• BMB Reports
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• 제35권1호
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• pp.67-86
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• 2002

Three routes have been identified triggering neuronal death under physiological and pathological conditions. Excess activation of ionotropic glutamate receptors cause influx and accumulation of $Ca^{2+}$ and $Na^+$ that result in rapid swelling and subsequent neuronal death within a few hours. The second route is caused by oxidative stress due to accumulation of reactive oxygen and nitrogen species. Apoptosis or programmed cell death that often occurs during developmental process has been coined as additional route to pathological neuronal death in the mature nervous system. Evidence is being accumulated that excitotoxicity, oxidative stress, and apoptosis propagate through distinctive and mutually exclusive signal transduction pathway and contribute to neuronal loss following hypoxic-ischemic brain injury. Thus, the therapeutic intervention of hypoxic-ischemic neuronal injury should be aimed to prevent excitotoxicity, oxidative stress, and apoptosis in a concerted way.

• 대한원격탐사학회:학술대회논문집
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• 대한원격탐사학회 2008년도 International Symposium on Remote Sensing
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• pp.192-195
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• 2008

Radio occultation (RO) has been used in the planetary science since Microlab-1 was launched in 1995. With the RO technique, the profiles of atmosphere and the global atmospheric data can be obtained. In 2006, Taiwan launched six low Earth orbit (LEO) satellites as the RO constellation mission, known as FORMOSAT-3. In order to retrieve the RO data from original data, a retrieval algorithm, NCURO, is developed. The input of NCURO algorithm is mainly the excess phase of GPS signal, and the output is the dry pressure and dry temperature. Using temperature profiles retrieved by NCURO algorithm, temperature perturbation and potential energy of gravity wave have been evaluated. In this paper, the retrieval algorithm and the global distribution of energy of gravity waves are described and demonstrated.

• Journal of applied mathematics & informatics
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• 제29권1_2호
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• pp.427-442
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• 2011

Calcium is a vital second messenger for signal transduction in neurons. Calcium plays an important role in almost every part of the human body but in neuronal cytosol, it is of utmost importance. In order to understand the calcium signaling mechanism in a better way a finite element model has been developed to study the flow of calcium in two dimensions with time. This model assumes EBA (Excess Buffering Approximation), incorporating all the important parameters like time, association rate, influx, buffer concentration, diffusion constant etc. Finite element method is used to obtain calcium concentration in two dimensions and numerical integration is used to compute effect of time over 2-D Calcium profile. Comparative study of calcium signaling in two dimensions with time is done with other important physiological parameters. A MATLAB program has been developed for the entire problem and simulated on an x64 machine to compute the numerical results.

• 한국통신학회논문지
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• 제21권8호
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• pp.2033-2042
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• 1996

In this papre, we describe a recently implemented echo canceller for digital cellular communication of Code Division Multiple Access(CDMA) that features time sharing of digital signal processor(DSP) over four channels in one DSP to reduce per channel costs. In the Public Land Mobile Network(PLMN), it is important to cancel the echo reflected from the Public Switched Telephone Network(PSTN) side. In case of digital mobile system, the round-trip delay of the echo is in excess of about 180 milliseconds due to frame-by-frame voice coding. It is necessary to cancel the echo in PLMN. We have developed a multi-channel echo canceller tht operates with Time Switch Module in a Mobile Switching Center(MSC). The general echo canceller needs PCM trunk interface circuits and the tone detection and disabling circuits, but the multi-channel echo canceller linked with Time Switch Module does not need them. Therefore we could develop the effective and economical echo canceller.

• 센서학회지
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• 제22권4호
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• pp.297-301
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• 2013

We proposed and demonstrated a distributed fiber-optic overheating detection sensor using optical time domain refrectometry. With increased of temperature the optical fiber is bended by a bi-metal and it result in optical leaky loss of the fiber. The sensor structure is designed in such a way that the signal of overheating is happen when the temperature exceeding a threshold temperature and the optical fiber is protected from excess bending.

• Geomechanics and Engineering
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• 제19권3호
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• pp.229-240
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• 2019

The physical models are useful to understand the soil behaviour. Hence, these tools allow validating analytical theories and numerical data. This paper addresses the design, construction and implementation of a physical model able to simulate the soil liquefaction under different cyclic actions. The model was instrumented with a piezoelectric actuator and a set of transducers to measure the porewater pressures, displacements and accelerations of the system. The soil liquefaction was assessed in three different grain size particles of a natural sand by applying a sinusoidal signal, which incorporated three amplitudes and the fundamental frequencies of three different earthquakes occurred in Colombia. In addition, such frequencies were scaled in a micro shaking table device for 1, 50 and 80 g. Tests allowed identifying the liquefaction susceptibility at various frequency and displacement amplitude combinations. Experimental evidence validated that the liquefaction susceptibility is higher in the fine-grained sands than coarse-grained sands, and showed that the acceleration of the actuator controls the phenomena trigging in the model instead of the displacement amplitude.

• 마이크로전자및패키징학회지
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• 제17권4호
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• pp.73-76
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• 2010

A two-facet approach was used to investigate the parametric performance of functional high-speed DDR3 (Double Data Rate) DRAM (Dynamic Random Access Memory) die placed in different types of BGA (Ball Grid Array) packages: wire-bonded BGA (FBGA, Fine Ball Grid Array), flip-chip (FCBGA) and lead-bonded $microBGA^{(R)}$. In the first section, packaged live DDR3 die were tested using automatic test equipment using high-resolution shmoo plots. It was found that the best timing and voltage margin was obtained using the lead-bonded microBGA, followed by the wire-bonded FBGA with the FCBGA exhibiting the worst performance of the three types tested. In particular the flip-chip packaged devices exhibited reduced operating voltage margin. In the second part of this work a test system was designed and constructed to mimic the electrical environment of the data bus in a PC's CPU-Memory subsystem that used a single DIMM (Dual In Line Memory Module) socket in point-to-point and point-to-two-point configurations. The emulation system was used to examine signal integrity for system-level operation at speeds in excess of 6 Gb/pin/sec in order to assess the frequency extensibility of the signal-carrying path of the microBGA considered for future high-speed DRAM packaging. The analyzed signal path was driven from either end of the data bus by a GaAs laser driver capable of operation beyond 10 GHz. Eye diagrams were measured using a high speed sampling oscilloscope with a pulse generator providing a pseudo-random bit sequence stimulus for the laser drivers. The memory controller was emulated using a circuit implemented on a BGA interposer employing the laser driver while the active DRAM was modeled using the same type of laser driver mounted to the DIMM module. A custom silicon loading die was designed and fabricated and placed into the microBGA packages that were attached to an instrumented DIMM module. It was found that 6.6 Gb/sec/pin operation appears feasible in both point to point and point to two point configurations when the input capacitance is limited to 2pF.

• 농약과학회지
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• 제8권2호
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• pp.88-94
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• 2004

농약제품 중 개별부자재의 확인을 위한 분석도구로서 NMR 분광기를 사용하였고 부자재의 표준품 및 농약제품을 분석 비교하였다. 고분자물질인 계면활성제는 co-polymer였고 많은 ethylene 그룹으로 이루어졌다. 가장 두드러진 signal은 긴 체인의 polyoxyethylene 그룹으로 70.5 ppm에서 나타났고 Ester의 carbnyl 그룹은 173.5 ppm에서 자기공명 signal을 확인할 수 있었다. 분석 시료는 정제, 농축, 또는 크로마토그래피의 과정 없이 준비되었고 개별부자재의 확인은 분석된 시료와 표준품 스펙트럼과의 비교에 의하여 가능할 수 있었다. NMR 분광기는 전처리과정 없이 농약제품 중 개별부자재의 분석이 가능하였다.

• 한국인터넷방송통신학회논문지
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• 제14권6호
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• pp.251-257
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• 2014

모터의 일종으로서 엑츄에이터는 전기 에너지를 운동 에너지로 변환하기 위하여 전류를 이용하여 동작하는 메커니즘을 제어하는 시스템이다. 전압을 가청 신호로 변환하는 기능을 갖는 오디오 액츄 에이터로서는 스피커와 증폭기가 흔히 사용된다. 산업 현장에서는 고출력 고양질의 전력 시스템이 필요하다. 이러한 시스템들이 품질이 좋은 출력을 생성하기 위하여 오디오 시스템의 출력 임피던스를 제어해야 만 한다. 우리는 이 논문에서 가변 부하가 연결되어 있는 능동 증폭기 시스템을 구동하기 위한 적응 특성을 전력 공급기를 제시한다. 전기 신호를 오디오 신호로 변환하는 스피커의 저항값이 변동함에 따라 능동 증폭기에 대한 전력 공급 장치는 부하값의 변동에 적응하여 스피커에 최대 전력을 공급하며, 피크전류의 급격한 변동과 과잉전류의 흐름으로부터 증폭기를 보호하게 된다.

• 융합신호처리학회논문지
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• 제7권4호
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• pp.195-200
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• 2006

자동차용 ABS/TCS 시스템의 기존 개별소자 회로를 시험하고, 시스템의 문제점을 컴퓨터 시뮬레이션으로 분석하였다. ABS/TCS 시스템의 성능을 개선하기 위해 에러 보상회로, 비교기 및 UVLO 회로를 가진 인터페이스 IC를 설계하고, 전기적 특성을 조사하였다. 전압 조절기는 자동차 환경에 견디기 위해 $-20^{\circ}C$에서 $120^{\circ}C$ 사이의 온도 범위에서 온도변화를 보상하도록 하였고, ABS와 브레이크는 같은 주파수와 다른 주파수의 듀티 계수를 사용하여 분리하였다. UVLO 회로와 정전압 회로는 잡음을 제거하기 위해 적용하였고, 과도 전류를 제한하기 위해 보호회로를 사용하였다. ABS/TCS 시스템의 전기적 성능을 향상시키기 위해 IC 제조를 위한 레이아웃을 설계하였다. 제작된 마스크 패턴은 11개로 구성하였으며, 전류 손실을 줄이기 위해 8개의 패드를 유효하게 배치하였다. 브레드보드 시험치와 레이아웃을 설계한 후 시뮬레이션의 시험치를 비교한 결과 시뮬레이션과 브레드보드 실험치가 거의 일치하거나 우수한 결과를 가짐을 알 수 있었다.