• BMB Reports
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• v.29 no.6
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• pp.549-554
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• 1996

Phosphoinositide turnover in response to platelet-derived growth factor, epidermal growth factor, and bradykinin was evaluated in NIH 3T3 cells. Platelet-derived growth factor and bradykinin induced a significant increase in incorporation of $^{32}P$ into phosphatidylinositol (PI), phosphatidylinositol 4-monophosphate (PIP), and phosphatidylinositol 4.5-bisphosphate ($PIP_2$) in serum-starved NIH 3T3 cells. However, epidermal growth factor increased incorporation of $^{32}P$ into these phosphoinositides by only a small amount. Stimulation with platelet-derived growth factor, not bradykinin, caused a rapid elevation of PI and PIP kinase activities that were maximally activated within 10 min. The maximal levels of their elevation in cells with plateletderived growth factor stimulation were 3.2-fold for PI kinase, and 2.1-fold for PIP kinase. Short term pretreatment of NIH 3T3 cells with phorbol 12-myristate 13-acetate, activator of protein kinase C. caused an approximately 60% decrease in platelet-derived growth factor-induced PI kinase activities, indicating the feedback regulation of phosphoinositide turnover by protein kinase C. These results suggest that although the enhancement of phosphoinositide turnover is a rapidly occurring response in platelet-derived growth factor- or bradykinin-stimulated NIH 3T3 cells, phosphoinositide kinases may be associated with initial signal transduction pathway relevant to platelet-derived growth factor but not to bradykinin.

• Journal of Korean Society of Transportation
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• v.19 no.4
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• pp.73-84
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• 2001

Korean Highway Capacity Manual applies 7 adjustment factors to estimate saturation flows at signalized intersections. Among the adjustment factors, the right-turn adjustment factor uses equation hard to understand and requires complicated computing process comparing other adjustment factors. Thus. this study was conducted in order to suggest a new technique of estimating the right-turn adjustment factor which is easy to understand and simple to computer by having reasonable degree of accuracy. In this study the right-turn saturation flow ratios which are important in estimating the factor are suggested and the equation to estimate the volume of right-turn on red signal(RTOR) is developed based on observed data. The right-turn saturation flow rates can be estimated according to turning radius and number of lanes of crossing road dividing right-turn lanes into canalized and uncanalized lanes. The RTOR volume is estimated using the proportion of the time during which RTOR is possible to the whole time of red signal according to the through traffic volume per lane of the approach at signalized intersections. The technique of estimating the right-turn adjustment factor suggested in this study, which follows the HCM2000 of U.S. in principal, first judges the right-turn lane to be used exclusively for right-turn or not by employing the RTOR factor and the judging equation developed in this study. Next, if the right-turn lane is not exclusive right-turn lane, the shared right-turn lane is classified into single lane approach or multi lane approach. Thus, a total of three methods of estimating the right-turn adjustment factor to the three cases are suggested in this study.

• Journal of Advanced Navigation Technology
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• v.19 no.3
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• pp.244-249
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• 2015

High-altitude electromagnetic pulse (HEMP) is generated from a nuclear burst at high altitudes above the Earth, the electromagnetic fields reach the ground nearly simultaneously with regard to the operation time of systems. The aim of this analysis is to inquire about HEMP characteristics and to analyze about effect in orthogonal frequency division multiplexing (OFDM) system. Specifically, HEMP characteristics are classified field sources, spatial coverage, time domain behavior, frequency spectrum and field intensities in this study. Bits error rate (BER) of the receiver with the software simulation is confirmed for the HEMP effect. Q-factor made a difference about interference duration by transfer characteristics of system. When Q factor is smaller, the recovery time from HEMP interference is short. To the contrary, if the Q factor is larger, the recovery duration is lasted longer by 300-600%.

• Proceedings of the Korean Society for Noise and Vibration Engineering Conference
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• 2014.10a
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• pp.713-717
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• 2014

This paper presents a beamforming technique for locating impulsive sound source. The conventional frequency-domain beamformer is advantageous for localizing noise sources for a certain frequency band of concern, but the existence of many frequency components in the wide-band spectrum of impulsive noise makes the beamforming image less clear. In contrast to a frequency-domain beamformer, it has been reported that a time-domain beamformer can be better suited for transient signals. Although both frequency- and time-domain beamformers produce the same result for the beamforming power, which is defined as the RMS value of its output, we can use alternative directional estimators such as the peak value and crest factor to enhance the performance of a time-domain beamformer. In this study, the performance of three different directional estimators, the peak, crest factor and RMS output values, are investigated and compared with the incoherent interfering noise embedded in multiple microphone signals. The proposed formula is verified via experiments in an anechoic chamber using a uniformly spaced linear array. The results show that the peak estimation of beamformer output determines the location with better spatial resolution and a lower side lobe level than crest factor and RMS estimation in noise free condition, but it is possible to accurately estimate the direction of the impulsive sound source using crest factor estimation in noisy environment with stationary interfering noise.

• KSII Transactions on Internet and Information Systems (TIIS)
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• v.10 no.2
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• pp.703-722
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• 2016

Passive wireless devices have increasing civilian and military applications, especially in the scenario with wearable devices and Internet of Things. In this paper, we study indoor localization of a target equipped with radio-frequency identification (RFID) device in ultra-wideband (UWB) wireless networks. With known room layout, deterministic multipath components, including the line-of-sight (LOS) signal and the reflected signals via multipath propagation, are employed to locate the target with one transmitter and a single inaccurate receiver. A factor graph corresponding to the joint posterior position distribution of target and receiver is constructed. However, due to the mixed distribution in the factor node of likelihood function, the expressions of messages are intractable by directly applying belief propagation on factor graph. To this end, we approximate the messages by Gaussian distribution via minimizing the Kullback-Leibler divergence (KLD) between them. Accordingly, a parametric message passing algorithm for indoor passive localization is derived, in which only the means and variances of Gaussian distributions have to be updated. Performance of the proposed algorithm and the impact of critical parameters are evaluated by Monte Carlo simulations, which demonstrate the superior performance in localization accuracy and the robustness to the statistics of multipath channels.

• Journal of the Korea Society for Simulation
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• v.24 no.4
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• pp.23-28
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• 2015

The detection field is an important sector of the factors influencing the battle field. Basically, The radar emits a radio wave to perform the detection in the existing way. However, When most existing radars identify target by signal processing to return radio wave, Environmental attenuation factor does not reflected. The radar using this radio wave has got the possibility changing detect result depending on attenuation factor by environmental conditions, The operational problems may arise in a real battle field. Therefore, In this paper, When emitted radio waves were come back, Reflecting the environmental attenuation factor, Experimental attempts to identify the target to enable more accurately.

• Journal of the Korean Magnetics Society
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• v.26 no.3
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• pp.92-98
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• 2016

To aim of this study was to assess the full scan and half scan of imaging with half scan factor. Patients without a cerebral vascular disease (n = 30) and were subject to the full scan half scan, and set a region of interest in the cerebral artery from the three regions (C1, C2, C3) in the range of 7 to 8 mm. MIP (maximum intensity projection) to reconstruct the images in signal strength SNR (signal to noise ration), PSNR (peak signal noise to ratio), RMSE (root mean square error), MAE (mean absolute error) and calculated by paired t-test for use by statistics were analyzed. Scan time was half scan (4 minutes 53 seconds), the full scan (6 minutes 04 seconds). The mean measurement range (7.21 mm) of all the ROI in the brain blood vessel, was the SNR of the first C1 is completely scanned (58.66 dB), half-scan (62.10 dB), a positive correlation ($r^2=0.503$), for the second C2 SNR is completely scanned (70.30 dB), half-scan (74.67 dB) the amount of correlation ($r^2=0.575$), third C3 of a complete scan SNR (70.33 dB), half scan SNR (74.64 dB) in the amount of correlation between the It was analyzed with ($r^2=0.523$). Comparative full scan with half of SNR ($4.75{\pm}0.26dB$), PSNR ($21.87{\pm}0.28dB$), RMSE ($48.88{\pm}1.61$), was calculated as MAE ($25.56{\pm}2.2$). SNR is also applied to examine the half-scans are not many differences in the quality of the two scan methods were not statistically significant in the scan (p-value > .05) image takes less time than a full scan was used.

• Molecules and Cells
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• v.40 no.10
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• pp.706-713
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• 2017

Osteoclasts are bone-resorbing cells that are derived from hematopoietic precursor cells and require macrophage-colony stimulating factor and receptor activator of nuclear factor-${\kappa}B$ ligand (RANKL) for their survival, proliferation, differentiation, and activation. The binding of RANKL to its receptor RANK triggers osteoclast precursors to differentiate into osteoclasts. This process depends on RANKL-RANK signaling, which is temporally regulated by various adaptor proteins and kinases. Here we summarize the current understanding of the mechanisms that regulate RANK signaling during osteoclastogenesis. In the early stage, RANK signaling is mediated by recruiting adaptor molecules such as tumor necrosis factor receptorassociated factor 6 (TRAF6), which leads to the activation of mitogen-activated protein kinases (MAPKs), and the transcription factors nuclear factor-${\kappa}B$ (NF-${\kappa}B$) and activator protein-1 (AP-1). Activated NF-${\kappa}B$ induces the nuclear factor of activated T-cells cytoplasmic 1 (NFATc1), which is the key osteoclastogenesis regulator. In the intermediate stage of signaling, the co-stimulatory signal induces $Ca^{2+}$ oscillation via activated phospholipase $C{\gamma}2$ ($PLC{\gamma}2$) together with c-Fos/AP-1, wherein $Ca^{2+}$ signaling facilitates the robust production of NFATc1. In the late stage of osteoclastogenesis, NFATc1 translocates into the nucleus where it induces numerous osteoclast-specific target genes that are responsible for cell fusion and function.

• The Korean Journal of Pain
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• v.29 no.4
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• pp.239-248
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• 2016

Background: The present study was undertaken to evaluate the incidence of chronic persistent post-surgical pain (CPPP) and the role of signal transduction genes in patients undergoing staging laparotomy for carcinoma ovary. Methods: The present observational study was undertaken following institutional ethical committee approval and informed consent from all the participants. A total 21 patients of ASA grade I to III with age 20-70 years, scheduled for elective staging laparotomy for carcinoma ovary were included. Patients were excluded if had other causes of pain, cognitive dysfunction or chronic neurological disorders. Statistical analysis of pool data was done using SPSS version-17. For various scales like GPE, PDQ, NPSI, the visual analogue scale (VAS), global perceived effect (GPE), the pain DETECT questionnaire (PDQ), and neuropathic pain symptoms inventory (NPSI), one factor repaeted measure ANOVA applied with simple contrast with baseline as on post-operative day 1 (considered as reference and compared with subsequent time-interval), and the P values were adjusted according to "Bonferroni adjustments". In patients with CPPP, the ${\Delta}ct$ values of mRNA expressions of genes at the end of postoperative day 90 were compared with the baseline control values by one factor repeated ANOVA. P value < 0.005 significant. Results: The present study demonstrates 38.1% (8 out of 21 patients) incidence of CPPP. The functional status and quality of life as were observed to be significantly diminished in all patients with chronic pain. An up-regulation in the mRNA expression of signal transduction and a positive correlation was noted between the mRNA expression of signal transduction genes and VAS score in all patients with CPPP at the end of postoperative day 90. Conclusions: The reported incidence of CPPP in patients with carcinoma ovary was 38.1%. An up-regulation and positive correlation between mRNA expression of signal transduction genes and VAS score depicts its potential role in the pathogenesis of CPPP.

• Proceedings of the Korean Institute of Electrical and Electronic Material Engineers Conference
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• 2007.06a
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• pp.328-328
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• 2007

Large area matrix-addressed image detectors are a recent technology for x-ray imaging with medical diagnostic and other applications. The imaging properties of x-ray pixel detectors depend on the quantum efficiency of x-rays, the generated signal of each x-ray photon and the distribution of the generated signal between pixels. In a phosphor coated detector the light signal is generated by electrons captured in the phosphor screen. In our study we simulated the lateral spread distributions for phosphor coupled detector by Monte Carlo simulations. Most simulations of such detectors simplify the setup by only taking the conversion layer into account neglecting behind. The Monte Carlo code MCNPX has been used to simulate the complete interaction and subsequent charge transport of x-ray radiation. This has allowed the analysis of charge sharing between pixel elements as an important limited factor of digital x-ray imaging system. The parameters are determined by lateral distribution of x-ray photons and x-ray induced electrons. The primary purpose of this study was to develop a design tool for the evaluation of geometry factor in the phosphor coupled optical imaging detector. In order to evaluate the spatial resolution for different phosphor material, phosphor geometry we have developed a simulation code. The developed code calculates the energy absorption and spatial distribution based on both the signal from the scintillating layer and the signal from direct detection of x-ray in the detector. We show that internal scattering contributes to the so-called spatial resolution drop of the image detector. Results from the simulation of spatial distribution in a phosphor pixel detector are presented. The spatial resolution can be increased by optimizing pixel size and phosphor thickness.