Pharmacological Actions of New Woohwangchungsimwon Liquid on Cerebral Ischemia and Central Nervous System

신우황청심원액의 뇌허혈 및 중추신경계에 관한 약효연구

  • 조태순 (성균관대학교) ;
  • 이선미 (성균관대학교) ;
  • 이은방 (서울대학교 천연물 과학연구소) ;
  • 조성의 (서울대학교 천연물 과학연구소) ;
  • 김용기 (조선무약(주)생명과학연구소) ;
  • 신대희 (조선무약(주)생명과학연구소) ;
  • 박대규 (조선무약(주)생명과학연구소)
  • Published : 1997.12.01

Abstract

ln order to investigate pharmacological properties of New Woohwangchungsimwon Liquid (NCL) and Woohwangchungsimwon Liquid (CL), effects of NCL and CL on cerebral ischemia and central nervous system were compared. Cerebral ischemia insult was performed using unilateral carotid artery occlusion in Mongolian gerbils. The histological observations showed a preventive effect of NCL and CL treatments with ischemia-induced brain damage. The ATP in brain tissue was decreased in vehicle-treated ischemic gerbils. This decrease was prevented by CL treatment. In contrast to what was seen with ATP, the lactate and lipid peroxide were both elevated in vehicle-treated ischemic gerbils. This elevation was inhibited by NCL and CL treatments. While NCL and CL had no effects on the hexobarbital-induced sleeping time, they prevented the seizures induced by electric shock and pentetrazol. NCL and CL showed sedative effect in rotarod and spontaneous activity test. Respiration rate and depth were increased at the high dose of NCL and CL. Furthermore, NCL and CL showed anti-stress effect. Our findings suggest that the pharmacological profile of NCL on cerebral ischemia and central nervous system are similar to that of CL.

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