• The Korean Journal of Pain
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• v.10 no.2
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• pp.235-240
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• 1997

Hemifacial spasm is a distressing condition characterized by involuntary, intermittent, unilateral twitching of, all or parts, of the muscles innervated by facial nerve. This ailment is most common among middle-aged women. Neither causative agent nor reliable treatment has been established because etiology of idiopathic hemifacial spasm has remained undefined to date. This report describes two cases of hemifacial spasm treatment by injection of Botulinum toxin. An injection of Botulinum toxin provided relief of hemi facial spasm. Botulinum toxin therapy is an effective and convenient treatment of hemifacialspasm.

• Proceedings of the Korean Society of Computer Information Conference
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• 2010.07a
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• pp.499-502
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• 2010

인터넷의 발달로 인한 수많은 정보의 공유는 지식 정보사회의 발전을 가져왔다. 이러한 정보사회의 발전과 동시에 표절과 같은 새로운 지식 범죄도 급증하고 있다. 표절은 연구의 정직성과 창의성을 떨어뜨리고 학문의 발전을 저해하는 요소이다. 이러한 표절을 근절하기 위해서 그동안 많은 방법들과 시스템들이 제시되었다. 이중 자연어로 구성된 구조가 없는 일반 문서의 표절을 검사하는 방법은 지문법을 이용하였다. 지문법과 같이 통계적인 방법을 이용한 유사도 검사 방법은 문서 대 문서 전체를 비교하기 때문에 부분적 유사성, 즉 문장이나 문단 단위의 비교를 할 수 없는 단점이 있다. 본 논문에서 제시하는 시스템은 자연어로 이루어진 일반문서 중 특별한 문서의 구조 정보를 가질 수 있는 일반 텍스트 문서를 대상으로 유사도를 측정하였다. 즉 텍스트 문서 구조를 AST 형태의 자료구조로 표시하고 이를 이용하여 사용자가 원하는 부분 또는 전체 유사도 측정 방법을 제시한다.

• Transactions of the Korean Society of Pressure Vessels and Piping
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• v.6 no.2
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• pp.9-15
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• 2010

US NRC issued rulemaking of 10CFR50.55a to perform the Perservice and Inservice inspection for Reactor Vessel Head Penetration Nozzle of US Nuclaer plant. The rulemaking was required the EPRI Demonstration to verify the NDE technique performing special Ultrasonic examination. In order to meet this requirement, the UT and ECT procedures was demonstrated and the NDE personnel were qualified by EPRI. In this paper, the NDE technique and analysis method are described the Preservice inspection for the Palo Verde #1/2/3 Replacement Reactor Vessel Head Penetration Nozzle using the qualified procedures and personnel.

• Proceedings of the Korean Society of Crop Science Conference
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• 2004.04a
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• pp.134-135
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• 2004

• Korean Journal of Veterinary Research
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• v.60 no.4
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• pp.241-244
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• 2020

Three neonatal pigs from the same litter in a domestic farm were born with skin lesions. Grossly, multiple well-circumscribed, round papules distributed over the skin of the three piglets. Two piglets were submitted for a diagnosis of skin disease. Microscopically, epidermal hyperplasia with ballooning degeneration of stratum spinosum keratinocytes was observed. Some keratinocytes contained eosinophilic intracytoplasmic inclusions and a central nuclear vacuole and chromatin margination. Swinepox (SWP) virus was detected by polymerase chain reaction and nucleotide sequencing, and Staphylococcus hyicus was isolated in skin lesions. Based on the gross findings and laboratory results, these piglets were diagnosed with congenital SWP with a secondary staphylococcal infection.

• Journal of Society of Preventive Korean Medicine
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• v.12 no.3
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• pp.1-8
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• 2008

Background : 'Yangsaeng' means health preservation concept in TKM(Traditional Korean Medicine). Health promotion using by traditional medicine was increased recently, but, has little measurement tools in evaluating traditional health care program. This study accomplished to analyze internal consistency reliability by Hong-Cheon survey data Method : Internal consistency reliability analysis within survey items Result : There was little reliability in mind and sexual life yangsaeng factor(Cronbach's alpha value 0.325, 0.273), higher reliability in lifestyle yangsaeng factor(0.718). And reliability was various within items according to age and health insurance type.

• Toxicological Research
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• v.20 no.3
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• pp.213-223
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• 2004

This work aimed to study the effectiveness of cellular oxidative parameter (malondial-dehyde, protein carbonyl, and 8-hydroxy-2'deoxyguanosine). The experimental groups were aluminum treated rats and control rats. Aluminum treatd rats were given intraperitoneally aluminum nitrate nonahydrate ($Al^{3+}$, 0.2 mmol/kg) daily for 30 days except Sunday. Control rats were injected 1 ml of saline. After the dose, rats were decapitated and hippocampus and cerebral cortex were removed. The measured parameters were tissue malondialdehyde (MDA, index of lipid peroxidation), protein carbonyl (index of protein oxidation), 8-hydroxy-2'-deoxy-guanosine (8-OHdG, index of DNA oxidation), reduced glutathione (GSH) levels as well as glutathione reductase (GR) and catalase. AI concentrations in the tissues were also measured. All results were corrected by tissue protein levels. The results were as followed; 1. The concentrations of AI in the cortex and hippocampus were significantly higher in the AI-treated rats than in the control rats. 2. Antioxidative enzyme's activity, catalase and GR, were significantly higher in the AI-treated rats than the control rats. GSH levels were also higher in the AI-treated rats. 3. MDA, protein carbonyl, and 8-OHdG concentration of AI-treated rats were significantly higher than those of control rats. 4. The concentrations of antioxidants, and oxidative stress parameter were correlated with the concentrations of AI in hippocampus and cerebral cortex. Catalase and GR activity were also correlated with the concentration of AI. Based on these results, it can be suggested that intraperitoneally injected AI was accumulated in the brain and induced the increase of antioxidant levels and antioxidative enzyme activity. Also, the oxidative products of cellular macromolecules are significantly related to tissue AI concentration. Therefore MDA, protein carbonyl, and 8-OHdG are useful markers for oxidative stress on cellular macromolecules.

• KSBB Journal
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• v.19 no.6 s.89
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• pp.437-440
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• 2004

To determine the inhibition of tyrosinase activity and melanogenesis, gardenia fruit was extracted initially with $95\%$ ethanol (w/v), The ethanol extract was fractionated subsequently with hexane, chloroform and ethyl acetate in that order. The inhibitory effect of the ethanol extract on tyrosinase activity was higher than water extract. When 10 mg/mL of ethyl acetate fraction was applied, the inhibition ratio of tyrosinase activity was much higher ($99.7{\pm}0.1\%$) than that of arbutin. The inhibition of melanogenesis using B16F10 melanoma cell, the ethanol extract also showed higher inhibitory effect than water extract. The highest inhibitory activity of melanogenesis was also shown in ethyl acetate fraction ($89.1{\pm}1.4\%$ at the cone. of $100\;{\mu}g/mL$). These results suggests that gardenia extracts might be used to be a potential agents for whitening.

• Biomolecules & Therapeutics
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• v.27 no.2
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• pp.193-200
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• 2019

Ceramide metabolism is known to be an essential etiology for various diseases, such as atopic dermatitis and Gaucher disease. Glucosylceramide synthase (GCS) is a key enzyme for the synthesis of glucosylceramide (GlcCer), which is a main ceramide metabolism pathway in mammalian cells. In this article, we developed a liquid chromatography-tandem mass spectrometry (LC-MS/MS) method to determine GCS activity using synthetic non-natural sphingolipid C8-ceramide as a substrate. The reaction products, C8-GlcCer for GCS, could be separated on a C18 column by reverse-phase high-performance liquid chromatography (HPLC). Quantification was conducted using the multiple reaction monitoring (MRM) mode to monitor the precursor-to-product ion transitions of m/z $588.6{\rightarrow}264.4$ for C8-GlcCer at positive ionization mode. The calibration curve was established over the range of 0.625-160 ng/mL, and the correlation coefficient was larger than 0.999. This method was successfully applied to detect GCS in the human hepatocellular carcinoma cell line (HepG2 cells) and mouse peripheral blood mononuclear cells. We also evaluated the inhibition degree of a known GCS inhibitor 1-phenyl-2-decanoylamino-3-morpholino-1-propanol (PDMP) on GCS enzymatic activity and proved that this method could be successfully applied to GCS inhibitor screening of preventive and therapeutic drugs for ceramide metabolism diseases, such as atopic dermatitis and Gaucher disease.

• Journal of Physiology & Pathology in Korean Medicine
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• v.16 no.5
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• pp.1055-1059
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• 2002

Liuweidihuang-tang has been traditionally used for the treatment of delayed mental and physical development in children, complications of diabetes. and glomerulonephritis. In the present study, the effect of Liuweidihuang-tang on cell proliferation in the dentate gyrus of alcohol-intoxicated Sprague-Dawley rats was investigated via 5-bromo-2' -deoxyuridine (BrdU) immunohistochemistry. Alcohol administration was shown to decrease the number of BrdU-positive cells in the dentate gyrus, while Liuweidihuang-tang treatment increased new cell formation in the dentate gyrus under normal conditions and alcohol intoxication. It was thus demonstrated that aqueous extract of Liuweidihuang-tang exerts a protective effect against alcohol-induced decrease in new cell formation.