibility of hyperpolarization in different alcohol solvents, methanol and propanol are used for SABRE in the same condition. The overall polarization trend in different external magnetic field is similar but its polarization number is decreased with higher molecular weight solvents (the order from methanol to propanol). This result indicates that the efficiency of SABRE is different from solvent system despite its same functional group and similar properties. Higher para-hydrogen concentration, higher partial pressure of para-hydrogen, and deuterated solvent can increase the hyperpolarization in any solvents. With these series of successful SABRE results, future studies on SABRE in more biofriendly environment, on more various solvent systems, and with more substrates are needed and it will be the firm basis for applying the SABRE system on the future bio-NMR/MRI.

• 대한기계학회:학술대회논문집
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• 대한기계학회 2001년도 춘계학술대회논문집B
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• pp.42-47
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• 2001

Analyzing the ECG signal, we can find heart disease, for example, arrhythmia and myocardial infarction, etc. Particularly, detecting arrhythmia is more important, because serious arrhythmia can take away the life from patients within ten minutes. In this paper, we would like to introduce the signal processing for ECG analysis and the device made for wireless communication of ECG data. In the signal processing, the wavelet transform decomposes the ECG signal into high and low frequency components using wavelet function. Recomposing the high frequency bands including QRS complex, we can detect QRS complex and eliminate the noise from the original ECG signal. To recognize the ECG signal pattern, we adopted the polynomial approximation partially and statistical method. The ECG signal is divided into small parts based on QRS complex, and then, each part is approximated to the polynomials. Comparing the approximated ECG pattern with the database, we can detect and classify the heart disease. The ECG detection device consists of amplifier, filters, A/D converter and RF module. After amplification and filtering, the ECG signal is fed through the A/D converter to be digitalized. The digital ECG data is transmitted to the personal computer through the RF transceiver module and serial port.

• 센서학회지
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• 제3권1호
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• pp.54-60
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• 1994

본 논문에서는 멀티센서 신호처리용 집적회로를 구성하였다. 제안된 회로는 멀티센서 신호 선택을 위한 아날로그 멀티플렉서, 노이즈 제거와 신호증폭을 위한 능동 필터, 디지탈 신호처리부와의 인터페이스를 위한 샘플-홀드 회로 등으로 구성하였다. 이러한 기능회로들을 CMOS 트랜지스터로 설계하여 집적화를 가능케 하였으며, 이로 인해 멀티센서 신호처리 시스템의 저소비전력화, 소형화를 구현케하였다.

• Biomolecules & Therapeutics
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• 제8권1호
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• pp.63-72
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• 2000

We intended to show some basic requirements for spectrum analysis of electroencephalogram (EEG) by visualizing the differences of the results according to different values of some parameters for analysis. Spectrum analysis is the most popular technique applied for the quantitative analysis of the electroen- cephalographic signals. Each step from signal acquisition through spectrum analysis to presentation of parameters was examined with providing some different values of parameters. The steps are:(1) signal acquisition; (2) spectrum analysis; (3) parameter extractions; and (4) presentation of results. In the step of signal acquisition, filtering and amplification of signal should be considered and sampling rate for analog-to-digital conversion is two-time faster than highest frequency component of signal. For the spectrum analysis, the length of signal or epoch size transformed to a function on frequency domain by courier transform is important. Win dowing method applied for the pre-processing before the analysis should be considered for reducing leakage problem. In the step of parameter extraction, data reduction has to be considered so that statistical comparison can be used in appropriate number of parameters. Generally, the log of power of all bands is derived from the spectrum. For good visualization and quantitative evaluation of time course of the parameters are presented in chronospectrogram.

• 전기학회논문지
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• 제57권12호
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• pp.2300-2307
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• 2008

This study receives the noise transmitted in a constant audio frequency range through a microphone array in which the noise(like grease in a pan) occurs on the power supply line due to the troublesome partial discharge(arc). Then by going through a series of signal processing of removing noise, this study measures the distance and direction up to the noise caused by the troublesome partial discharge(arc) and monitors the result by displaying in the analog and digital method. After these, it determines the state of each size and judges the distance and direction of problematic part. When the signal sound transmitted by the signal source of bad insulator is received on each microphone, the signal comes only in the frequency range of 20 kHz by passing through the circuit of amplification and 6th low pass filter. Then, this signal is entered in a digital value of digital signal processing(TMS320F2812) through the 16-bit A/D conversion. By doing so, the sound distance, direction and coordinate of bad insulator can be detected by realizing the correlation method of detecting the arriving time difference occurring on each microphone and the algorithm of detecting maximum time difference.

• 터널과지하공간
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• 제30권1호
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• pp.1-14
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• 2020

미소진동 모니터링은 구조물의 미세 수준의 손상을 감지하여 구조물의 성능확인 및 안전관리에 활용된다. 신뢰도 높은 미소진동 모니터링 시스템을 구성하기 위해서는 수집된 신호를 변환하는 시그널 컨디셔너의 역할이 매우 중요하다. 시그널 컨디셔너는 정확한 데이터 수집과 기기 정밀 제어에 도움을 주며 신호변환, 선형화, 증폭 등의 추가적인 기능을 수행한다. 본 기술보고는 기존에 개발한 미소진동 모니터링 시스템의 성능을 향상하여 보다 정밀한 모니터링 구현을 목적으로 광산현장에 적합한 노이즈 저감형 시그널 컨디셔너를 개발하고 이를 검토하였다.

• 한국정밀공학회:학술대회논문집
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• 한국정밀공학회 2004년도 추계학술대회 논문집
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• pp.1282-1285
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• 2004

The high voltage driving system with multi-phase shifter including piezoelectric actuators comprised a driving power unit for outputting the driving power by converting input alternate current into direct current, a frequency shifting unit for supplying the direct current power and shifting or generating a frequency, a high-voltage amplification unit for amplifying the input signal outputted from the driving power unit and the frequency shifting unit into a high-voltage signal, and a phase shifting unit for shifting the phase difference of the amplified signal applied to the high-voltage amplification unit and driving plural piezoelectric actuators sequentially. The results that the operating voltage was stable, the voltage loss ratio was low and the response velocity was fast could be obtained. An experiment on performance of the high voltage driving system with multi-phase shifter designed and manufactured as above described was conducted by using a piezoelectric pump having 3 sheets of round unimorph piezoelectric actuators laminated respectively in a rectangular case. It sucks any fluid by causing the first piezoelectric actuator to shift from the inlet porter side, the phase delay of 60$^{\circ}$ causes the second piezoelectric actuator to begin to shift, and the phase delay of 120$^{\circ}$ causes the third piezoelectric actuator to begin to shift. As a result of measuring each change in the outlet flow rate of the piezoelectric pump, it was shown that the frequency-flow rate characteristic, the voltage-flow characteristic, and the load pressure-flow rate characteristic were improved.