• The Journal of Korean Institute of Electromagnetic Engineering and Science
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• v.19 no.9
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• pp.1010-1019
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• 2008

In this paper, we present a noise analysis and measurement results of a bio-radar system that can detect human heartbeat and respiration signals. The noise analysis including various phase noise effects is very important in designing the bio-radar system, since the frequency difference between the received signal and local oscillator is very small and the received power is very low. All of the noise components in a bio-radar system are considered from the point of view of SNR. From this analysis, it can be concluded that the phase noise due to antenna leakage is a dominant factor and is a function of range correlation. Therefore, the phase noise component with range correlation effect, which is the most important noise contribution, is measured using the measurement setup and compared with the calculated results. From the measurement results, our measurement setup can measure a closed-in phase noise of a free-running oscillator. Based on these results, it is possible to design a 2.4 GHz bio-radar system quantitatively which has a detection range of 50 cm and low power of 1 mW without additional PLL circuits.

• International Journal of Oral Biology
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• v.30 no.1
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• pp.23-30
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• 2005

Bone remodeling is a process controlled by the action of two major bone cells; the bone forming osteoblast and the bone resorbing osteoclast. In the process of osteoclastogenesis, stromal cells and osteoblast produce RANKL, OPG, and M-CSF, which in turn regulate the osteoclastogenesis. During the bone resorption by activated osteoclasts, extracellular $Ca^{2+}/{PO_4}^{2-}$ concentration and degraded organic materials goes up, providing the hypertonic microenvironment. In this study, we tested the effects of hypertonicity due to the degraded organic materials on osteoclastogenesis in co-culture system. It was examined the cellular response of osteoblastic cell in terms of osteoclastogenesis by applying the sucrose, and mannitol, as a substitute of degraded organic materials to co-culture system. Apart from the sucrose, mannitol, and NaCl was tested to be compared to the effect of organic osmotic particles. The addition of sucrose and mannitol (25, 50, 100, 150, or 200 mM) to co-culture medium inhibited the number of tartrate-resistant acid phosphatase (TRAP) positive multinucleated cells induced by 10 nM $1{\alpha},25(OH)_2vitaminD_3$ ($1{\alpha},25(OH)_2D_3$). However, NaCl did exert harmful effect upon the cells in this co-culture system, which is attributed to DNA damage in high concentration of NaCl. To further investigate the mechanism by which hypertonicity inhibits $1{\alpha},25(OH)_2D_3$-induced osteoclastogenesis, the mRNA expressions of receptor activator of nuclear factor (NF)-kB ligand (RANKL) and osteoprotegerin (OPG) were monitored by RT-PCR. In the presence of sucrose (50 mM), RANKL mRNA expression was decreased in a dose-dependent manner, while the change in OPG and M-CSF mRNA were not occurred in significantly. The RANKL mRNA expression was inhibited for 48 hours in the presence of sucrose (50 mM), but such a decrement recovered after 72 hours. However, there were no considerable changes in the expression of OPG and M-CSF mRNA. Conclusively, these findings strongly suggest that hypertonic stress down-regulates $1{\alpha},25(OH)_2D_3$-induced osteoclastogenesis via RANKL signal pathway in osteoblastic cell, and may playa pivotal role as a regulator that modulates osteoclastogenesis.

• The Journal of Korean Institute of Communications and Information Sciences
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• v.29 no.12A
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• pp.1319-1332
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• 2004

Multicarrier direct sequence code-division multiple access CDMA(MC DS-CDMA) is an attractive technique for achieving high data rate transmission even if the potentially large peak-to-average power ratio(PAPR) is an important factor for its application. On the other hand, code select CDMA(CS-CDMA) is an attractive technique with constant amplitude transmission of multicode signal irregardless of subchannels by introducing code selection method. In this paper we propose a new multiple access scheme based on the combination of MC DS-CDMA and CS-CDMA. Proposed scheme, which we called MC CS-CDMA, includes the sutclasses of MC DS-CDMA and CS-CDMA as special cases. The performance of this system is investigated for multipath Sequency selective fading channel and maximal ratio combining with rake receiver. In addition the PAPR of proposed system is compare with that of both MC BS-CDMA and CS-CDMA. Simulation results show that proposed system improves PAPR reduction than MC DS-CDMA at the expense of the complexity of receiver and the number of available non. Also, the numerical result shows that the proposed system is better performance than MC DS-CDMA due to the increasing processing gain and the number of time diversity gain.

• Journal of the Institute of Electronics Engineers of Korea TC
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• v.46 no.5
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• pp.26-35
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• 2009

OFDM (Orthogonal Frequency Division Multiplexing) system is robust to frequency selective fading and narrowband interference in high-speed data communications. However, an OFDM signal consists of a number of independently modulated subcarriers and the superposition of these subcarriers causes a problem that can give a large PAPR(Peak-to-Average Power Ratio). Phase rotation method can reduce the PAPR without nonlinear distortion by multiplying phase weighting factors. But computational complexity of searching phase weighting factors is increased exponentially with the number of subblocks and considered phase factor. Therefore, a new method, which can reduce computational complexity and detect phase weighting factors efficiently, should be developed. In this paper, a modeling process is introduced, which apply metaheuristic algerian in phase rotation method and optimize in PTS (Particle Swarm Optimization) scheme. Proposed algorithm can solve the computational complexity and guarantee to reduce PAPR We analyzed the efficiency of the PAPR reduction through a simulation when we applied the proposed method to telecommunication systems.

• Journal of the Institute of Electronics and Information Engineers
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• v.50 no.3
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• pp.102-112
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• 2013

In this paper, two step processing method of contour extraction and complement which contain hexagonal shape for low contrast and noisy images is proposed. This method is based on the combination of Laplacian-Gaussian filter and an idea of filters which are dependent on the shape. At the first step, an algorithm which has six masks as its extractors to extract the hexagonal edges especially in the corners is used. Here, two tricorn filters are used to detect the tricorn joints of hexagons and other four masks are used to enhance the line segments of hexagonal edges. As a natural image, a corneal endothelial cell image which usually has regular hexagonal form is selected. The edge extraction of hexagonal shapes in corneal endothelial cell is important for clinical diagnosis. The proposed algorithm and other conventional methods are applied to noisy hexagonal images to evaluate each efficiency. As a result, this proposed algorithm shows a robustness against noises and better detection ability in the aspects of the output signal to noise ratio, the edge coincidence ratio and the extraction accuracy factor as compared with other conventional methods. At the second step, the lacking part of the thinned image by an energy minimum algorithm is complemented, and then the area and distribution of cells which give necessary information for medical diagnosis are computed.

• The Journal of Korean Institute of Electromagnetic Engineering and Science
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• v.16 no.11 s.102
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• pp.1059-1066
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• 2005

This paper reports an application of Doherty amplifier for efficiency improvement of feedforward power amplifier(FPA). For performance analysis, we measured 15 W average output power using WCDMA 4FA input signal with a center frequency 2.14 GHz. The applied Doherty amplifier presents the characteristics of high efficiency and low linearity in comparison to the class AB amplifier, and it was used as main amplifier of FPA fir efficiency improvement. To analyze the change of characteristic, tow Doherty amplifiers whose linearity and efficiency are different were applied. The applied FPAs are improved about $2\%$ or more performance in efficiency, but decreased in linearity on 15 W average output power. We additionally modified the coupling factor(CF) of the error loop and the error amplifier capacity for linearity improvement. Aa a result, the efficiency improvement and high linearity resulted from the change of CF and error amplifier capacity. However, we think if the linearity of Doherty amplifier were more than 35 dBc, the FPA would improve the performance about $2\%$ or more efficiency and maintain enough linearity.

• The Journal of Korean Institute of Electromagnetic Engineering and Science
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• v.19 no.3
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• pp.376-383
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• 2008

Generally a return current plane(RCP) of high speed digital and analog part is partitioned. This is achieved in order to decrease the noise interference between subsystem in PCBs(Printed Circuit Boards). However, when the connected signal line exists between each subsystem, this partition will cause unwanted effects. In a EMI(Electromagnetic Interference) point of view, the partition of the return current plane becomes a primary factor to increase the radiated emission. Component bridge(CB) is used for the way of maintaining radiated emission, still specific user's guide doesn't give sufficient principle. In a view point of EMI, design principle of multi-CB using method will be analyzed by measurement. And design principle of noise mitigation will be provided. Generally interval of multi-CB is ${\lambda}/20$ ferrite bead. In this study, When multi-CB connection is applied, design principle of ferrite bead and chip resistor is proved by measurement. Multi-connected chip resistance$(0{\Omega})$ is proved to be more effective design method in the point of EMI.

• Journal of the Korean Society of Radiology
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• v.10 no.5
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• pp.367-373
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• 2016

This study conducted an analysis to compare the differences in the properties of the magnetic field and the generation of artifacts because of the difference in the magnetic field between 1.5 T equipment and 3.0 T equipment, centering around four types of pulse sequences, mainly applied to the abdominal Magnetic Resonance Imaging (MRI). With data on 500 persons transmitted to the PACS, this study analyzed the SNR value, quantitatively and carried out a qualitative evaluation, dividing MSA, CSA, and DA into three steps. As a result of the quantitative evaluation, the SNR value was significantly higher in the 1.5 T equipment; however, there was a factor deteriorating the image quality, too, as artifacts were generated in the images. The 1.5 T equipment generated fewer artifacts than the 3.0 T equipment did, so it could compensate the image quality for 3.0 T. In conclusion, based on these findings, this study could understand the differences in the properties of the magnetic field and the generation of artifacts occurring because of the difference in the magnetic field and could provide a measure for them. This study would be guidelines for MRI users who directly examine the patients in abdominal MRI using the two types of equipment in the clinical setting in the future.

• Journal of the Korean Society of Radiology
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• v.4 no.3
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• pp.13-18
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• 2010

Purpose : Diffusion tensor imaging(DTI) allows the visualization of fiber tract damage in patients with cerebral infarction. The purpose of this study is to evaluate the correlation between degree of NIH stoke scale and fractional anisotropy (FA) in patient with cerebral infarction. Material and Methods : 16 patients aged 36~77 years(male : 11, female : 5, mean age : 61y), diagnosed cerebral infarction by diffusion weighted imaging(DWI), underwent 24 directional diffusion tensor imaging(DTI). Patients had the DTI taken within 3days of stroke onset. Comparison of DWI, FA value on DTI were measured infarcted area and counter part of specific region of interest (ROI). And evaluation of differences between clinically improved patient group (n=9) and unimproved patient group (n=7) until 2 week follow up after development of cerebral infarction. Clinical status was scaled by NIH stroke scale. Results : Quantitative measurements of FA confirmed statistically the significant diffusion changes in the infarct compared with the matched-counter part region. In DWI, the infarcted area shows high signal intensity, however FA value on DTI was lower than normal brain parenchyma. The FA value of clinically improved patient by NIH stroke scale was 0.49, and the value of contralateral normal brain parenchyma was 0.41. On the contrary, FA value of infarcted area shows about 15% lower than normal brain parenchyma. But, the FA value of unimproved patient by NIH stroke scale represents a half those of contralateral normal brain parenchyma (0.28 on infarcted area vs. 0.56 on normal brain parenchyma). So, the FA value of unimproved patient group was considerably less than those of improved. Conclusion : It is concluded that the unimproved patient group after cerebral infarction showed much less FA value than that of normal brain parenchyma. The FA value of DTI may be one of the useful parameter to predict outcome of cerebral infarction patients.

• Biomolecules & Therapeutics
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• v.24 no.5
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• pp.529-535
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• 2016

Atopic dermatitis (AD) results from gene and environment interactions that lead to a range of immunological abnormalities and breakdown of the skin barrier. Protease-activated receptor 2 (PAR2) belongs to a family of G-protein coupled receptors and is expressed in suprabasal layers of the epidermis. PAR2 is activated by both trypsin and a specific agonist peptide, SLIGKV-$NH_2$ and is involved in both epidermal permeability barrier homeostasis and epithelial inflammation. In this study, we investigated the effect of lobaric acid on inflammation, keratinocyte differentiation, and recovery of the skin barrier in hairless mice. Lobaric acid blocked trypsin-induced and SLIGKV-$NH_2$-induced PAR2 activation resulting in decreased mobilization of intracellular $Ca^{2+}$ in HaCaT keratinocytes. Lobaric acid reduced expression of interleukin-8 induced by SLIGKV-$NH_2$ and thymus and activation regulated chemokine (TARC) induced by tumor necrosis factor-a (TNF-${\alpha}$) and IFN-${\gamma}$ in HaCaT keratinocytes. Lobaric acid also blocked SLIGKV-$NH_2$-induced activation of ERK, which is a downstream signal of PAR2 in normal human keratinocytes (NHEKs). Treatment with SLIGKV-$NH_2$ downregulated expression of involucrin, a differentiation marker protein in HaCaT keratinocytes, and upregulated expression of involucrin, transglutamase1 and filaggrin in NHEKs. However, lobaric acid antagonized the effect of SLIGKV-$NH_2$ in HaCaT keratinocytes and NHEKs. Topical application of lobaric acid accelerated barrier recovery kinetics in a SKH-1 hairless mouse model. These results suggested that lobaric acid is a PAR2 antagonist and could be a possible therapeutic agent for atopic dermatitis.