• KSII Transactions on Internet and Information Systems (TIIS)
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• 제5권10호
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• pp.1862-1878
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• 2011

With the advances in wireless communication technology and the advent of smartphones, research on location-based services (LBSs) is being actively carried out. In particular, several spatial index methods have been proposed to provide efficient LBSs. However, finding an optimal indexing method that balances query performance and index size remains a challenge in the case of wireless environments that have limited channel bandwidths and device resources (computational power, memory, and battery power). Thus, mechanisms that make existing spatial indexing techniques more efficient and highly applicable in resource-limited environments should be studied. Bitmap-based Spatial Indexing (BSI) has been designed to support LBSs, especially in wireless broadcast environments. However, the access latency in BSI is extremely large because of the large size of the bitmap, and this may lead to increases in the search time. In this paper, we introduce a Selective Bitmap-based Spatial Indexing (SBSI) technique. Then, we propose an Adaptive Bitmap-based Spatial Indexing (ABSI) to improve the tuning time in the proposed SBSI scheme. The ABSI is applied to the distribution of geographical objects in a grid by using the Hilbert curve (HC). With the information in the ABSI, grid cells that have no objects placed, (i.e., 0-bit information in the spatial bitmap index) are not tuned during a search. This leads to an improvement in the tuning time on the client side. We have carried out a performance evaluation and demonstrated that our SBSI and ABSI techniques outperform the existing bitmap-based DSI (B DSI) technique.

• Natural Product Sciences
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• 제23권1호
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• pp.40-45
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• 2017

Epilepsy is a brain disorder that affects millions of people worldwide. It is characterized by recurrent and unpredictable seizures that are usually controlled with antiepileptic/anticonvulsive drugs. However, most antiepileptic drugs produce various side effects such as tolerance and sedation. Thus, there is a growing interest for alternative anticonvulsive drugs, preferably from natural or herbal sources. In this study, we evaluated the anticonvulsive effects of Rehmannia glutinosa (RG). The anticonvulsive effect of RG extract was evaluated using electroshock- and chemical-induced seizure tests in mice. To identify its probable mechanism of action, the effects of RG extract on $Cl^-$ influx was measured in vitro. We found that RG extract has anticonvulsive effects against electroshock-induced seizures, as indicated by an increased seizure threshold in mice. The RG extract also decreased the percentage of seizure responses induced by the GABAergic antagonist, pentylenetetrazole. These results suggest that the anticonvulsive effects of RG extract are mediated through a GABAergic mechanism. In support of this mechanism, our in vitro test showed that RG extract increases intracellular $Cl^-$ influx. Furthermore, RG extract did not show sedative and/or muscle relaxant effects in the open-field and rota-rod tests. Altogether, these results confirm that RG extract could be a herbal anticonvulsant and a potential alternative for clinical use.

• KSII Transactions on Internet and Information Systems (TIIS)
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• 제8권12호
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• pp.4568-4587
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• 2014

Authentication of videos and images based on the content is becoming an important problem in information security. Unfortunately, previous studies lack the consideration of Kerckhoffs's principle in order to achieve this (i.e., a cryptosystem should be secure even if everything about the system, except the key, is public knowledge). In this paper, a solution to the problem of finding a relationship between a frame's index and its content is proposed based on the creative utilization of a robust manifold feature. The proposed solution is based on a novel semi-fragile watermarking scheme for H.264/AVC video content authentication. At first, the input I-frame is partitioned for feature extraction and watermark embedding. This is followed by the temporal feature extraction using the Isometric Mapping algorithm. The frame index is included in the feature to produce the temporal watermark. In order to improve security, the spatial watermark will be encrypted together with the temporal watermark. Finally, the resultant watermark is embedded into the Discrete Cosine Transform coefficients in the diagonal positions. At the receiver side, after watermark extraction and decryption, temporal tampering is detected through a mismatch between the frame index extracted from the temporal watermark and the observed frame index. Next, the feature is regenerate through temporal feature regeneration, and compared with the extracted feature. It is judged through the comparison whether the extracted temporal watermark is similar to that of the original watermarked video. Additionally, for spatial authentication, the tampered areas are located via the comparison between extracted and regenerated spatial features. Experimental results show that the proposed method is sensitive to intentional malicious attacks and modifications, whereas it is robust to legitimate manipulations, such as certain level of lossy compression, channel noise, Gaussian filtering and brightness adjustment. Through a comparison between the extracted frame index and the current frame index, the temporal tempering is identified. With the proposed scheme, a solution to the Kerckhoffs's principle problem is specified.

• 센서학회지
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• 제23권2호
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• pp.114-121
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• 2014

We report a polysilicon active area membrane field effect transistor (PSAFET) pressure sensor for low stress deflection of membrane. The PSAFET was produced in conventional FET semiconductor fabrication and backside wet etching. The PSAFET located at the front side measured pressure change using 300 nm thin-nitride membrane when a membrane was slightly strained by the small deflection of membrane shape from backside with any physical force. The PSAFET showed high sensitivity around threshold voltage, because threshold voltage variation was composed of fractional function form in sensitivity equation of current variation. When gate voltage was biased close to threshold voltage, a fractional function form had infinite value at $V_{tn}$, which increased the current variation of sensitivity. Threshold voltage effect was dominant right after the PSAFET was turned on. Narrow transistor channel established by small current flow was choked because electron could barely cross drain-source electrodes. When gate voltage was far from threshold voltage, threshold voltage effect converged to zero in fractional form of threshold voltage variations and drain current change was mostly determined by mobility changes. As the PSAFET fabrication was compatible with a polysilicon FET in CMOS fabrication, it could be adapted in low pressure sensor and bio molecular sensor.

• 생명과학회지
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• 제19권11호
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• pp.1666-1671
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• 2009

배추과에 있어서 SLG (S locus glycoprotein)와 SRK (S locus receptor kinase) 유전자는 자가불화합성의 인식반응에 관여한다. 또한 수화작용에 중요한 aquaporin (MOD) 유전자 역시 자가불화합성 작용에 요구된다. 본 실험은 양배추 자가화 합성(SC) 계통으로부터 SC-SLG, SC-SRK, 및 SC-MOD 유전자들을 동정하고 이들 유전자의 물리적 구조를 분석하였다. 그 결과 이들 유전자들은 기존에 보고된 유전자들과 높은 상동성을 보였고 RT-PCR에 의한 발현 해석에 있어서 정상적인 발현을 나타내었다. 이들 결과들로 부터, 자가화합 양배추 계통은 주두측 자가불화합성 유전자에 이상이 있는 것이 아니라 화분측 자가불화합성 유전자의 이상 그리고/또는 S-locus에 연쇄 되어 있지 않지만 자가불화합성에 관여하는 유전자의 변이에 의해 자가불화합성이 타파되었다고 생각된다.

• Molecules and Cells
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• 제39권3호
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• pp.211-216
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• 2016

CYP107W1 from Streptomyces avermitilis is a cytochrome P450 enzyme involved in the biosynthesis of macrolide oligomycin A. A previous study reported that CYP107W1 regioselectively hydroxylated C12 of oligomycin C to produce oligomycin A, and the crystal structure of ligand free CYP107W1 was determined. Here, we analyzed the structural properties of the CYP107W1-oligomycin A complex and characterized the functional role of the Trp178 residue in CYP107W1. The crystal structure of the CYP107W1 complex with oligomycin A was determined at a resolution of $2.6{\AA}$. Oligomycin A is bound in the substrate access channel on the upper side of the prosthetic heme mainly by hydrophobic interactions. In particular, the Trp178 residue in the active site intercalates into the large macrolide ring, thereby guiding the substrate into the correct binding orientation for a productive P450 reaction. A Trp178 to Gly mutation resulted in the distortion of binding titration spectra with oligomycin A, whereas binding spectra with azoles were not affected. The Gly178 mutant's catalytic turnover number for the 12-hydroxylation reaction of oligomycin C was highly reduced. These results indicate that Trp178, located in the open pocket of the active site, may be a critical residue for the productive binding conformation of large macrolide substrates.

• 한국농공학회논문집
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• 제60권1호
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• pp.31-36
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• 2018

A rainwater harvesting device was developed for runoff flow harvesting in a small stream or channel and its performance was evaluated in small fields. The rainwater harvesting device has slits on its side of cylindrical volume in 15 cm diameter and 70 cm length, which is designed to increase its water flow harvesting capacity. The maximum collectable water quantity was about 0.0022 ton/sec (130 L/min). Rainwater harvesting device were installed in two locations (P1, P2). P1 is a point for rainfall runoff flow harvesting. P2 is a point for ordinary flow harvesting. During this study, total rainfall depth was 334.5 mm. Runoff of 1,722 ton and 7,984 ton occurred in P1 and P2, and 273 ton and 125 ton were collected by this rainwater harvesting device. Harvesting efficiency was calculated as 15.85 % and 1.57 % in P1 and P2. Clogging of screen filter media in the cylinder due to soil and suspended solids has lowered the harvesting efficiency. However, it was possible to harvest 30 ton/month of rainwater harvesting and it is expected that it will help to solve short-term water shortage.

• 대한전자공학회논문지SD
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• 제38권6호
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• pp.390-397
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• 2001

GIDL(Gate-Induced Drain-Leakage)을 줄일 수 있는 새로운 구조의 ESD(Elevated Source Drain) MOSFET을 제안하고 분석하였다. 제안된 구조는 SDE(Source Drain Extension) 영역이 들려진 형태를 갖고 있어서 SDE 임플란트시 매우 낮은 에너지 이온주입으로 인한 저활성화(low-activation) 효과를 방지 할 수 있다. 제안된 구조는 건식 식각 및 LAT(Large-Angle-Tilted) 이온주입 방법을 사용하여 소오스/드레인 구조를 결정한다. 기존의 LDD MOSFET과의 비교 시뮬레이션 결과, 제안된 ESD MOSFET은 전류 구동능력은 가장 크면서 GIDL 및 DIBL(Drain Induced Barrier Lowering) 값은 효과적으로 감소시킬 수 있음을 확인하였다. GIDL 전류가 감소되는 원인으로는 최대 전계의 위치가 드레인 쪽으로 이동함에 따라 최대 밴드간 터널링이 일어나는 곳에서의 최대 전계값이 감소되기 때문이다.

• 한국전자파학회논문지
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• 제15권4호
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• pp.379-386
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• 2004

OFDM(orthogonal frequency division multiplexing) 통신 방식은 무선 고속 데이터 전송에 적합한 방식이다. 하지만 높은 PAPR(peak-to-average power ratio)의 발생으로 HPA(high power amplifier)에서 비선형 왜곡된다. 따라서 본 논문에서는 이 문제점을 개선시키기 위한 PAPR 저감 방법으로 dummy sequence를 삽입하는 새로운 방식의 SLM 기법(dummy sequence insertion - selected mapping: DSI-SLM)을 제안한다. 이 DSI-SLM 기법은 각각의 브렌치에 서로 다른 위상 factor를 곱하는 대신 각각에 일정비율의 부반송파에 dummy 시퀀스를 삽입하여 IFFT 후 가장 낮은 PAPR을 갖는 브렌치의 데이터를 전송한다. 이 방식들에 사용된 dummy 시퀀스는 송신단의 PAPR 저감만을 위해 사용하며 위상 회전 부가 정보 전송 및 복원 과정이 필요치 않아 기존 SLM에 비해 계산량 및 복잡도를 감소시킬 수 있다. 또한 PTS 방식에서 최적의 rotation factor를 찾기 위한 peak value optimization에 의한 계산량 증가 및 송신기의 시간 지연 문제 등을 해결할 수 있다.

• 정보보호학회논문지
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• 제26권3호
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• pp.587-601
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• 2016

본 논문에서는 SPA와 DPA 모두에 안전한 스칼라 레코딩 방법을 제안한다. 제안하는 방법은 스칼라 레코딩을 이용한 전력분석공격의 대응방법으로써 음수 표현을 사용한 스칼라 레코딩 방법이다. 제안하는 방법은 각 digit에 대해 모두 동일한 패턴의 연산을 수행하도록 레코딩하여 SPA에 안전하다. 또한 랜덤수에 따라 랜덤한 레코딩 결과를 생성하도록 하여 DPA에 안전하다. 그리고 타원곡선 덧셈 연산이 digit의 부호에 대한 SPA에 안전하도록 사전연산 테이블과 변형한 타원곡선 덧셈 알고리즘을 적용한다. 제안하는 방법은 단독 사용으로 SPA와 DPA 모두에 안전하므로 보다 효율적인 안전성을 제공한다. 제안하는 방법을 사용하면 SPA와 DPA에 안전한 기존의 스칼라 레코딩에 비해 연산효율이 11% 이상 향상된다.