• Proceedings of the KIEE Conference
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• 1998.11c
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• pp.764-766
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• 1998

An evaluation method for oxygen permeable characteristics of the membrane covering to each cathode of multiple cathode - single anode type dissolved oxygen sensor, which has high reproducibility and is capable of measuring multiple components in solutions. For this purpose, a measuring circuit for the multiple cathode type DO sensor was designed to lower the noise signal by adapting a digital LPF to readout the sensor output accurately. Digital LPF is designed by setting up the transfer function to set the cutoff frequency to 10Hz, and the transfer function is programmed by C language, and then the filtering characteristics are evaluated with the simulation and experiments. Using this LPF added measuring circuit for the multiple cathode type DO sensor, we have obtained the calibration factor for each cathode to calibrate the variation of the output signals. The calibration factor was obtained by measuring the sensor output signal followed by oxygen partial pressure, using the same oxygen permeable membrane at each cathode of the multiple cathode type DO sensor.

• The Journal of Korean Medicine Ophthalmology and Otolaryngology and Dermatology
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• v.22 no.2
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• pp.104-117
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• 2009

Objective : Melanin is one of the most important facor in skin color. Melanin protects human skin from ultraviolet radiation otherwise it causes melanin pigmentation. So this experiment is carried out for test whether Scutellaria baicalensis Georgi(SBG) inhibits melanin synthesis and tyrosinase activity in mouse B16 melanoma cells. Method : The melanin synthesis inhibition effects of SBG were examined by in vitro melanin production assay. We assessed inhibitory effects of SBG on melanin contents from B16F1 melanoma cell, on tyrosinase activity(cell and cell free system), effect of SBG on the expression tyrosinase, Microphthalmia-associated Transcription Factor(MITF), Extracellular signal-regulated Kinase(ERK). Result : SBG inhibited melanin synthesis induced $\alpha$-MSH($\alpha$-Melanin Stimulating Hormone) in B16F1. SBG inhibited tyrosinase activity and expression. And SBG down-regulates MITF and stimulated ERK activation in B16F1. Conclusion : According to above results, SBG was improved its suppression effect to the inhibition of melanin synthesis, tyrosinase activation, and tyrosinase promotor activation. So SBG is considered to be used for an strong source of skin whitening effect.

• The Journal of Korean Institute of Communications and Information Sciences
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• v.11 no.6
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• pp.411-420
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• 1986

Quantization noise of nonadaptive Linear Delta Modulation(LDM) and adaptive Constant Factor Delta Modulation(CFDM) systems is studied. The formulas for quantization noise of CFDM system are derived on the basis of the rusults of LDM. And the output signal-to-quantization noise ratios(SNR) in LDM and CFDM systems are calculated in the range of bit rates from 16[Kb/s] to 96[Kb/s]. By comparing LDM and CFDM, it is known that the adaptive DM is superior to non-adaptive DM by 8[dB] when bit rate is 20[Kb/s] and SNR advantage increases to 14[dB] when bit rate is 56[Kb/s]. All the theoretical results agree well with the experimental results.

• BMB Reports
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• v.31 no.5
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• pp.468-474
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• 1998

Membrane depolarization in PC12 cells induces calcium influx via an L-type voltage-sensitive calcium channel (L-VSCC) and increases intracellular free calcium, which leads to tyrosine phosphorylation of epidermal growth factor (EGF) receptor and the associated adaptor protein, She. This activated EGF receptor complex then can activate mitogen-activated protein (MAP) kinase, as in nerve growth factor (NGF) receptor activation. In the present study, we investigated the role of EGF receptor in the signaling pathway initiated by membrane depolarization of PC12 cells. Prolonged membrane depolarization induced phosphorylation of extracellular signal-regulated kinase (ERK) within 1 min in undifferentiated PC12 cells. Pretreatment of PC12 cells with the calcium chelator EGTA abolished depolarization-stimulated ERK phosphorylation, but NGF-induced phosphorylation of ERK was not affected. The chronic treatment of phorbol ester, which down-regulated the activity of protein kinase C (PKC), did not affect the phosphorylation of ERK upon depolarization. In the presence of an inhibitor of EGF receptor, neither depolarization nor calcium ionophore increased the level of ERK phosphorylation. These data imply that the EGF receptor is functionally necessary to activate ERK and neurite outgrowth in response to the prolonged depolarization in PC12 cells, and also that PKC is apparently not involved in this signaling pathway.

• Journal of Institute of Control, Robotics and Systems
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• v.20 no.1
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• pp.12-17
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• 2014

In this paper, we propose a controller capable of reducing the effect of measurement errors under AC and DC noise. Typically, the control system measures data through a sensor. If sensor noise is included in a controller via the feedback channel, the signal is distorted and the entire system cannot work normally. Therefore, some appropriate action to counter the measurement error effect is essential in the controller design. Our controller is equipped with a gain-scaling factor and a compensator to reduce the effect of measurement error in the feedback signal. Also, we use a switching control strategy to enhance the performance of the controller regarding convergence speed. Our proposed controller can therefore effectively reduce the AC and DC noise of the sensor. We analyze the proposed controller by Laplace transform technique and our control method is verified via MATLAB simulation.

• Natural Product Sciences
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• v.23 no.1
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• pp.1-4
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• 2017

Sinensetin, a pentamethoxyflavone, is known to exert various pharmacological activities including anti-angiogenesis, anti-diabetic and anti-inflammatory activities. However, its effects on the human mast cell - 1 (HMC-1) mediated inflammatory mechanism remain unknown. To explore the mediator and cellular inflammatory response of sinensetin, we examined its influence on phorbol 12-myristate 13-acetate (PMA) plus A23187 induced inflammatory mediator production in a human mast cell line. In this study, interleukin (IL)-6 production was measured using the enzyme-linked immunosorbent assay and reverse transcription polymerase chain reaction. Sinensetin inhibited PMA plus A23187 induced IL-6 production in a dose-dependent manner as well as IL-4, IL-5 and IL-8 mRNA expression. Furthermore, sinensetin inhibited signal transducer and activator of transcription 3 (STAT3) phosphorylation, suggesting that sinensetin inhibits the production of inflammatory mediators by blocking STAT3 phosphorylation. Moreover, sinensetin was found to inhibit nuclear factor kappa B activation. These findings suggest that sinensetin may be involved in the regulation of mast cell-mediated inflammatory responses.

• Journal of Institute of Control, Robotics and Systems
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• v.20 no.6
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• pp.641-646
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• 2014

In this paper, we propose a controller for a ball and beam system which reduces the measurement error effect under AC and DC noise. The ball and beam system measures data through a sensor. If sensor noise is included in a controller via the feedback channel, the signal is distorted and the entire system cannot work normally. Therefore, some appropriate action for the measurement error effect is essential in the controller design. Our controller is equipped with a gain-scaling factor and a compensator to reduce the effect of measurement error in the feedback signal. Effectively, our proposed controller can reduce the AC and DC noise of a feedback sensor. We analyze the proposed controller by Laplace transform technique and illustrate the improved control performance via an experiment for a ball and beam system.

• Journal of Ginseng Research
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• v.39 no.4
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• pp.299-303
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• 2015

Panax ginseng is a well-known economic medical plant that is widely used in Chinese traditional medicine. This species contains a unique class of natural products-ginsenosides. Recent clinical and experimental studies have presented numerous lines of evidence on the promising role of ginsenosides on different diseases including neurodegenerative diseases, cardiovascular diseases, and certain types of cancer. Nowadays, most of the attention has focused on ginsenoside Rd as a neuroprotective agent to attenuate ischemic stroke damages. Some of the evidence showed that ginsenoside Rd ameliorates ischemic stroke-induced damages through the suppression of oxidative stress and inflammation. Ginsenoside Rd can prolong neural cells' survival through the upregulation of the endogenous antioxidant system, phosphoinositide-3-kinase/AKT and extracellular signal-regulated protein kinase 1/2 pathways, preservation of mitochondrial membrane potential, suppression of the nuclear factor-kappa B, transient receptor potential melastatin, acid sensing ion channels 1a, poly(ADP-ribose) polymerase-1, protein tyrosine kinase activation, as well as reduction of cytochrome c-releasing and apoptosis-inducing factor. In the current work, we review the available reports on the promising role of ginsenoside Rd on ischemic stroke. We also discuss its chemistry, source, and the molecular mechanism underlying this effect.

• Journal of Environmental Science International
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• v.29 no.3
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• pp.249-255
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• 2020

Particulate matter with an aerodynamic diameter of less than 2.5 μM (PM_2.5) is one of the major environmental pollutants. Di(2-ethylhexyl) phthalate (DEHP), an endocrine disrupting chemical in PM_2.5, has been utilized for the manufacturing of polyvinyl chloride to increase the flexibility of final products. In the present study, we investigated the ecotoxicological effect of DEHP on the viability of skin keratinocytes (HaCaT). DEHP induced apoptotic cell death mediated by phosphorylation of extracellular signal-regulated kinase through the production of intracellular Reactive Oxygen Species (ROS). Interestingly, we found that DEHP induces the phosphorylation of the nuclear factor-kappa B responsible for the expression of cleaved caspase-3 as an executional cell death protease in HaCaT cells. On the basis of these results, we suggest that DEHP in PM_2.5 induces the apoptotic death of human keratinocytes via ROS-mediated signaling events.

• Journal of the Institute of Convergence Signal Processing
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• v.3 no.4
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• pp.42-48
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• 2002

The case that cannot show the satisfactory control results with a modeling error and a shortage of related knowledge about a plant is if a fuzzy controller designed based on the plant model or the experience applies to an actual plant. We must adjust the scale factor which is a controller again in order to improve control performance in case of this and needs a lot of time and costs because this regulation process is carried out with a trial and error way We proposes the fuzzy controller that an automatic control adjust scale factors according to fuzzy logic and normalizer in this paper We confirmed that an automatic adjusted fuzzy controller displayed good performance than the fuzzy controller that scale factors was fixed through simulation. We implemented the controller using the DSP processor and applied in a hydraulic servo system. And then we observed an experimental results.