• The Korean Journal of Physiology and Pharmacology
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• v.13 no.3
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• pp.215-220
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• 2009

Chlorpheniramine is a potent first-generation histamine $H_1$ receptor antagonist that can increase action potential duration and induce QT prolongation in several animal models. Since block of cardiac human ether-a-go-go-related gene (hERG) channels is one of leading causes of acquired long QT syndrome, we investigated the acute effects of chlorpheniramine on hERG channels to determine the electrophysiological basis for its proarrhythmic potential. We examined the effects of chlorpheniramine on the hERG channels expressed in Xenopus oocytes using two-microelectrode voltage-clamp techniques. Chlorpheniramine induced a concentration-dependent decrease of the current amplitude at the end of the voltage steps and hERG tail currents. The $IC_{50}$ of chlorpheniramine-dependent hERG block in Xenopus oocytes decreased progressively relative to the degree of depolarization. Chlorpheniramine affected the channels in the activated and inactivated states but not in the closed states. The S6 domain mutations Y652A and F656A partially attenuated (Y652A) or abolished (F656A) the hERG current block. These results suggest that the $H_1$ antihistamine, chlorpheniramine is a blocker of the hERG channels, providing a molecular mechanism for the drug-induced arrhythmogenic side effects.

• Proceedings of the Korea Water Resources Association Conference
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• 2008.05a
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• pp.624-628
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• 2008

Two-dimensional flow analysis is a way to provide good estimates for complex flow features in flow around islands and obstructions, flow at confluence and flow in braided channel. One of difficult problems to develop a two-dimensional hydraulic model is to analyze dry and wet area in river channel. Dry/wet problem can be encountered in river and coastal engineering problems, such as flood propagation, dam break analysis, tidal processes and so on. The objective of this study is to develop an accurate and robust two-dimensional finite element method with dry/wet technique in complex natural rivers. The dry/wet technique with Deforming Grid Method was developed in this study. The Deforming Grid Method was used to construct new mesh by eliminating of dry nodes and elements. The eliminated nodes and elements were decided by considering of the rising/descending velocity of water surface elevation. Several numerical simulations were carried out to examine the performance of the Deforming Grid Method for the purpose of validation and verification of the model in rectangular and trapezoidal channel with partly dry side. The application results of the model were displayed reasonable flow distribution.

• Journal of the Korean Institute of Electrical and Electronic Material Engineers
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• v.25 no.9
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• pp.671-676
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• 2012

In this paper, TCAD assessment of 30-V class n-channel EDMOS (extended drain metal-oxide-semiconductor) transistors with DWFG (dual work function gate) structure are described. Gate of the DWFG EDMOS transistor is composed of both p- and n-type doped region on source and drain side. Additionally, lengths of p- and n-type doped gate region are varied while keeping physical channel length. Two-dimensional device structures are generated trough TSUPREM-4 and their electrical characteristics are investigated with MEDICI. The DWFG EDMOS transistor shows improved electrical characteristics than conventional device - i.e. higher transconductance ($g_m$), better drain output current ($I_{ON}$), reduced specific on-resistances ($R_{ON}$) and higher breakdown characteristics ($BV_{DSS}$).

• Journal of electromagnetic engineering and science
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• v.7 no.4
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• pp.169-174
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• 2007

This paper presents a method of superimposing the rotation phases over the pilot and data symbols in order to reduce the peak-to-average power ratio(PAPR) in orthogonal frequency division multiplexing(OFDM). The phases of the rotation vector are added to those of the pilot symbols and those of the data symbols by interlaying them between any two pilot symbols. The receiver restores the data symbols by utilizing the channel estimation of the pilot symbols. Therefore, the bandwidth efficiency is improved by not using the subcarriers that are assigned for the reduction of the PAPR. Also, the enormous increase of the bit error rate which would be caused by incorrectly receiving the side information, i.e. the phases of the rotation vector, is prevented. The simulation results of the bit error rate performance for the BPSK are given using the COST-207 channel model.

• 한국전산유체공학회:학술대회논문집
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• 2008.03b
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• pp.2-5
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• 2008

This study describes the numerical simulation of three-dimensional droplet formation and the following motion in a cross-junction microchannel by using the Lattice Boltzmann Method (LBM). Our aim is to develop the three-dimensional binary fluids model, consisting of two sets of distribution functions to represent the total fluid density and the density difference, which introduces the repulsive interaction consistent with a free-energy function between two fluids. We validated the LBM code with the velocity profile in a 3-dimensional rectangular channel. Then, we applied our code to the numerical simulation of a binary fluid flow in a cross-junction channel focusing on the investigation of the droplet formulation. Due to the pressure and interfacial-tension effect, one component of the fluids which is injected from one inlet is cut off into many droplets periodically by the other component which is injected from the other inlets. We considered the effect of the boundary conditions for density difference (order parameter) on the wetting of the droplet to the side walls.

• Transactions of the Korean Society of Mechanical Engineers A
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• v.33 no.3
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• pp.261-264
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• 2009

We present a three-dimensional (3D) particle focusing channel using the positive dielectrophoresis (pDEP) guided by a dielectric structure between two planar electrodes. The dielectric structure between two planar electrodes induces the maximum electric field at the center of the microchannel, and particles are focused to the center of the microchannel by pDEP as they flow from the single sample injection port. Compared to the previous 3D particle focusing methods, the present device achieves the simple and effective particle focusing function without any additional fluidic ports and top electrodes. In the experimental study, approximately 90 % focusing efficiency were achieved within the focusing length of 2mm, on both x-z plane (top-view) and y-z plane (side-view) for $2{\mu}m$-diameter polystyrene (PS) bead at the applied voltage over 15 Vp-p (square wave) and at the flow rate below 0.01 ${\mu}l$/min. The present 3D particle focusing channel results in a simple particle focusing method suitable for use in integrated microbiochemical analysis system.

• Transactions of the Korean Society of Mechanical Engineers A
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• v.35 no.8
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• pp.899-904
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• 2011

This This study aims to verify burr formation and to remove the burrs in micro-channel fabrication using micro-machining tools. The machining processes are combined with micro-milling and magnetic abrasive deburring for AISI316 stainless steel. Depending on the micro-milling conditions that are applied, burrs are formed around the side walls. Magnetic abrasive deburring is used to remove these burrs. AISI316 stainless steel is a nonferrous material and its magnetic flux density, which is an important parameter for efficient magnetic abrasive deburring, is low. To enhance this magnetic flux density, we design and build a magnetic array table. The effect of removing burrs is evaluated via SEM and a surface tester.

• Journal of the Korea Institute of Information and Communication Engineering
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• v.10 no.5
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• pp.851-856
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• 2006

This paper studies about design of a transceiver using a single PLL. The transceiver has bandwidth of $424.7\sim424.95MHz$ and the communication method used 21 channels 12.5 KHz channel bandwidth and FSK modulation/demodulation method. Also, we designed low power wireless transceiver for data transmission using a single PLL. Finally, the transceiver set achieves the following characteristics : 8.15dBm output power, 45.97dBc spurious property.

• Proceedings of the KSME Conference
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• 2000.04b
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• pp.625-630
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• 2000

Numerical and experimental investigations are peformed for the rarefied gas flows in pumping channels of a helical-type drag pump. Modern turbomolecular pumps include a drag stage in the discharge side, operating roughly in $10^{-2}{\sim}10Torr$. The flow occurring in the pumping channel develops from the molecular transition to slip flow traveling downstream. Two different numerical methods are used in this analysis: the first one is a continuum approach in solving the Navier-Stokes equations with slip boundary conditions, and the second one is a stochastic particle approach through the use of the direct simulation Monte Carlo(DSMC) method. The flow in a pumping channel is three-dimensional(3D), and the main difficulty in modeling a 3D case comes from the rotating frame of reference. Thus, trajectories of particles are no longer straight lines. In the Present DSMC method, trajectories of particles are calculated by integrating a system of differential equations including the Coriolis and centrifugal forces. Our study is the first instance to analyze the rarefied gas flows in rotating frame in the presence of noninertial effects.

• The Korean Journal of Pain
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• v.24 no.2
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• pp.74-80
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• 2011

Background: Lidocaine patch (L5P) has demonstrated short-term efficacy in treating both acute surgical pain and chronic neuropathic pain with tolerable side effects. Percutaneous endoscopic lumbar discectomy (PELD) is the mainstay of minimally invasive spine surgery (MISS). Sufficient analgesia during PELD surgery makes the patient consider it real MISS. This study was performed to evaluate the efficacy and adverse effects of lidocaine patch in patients who underwent PELD under local anesthesia. Methods: L5P (L group) or placebo (P group) was randomly applied on the skin of the back covering the anticipated path of the working channel before 1 hour of surgery in 100 patients who underwent a single level PELD at L4-L5. Efficacy of the lidocaine patch was assessed by patient's numeric rating scale (NRS) of pain at each stage during the surgery and by a 5-scale grading of the satisfaction with the anesthesia of the operator and patients after surgery. Results: Mean NRS scores at the stages of needle insertion, skin incision, serial dilation and insertion of working channel, and subcutaneous suture were significantly lower in the L group than the P group. Postoperative operator's and patients' satisfaction scores were also significantly higher in L group than in the P group. There were subtle adverse effects in both groups. Conclusions: L5P provided better pain relief during PELD, especially at the stage of needle insertion, skin incision, serial dilation and insertion of working channel, and subcutaneous suture. It also provided higher patient and operator postoperative satisfaction, with only subtle adverse effects.