Journal of Korean Society of Health-System Pharmacists (병원약사회지)

The Korean Society of Health-System Pharmacists (한국병원약사회)
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Analysis of Clinical Effects of Palivizumab for Children with Older Siblings

손위형제 또는 자매가 있는 소아에서 Palivizumab 투여 여부에 따른 임상적 효과 분석

  • Kim, Jin Yeo (Department of Pharmacy, Severance Hospital, Yon-sei University Health System) ;
  • Park, Ji Eun (Department of Pharmacy, Severance Hospital, Yon-sei University Health System) ;
  • Jung, Min Jae (Department of Pharmacy, Severance Hospital, Yon-sei University Health System) ;
  • Kim, Jae Song (Department of Pharmacy, Severance Hospital, Yon-sei University Health System) ;
  • Kim, Soo Hyun (Department of Pharmacy, Severance Hospital, Yon-sei University Health System) ;
  • Son, Eun Sun (Department of Pharmacy, Severance Hospital, Yon-sei University Health System)
  • 김진여 (연세대학교의료원 세브란스병원 약무국) ;
  • 박지은 (연세대학교의료원 세브란스병원 약무국) ;
  • 정민재 (연세대학교의료원 세브란스병원 약무국) ;
  • 김재송 (연세대학교의료원 세브란스병원 약무국) ;
  • 김수현 (연세대학교의료원 세브란스병원 약무국) ;
  • 손은선 (연세대학교의료원 세브란스병원 약무국)
  • Received : 2018.02.08
  • Accepted : 2018.09.14
  • Published : 2018.12.31
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Abstract

Background : Palivizumab is an intravenous monoclonal antibody which is used in the prevention of respiratory syncytial virus (RSV) infection. It is currently recommended for infants who are at high-risk for RSV infections due to preterm birth or other medical conditions such as congenital heart disease. Palivizumab is a humanized monoclonal antibody directed against an epitope in the antigenic site A of the protein F of RSV particles. Palivizumab is given once a month via intramuscular (IM) injection throughout the duration of the RSV season. Since palivizumab is known to have preventive effects against RSV infection for children with older siblings, the insurance coverage for palivizumab was expanded in October 2016. Methods : The electronic medical records of children under 2 years old who have older siblings who visited or were admitted to the Severance Hospital from October 2015 to May 2016 and from October 2016 to May 2017 were reviewed retrospectively. The data were then divided into two groups depending on the pilivizumab administration. Results : A total of 67 patients were enrolled in this study. The effectiveness in the reduction of hospitalization was statistically significant (p=0.009). Palivizumab decreased respiratory symptoms such as cough, rhinorrhea, and fever in patients with older siblings (p 0.05). Conclusions : In this study, palivizumab administration was effective in preventing RSV infection in infants with older siblings. Expanding palivizumab-prophylaxis administration to infants with older siblings may be effective in the prevention of upper respiratory infections.

Keywords

References

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