• The Journal of Korean Institute of Communications and Information Sciences
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• v.34 no.11A
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• pp.882-890
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• 2009

In this paper, we describe a compensation method that can be used for the situation where Loran receivers lose their phase lock to the received Loran signals when Loran signals are employed for the synchronization of national infrastructures such as telecommunication networks, electric power distribution and so on. In losing the phase lock to the received signals in a Loran receiver, the inner oscillator of the receiver starts free-running and the performance of the timing synchronization signals which are locked to the oscillator's phase is very severly degraded, so the timing accuracy under 1 us for a Primary Reference Clock (PRC) required in the International Telecommunications Union (ITU) G.811 standard can not be satisfied in the situation. Therefore, in this paper, we propose a method which can compensate the phase jump by using a compensation algorithm when a Loran receiver loses its phase lock and the performance evaluation of the proposed algorithm is achieved by the Maximum Time Interval Error (MTIE) of the measured data. From the performance evaluation results, it is observed that the requirement under 1 us for a PRC can be easily achieved by using the proposed algorithm showing about 0.6 us with under 30 minutes mean interval of smoothing with 1 hour period when the loss of phase lock occurs.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.16 no.11
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• pp.7575-7581
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• 2015

Corticotropin-releasing factor(CRF), one of the stress driven neuropeptides, was widely proposed to influence hair loss and re-growth. For the development of receptor antagonists, the screening system based on intracellular calcium signal process was developed and optimized. The aequorin parental cells were transfected with CRF1 receptor and alpha 16 promiscuous G protein cDNA to establish HEK293a16/hCRF1, a stable cell line for the human CRF1 receptor. In HEK293a16/hCRF1 cells, the range of sauvagine dose response was 12-fold higher($EC_{50}:15.21{\pm}1.83nM$) than in the transiently expressed cells, hence essential conditions for the antagonist screening experiments such as the robust signals and high solvent tolerance were secured. The standard antagonists for the CRF1 receptor, antalarmin and CP154526, resulted $IC_{50}$ values of $414.1{\pm}5.5$ and $290.7{\pm}1.9nM$, respectively. Similar results were presented with frozen HEK293a16/hCRF1 cells. Finally, our HEK293a16/hCRF1 cells with the aequorin based cellular functional assay can be a model system for the development of functional cosmetics and modulators that can have a clinical efficacy on hair re-growth.

• Journal of Microbiology and Biotechnology
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• v.22 no.12
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• pp.1629-1635
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• 2012

Previously, we demonstrated that the erythropoietin receptor (EpoR) is present on fibroblasts, where it regulates focal contact. Here, we assessed whether this action of EpoR is involved in the reduced cell adhesion observed in colonocytes exposed to Clostridium difficile toxin A. EpoR was present and functionally active in cells of the human colonic epithelial cell line HT29 and epithelial cells of human colon tissues. Toxin A significantly decreased activating phosphorylations of EpoR and its downstream signaling molecules JAK-2 (Janus kinase 2) and STAT5 (signal transducer and activator of transcription 5). In vitro kinase assays confirmed that toxin A inhibited JAK 2 kinase activity. Pharmacological inhibition of JAK2 (with AG490) abrogated activating phosphorylations of EpoR and also decreased focal contacts in association with inactivation of paxillin, an essential focal adhesion molecule. In addition, AG490 treatment significantly decreased expression of occludin (a tight junction molecule) and tight junction levels. Taken together, these data suggest that inhibition of JAK2 by toxin A in colonocytes causes inactivation of EpoR, thereby enhancing the inhibition of focal contact formation and loss of tight junctions known to be associated with the enzymatic activity of toxin A.

• Nutrition Research and Practice
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• v.11 no.1
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• pp.3-10
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• 2017

BACKGROUND/OBJECTIVES: Sargassum horneri is an edible brown alga that grows in the subtidal zone as an annual species along the coasts of South Korea, China, and Japan. Recently, an extreme amount of S. horneri moved into the coasts of Jeju Island from the east coast of China, which made huge economic and environmental loss to the Jeju Island. Thus, utilization of this biomass becomes a big issue with the local authorities. Therefore, the present study was performed to evaluate the anti-inflammatory potential of crude polysaccharides (CPs) extracted from S. horneri China strain in lipopolysaccharide (LPS)-stimulated RAW 264.7 cells. MATERIALS/METHODS: CPs were precipitated from S. horneri digests prepared by enzyme assistant extraction using four food-grade enzymes (AMG, Celluclast, Viscozyme, and Alcalase). The production levels of nitric oxide (NO) and pro-inflammatory cytokines, including tumor necrosis factor (TNF)-${\alpha}$ and interleukin (IL)-$1{\beta}$ were measured by Griess assay and enzyme-linked immunosorbent assay, respectively. The levels of inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2), nuclear factor (NF)-${\kappa}B$, and mitogen-activated protein kinases (MAPKs) were measured by using western blot. The IR spectrums of the CPs were recorded using a fourier transform infrared spectroscopy (FT-IR) spectrometer. RESULTS: The polysaccharides from the Celluclast enzyme digest (CCP) showed the highest inhibition of NO production in LPS-stimulated RAW 264.7 cells ($IC_{50}$ value: $95.7{\mu}g/mL$). Also, CCP dose-dependently down-regulated the protein expression levels of iNOS and COX-2 as well as the production of inflammatory cytokines, including TNF-${\alpha}$ and IL-$1{\beta}$, compared to the only LPS-treated cells. In addition, CCP inhibited the activation of NF-${\kappa}B$ p50 and p65 and the phosphorylation of MAPKs, including p38 and extracellular signal-regulated kinase, in LPS-stimulated RAW 264.7 cells. Furthermore, FT-IR analysis showed that the FT-IR spectrum of CCP is similar to that of commercial fucoidan. CONCLUSIONS: Our results suggest that CCP has anti-inflammatory activities and is a potential candidate for the formulation of a functional food ingredient or/and drug to treat inflammatory diseases.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.12 no.7
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• pp.3169-3175
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• 2011

This paper describes the design of size-reduced directional coupler using the artificial dielectric substrate and its increased effective permittivity. Directional couplers are widely used in measuring RF power indirectly and coupling signal power. Artificial dielectric substrates have higher effective dielectric constant than standard dielectric substrate due to the lots of metalized via-holes, and the increased effective permittivity results in size-reduction of circuits. As a design example, 15dB directional couplers are designed on the standard substrate and artificial dielectric substrate and their size are compared. The size of the directional coupler using the artificial dielectric substrate is only 1/3 of that designed using the standard substrate, while the performances are preserved. In addition, the measured performances of the size-reduced coupler are well agreed with the simulated ones. The measured coupling coefficient, matching, and insertion loss at 2GHz are -14.62dB, -24.1dB, and -0.38dB, respectively.

• Journal of the Korean Institute of Intelligent Systems
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• v.21 no.3
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• pp.383-388
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• 2011

This paper presents to study the accuracy improvement of the laser navigation using FIS(fuzzy inference system) and the reliability. As wireless guidance system, the top-mounted laser with the laser navigation can rotate $360^{\circ}$ with phototransistor or other optical sensors that read the return signal from reflectors mounted at the perimeter of the workspace. The type of major existing guidance systems is a wire guidance system. Because they have high accuracy and fast response time, they are used to most industries. However, their installation cost is very expensive and maintenance is very difficult because their sensors are placed approximately 1 inch below the ground or embedded in the floor. To solve those problems, the laser navigation was developed as a wire guidance system. It does not need to reconstruct a floor or ground. And it can reduce costs of installation and maintenance because changing the layout is easy. However, it is difficult to apply to an industrial field because it is easily affected by disturbances which cause loss and damage of data, and has slow respond time. Therefore, we study the accuracy improvement of the laser navigation. The proposed method is a correction method using reliability of the laser navigation. here, reliability is calculated by FIS which is designed with the analyzed characteristics of the laser navigation. For performance comparison, we use original position data form the laser navigation and position data corrected by original reliability from the laser navigation. In experimental result, we verified that the performance of the proposed method compared the others is improved by about 50% or more.

• The Journal of the Institute of Internet, Broadcasting and Communication
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• v.21 no.6
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• pp.25-32
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• 2021

In this study, it proposes a mode converter that is relatively easy to implement and can shorten the transmission line length of the final combining port and it was fabricated and tested by applying it to an 8-way spatial combiner. The proposed mode converter converts the signal converted from the doorknob-shaped circular disk connected to the ground into the TM₀₁ mode by opening it in the circular waveguide. The 8-way waveguide spatial combiner is designed and implemented so that 8 signals input from the H-plane are combined in a circular waveguide at the center, and the final combining mode is TM₀₁. The test results confirmed excellent performance with an insertion loss of less than 0.4dB and a combining efficiency of 95% or more. In addition, it was confirmed that it is suitable for high output by calculating the breakdown voltage and discharge threshold power of the new mode conversion structure through electric field analysis. The results confirmed through this study are expected to be applicable to high-power, high-efficiency SSPA in various fields in the future.

• Korean Journal of Optics and Photonics
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• v.32 no.2
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• pp.49-54
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• 2021

In this paper, we design and construct the equipment to manufacture large-diameter optical fiber end caps, which are the core parts of high-power fiber lasers, and we fabricate large-diameter optical fiber end caps using the home-made equipment. This equipment consists of a CO2 laser as a fusion-splice heat source, a precision stage assembly for transferring the position of a large-diameter optical fiber and an end cap, and a vision system used for alignment when the fusion splice is interlocked with the stage assembly. The output of the laser source is interlocked with the stage assembly to control the output, and the equipment is manufactured to align the polarization axis of the large-diameter polarization-maintaining optical fiber with the vision system. Optical fiber end caps were manufactured by laser fusion splicing of a large-diameter polarization-maintaining optical fiber with a clad diameter of 400 ㎛ and an end cap of 10×5×2 ㎣ (W×D×H) using home-made equipment. Signal-light insertion loss, polarization extinction ratio, and beam quality M2 of the fabricated large-diameter optical fiber end caps were measured to be 0.6%, 16.7 dB, and 1.21, respectively.

• Journal of the Korea Institute of Information and Communication Engineering
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• v.23 no.2
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• pp.165-172
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• 2019

Using two or more coaxial lines, if one port is connected in series and the other port is connected in parallel, it can be implemented the wideband transmission line transformer(TLT). Because the wideband TLT utilizes the outer conductor of the coaxial line, it is difficult to predict the characteristics. In this paper, based on the analysis for the transfer characteristic(S21) according to the loss of the each line in ${\lambda}/4$-microstrip line TLT, the operating characteristic of the fabricated wideband 4:1 TLT using two $25{\Omega}$-coaxial lines is investigated. The fabricated wideband TLT shows the notch characteristic in which the transfer signal sharply decreases at ${\lambda}/4$ frequency of the coaxial line and has a value within -0.2dB of the transfer characteristic(S21) in $0.06{\sim}0.2{\lambda}$ frequency range of the coaxial line. This transfer characteristics(S21) can change the operating frequency range slightly and set the optimum transfer characteristic(S21) at the desired frequency by changing the length of the microstrip line.

• Science of Emotion and Sensibility
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• v.24 no.2
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• pp.49-56
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• 2021

In this study, we investigated the necessary mechanical properties of conductive multifilament yarns for fabricating the electrodes of biosignal measurement pressure and stretch textile sensors using embroidery. When electrodes and circuits for smart wearable products are produced through the embroidery process using conductive multifilament yarns, unnecessary material loss is minimized, and complex electrode shapes or circuit designs can be produced without additional processes using a computer embroidering machine. However, because ordinary missionary threads cannot overcome the stress in the embroidery process and yarn cutting occurs, herein, we analyzed the S-S curve, thickness, and twist structure, which are three types of silver-coated multifilament yarns, and measured the stress in the thread of the embroidery simultaneously. Thus, the required mechanical properties of the yarns in the embroidery process were analyzed. In the actual sample production, cutting occurred in silver-coated multifilament rather than silver-coated polyamide/polyester, which showed the lowest S-S curve. In the embroidery process, the twist was unwound through repetitive vertical movement. Further, we fabricated a piezoresistive pressure/tension sensor to measure gauge factor, which is an index for measuring biological signals. We confirmed that the sensor can be applied to the fabrication of embroidery electrodes, which is an important process in the mass production of smart wearable products.