• 제목/요약/키워드: Side-effect

검색결과 5,236건 처리시간 0.046초

인공고관절 골흡수로 인한 응력분포 변화의 2차원 유한요소 해석 (Two-Dimensional Finite Element Analysis of Bone Resorption from the Artificial Hip Replacement)

  • 최형연;채수원;김성곤
    • 대한의용생체공학회:의공학회지
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    • 제16권1호
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    • pp.25-32
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    • 1995
  • Clinically, proximal bone resorption in the femur is frequently seen postoperatively on the follow up XI-rays after total hip replacement (THR). We developed the finite element model of cementless THR. The model is two dimensional side plate model, whereby the three dimensional structural integrity of the bone can be accounted for by a separate two dimensional mesh, a side plate. The subject of this article is the development and application of this two dimensional side plate FEM to study the reverse effect of the various degree of bone resorption of femur after THR. The results of this study indicates that 1) two dimensional side plate model is good and simple alternative to complex three dimensional model and 2) the severity of the proximal bone resorption has the effect of more increasing stress on the cortex at the level of femoral stem tip.

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암반에 근입된 현장타설말뚝의 주면지지력 (Side Shear Resistance of Drilled Shafts in Rock)

  • 권오성;김병철;김명모
    • 한국지반공학회:학술대회논문집
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    • 한국지반공학회 2005년도 춘계 학술발표회 논문집
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    • pp.611-618
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    • 2005
  • In this research, the effect of rock mass weathering on the side shear resistance of drilled shaft socketed into weathered rock was investigated. For that, a database of 23 cast-in-place concrete piles with diameters varying from 400mm to 1,500mm were socketed into weathered igneous/meta-igneous rock at four different sites. The static axial load tests were performed to examine the resistant behavior of the piles, and a comprehensive field/laboratory testing program at the field test site was also performed to describe the in situ rock mass conditions quantitatively. No correlation was found between the compressive strengths of intact rock and the side shear resistance of weathered/soft rock. The ground investigation data regarding the rock mass conditions (e.g. $E_m,\;E_{ur},\;_{plm}$, RMR, RQD, j) was found to be highly correlated with the side shear resistance, showing the coefficients of correlation greater than 0.7 in most cases. Additionally, the applicability of existing methods for the side shear resistance of piles in rock was verified by comparison with the field test data. The existing empirical relations between the compressive strength of intact rock and the side shear resistance(Horvath (1982), Rowe & Armitage(1987) etc.) appeared to overestimated the side shear resistance of all piles tested in this research unless additional consideration on the effect of rock mass weathering or fracturing was applied. The existing methods which consider the effect of rock mass condition were modified and/or extended for weathered rock mass where mass factor j is lower than 0.1, and RQD is below 50%.

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고참(苦參)이 항암제(抗癌劑) cisplatin의 간(肝).신장(腎臟) 부작용(副作用) 감소(減少)에 미치는 영향(影響) (Inhibitory Effects of Sophora flavescens on the Hepatic & Renal Side Effects of Chemotherapy by Cisplatin)

  • 김진철;이경민;변부형;임성철;정태영;서정철;한상원
    • Korean Journal of Acupuncture
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    • 제22권3호
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    • pp.165-174
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    • 2005
  • Objective : The objective of this study is to investigate the inhibitor effects of an traditional oriental herb, Sophora flavescens on the hepatic and renal side effects of chemotherapy by using B16-BL6 melanoma-injected C57BL6 mouse tumor model. Methods : In this study, the effects of an traditional oriental herb, Sophora flavescens, on the side effects of chemotherapy were studied using B16 melanoma-injected C57BL6 mouse tumor model. Results : Sophora flavescen has significant effect on the reduction of the side effects of chemotherapy. Sophora flavescen recovered the reduction of WBC and RBC during cisplatin chemotherapy. Water extract of Sophora flavescens significantly inhibited cisplatin-induced increase of serum blood urea nitrogen (BUN) which is a good indicator of renal toxicity. Sophora flavescens extract does not decrease the anti-tumor activity of cisplatin showing that it can selectively inhibit side effects of anticancer drugs preserving beneficial effort. Conclusion : Theses results suggest a possibility that Sophora flavescens extract can be used for cancer patients for the reduction of the side effects and improving the quality of life during chemotherapy of cancer patients.

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정규압밀된 연약점토의 압밀시험시 측면 마찰의 영향 (Effect of Side Friction on Consolidation Test of Normally Consolidated Kaolinite Slurry)

  • 이장근
    • 한국지반환경공학회 논문집
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    • 제9권3호
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    • pp.61-68
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    • 2008
  • 압밀시험시 시료의 두께에 대한 직정의 비율이 크면 일반적으로 측면마찰은 없다고 간주된다. 그러나, 시료의 두께가 커질수록 측면 마찰의 영향은 무시할 수 없게 된다. 본 연구에서는 정규압밀된 카올리나이트 슬러리의 압밀시험시 측면마찰의 영향을 조사하였다. 압밀시험을 통해 압밀시험곡선, 과잉간극수압, 압밀-간극비, 투수계수-간극비 관계를 측정하였고, 압밀-간극비 관계에 있어 측면마찰의 영향을 고려하기 위해 Taylor(1942)가 제안한 식을 적용하였다. 측정된 압밀시험곡선과 과잉간극수압에 대해 수치해석 결과와 비교 분석을 통해 측면 마찰이 압밀시험에 미치는 영향을 검토하였다. 그 결과, 측면 마찰의 영향을 고려한 수치해석 결과는 측면 마찰을 무시한 결과보다 측정값에 근사한 것으로 나타났으며, 측면 마찰은 압밀-간극비 관계 뿐만 아니라 압밀시간에도 영향을 주는 요인이라는 결과를 얻을 수 있었다.

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열전소자를 이용한 배수형 전자제습기 개발 (Development of a Drain-Type Electronic Dehumidifier Using Thermoelectric Element)

  • 강덕홍;김성완;김기홍
    • 대한기계학회:학술대회논문집
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    • 대한기계학회 2007년도 춘계학술대회B
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    • pp.3524-3528
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    • 2007
  • In this study, the Peltier effect was applied to eliminate moistures in the air enclosed by a cabinet. We have developed the new electronic dehumidifier which has a new function of automatically evaporating the condensed water inner cabinet into the outside air. To obtain this function, the processes of dehumidification is that it condensed the moistures on the cold side heat sink and drained it into the hot side heat sink by the both gravitational and capillary forces and the droplets on the hot side heat sink surface was evaporated into the air outside the cabinet by the heat conducted through the hot side heat sink surface and the forced heat convection through the fan for cooling hot side heat sink. Compared to existing electronic dehumidifiers, this manufactured one showed a good performance that the electric power consumption for the same dehumidifying quantity was reduced by 50% compared with that of existing ones.

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비정렬 격자 직접모사법을 이용한 희박 유동과 측면 제트의 상호 작용에 관한 연구 (DSMC Calculation of the Hypersonic Free Stream and the Side Jet Flow Using Unstructured Meshes)

  • 김민규;권오준;안창수
    • 한국전산유체공학회:학술대회논문집
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    • 한국전산유체공학회 2004년도 춘계 학술대회논문집
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    • pp.126-131
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    • 2004
  • The interaction between the hypersonic free stream and the side jet flow at high altitudes is investigated by direct simulation Monte Carlo(DSMC) method. Since there is a great difference in density between the free stream and the side jet flow, the weighting factor technique which could control the number of simulation particles, is applied to calculate these two flows simultaneously. Chemical reactions are not considered in the calculation. For validation, the corner flow passing between a pair of plates that are perpendicularly attached is solved. The side jet flow is then injected into this comer flow and solution is found for the merged flow. Results are compared with the experiments. For a more realistic rocket model, the flow past a blunted cone cylinder shape is solved. The leeward or windward jet injection is merged with this flow. The effect on the rocket surface is observed at various flow angles. The lambda effect and the wake structure are found like low attitudes. High interaction between the free stream and the side jet flow is observed when the side jet is injected in the windward direction.

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그라우저에 의해 발생되는 궤도의 측면추진력 예측 (The Prediction of Side Thrust Generated by Grousers Under Track)

  • 박원엽;이규승;박준걸
    • Journal of Biosystems Engineering
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    • 제25권1호
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    • pp.1-10
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    • 2000
  • This study was conducted to develop the mathmatical model for predicting the side thrust which is generated by the shearing action on the vertical surfaces of the sides of the track. Experiments were conducted with the three different shear plates with grouser length of 1, 3 and 5 cm for two different soil condition using soil bin system. The measured side thrust were compared with the values predicted by the new model developed in this study and by Bekker's model respectively. The values of side thrust predicted by the new model were more close to the measured values than those of the side thrust predicted by Bekker's model . The total thrust measured were also compared with the values predicted by the conventional model which considers only bottom thrust effect and by the new model which contains not only bottom thurst but side thrust effect. The values of the thrust predicted by conventional modelwere lower than measured values for both of the soil conditions and the three levels of grouser length. The maximum errors of conventional model were increased with the increase of grouser length. but the values of the total thrust predicted by the model developed in this study were well matched to the measured ones for both of the soil conditions and the three levels of grouser lengths.

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고효율 기기의 수요자측 입찰을 고려한 수요관리 모니터링 시스템 (Demand-Side Management Monitoring System of High Efficient End-Use Appliances Considering the Demand-Side Bidding)

  • 심건보;김정훈;원종률
    • 대한전기학회:학술대회논문집
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    • 대한전기학회 2003년도 하계학술대회 논문집 A
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    • pp.68-70
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    • 2003
  • This paper proposes the demand-side management(DSM) monitoring system of high efficient end-use appliances considering demand-side bidding (DSB). The effect on the market propagation of high efficient appliances by demand side bidding is analysed. Seasonal Peak demand forecasting and propagation capacity of these appliances are analysed.

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레보도파제제의 위장관계 부작용에 대한 침치료 효과 연구-특발성 파킨슨병 환자를 대상으로- (Clinical Study of Acupuncture Theraphy of Gastrointestinal Side Effect of Levodopa: Focused on Idiopathic Pakinson's Disease Patients)

  • 양동호;이경윤;신현승;조송현;임창선;임준혁;윤석훈;이한;강명진
    • Journal of Acupuncture Research
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    • 제27권6호
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    • pp.11-21
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    • 2010
  • Objective : This study was aimed at investigating the therapeutic effects of acupuncture on gastrointestinal side effect of Levodopa on idiopathic Pakinson's disease patients. Methods : The subjects of this study were 42 patients with idiopathic Parkinson's disease. We divided them into two groups; acupuncture treatment group, no treatment group. We treated the former group with acupuncture therapy focusing on gastrointestinal side effect of Levodopa while administering Levodopa as well. And the latter group was also dosed up with Levodopa without acupuncture therapy. To see the effect of acupuncture treatment clearly, we used gastrointestinal syndrome rating scale (GSRS) and visual analog scale (VAS) and compared the GSRS grade and VAS score of two groups statistically, after 1, 2, 3, 4 weeks since they have been under the treatment. Results : This study suggests that the group who has been treated with acupuncture on gastrointestinal side effect of Levodopa on idiopathic pakinson's disease patients showed higher GSRS grade and VAS score than the one that has not. But, We could't find statistical significance between the two groups on improvement of GSRS grade and VAS score. Conclusions : These results proved that acupucture theraphy might be available for re lieving symptoms related with gastrointestinal side effect of Levodopa than the one that has not. But further studies are necessary.

술후 제통에 사용된 Piroxicam 첩포의 선행진통효과 (Efficacy of Transdermal Piroxicam as Preemptive Analgesia)

  • 국은영;안용미;이철;박천희;이철승;김원태
    • The Korean Journal of Pain
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    • 제12권1호
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    • pp.70-74
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    • 1999
  • Background: Preemptive analgesia has been suggested recently as an another technique of postoperative pain control. Combination of low dose opioid and NSAIDs was used to lessen systemic opioid side effect, however, the use of NSAIDs may hinder their side effects in perioperative period. The local application of small dose at the target site can be effective without systemic effect. The aim of this study is evaluating the additive effect and side effect of transdermal piroxicam as preemptive adjuvant to intravenous nalbuphine on pain relief after major abdominal surgery. Methods: We reviewed the records of patients received piroxicam patch for preemptive analgesia before operation and compared it with control group. Two sheets of piroxicam patch to the skin incision site for 12 hours before operation were attached (Group 1, n=20) and no patch were applied (Group 2, n=20). Both groups were received nalbuphine continuously after operation using two days infuser (2 ml/hr) containing 80 mg (96 ml). Pain is evaluated by VAS score at each time; 30 min, 1, 6, 12, 24, 36, 48 hours after operation and side effects of NSAIDs were observed for 3days postoperatively. Results: There was no significant VAS score difference between two groups following time in progress. And no significant side effect was noted in both groups, either. Conclusion: There is no preemptive or synergistic analgesic effect of piroxicam patch attached at planned operation site before operation.

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