• Economic and Environmental Geology
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• v.47 no.3
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• pp.291-302
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• 2014

The Chinese government and its agencies were trying in order to solve the unstability of resource supply and demand. Ministry of Land and Resources of China(MLR) carried out a lot of national-level policy and planning for estimating the domestic mineral and energy resources potential and recoverable reserves, as the Chinese land and resources survey plan(1999~2010), the Chinese mineral resource survey and exploration plan(2008~2020), announcement for shale gas industry policies of China, the Chinese shale gas resources evaluation and selection project for its development priority areas(2012), and the plan for Chinese shale gas development(2011~2015). The two large sedimentary basins of Chinese shale gas reserves are Sichuan and Tarim basins with excellent potential, accounting for majority of the estimated national reserves. Recoverable gas-bearing shale of China was surveyed to be widespread. The volume of recoverable shale gas reservoirs in China has been estimated to be around 31 trillion cubic meters(1,115 trillion cubic feet). China is one of only three countries with the US and Canada to produce shale gas in commercial quantities. China is concentrating on technology development to enhance commercial production of shale gas, and on survey and exploration activities to increase its recoverable reserves. The trends related to shale gas development and R&D activities in China to respond to changes in international oil market should be actively monitored based on analysis of Chinese policies and technology.

• Asian Pacific Journal of Cancer Prevention
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• v.13 no.6
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• pp.2437-2444
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• 2012

Tumor metastasis remains the principal cause of treatment failure and poor prognosis in patients with colorectal cancer. It is a multistage process which includes proteolysis, motility and migration of cells, proliferation in a new site, and neoangiogenesis. A crucial step in the process of intra- and extra-vasation is the activation of proteolytic enzymes capable of degrading the extracellular matrix (ECM). In this stage, urokinase plasminogen activator receptor (uPAR) and matrix metalloproteinases (MMPs) are necessary. Micrometastases need the presence of growth factor and vascular growth factor so that they can form macrometastasis. In addition, cell adhesion molecules (CAMs) and guanine nucleotide exchange factors (GEFs) play important roles in the progression of colorectal cancer and metastatic migration. Further elucidation of the mechanisms of how these molecules contribute will aid in the identification of diagnostic and prognostic markers as well as therapeutic targets for patients with colorectal metastasis.

• Journal of the Korea Construction Safety Engineering Association
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• s.49
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• pp.92-102
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• 2009

Earthquake is one of the hazard so hard because it is difficult predicted occurred time, scale and characters. Due to a recent Sichuan earthquake in China with a magnitude of 7.8, it is worried about having a major earthquake in Korea peninsula in near future. The earthquake in Kobe, Japan showed that the damages were concentrated on the buildings which were not considered to be protected from the earthquakes. In this study, apartment structures in Korea analyze about earthquake hazard and evaluate seismic performance. Through the this study we have notice of earthquake hazard for apartment structures which live a lot of population of Korea and suppose necessary for seismic retrofit.

• Journal of Contemporary Eastern Asia
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• v.14 no.2
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• pp.37-44
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• 2015

Many people criticized how the Chinese government responded to the Wenchuan Earthquake. They focused on how it failed to address the psychological needs of the survivors. The study presented here approached this issue from a human resources perspective. It was determined that the Chinese government approached the situation in a bureaucratic way that limited the government's capacity and barred non-profit organizations and community groups from participating. It was also found that survivors could not contact these organizations for psychological support. This study concludes that the situation called for a more flexible and improvised institution that would respond to the emerging needs of survivors.

• Journal of Power Electronics
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• v.11 no.5
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• pp.751-758
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• 2011

This paper presents an effective robust predictive control scheme for the active power filter (APF) using a smith-predictor based current regulator, which show superior features when compared to proportional-integral (PI) controllers in terms of an enhanced closed-loop bandwidth and an improved current tracking accuracy. A moving average filter (MAF) is implemented using a field programmable gate array (FPGA) for signal pre-processing to eliminate the switching ripple contamination. An adaptive linear neural network (ADALINE) is used for individual harmonic estimation to achieve selective compensation purpose. The effectiveness and validity of the devised control algorithm are confirmed by extensive simulation and experimental results.

• Journal of the Korean Society of Safety
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• v.23 no.6
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• pp.100-107
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• 2008

Earthquake is one of the hazard so hard because it is difficult predicted occurred time, scale and characters. Due to a recent Sichuan earthquake in China with a magnitude of 7.8, it is worried about having a major earthquake in Korea peninsula in near future. The earthquake in Kobe, Japan showed that the damages were concentrated on the buildings which were not considered to be protected from the earthquakes. In this study, apartment structures in Korea analyze about earthquake hazard and evaluate seismic performance. Through the this study we have notice of earthquake hazard for apartment structures which live a lot of population of Korea and suppose necessary for seismic retrofit.

• Current Optics and Photonics
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• v.6 no.4
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• pp.400-406
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• 2022

We numerically demonstrate that the inherent spiking behavior in the quasi-continuous-wave (QCW) operation of an Nd:YAG laser can be suppressed by adopting bias pumping. After spiking suppression, the output QCW pulses from a bias-pumped Nd:YAG laser are very stable, and they can maintain nearly the same temporal shape as that of pump pulse under different pump repetition rates and peak powers. Our study implies that bias pumping is an alternative method of spiking suppression in solid-state lasers, and the application areas of an Nd:YAG laser may be extended by bias pumping.

• Geomechanics and Engineering
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• v.30 no.5
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• pp.401-411
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• 2022

To obtain the dynamic mechanical properties, fracture modes, energy and brittleness characteristics of Furong Baijiao coal rock, the dynamic impact compression tests under 0, 4, 8 and 12 MPa confining pressure were carried out using the split Hopkinson pressure bar. The results show that failure mode of coal rock in uniaxial state is axial splitting failure, while it is mainly compression-shear failure with tensile failure in triaxial state. With strain rate and confining pressure increasing, compressive strength and peak strain increase, average fragmentation increases and fractal dimension decreases. Based on energy dissipation theory, the dissipated energy density of coal rock increases gradually with growing confining pressure, but it has little correlation with strain rate. Considering progressive destruction process of coal rock, damage variable was defined as the ratio of dissipated energy density to total absorbed energy density. The maximum damage rate was obtained by deriving damage variable to reflect its maximum failure severity, then a brittleness index BD was established based on the maximum damage rate. BD value declined gradually as confining pressure and strain rate increase, indicating the decrease of brittleness and destruction degree. When confining pressure rises to 12 MPa, brittleness index and average fragmentation gradually stabilize, which shows confining pressure growing cannot cause continuous damage. Finally, integrating dynamic deformation and destruction process of coal rock and according to its final failure characteristics under different confining pressures, BD value is used to classify the brittleness into four grades.

• Journal of Ginseng Research
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• v.48 no.1
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• pp.40-51
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• 2024

Background: Ginsenoside 20(S)-Rg3 shows promising tumor-suppressive effects in ovarian cancer via inhibiting NF-kB signaling. This study aimed to explore the downstream tumor suppressive mechanisms of ginsenoside Rg3 via this signaling pathway. Materials and methods: A systematical screening was applied to examine the expression profile of 41 kinesin family member genes in ovarian cancer. The regulatory effect of ginsenoside Rg3 on KIF20A expression was studied. In addition, we explored interacting proteins of KIF20A and their molecular regulations in ovarian cancer. RNA-seq data from The Cancer Genome Atlas (TCGA) was used for bioinformatic analysis. Epithelial ovarian cancer cell lines SKOV3 and A2780 were used as in vitro and in vivo cell models. Commercial human ovarian cancer tissue arrays were used for immunohistochemistry staining. Results: KIF20A is a biomarker of poor prognosis among the kinesin genes. It promotes ovarian cancer cell growth in vitro and in vivo. Ginsenoside Rg3 can suppress the transcription of KIF20A. GST pull-down and co-immunoprecipitation (IP) assays confirmed that KIF20A physically interacts with BTRC (β-TrCP1), a substrate recognition subunit for SCF^β-TrCP E3 ubiquitin ligase. In vitro ubiquitination and cycloheximide (CHX) chase assays showed that via interacting with BTRC, KIF20A reduces BTRC-mediated CDC25A poly-ubiquitination and enhances its stability. Ginsenoside Rg3 treatment partly abrogates KIF20A overexpression-induced CDC25A upregulation. Conclusion: This study revealed a novel anti-tumor mechanism of ginsenoside Rg3. It can inhibit KIF20A transcription and promote CDC25A proteasomal degradation in epithelial ovarian cancer.

• IMMUNE NETWORK
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• v.23 no.4
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• pp.34.1-34.15
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• 2023

Lung cancer, particularly non-small cell lung cancer (NSCLC) which contributes more than 80% to totally lung cancer cases, remains the leading cause of cancer death and the 5-year survival is less than 20%. Continuous understanding on the mechanisms underlying the pathogenesis of this disease and identification of biomarkers for therapeutic application and response to treatment will help to improve patient survival. Here we found that a molecule known as DUSP10 (also known as MAPK phosphatase 5) is oncogenic in NSCLC. Overexpression of DUSP10 in NSCLC cells resulted in reduced activation of ERK and JNK, but increased activation of p38, which was associated with increased cellular growth and migration. When inoculated in immunodeficient mice, the DUSP10-overexpression NSCLC cells formed larger tumors compared to control cells. The increased growth of DUSP10-overexpression NSCLC cells was associated with increased expression of tumor-promoting cytokines including IL-6 and TGFβ. Importantly, higher DUSP10 expression was associated with poorer prognosis of NSCLC patients. Therefore, DUSP10 could severe as a biomarker for NSCLC prognosis and could be a target for development of therapeutic method for lung cancer treatment.