• 한국응급구조학회지
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• 제9권1호
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• pp.5-13
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• 2005

Purpose : The purpose of this study was to investigate dual gender identity, masculine gender identity, feminine gender identity, undifferentiated gender identity with related to Sex, home environments, parental child-rearing attitude of warmth, parental child-rearing attitude of control, role division of parents and determine predictors for dual gender identity. Method : Study subjects were $6^{th}$ grade of primary students with 2,118. Data was collected from Oct to Nov 2003 by using structured questionnaire. Results : ${\cdot}$ Among the children, 345 had masculine gender identity, 529 had feminine gender identity, 526 had undifferentiated gender identity, and 718 had dual gender identity. ${\cdot}$ There were significant differences in the children's sex, mother's age, father's age, mother's educational level, father's educational level, existence of mother's job, father's job, social economic status, sex of siblings, mother's job satisfaction, family structure, family atmosphere, child-rearing attitude(warmth and control), role division of parents($p{\leq}0.001$) among 4 groups. ${\cdot}$ The significant predictors for dual gender identity were children's sex (OR = 0,196, P =0.001), father's age(OR = 31.053, p = 0.020), mother's educational level(OR = 43,980, p = 0.001), father's job(OR=27.465, p = 0.001), social economic status(OR=O.941, p=0.001), sex of siblings(OR = 0.329, p = 0.005), mother's job satisfaction(OR = 0.673, p =0.001), family structure(OR = 0.887, p = 0.001), family atmosphere(OR = 23.786, p = 0.001), parental Child-rearing attitude of warmth(OR = 8.043, p = 0.001) and child-rearing attitude of control(OR = 0.666, p = 0.005), role division of parents(OR = 3.009, p = 0.001). Conclusions : These findings suggest the necessity of broad understandings about factors which influence dual gender role, and construction of combinative model. Also they suggest parent education for establishment of children's dual gender identity.

• Journal of Genetic Medicine
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• 제11권1호
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• pp.22-26
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• 2014

Maple syrup urine disease (MSUD) is a disorder that involves the metabolism of branched chain amino acids, arising from a defect in branched-chain ${\alpha}$-keto acid dehydrogenase complex. Mutations have been identified in the BCKDHA, BCKDHB, or DBT genes, which encode different subunits of the BCKDH complex. Although encephalopathy and progressive neurodegeneration are its major manifestations, the severity of the disease may range from the severe classic type to milder intermediate variants. We report two Korean siblings with the milder intermediate MSUD who were diagnosed with MSUD by a combination of newborn screening tests using tandem mass spectrometry and family genetic screening for MSUD. At diagnosis, the patients' plasma levels were elevated for leucine, isoleucine, valine, and alloisoleucine, and branched-chain ${\alpha}$-keto acids and branched-chain ${\alpha}$-hydroxy acids were detected in their urine. BCKDHA, BCKDHB, and DBT analysis was performed, and two novel mutations were identified in BCKDHB. Our patients were thought to have the milder intermediate variant of MSUD, rather than the classic form. Although MSUD is a typical metabolic disease with poor prognosis, better outcomes can be expected if early diagnosis and prompt management are provided, particularly for milder forms of the disease.

• 응용통계연구
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• 제23권5호
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• pp.845-855
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• 2010

의학의 여러 분야의 연관성 연구에서 효율성이 높은 방법으로 채택되고 있는 질병-대조 연구계획을 다수 형제 자료에 근거한 유전연관성 연구에 적용하기 위해서는 가족 자료에 근거한 추세 검정통계량이 요구된다. 독립된 개체에 적용하는 Cochran-Armitage 추세 검정통계량은 가족 자료의 경우 제 1종 오류가 보장되지 않으며, 동일 가족의 다수 형제 자료로 인한 공분산을 감안한 추세 검정통계량이 제시되어야 한다. 본 논문에서는 특히 동일 가족의 질병형제수에 따른 가중을 도입하여 질병과 관련된 마커좌위에서의 유전자형 자료가 수집되는 경우에 검정력이 더욱 높게 되는 검정통계량을 제안한다. 예제 가족 자료로 가중을 고려한 경우와 고려하지 않은 경우의 검정통계량을 계산하여 비교한다.

• International Journal of Advanced Culture Technology
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• 제6권3호
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• pp.12-21
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• 2018

This study was a cross-sectional survey of the effects of pregnancy necessity recognition on emotional happiness and mediation effect of health control behavior on it. A total of 200 participants in the study were collected from structured questionnaire online and the data collection was from July $1^{st}$ to July $31^{st}$, 2018. Health control behavior questionnaire was developed by Wallston, K.A., Wallston, B.S. & Devellis, R (1978), Emotional happiness was analyzed by using PANAS (positive and negative affect schedule) developed by Watson, Clark and Tellegen (1988). The collected data were chai-square($X^2$), Pearson correlation, Dummy regression analysis, simple regression analysis, and the mediated effect analysis by SPSS 18.0. As a result, Under statistical significance, there were differences in the recognition of pregnancy necessity were depending on religion, participant's age, number of siblings, thought of optimal marriage age(p<0.05). More siblings, more religious, older age, and more recognized the pregnancy necessity. The analysis of Pearson correlation with the pregnancy necessity, health control behavior, and emotional happiness reveled that it was relevant (p<0.01). Dummy regression analysis showed that people who thought that pregnancy was necessary were 0.700 times more likely to felt emotional happiness that people who thought it was unnecessary (p<0.01). Analysis on the mediation of health control behavior, in which the effects of pregnancy recognition on emotional happiness, showed that it was effect (other people's health control behavior: B:.299, p<0.01, internal health control behavior : B:.217, p<0.05). Based on these results, this study suggested that to promote pregnancy recognition, families with brother and sister should be programmed with recommendations for exercise and alcohol abstinence, religious belief and health control programs.

• 기본간호학회지
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• 제17권4호
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• pp.470-477
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• 2010

Purpose: The purpose of this study was to explore the levels of depression and predictors of depression in middle-school girls. Method: A self-report survey was conducted with 2nd and 3rd grade students in a girls'middle school (N=401) in Pusan. Data were analyzed with descriptive statistics, Pearson correlation, and simultaneous multiple regression using the SPSS program. Results: The mean score for the Center for Epidemiologic Studies-Depression Scale (CES-D) was 20.63. The level of depression was negatively related to problem-solving ability, self-esteem, total household income, school achievement, self-perception of body-image, and satisfaction in relationships with siblings, parents, and friends. A multivariate approach showed that predictors explained 61% of variance in depression. Significant predictors of depression were self-esteem (${\beta}$=-.38), problem-solving ability (${\beta}$=-.34), and satisfaction in relationships with friends (${\beta}$=-.14) and parents (${\beta}$=-.08). Conclusion: The findings suggest that it is important to develop educational programs to increase self-esteem and problem-solving abilities in middle school girls. Considering the high levels of depression in middle school girls, school nurses play an important role in detecting and reducing emotional tension among these students. Nursing interventions, including art therapy, problem-solving counseling, and bibliotherapy could be useful in enhancing self-esteem, problem-solving abilities, and satisfaction in relationship with friends, siblings and parents.

• Journal of Chest Surgery
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• 제43권1호
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• pp.67-72
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• 2010

전체 심장 점액종의 10% 정도가 가족성이며 상염색체 우성 유전을 보인다. 저자들은 21세에 좌심방 점액종 제거술을 받고 6년 후에 우심방과 좌심방에 점액종이 재발한 여자 환자와 26세에 우심실과 우심방에 점액종이 발생하여 제거술을 받은 남동생에서 가족성 점액종의 원인이 되는 PRKAR1A 유전자의 돌연변이(c.537delA; p.Gly180GlufsX26)를 확인하였다. 유전자 검사를 통한 가족성 점액종의 진단은 효과적인 치료계획을 세우는데 도움이 된다. 가족성 점액종의 경우 처음부터 다발성으로 존재할 가능성과 잦은 재발을 고려하여 수술 시 종양의 완전 절제와 수술 후 재발에 대한 추적검사가 필수적이다.

• 대한미생물학회지
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• 제21권2호
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• pp.171-179
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• 1986

The HLA class II region encodes a series of polymorphic glycoproteins that form cell surface heterodimers each consisting of one $\alpha$ and one $\beta$ chain. Thess class II molecules are encoded by genes clustered within three loci. DP, DQ, and DR are functfonally implicated as regulatory signals in intercellular communication during the immune resposes. The phenotypic hallmark of the HLA complex is a high degree of structural and functional polymorphism. Detailed analysis. of such polymorphisms should aid in understanding the molecular basis for associations between HLA and diseases. We have used techniques of restriction enzyme fragment analysis by Southern blotting to investigate polymorphisms associated with DQ $\beta$ class II genes on haplotypes expressing the HLA-DR4 and -DQw3 specificities. The endonucleases Hind III and Bam HI were used to identify a specific DQ $\beta$ genomic polymorphism that precisely corrresponds with the reactivity of a monoclonal antibody A-10-83, previously shown to define a serologic split of DQw3. This study identifies two allelic DQ va. riants. DQw3.1 and DQw3.2. We used these specific genotypic markers to investigate the genomic basis of the association of DR4 with insulin-dependent diabetes mellitus(IDDM) and seropositive juvenile rheumatoid arthritis(JRA). The DR4 positive IDDM demonstrate the predominant expression of DQw3.2 and the very rare expression of DQw3.l. However, in haplotype matched siblings from two IDDM families, all of the DR4 positive siblings display a IDDM-associated DQw3.2 allele. Thus, both affected and healthy individuals can carry the same haplotypes and genomic markers, demonstrating that thess specific allelic variants are genetic elements that indicate a increased risk of IDDM but are not in fact disease specific. We contrasted this result with a similar analysis of patients with another DR4-associated disease, JRA. In contrast to the preponderance of the DQw3.2 allele in IDDM, the JRA patients expressed either the DQw3.1 or the DQw3.2 allele and sometimes both, without apparent association with disease expession. The different genomic markers reported here within HLA-DQ region potentially an analysis of HLA-associated function and disease susceptibility.

• 가정과삶의질연구
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• 제32권2호
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• pp.131-141
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• 2014

This study attempted to achieve an understanding of how ever-single women in their 40s and 50s deconstructed and restructured on marriage and family. For this aim, this study adopted a qualitative method. The participants were 13 single women in their 40s and 50s who had never been married. In-depth individual interviews were carried out, focusing on ever-single women's views about marriage and family. The result of theme analysis indicated that the participants considered marriage as an unfavorable lifestyle for women. The participants could be split into two types based on their perspectives on marriage. The first type had a universal concept of marriage. In other words, they believed that when they growup, they should be married women. The other type had a negative concept of marriage because of their parents'unhappy marriage. Despite their view of marriage, all of the participants recognized marriage as a patriarchal structure. Also, they had a strong sense of responsibility to their original families. They had a broad definition of family, so they considered their parents, siblings, and siblings' family members as their family. In addition, they interacted with their families, especially their mothers, who did not have control over their lives but supported them and showed interest in their lives. Like this, the participants maintained their views of married life and family without changing after their single status and had close relationships with their family members.

• Child Health Nursing Research
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• 제8권2호
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• pp.164-173
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• 2002

The vision disturbances of school-age children has been recognized as and important school health problem. The purpose of this study is to describe the current status of the visual health and to explore the related factors for the decrease in visual acuity in the elementary school age children. The study subjects were 697 children (Boys: 338, Girls: 359) of 4th to 6th grade in two school in urban area. The visual acuity data of the school health examination in 1999 and 2000 were utilized for analysis. The questionnaire for children and parents was used for survey. The findings were as follows. 1. The prevalance rate of the children with the visual acuity less than 0.7 on the left eye were 26.84％ ( Grade 4), 31.30％ (Grade 5), and 38.39％ (Grade 6). The rate on the right eye were 28.31％ (Grade4), 30.37％ (Grade 5), and 37.92％ (Grade 6). There was a significant difference in the rate of the visual acuity less than 0.7 according to grade (p<.01). 2.The rate of visual acuity decrease was 40.12％. 3. The factors related to the decrease in the visual acuity were grade, sex, genetic factor, posture, and the awareness of the visual acuity. There was more decrease in the visual acuity when the children were in higher grade (O.R= 1.06), girls (O.R=2.29). Children having parents with better vision (Father: O.R=1.26; Mother O.R= 1.25) showed better vision. On the other hand, when the children have siblings with glasses, there was more decrease in the visual acuity (O.R=2.31). Students with good posture during study (sitting on the chair) and watching TV to the lower direction showed less decrease in the visual acuity. Also, when the students know their visual acuity, the rate of decrease were lower. The variables which odds ratio were statistically significant were sex (p<.01), siblings with glasses (p <.01), and awareness of visual acuity (p<.01).

• 한국학교보건학회지
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• 제22권1호
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• pp.17-32
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• 2009

Purpose: This study was performed to investigate the attitude and recognition on how to describe the elderly of elementary school students. Methods: The subject of this study was total 806 students of 4, 5, 6 grade at 2 elementary schools in Gyunggi-do. The data were collected through self-reporting questionnaires for a month. Results: First, the score of attitude about the elderly was 107.8 and image score was the highest. Second, there were significant differences in the attitude about the elderly according to grade, birth order of siblings, domestic atmosphere, and economic status, domestic education on respect about the elderly, and education about the elderly at school. Third, there were significant differences in the attitude about the elderly according to parent-grandparent relationship, health and economic status of grandparents, meeting frequency with grandparents. Fourth, the score of word recognition about the elderly was 43.3 and social score was the highest. fifth, there were significant differences in recognition on how to describe the elderly according to grade, birth order of siblings of students and parents, domestic atmosphere, and economic status, domestic education on respect about the elderly. Sixth, there were significant differences in recognition on how to describe according to parent-grandparent relationship, health status and economic status of grandparents, meeting frequency with grandparents. Lastly, The attitude and recognition about the elderly showed significant positive relationship. Conclusion: We should provide qualitative education programs to improve the attitude and recognition about the elderly of elementary school students.