• Journal of the Korean Academy of Child and Adolescent Psychiatry
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• v.24 no.4
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• pp.220-227
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• 2013

Objectives : This study aims to investigate the clinical characteristics and neuropsychological profiles of children with attention-deficit hyperactivity disorder (ADHD) and their siblings. Methods : Eighteen children (age $8.2{\pm}1.7$ years, 12 boys) with ADHD and their 18 siblings (age $7.8{\pm}1.6$ years, 8 boys) completed Continuous Performance (CPT), Stroop, Children's Trail Making, Rey-Kim Memory, and Kim's Frontal Executive Function tasks. The parents of these subjects underwent the Attention-Deficit/Hyperactivity Disorder Rating Scale (ARS), 10-item Parent General Behavior Inventory (P-GBI), and the Social Responsiveness Scale (SRS). Paired t-tests were used. Results : The inattention (p=.020), and hyperactivity-impulsivity (p=.001), scores of the ARS and the P-GBI score (p=.004) were significantly higher in children with ADHD than in their siblings. Deficits in social communication and motivation on SRS were higher in children with ADHD than in their siblings (p=.017 and p=.011, respectively). Z-scores of omission and commission errors as well as response time variability on visual CPT and omission errors on auditory CPT were in clinically significant range, and z-score of omission errors on auditory CPT was in borderline range in siblings. Omission (p=.018) and commission errors on Visual CPT (p=.007) were significantly higher in children with ADHD compared to their siblings. Recognition efficiency on Kim's Frontal Executive Function Task was lower in children with ADHD compared to their siblings, but in normal range in both groups. Stroop interference and figure fluency on Kims Frontal Executive Function Task were in borderline range in ADHD group, and figure fluency was in borderline range in siblings. Conclusion : Our results support a preliminary evidence for mild degree of attention deficit in ADHD siblings. Further studies are needed to examine the cognitive functions of siblings with ADHD in larger samples.

• Clinical and Experimental Pediatrics
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• v.45 no.12
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• pp.1540-1545
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• 2002

Purpose : Vesicoureteral reflux(VUR) is defined as a retrograde flow of urine from the bladder into the upper urinary tract. It has been shown to predispose patients to hypertension, renal scarring, and end-stage renal failure if not recognized and treated. The observation that VUR occurs in siblings of children with reflux at a significantly higher rate than the general pediatric population has been recognized for many years and VUR was detected in 26% to 51% of siblings of patients with VUR. The purpose of this study is to determine the incidence of VUR in asymptomatic siblings of children with VUR and to see if this form of screening would be practical. Methods : We retrospectively reviewed the records of 28 patients with VUR and their siblings. The total number of asymptomatic siblings investigating VUR were 28 persons. All patients and siblings were evaluated for VUR by a voiding cystourethrography and all patients and siblings with VUR were performed $^{99m}Tc$ 2,3-dimercaptosuccinic acid renal scan. Results : A total of 28 patients(14 boys, 14 girls) with VUR were studied; the mean patient age was 2.7 years(range 1 month to 8.4 years). The total number of asymptomatic siblings investigating VUR were 28 persons(17 boys, 11 girls) and the mean age was 3.3 years(range 2 months to 7.4 years). Renal scar was detected in 20 of 28(71.4%) patients with VUR. VUR was noted in three of 28(10.7%) siblings and renal scar was detected in one of three siblings with VUR. Conclusion : In this study, the predictive value of a positive family history alone in identifying VUR was 10.7%. This incidence suggests more investigation of asymptomatic siblings and continued study of this group of patients at risk is needed for clarifying the family screening of patients with VUR.

• Child Health Nursing Research
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• v.23 no.3
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• pp.394-404
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• 2017

Purpose: The purpose of this study was to review interventions available to nurses caring for siblings of children with cancer. Methods: Searches of CINAHL, MEDLINE, PubMed, EMBASE, and RISS identified ten intervention studies published from January, 2000 to November, 2016. Results: Ten studies on interventions for siblings of pediatric cancer patients were identified as follows: 4 included camps, 4 included support groups, and 2 provided individual interventions. Theoretical frameworks were mainly cognitive behavioral theory and most studies were led by psychologists and multidisciplinary teams. The purpose of the interventions was primarily enhancing psychosocial adjustment. Siblings' fear of disease, self-esteem, and social support were improved significantly after the interventions. Findings were inconsistent with regard to depression, anxiety, behavioral problems, post-traumatic stress, health-related quality of life, and siblings' perceptions of the illness. Conclusion: Study findings showed the potential for enhancing emotional and behavioral outcomes in siblings of children with cancer. However, the number of studies was very small, and several methodological limitations were identified. In the future, more randomized controlled trials with larger samples are needed to extend the evidence base. Moreover, future research should identify sibling's characteristics and circumstances most likely to bring benefits to the siblings.

• Korean Journal of Child Studies
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• v.31 no.3
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• pp.199-214
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• 2010

This study examined the effects of siblings, emotional intelligence (E.I.), and conflict solving strategies (integrating-compromising strategy/ dominating strategy) on children's social competence. The subjects were 421 6th graders (231 boys, 190 girls) in Seoul. The children filled out questionnaires on their siblings, E.I., and conflict solving strategies. Their teachers were asked to rate the children's social competence. Mediational analyses were conducted using structural equation modeling. Both integrating-compromising strategies and dominating strategies mediated the relationship between E.I. and social competence. Children with higher E.I. reported that they used more integrating-compromising strategies, which in turn was related to higher social competence. Those who scored low on E.I. reported that they used more dominating strategies, which in turn was related to lower social competence. Although the effects of siblings did not have any direct effects on social competence, it was found to be related to the type of conflict solving strategies most frequently used. Compared to the children with siblings, the children without siblings used more dominating strategies, which in turn contributed to lower social competence.

• Korean Journal of Biological Psychiatry
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• v.23 no.4
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• pp.179-184
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• 2016

Objectives This study was conducted to investigate the possibility of neurological soft signs as an endophenotype for schizophrenia by examining neurological soft signs in patients, their unaffected siblings and normal comparison subjects. Methods The study sample consisted of 32 patients, 25 of their unaffected siblings and 30 normal comparison subjects. Neurological soft signs were evaluated using the Cambridge Neurological Inventory Part 2. soft sign assessment. Results The patients were significantly more impaired than normal comparison subjects (p = 0.047) on primitive reflex. The patients were significantly more impaired than siblings (p = 0.004) and normal comparison subjects (p = 0.021) on motor coordination. The siblings performed better on sensory integration than the patients (p = 0.020) and normal comparison subjects (p = 0.036). Conclusions This study suggests that neurological soft signs might be a potential biomarker for schizophrenia, but might not be an endophenotype for schizophrenia.

• Korean Journal of Social Welfare Studies
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• no.37
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• pp.63-89
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• 2008

This study attempts to examine the factors influencing the Caregiving responsibility of sibling without disability on their adult siblings with intellectual disability. For this purpose, a questionnaire survey was conducted on siblings without disability who have adult siblings with intellectual disability aged 18 years old or more and also who use services provided by 8 welfare centers for persons with disabilities in Seoul. With 132 valid responses, multiple regression technique was adopted in exploring a model for characteristics of adult with intellectual disability, a model for characteristics of siblings without disability, a model for relationship factors, and a comprehensive model. The findings of the study showed that the degree of disability in the model for characteristics of adult siblings with intellectual disability and the intimacy of siblings and social support in the model of relationship factors were significant. The result of the comprehensive model revealed that the degree of disability, the gender of the siblings without disability, the intimacy of siblings, and social support were significant. Especially, the relationship factors including the intimacy of siblings and social support were found to be the most significant factors in order to explain the caregiving responsibility. The findings of the study suggest that sibling program needs to be developed and disseminated in order to increase the understanding and the trust between adult with intellectual disability and sibling without disability, that a help is critical for adult with intellectual disability to extend the social network in which sibling without disability receives support from sibling without disability, family, friends, and other acquaintances around, and that different approach is needed in order to reduce caregiveing difficulties depending on the dependence of disability.

• Journal of Korean Society of Health-System Pharmacists
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• v.35 no.4
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• pp.400-408
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• 2018

Background : Palivizumab is an intravenous monoclonal antibody which is used in the prevention of respiratory syncytial virus (RSV) infection. It is currently recommended for infants who are at high-risk for RSV infections due to preterm birth or other medical conditions such as congenital heart disease. Palivizumab is a humanized monoclonal antibody directed against an epitope in the antigenic site A of the protein F of RSV particles. Palivizumab is given once a month via intramuscular (IM) injection throughout the duration of the RSV season. Since palivizumab is known to have preventive effects against RSV infection for children with older siblings, the insurance coverage for palivizumab was expanded in October 2016. Methods : The electronic medical records of children under 2 years old who have older siblings who visited or were admitted to the Severance Hospital from October 2015 to May 2016 and from October 2016 to May 2017 were reviewed retrospectively. The data were then divided into two groups depending on the pilivizumab administration. Results : A total of 67 patients were enrolled in this study. The effectiveness in the reduction of hospitalization was statistically significant (p=0.009). Palivizumab decreased respiratory symptoms such as cough, rhinorrhea, and fever in patients with older siblings (p 0.05). Conclusions : In this study, palivizumab administration was effective in preventing RSV infection in infants with older siblings. Expanding palivizumab-prophylaxis administration to infants with older siblings may be effective in the prevention of upper respiratory infections.

• Korean Journal of Child Studies
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• v.35 no.2
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• pp.63-84
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• 2014

The purpose of this study was to explore the effects of parental differential treatment and social support perceived by adolescents with siblings with special needs on their self-esteem and internalized problems. The subjects comprised one hundred 12- to 18-year-old adolescents with siblings with special needs. The major results of this study were as follows. First, there were significant differences in adolescents' self-esteem by participation in support programs for siblings of children with special needs. Second, there was no significant effect of parental differential treatment on adolescents' self-esteem. Third, there was a significant effect of social support (family, friends, and teachers) on adolescents' self-esteem. Fourth, there was no effects of paternal differential parenting on adolescents' internalized problems. However, there was a significant effect of differential maternal affection on adolescents' internalized problems. Fifth, there was a significant effect of social support, especially in terms of support provided by friends, on adolescents' internalized problems. In conclusion, social support and differential maternal affection both have an important role in adolescents' self-esteem and internalized problems.

• Journal of the Korean Home Economics Association
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• v.39 no.4
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• pp.79-89
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• 2001

This study investigated institutionalized children's behavior problems depending on their family networks. Subjects were 250 institutionalized children in 15 child-welfare facilities in Seoul(132 preschooler, 55 first and 63 second grade children; 144 boys and 106 girls). Data were analyzed with t-test, ANOVA, and Duncan test. Measures of behavior problems included internalizing (anxiety, immaturity, withdrawal, physical symptom) and externalizing behavior problems (hyperactivity, aggression). Results showed that institutionalized children having parents were higher in internalizing problems than children not having parents, while children living with siblings in the facilities were lower in externalizing problems than children living without siblings. Furthermore, institutionalized children having parents and living without siblings were higher in both internalizing and externalizing problems than children not having parents and living with siblings.

• Korean Journal of Child Studies
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• v.10 no.1
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• pp.43-63
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• 1989

The present study compared mother-child relationships and sociability of only children with that of children with siblings. The mother of 105 only children and 179 children with siblings responded to questionnaires on maternal attitudes and children's sociability. The children were all enrolled in kindergartens in Seoul. The data analysis was with t-test and Pearson's correlation. The mothers of only children reported that they were more overprotective and obedient to the children than mothers of children with siblings. Only children were less autonomous in sociability than children with siblings. 'Protective' and 'obedient' attitudes of mothers of only children were positively correlated with the 'egocentrism' of the child and negatively correlated with 'autonomy' of the child.