• Asian Pacific Journal of Cancer Prevention
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• v.16 no.6
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• pp.2495-2499
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• 2015

Mitogen-activated protein kinase/extracellular signal-regulated kinase kinase kinase 3 (MEKK3) is an important serine/threonine protein kinase and a member of the MAPK family. MEKK3 can effectively activate the MEK/ERK signaling pathway and promote an autocrine growth loop critical for tumor genesis, cell proliferation, terminal differentiation, apoptosis and survival. To explore the relationship between MEKK3 and cell apoptosis, clinicopathology and prognosis, we characterize the expression of MEKK3, pERK and FoxP3 in the renal clear cell carcinoma (RCCC). Protein expression was detected by tissue microarray and immunochemistry in 46 cases of RCCC and 28 control cases. Expression levels of CD3+,CD3+CD4+,CD3+CD8+,CD4+CD25+, CD4+CD25+ FoxP3+ were assessed by flow cytometry and analyzed for their association with pathological factors, correlation and prognosis in RCCC. Expression of MEKK3, pERK and FoxP3 was significantly up-regulated in RCCC as compared to control levels (p<0.01), associated with pathological grade (p<0.05)and clinical stage (p<0.05). CD4+CD25+ Foxp3+ Treg cells were also significantly increased in RCCC patients (p<0.05). Cox multivariate regression analysis showed that MEKK3, pERK expression and patholigical stage were independent prognostic factors in patients with RCCC (p<0.05). MEKK3 can be used as an important marker of early diagnosis and prognostic evaluation in RCCC. It may be associated with imbalance of anti-tumor immunity and overexpression of pERK. Expression of MEKK3 and pERK are significantly increased in RCCC, with protein expression and clinical stage acting as independent prognostic factors.

• Proceedings of the Korean Society for Cognitive Science Conference
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• 2006.06a
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• pp.53-58
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• 2006

We examined the cerebral activation of the emotional and linguistic attributes during the visual word recognition. This research investigated the affective priming effect preserving the behavioral paradigm. We used the primed-evaluation task in which the participants classify the target as positive or negative, and manipulated the emtional attributes by emtional relations of the prime-target word pairs(PP, PN, NP, NN). ROIs analyses for the semantic processing and emotional processing were performed. The results showed that the semantic processing areas including the IPL, SMG, and aSTS were activated differently according to the experimental condition. The activations of the IPL were increased only on the NN condition, whereas the activation of the SMG was decreased only on the PP condition. Furthmore, the activation of the emotional processing areas including the mPFC and ACC, was different according to the emotional realtions of word pairs. Similar to the SMG, the BOLD signal of the mPFC was decreaed only on the PP condition, whereas the activation of ACC was Increased only on the NN condition. These results were seemed to show the interact ive cerebral activations for processing the emtoional and linguistic attributes in a word, during visual word recognition.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.8 no.2
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• pp.185-188
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• 2007

Lately, the modulated EGR system that includes EGR valve and EGR cooler is being installed in diesel engines fur the purpose of the simultaneous reduction of NOx and PM. In this study. we designed and constructed a test bench for the performance evaluation of the modulated EGR system, and tested an electronically controlled EGR valve for 2.0 L diesel engines. The performance of the EGR valve was evaluated in terms of the valve lift behavior. the valve opening/closing response, and the mass flow rate through the valve. The valve lift with respect to the duty ratio of PWM signal was non-linear, and followed a different path fur valve opening and closing, that is, hysteresis. The valve opening response was concluded satisfactory falling within the usual standard response time. For the duty ratio of 40 to 60%, the mass flow rate through the valve was observed to depend on the pressure difference across the valve as well as the duty ratio, while it solely depended on the pressure difference fur the duty ratio above 60%.

• Journal of the Korea Institute of Information and Communication Engineering
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• v.5 no.1
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• pp.166-172
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• 2001

A RF wideband receiver for INMARSAT-B satellite communications system was composed of low noise amplifier and high gain amplifier, The low noise amplifier used to the resistive decoupling circuit for input impedance matching and self-bias circuits for low noise. The high gain amplifier consists of matched amplifier type to improve receiver gain. The active bias circuit can be used to provide temperature stability without requiring the large voltage drop or relatively high-dissipated power needed with a bias stabilization resistor. The bandpass filter was used to reduce a spurious level. As a result, the characteristics of the receiver implemented here show more than 60 dB in gain and less than 1.8:1 in input and output voltage standing wave ratio(VSWR), especially the carrier to noise ratio which is input signal level -126.7 dB m at 1537.5 MHz is a 45.23 dB /Hz at a 1.02 kHz.

• Journal of Korea Multimedia Society
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• v.16 no.10
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• pp.1171-1179
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• 2013

Interactive audio service provide with audio generating and editing functionality according to user's preference. A spatial audio object coding (SAOC) scheme is audio coding technology that can support the interactive audio service with relatively low bit-rate. However, when the SAOC scheme remove the specific one object such as vocal object signal for Karaoke mode, the scheme support poor quality because the removed vocal object remain in the SAOC-decoded background music. Thus, we propose a new SAOC vocal harmonic extranction and elimination technique to improve the background music quality in the Karaoke service. Namely, utilizing the harmonic information of the vocal object, we removed the harmonics of the vocal object remaining in the background music. As harmonic parameters, we utilize the pitch, MVF(maximum voiced frequency), and harmonic amplitude. To evaluate the performance of the proposed scheme, we perform the objective and subjective evaluation. As our experimental results, we can confirm that the background music quality is improved by the proposed scheme comparing with the SAOC scheme.

• Journal of Biomedical Engineering Research
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• v.20 no.4
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• pp.435-442
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• 1999

A fuzzy-ART(adaptive resonance theory) network for the PVC(premature ventricular contraction) classification using wavelet coefficient is designed. This network consists of the feature extraction and learning of the fuzzy-ART network. In the first step, we have detected the QRS from the ECG signal in order to set the threshold range for feature extraction and the detected QRS was divided into several frequency bands by wavelet transformation using Haar wavelet. Among the low-frequency bands, only the 6th coefficient(D6) are selected as the input feature. After that, the fuzzy-ART network for classification of the PVC is learned by using input feature which comprises of binary data converted by applying threshold to D6. The MIT/BIH database including the PVC is used for the evaluation. The designed fuzzy-ART network showed the PVC classification ratio of 96.52%.

• The Journal of Korean Institute of Communications and Information Sciences
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• v.31 no.3C
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• pp.237-244
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• 2006

I/Q phase unbalance caused by non-ideal circuit components is inevitable physical phenomenons and leads to performance degradation when we implement a practical coherent M-ary phase shift keying(M-PSK) demodulator. In this paper, we present an exact and general expression involving two-dimensional Gaussian Q-functions for the bit error rate(BER) of uniform M-PSK with I/Q phase unbalance over an additive white Gaussian noise(AWGN) channel. First we derive a BER expression for the k-th bit of 8, 16-PSK signal constellations when Gray code bit mapping is employed. Then, from the derived k-th bit BER expression, we present the exact and general average BER expression for M-PSK with I/Q phase unbalance. This result can readily be applied to numerical evaluation for various cases of practical interest in an I/Q unbalanced M-PSK system, because the one- and two-dimensional Gaussian Q-functions can be easily and directly computed using commonly available mathematical software tools.

• The Journal of Korean Institute of Communications and Information Sciences
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• v.19 no.6
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• pp.1064-1074
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• 1994

In this paper, an optimum TCM(trellis coded modulation)combined with CPM(continuous phase modulation) signal is investigated, and the performances are evaluated on the two-ray fading channel, which is one of the well-known frequency-selected because of their relatively good power and spectrum efficiency, and the modulation index is varied from 0.1 to 0.6. The performance is evaluated for each modulation index. The constraint length of the encoder, which is comprised in TCM, is chosen to be 2 and 3. From the performance evaluations, when the constraint length is 3 and modulation index 0.5, a power gain if the optimum TCM over the scheme without coding is observed to be 2.0dB for 1REC and 2.1dB for 3RC, respectively, on the fading channel. Thus, a significant improvement on the line quality is expected when the optimum TCM presented in this paper is employed in digital mobile radio applications.

• The Transactions of the Korean Institute of Electrical Engineers C
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• v.50 no.8
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• pp.387-393
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• 2001

This paper describes an advanced measuring method and precise evaluation of the ground resistance for the grounding system of energized substations and power equipments. A grounding system of substations consists of all interconnected grounding connections of grounded conductors, neutral ground wires, underground conductors of distribution lines, cable shields, grounding terminals of equipments, and etc. It is very difficult to measure the accurate ground resistance of the grounding terminals of equipments, and etc. It is very difficult to measure the accurate ground resistance of the grounding system of high voltage energized substations because of harmonic components caused by switched power supplies or overloads. The conventional fall-of-potential method may be subject to big error if stray ground currents and potentials are present. In this work, to improve the precision in measurements of the ground resistance by eliminating the effects of harmonic components and stray currents and potentials, the investigations of the ground resistance measurement by using a low pass filter in a model energized grounding system were conducted. The accuracy of ground resistance mesurements was evaluated as a function of the ratio of the test signal to noise (S/N). The errors due to the proposed ground resistance measurement method were decreased with increasing S/N and were less than 5[%] as S/N is 10. The proposed ground resistance measurement method appears to be considerably more accurate than the conventional fall-of -potential method. It is allows cancellation of the parasitic resistance of energized grounding systems, to employ the measurement method that allows cancellation of the parasitic effects due to other circulating ground currents and ground potential rises in practical situations.

• Journal of the Ergonomics Society of Korea
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• v.34 no.2
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• pp.85-101
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• 2015

Objective: The purpose of this study was to develop and evaluate smart secondary controls using iPad for the drivers with physical disabilities in the driving simulator. Background: The physically disabled drivers face problems in the operation of secondary control devices that accept a control input from a driver for the purpose of operating the subsystems of a motor vehicle. Many of conventional secondary controls consist of small knobs or switches that physically disabled drivers have difficulties in grasping, pulling or twisting. Therefore, their use while driving might increase distraction and workload because of longer operation time. Method: We examined the operation time of conventional and smart secondary controls, such as hazard warning, turn signal, window, windshield wiper, headlights, automatic transmission and horn. The hardware of smart secondary control system was composed of iPad, wireless router, digital input/output module and relay switch. We used the STISim Drive3 software for driving test, customized Labview and Xcode programs for interface control of smart secondary system. Nine subjects were involved in the study for measuring operation time of secondary controls. Results: When the driver was in the stationary condition, the average operation time of smart secondary devices decreased 32.5% in the normal subjects (p <0.01), 47.4% in the subjects with left hemiplegic disabilities (p <0.01) and 38.8% in the subjects with right hemiplegic disabilities (p <0.01) compared with conventional secondary devices. When the driver was driving for the test in the simulator, the average operation time of smart secondary devices decreased 36.1% in the normal subjects (p <0.01), 41.7% in the subjects with left hemiplegic disabilities (p <0.01) and 34.1% in the subjects with right hemiplegic disabilities (p <0.01) compared with conventional secondary devices. Conclusion: The smart secondary devices using iPad for people with hemiplegic disabilities showed significant reduction of operation time compared with conventional secondary controls. Application: This study can be used to design secondary controls for adaptive vehicles and to improve the quality of life of the people with disabilities.