• Structural Engineering and Mechanics
• /
• v.64 no.3
• /
• pp.301-310
• /
• 2017

For further development of passive control systems to dissipate larger seismic energy and prevent the structures from earthquake losses, this paper proposes an innovative two-level control system to improve behavior of chevron braced steel frames. Combining two Knee Braces, KB, and a Vertical Link Beam, VLB, in a chevron braced frame, this system can reliably sustain main shock and aftershocks in steel structures. The performance of this two-level system is examined through a finite element analysis and quasi-static cyclic loading test. The cyclic performances of VLB and KBs alone in chevron braced frames are compared with that of the presented two-level control system. The results show appropriate performance of the proposed system in terms of ductility and energy dissipation in two different excitation levels. The maximum load capacity of the presented system is about 30% and 17% higher than those of the chevron braced frames with KB and VLB alone, respectively. In addition, the maximum energy dissipation of the proposed system is about 78% and 150% higher than those of chevron braced frames with VLB and KB respectively under two separate levels of lateral forces caused by different probable seismic excitations. Finally, high performance under different earthquake levels with competitive cost and quick installation work for the control system can be found as main advantages of the presented system.

• IMMUNE NETWORK
• /
• v.8 no.2
• /
• pp.39-45
• /
• 2008

Background: Down regulation of major histocompatibility complex class II transactivator (CIITA) has been identified as a major factor of immunosuppression in sepsis and the level of CIITA expression inversely correlates with the degree of severity. However, it has not been fully elucidated whether the lower expression of CIITA is a cause of disease process or a just associated sign. Here we determined whether the CIITA deficiency decreased survival rate using murine sepsis model. Methods: Major histocompatibility complex class II (MHC-II) deficient, CIITA deficient and wild type B6 mice were subjected to cecal ligation puncture (CLP) surgery. CIITA and recombination activation gene (RAG)-1 double deficient mice were generated to test the role of lymphocytes in CIITA-associated sepsis progression. Results: Sepsis mortality was enhanced in CIITA deficient mice, not by impaired bacterial clearance resulted from CD4 T cell depletion, but hyper-inflammatory response such as excessive release of a pro-inflammatory cytokine, high-mobility group box 1 (HMGB1). Conclusion: Our results demonstrate that CIITA deficiency affects the course of sepsis via the unexpected function of CIITA, regulation of cytokine release.

• The Journal of Korean Medicine
• /
• v.23 no.2
• /
• pp.139-150
• /
• 2002

OBJECTIVES : Schizandra chinensis is well known for its efficacy at liver function reinforcement, relieving thirst and recovery from fatigue. In this study, we examined the effects of sports drink containing Schizandra chinensis on serum metabolic substrate, electrolyte, stress indicators, related-enzyme and exercise performance, rectal temperature, and heat shock proteinb70 (HSP70). METHODS : Elite long-distance runners (male, 21.3yrs, n=16) were selected and divided into two groups; an experimental group (EXP, n=8) and a control group (CON, n=8). A beverage containing Schizandra chinensis was supplemented 3 times per day to EXP for 4 weeks. Serum biochemical elements (glucose, lactate, total cholesterol, triglyceride, high density lipoprotein cholesterol, glutamate oxaloacetate transaminase, glutamate pyruvate transaminase, creatinine, creatine phosphokinase, lactate dehydrogenase, blood urea nitrogen, Na, K, Cl) were analyzed by auto blood analyzer. Exercise performance was measured by treadmill exercise test, HSP70 was detected by electrophoresis and Western blotting, and rectal temperature was measured by rectal temperature probe. RESULTS : Administration of the beverage increased significantly the rest level of blood Na, Cl and glucose and decreased significantly lactate dehydrogenase, glutamate oxaloacetate transaminase. No difference was found in exercise performance, rectal temperature increment or HSP70 concentration between groups. CONCLUSIONS : Administration of a sports drink containing Schizandra chinensis altered blood glucose, lactate dehydrogenase, glutamate oxaloacetate transaminase, Na and Cl levels.

• 유체기계공업학회:학술대회논문집
• /
• 2005.12a
• /
• pp.613-616
• /
• 2005

In general, the hollow jet valve, the fixed cone valve had been used for the urgency released or maintenance of the flow rate. Nowadays, the butterfly valve, the gate valve are applied in economic performance and operation maintenance more than the hollow jet valve, the fixed cone valve. However, in the case of butterfly valve, it should be required the strict application standard to the cavitation coefficient because the structural axis and disk were situated in pipe channel and the occurring the shock problem by Karman Vortex. And, the judgment data for choice were slight lowdown in water supply and drainage facilities standard or Japanese penstock technology standard, various standard of KOWACO etc. Therefore. there were investigated the valve inside phenomenon (cavitation, disk chattering, vibration) by velocity of flow and the stability examination of body by high velocity of flow through flow scale model test using the numerical analysis and PIV to establish the applicable extensibility of the butterfly valve for the urgency released valve.

• The Korean Journal of Physiology and Pharmacology
• /
• v.3 no.2
• /
• pp.231-236
• /
• 1999

This study was performed to examine 1) Whether hypothermic cardiac arrest produces myocardial HSP72 expression; 2) And if, whether it serves to protect the heart against the subsequent hypothermic arrest. In the present study, neonatal rats were placed in an icebath to induce hypothermia. To determine whether hypothermic cardiac arrest produces myocardial HSP72, experimental animals were subjected to 10-min hypothermic insult before the extraction of the heart. The intervals between the insult and extraction were 1 (1 HR), 4 (4 HR), 8 (8 HR), 24 (24 HR) or 72 (72HR) hours. A minimal amount of HSP72 was detected in control, 1 HR and 72 HR groups. In contrast, 8 HR and 24 HR groups showed a significant level of HSP72 expressions. To assess the cardioprotective effect of HSP72 against hypothermic cardiac arrest, we compared the proportion of recovery from the arrest between control and preconditioned (PREC) animals. Control animals were subjected to 20-min hypothermic insult, while PREC group was preconditioned by 10-min hypothermic insult 8 hours before the 20-min test hypothermic insult. Resuscitation rate from cardiac arrest induced by the 20-min hypothermic insult in PREC group was significantly higher than that in controls. These results suggest that the cardioprotective effect of hypothermic preconditioning is associated with an increase in HSP72 expression.

• Explosives and Blasting
• /
• v.27 no.1
• /
• pp.1-6
• /
• 2009

The strainer can be clogged by dusts in a well. As a result, the permeability of a strainer is extremely reduced. This paper is intended to propose a cleaning method of strainer using blasting pressure of the detonating cords and to examine the applicability of this method. The pressure range that was not expected to affect the strainer was estimated. Test results of $3,000\;kg/cm^2$ pressure with a diameter of 12 cm without damage to the strainer was found to be appropriate. The mortar attached to the strainer was almost completely eliminated.

• Transactions of the Korean Society for Noise and Vibration Engineering
• /
• v.19 no.3
• /
• pp.243-250
• /
• 2009

The clutch with torsional damper is installed on a passenger car with manual transmission, which not only transmits the power generated by engine to the transmission but also absorbs the shock and vibration from the engine. The torsional damper in the clutch dissipates the torsional vibration energy and eliminates the resonance in the driveline but high damping in the damper causes the increase of the vibration level which is against the comfort and durability. In this study, a dynamic model for the passenger car driveline with manual transmission was developed to investigate the vibration and the effects of characteristics of the driveline. With the dynamic model, the vibration characteristics of driveline were examined by the mode analysis and driving simulation, and the effects of hysteresis torque and spring constant were investigated. The vehicle tests with prototype torsional dampers were preformed and the test results showed good agreements with the simulation.

• Journal of the Korean Society for Precision Engineering
• /
• v.16 no.6
• /
• pp.141-147
• /
• 1999

Optical disk technology with a laser beam for data recording and retrieval is one of the most promising route for high density information storage in multimedia era. As the storage density and data transfer rates are increased, mechanical issues, mainly noise and vibration, become critical. Rubber materials are extensively used in various machine design application, mainly for vibration/shock/noise control devices. Over the years an enormous effort has been put into developing procedures to provide properties of rubber components with complex shape and under pre-deformed state. In this paper, non-linear large deformations of a rubber mount for optical disk drive were investigated using the finite element method. A tension test of rubber material was performed, to calculate a strain energy function. According to the pre-deformed state, the variation of rubber mount stiffness were calculated and the reliability of numerical results were checked by compared with the measuring the deflection values. Also, the effects of the pre-deformed rubber mount on the system dynamic characteristics were investigated and the relation between the static stiffness variation of rubber mount and the natural frequence variation of system was discussed.

• Journal of Chest Surgery
• /
• v.21 no.2
• /
• pp.373-378
• /
• 1988

Since the introduction of percutaneous; transluminal coronary angioplasty[PTCA] by Grunt-zig in 1977, this is widely used in some patients with coronary artery disease and is an effective alternative to surgery for many patients. Indications for emergency coronary artery bypass graft[CABG] after PTCA are prolonged chest pain, worsening of coronary artery obstruction, "current of injury" by electrocardiogram, cardiogenic shock, and in a lesser incidence, ventricular fibrillation, coronary artery dissection[without obstruction], heart block, and intractable cardiac arrest. Recently, we have experienced one case of emergency CABG following unsuccessful PTCA. The patient was 54 year-old male and admitted with complaint of angina pectoris. The routine electrocardiogram revealed within normal limit. The treadmill test revealed severe chest pain after 2 min. exercise. Coronary cineangiogram revealed 95% segmental stenosis of the proximal right coronary artery. Our cardiologist was planned PTCA. During PTCA, severe chest pain and ischemic pattern on electrocardiogram were developed. But they were not relieved even by morphine and nitroglycerin till 90 min. So we performed emergency single coronary artery bypass graft from aorta to proximal right coronary artery with great saphenous vein. The patient had an excellent postoperative recovery and was free from anginal attack. He has shown striking improvement in general status[NYHA functional class 1] during 6 months after operation.operation.

• Biomolecules & Therapeutics
• /
• v.5 no.4
• /
• pp.402-411
• /
• 1997

ln order to investigate pharmacological properties of New Woohwangchungsimwon Liquid (NCL) and Woohwangchungsimwon Liquid (CL), effects of NCL and CL on cerebral ischemia and central nervous system were compared. Cerebral ischemia insult was performed using unilateral carotid artery occlusion in Mongolian gerbils. The histological observations showed a preventive effect of NCL and CL treatments with ischemia-induced brain damage. The ATP in brain tissue was decreased in vehicle-treated ischemic gerbils. This decrease was prevented by CL treatment. In contrast to what was seen with ATP, the lactate and lipid peroxide were both elevated in vehicle-treated ischemic gerbils. This elevation was inhibited by NCL and CL treatments. While NCL and CL had no effects on the hexobarbital-induced sleeping time, they prevented the seizures induced by electric shock and pentetrazol. NCL and CL showed sedative effect in rotarod and spontaneous activity test. Respiration rate and depth were increased at the high dose of NCL and CL. Furthermore, NCL and CL showed anti-stress effect. Our findings suggest that the pharmacological profile of NCL on cerebral ischemia and central nervous system are similar to that of CL.